Use of centromeric and telomeric DNA probes in in situ hybridization for differentiation of micronuclei induced by lomefloxacin.

abstract：:Coal tar (CT) is a thick black liquid produced as a by-product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of polycyclic aromatic compounds, including a wide range of polycyclic aromatic hydrocarbons (PAHs), many of which are genotoxic and carcinogenic. CT is used in so...

journal_title：Environmental and molecular mutagenesis

authors： Long AS,Watson M,Arlt VM,White PA

更新日期：2016-08-01 00:00:00

abstract：:Cigarette smoking leads to various detrimental health outcomes. Tobacco companies produce different brands of cigarettes that are marketed as reduced harm tobacco products. Early examples included "light" cigarettes, which differ from regular cigarettes due to filter ventilation and/or differences in chemical constitu...

journal_title：Environmental and molecular mutagenesis

authors： Yauk CL,Williams A,Buick JK,Chen G,Maertens RM,Halappanavar S,White PA

更新日期：2012-05-01 00:00:00

abstract：:National and international regulatory agencies historically have used genotoxicity information as part of a weight-of-evidence approach to evaluate potential human carcinogenicity. Additionally, some agencies consider heritable mutation a regulatory endpoint. Furthermore, genotoxicity has the potential to contribute t...

journal_title：Environmental and molecular mutagenesis

authors： Cimino MC

更新日期：2006-06-01 00:00:00

abstract：:Early results from two transgenic mouse mutation assays, Big Blue [Kohler SW et al. (1991): Proc Natl Acad Sci USA 88:7958-7962] and Muta Mouse [Myhr BC (1991): Environ Mol Mutagen 18:308-315], raised questions about appropriate study design and methods for statistical analysis. First, there were a number of potential...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Thompson ED

更新日期：1994-01-01 00:00:00

abstract：:In the present work we analyse some properties of the pso4-1 (= xs9) mutant of the yeast Saccharomyces cerevisiae, which is blocked in both reverse mutation and recombination. We have applied the "apparent survival test" as a method to characterize putative inducible error-prone repair activities related to the PSO4 g...

journal_title：Environmental and molecular mutagenesis

authors： Severgnini A,Lillo O,Nunes E

更新日期：1991-01-01 00:00:00

abstract：:Aldehydes are widespread environmental and industrial compounds, able to stimulate a range of adverse health effects (e.g., general toxicity, allergenic reactions, mutagenicity, and carcinogenicity). We have previously presented quantitative structure-activity relationships (QSARs) for the genotoxicity of simple and a...

journal_title：Environmental and molecular mutagenesis

authors： Benigni R,Conti L,Crebelli R,Rodomonte A,Vari' MR

更新日期：2005-12-01 00:00:00

abstract：:The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow D...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Andrews JL,deBoer JG,Young R,Gibson DP,Walker VE

更新日期：1999-01-01 00:00:00

abstract：:DNA mutations play a crucial role in the origins of cancer, and the clonal expansion of mutant cells is one of the fundamental steps in multistage carcinogenesis. In this study, we correlated tumor incidence in B6C3F1 mice during the period after exposure to N-ethyl-N-nitrosourea (ENU) with the persistence of ENU-indu...

journal_title：Environmental and molecular mutagenesis

authors： Nakayama T,Sawai T,Masuda I,Kaneko S,Yamauchi K,Blyth BJ,Shimada Y,Tachibana A,Kakinuma S

更新日期：2017-10-01 00:00:00

abstract：:The term "the DNA damage response" (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair. More recent discoveries of signal ...

journal_title：Environmental and molecular mutagenesis

authors： Ljungman M

更新日期：2010-10-01 00:00:00

abstract：:Clustered damage induced by ionizing radiation--two or more oxidized bases, abasic sites, or strand breaks within a few DNA helical turns--have been postulated to be major lethal and/or mutagenic sites. Although they have recently been shown to be induced in genomic DNAs by ionizing photons and particles, little is kn...

journal_title：Environmental and molecular mutagenesis

authors： Sutherland BM,Bennett PV,Weinert E,Sidorkina O,Laval J

更新日期：2001-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-infected pregnant women are administered nucleoside-analogue antiretrovirals to reduce maternal-infant viral transmission. The current protocol recommends treating newborns for 6 additional weeks postpartum. The treatment is effective, but the risk of drug-induced chromosomal damage ...

journal_title：Environmental and molecular mutagenesis

authors： Bishop JB,Witt KL,Tice RR,Wolfe GW

更新日期：2004-01-01 00:00:00

abstract：:Alkylating treatments predominantly induce G: C = greater than A:T transitions, consistent with the predicted significance of the miscoding potential of the O6-alG lesion. However, the frequency and distribution of these events induced by any one compound may be diagnostic. SN1 agents that act via an alkyldiazonium ca...

journal_title：Environmental and molecular mutagenesis

authors： Horsfall MJ,Gordon AJ,Burns PA,Zielenska M,van der Vliet GM,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:Three carbamate insecticides (propoxur, methomyl, and aldicarb) were evaluated for their ability to induce micronuclei (MN) in vitro using cultured Chinese hamster ovary (CHO) cells, and in vivo in mouse bone marrow erythrocytes. In vitro, all three insecticides induced a significant increase in micronucleated binucle...

journal_title：Environmental and molecular mutagenesis

authors： Wei LY,Chao JS,Hong CC

更新日期：1997-01-01 00:00:00

abstract：:Comparison of spontaneous mutation spectra derived from different transgenic constructs can provide valuable insights for interpreting the mechanisms of spontaneous mutation. In this study, spontaneous mutation frequencies and spectra of the lacI transgene are compared in the liver of C57BL/6, B6C3F1, and BC-1 mice an...

journal_title：Environmental and molecular mutagenesis

authors： Zhang S,Glickman BW,de Boer JG

更新日期：2001-01-01 00:00:00

abstract：:Most women with breast cancer can become pregnant and give birth while undergoing radiation therapy and breastfeeding is generally not contraindicated. The induction of long-lived reactive species in proteins, such as casein by X-ray radiation and DNA damage to unexposed organisms, has been shown when ingesting irradi...

journal_title：Environmental and molecular mutagenesis

authors： Solórzano-Meléndez A,Rodrigo-Alarcón R,Gómez-Meda BC,Zamora-Pérez AL,Ortiz-García RG,Bayardo-López LH,González-Virgen R,Gallegos-Arreola MP,Zúñiga-González GM

更新日期：2021-01-26 00:00:00

abstract：:V(D)J recombinase-mediated recombination between the T-cell receptor (TCR) gamma variable (GV) genes at chromosome 7p15 and the TCR beta joining (BJ) genes at 7q35 leads to the formation of a hybrid TCR gene. These TCR gamma/beta interlocus rearrangements occur at classic V(D)J recombination signal sequences (RSS) and...

journal_title：Environmental and molecular mutagenesis

authors： Ballinger SW,Judice SA,Nicklas JA,Albertini RJ,O'Neill JP

更新日期：2002-01-01 00:00:00

abstract：:Occupational exposure to pesticides in tobacco fields causes genetic damage in farmers. The aim of this study was to analyze tobacco farmers chronically exposed to low doses of pesticides and nicotine (present in the tobacco leaves) in relation to absolute telomere length (aTL), and explore the influence of lifestyle ...

journal_title：Environmental and molecular mutagenesis

authors： Kahl VF,Simon D,Salvador M,Branco Cdos S,Dias JF,da Silva FR,de Souza CT,da Silva J

更新日期：2016-01-01 00:00:00

abstract：:Hypertension is often treated with diuretics, like hydrochlorothiazide (HCTZ). Previous results on the in vitro genotoxicity of HCTZ are equivocal. In the present study, we have evaluated the genotoxicity of HCTZ in cultured human lymphocytes using the Cytokinesis Blocked Micronucleus (CBMN) assay. In addition, micron...

journal_title：Environmental and molecular mutagenesis

authors： Andrianopoulos C,Stephanou G,Demopoulos NA

更新日期：2006-04-01 00:00:00

abstract：:Mitochondria are dynamic organelles that are involved in a number of diverse processes. Most often the mitochondrion is associated with energy generation, but other important processes occur in this organelle such as fatty acid synthesis and amino acid metabolism. Although mitochondria encode less than 40 genes, all o...

journal_title：Environmental and molecular mutagenesis

authors： Moore A,Golden A

更新日期：2009-10-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs), which are widely used as flame retardants, are considered persistent organic pollutants. To date, the available toxicological data on PBDEs are limited and were primarily obtained by studying technical blends. The present study was undertaken to investigate the genotoxicity of t...

journal_title：Environmental and molecular mutagenesis

authors： Evandri MG,Mastrangelo S,Costa LG,Bolle P

更新日期：2003-01-01 00:00:00

abstract：:Mitochondrial dysfunction is a global term used in the context of "unhealthy" mitochondria. In practical terms, mitochondria are extremely complex and highly adaptive in structure, chemical and enzymatic composition, subcellular distribution and functional interaction with other components of cells. Consequently, alte...

journal_title：Environmental and molecular mutagenesis

authors： Roede JR,Jones DP

更新日期：2010-06-01 00:00:00

abstract：:The 1960s witnessed detailed studies on the genetic properties of a large number of histidine-requiring mutants of Salmonella typhimurium. The early 1970s saw development of selected strains, the Ames strains, for use in rapid, cheap, sensitive, and manipulable tests of chemicals and chemical mixtures for genotoxic ac...

journal_title：Environmental and molecular mutagenesis

authors： Hartman PE

更新日期：1989-01-01 00:00:00

abstract：:Genotoxic effects of therapeutic ultrasound are poorly documented, when compared with the wide use of this physical agent. The aim of this work was to investigate the clastogenic and aneugenic potential of 1 MHz ultrasound, employing intensities (200 and 300 mW/cm2 ) above the cavitational threshold, but in the range ...

journal_title：Environmental and molecular mutagenesis

authors： Udroiu I,Marinaccio J,Bedini A,Giliberti C,Palomba R,Sgura A

更新日期：2018-01-01 00:00:00

abstract：:Big Blue Rat-2 cells were evaluated for mutagenesis and mutational spectra (spontaneous and ethylnitrosourea [ENU]-induced). Survival, mutant frequency, population doubling time, and kinetics of mutant increase (to 120 hr) were determined. Exposures were 100, 200, 400, 600, and 1,000 micrograms ENU/ml. The spontaneous...

journal_title：Environmental and molecular mutagenesis

authors： Zimmer DM,Zhang XB,Harbach PR,Mayo JK,Aaron CS

更新日期：1996-01-01 00:00:00

abstract：:Two freshwater species of planarians, Girardia schubarti Marcus and G. tigrina Girard, were used for measuring chromosome aberration (CA) induction under laboratory conditions. Three genotoxicants were tested: methyl methanesulfonate (MMS), a direct-acting genotoxicant; cyclophosphamide, a metabolism-dependent genotox...

journal_title：Environmental and molecular mutagenesis

authors： Lau AH,Knakievicz T,Prá D,Erdtmann B

更新日期：2007-07-01 00:00:00

abstract：:Nitrous acid (NA) is often presumed to cause base substitutions in organisms with double-stranded DNA as a direct consequence of oxidative deamination of adenine and of cytosine residues. Here we summarize evidence indicating that other mechanisms are involved in the case of NA-induced G/C-->A/T transition mutations. ...

journal_title：Environmental and molecular mutagenesis

authors： Hartman Z,Henrikson EN,Hartman PE,Cebula TA

更新日期：1994-01-01 00:00:00

abstract：:Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and ...

journal_title：Environmental and molecular mutagenesis

authors： Chulasiri M,Bunyapraphatsara N,Moongkarndi P

更新日期：1992-01-01 00:00:00

abstract：:Chlorinated drinking water contains several chlorohydroxyfuranone (CHF) by-products whose contribution to cancer risk is not presently known. 3,4-Dichloro-5-hydroxy-2(5H)-furanone (MCA), 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF), and 3- chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) were studied for th...

journal_title：Environmental and molecular mutagenesis

authors： Mäki-Paakkanen J,Laaksonen M,Munter T,Kronberg L,Komulainen H

更新日期：2001-01-01 00:00:00

abstract：:Heritable mutations may result in a wide variety of detrimental outcomes, from embryonic lethality to genetic disease in the offspring. Despite this, today's commonly used test batteries do not include assays for germ cell mutation. Current challenges include a lack of practical assays and concrete evidence for human ...

journal_title：Environmental and molecular mutagenesis

authors： Singer TM,Yauk CL

更新日期：2010-10-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00