Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields.

abstract：:Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother-to-child transmission of human immunodeficiency virus I. Combinations of AZT and 3'-thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in rodent models and 3TC ...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Shaddock JG,Mittelstaedt RA,Bishop ME,Lewis SM,Lee FW,Aidoo A,Leakey JE,Dunnick JK,Heflich RH

更新日期：2007-04-01 00:00:00

abstract：:Umu test is one of the in vitro genotoxicity test that has been used widely. It was developed as a high-throughput test system using the 96-well microplate. We have previously constructed new umu test strains for the evaluation of genotoxicity of procarcinogenic metabolic products formed by cytochrome P450 (CYP) enzym...

journal_title：Environmental and molecular mutagenesis

authors： Hori H,Hirata D,Fujii W,Oda Y

更新日期：2017-05-01 00:00:00

abstract：:The in vivo Pig-a mutation assay has been adapted for measuring mutation in rats, mice, monkeys, and humans. To date, the assay has been used mainly to assess the mutagenicity of chemicals that are known to be powerful point mutagens. The assay has not been used to measure the biological effects associated with ionizi...

journal_title：Environmental and molecular mutagenesis

authors： Ohtani S,Unno A,Ushiyama A,Kimoto T,Miura D,Kunugita N

更新日期：2012-10-01 00:00:00

abstract：:The aim of this study was to investigate genotoxic effects of lamivudine (an analogue of cytidine) using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. The cells were treated with 75, 100, 125, and 150 microg/ml concentrations of lamiv...

journal_title：Environmental and molecular mutagenesis

authors： Bayram S,Topaktaş M

更新日期：2008-05-01 00:00:00

abstract：:A cross-sectional study was designed to determine whether occupational exposure to a complex mixture of pesticides results in a significant increase of DNA damage in farmers chronically exposed to pesticides in open fields. Leukocytes from 47 agriculture workers exposed to pesticides and 50 controls were evaluated wit...

journal_title：Environmental and molecular mutagenesis

authors： Bhalli JA,Ali T,Asi MR,Khalid ZM,Ceppi M,Khan QM

更新日期：2009-01-01 00:00:00

abstract：:This study presents the first application of an in vivo alkaline comet assay using haemocytes of Drosophila melanogaster larvae. These cells, which play a role similar to that of mammalian blood, can be easily obtained and represent an overall exposure of the treated larvae. To validate the assay, we evaluated the res...

journal_title：Environmental and molecular mutagenesis

authors： Carmona ER,Guecheva TN,Creus A,Marcos R

更新日期：2011-03-01 00:00:00

abstract：:Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically via point mutation. To investigate the MOA for EO-induced mouse lung...

journal_title：Environmental and molecular mutagenesis

authors： Manjanatha MG,Shelton SD,Chen Y,Parsons BL,Myers MB,McKim KL,Gollapudi BB,Moore NP,Haber LT,Allen B,Moore MM

更新日期：2017-04-01 00:00:00

abstract：:The cytotoxicity of streptozotocin (STZ) was investigated in Chinese hamster fibroblast lines (CHO-9 and V79) in comparison to two other alkylating agents, methylnitrosourea (MNU) and ethylnitrosourea (ENU), using cell survival as the endpoint. It was found that V79 cells were far more resistant to methylation induced...

journal_title：Environmental and molecular mutagenesis

authors： Capucci MS,Hoffmann ME,De Groot A,Natarajan AT

更新日期：1995-01-01 00:00:00

abstract：:Tandem-base mutations (TBM) are associated with ultraviolet light and other mutagens. Herein, we report an age- and tissue-specific difference in the frequency of spontaneous TBM in Big Blue transgenic mice. A total of 390 mutants from liver and adipose tissue contained 17 and 4 TBM, respectively, while no TBM were de...

journal_title：Environmental and molecular mutagenesis

authors： Buettner VL,Hill KA,Halangoda A,Sommer SS

更新日期：1999-01-01 00:00:00

abstract：:In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not express cytochrome P450...

journal_title：Environmental and molecular mutagenesis

authors： Yauk CL,Buick JK,Williams A,Swartz CD,Recio L,Li HH,Fornace AJ Jr,Thomson EM,Aubrecht J

更新日期：2016-05-01 00:00:00

abstract：:Clustered damage induced by ionizing radiation--two or more oxidized bases, abasic sites, or strand breaks within a few DNA helical turns--have been postulated to be major lethal and/or mutagenic sites. Although they have recently been shown to be induced in genomic DNAs by ionizing photons and particles, little is kn...

journal_title：Environmental and molecular mutagenesis

authors： Sutherland BM,Bennett PV,Weinert E,Sidorkina O,Laval J

更新日期：2001-01-01 00:00:00

abstract：:Genotoxic effects of therapeutic ultrasound are poorly documented, when compared with the wide use of this physical agent. The aim of this work was to investigate the clastogenic and aneugenic potential of 1 MHz ultrasound, employing intensities (200 and 300 mW/cm2 ) above the cavitational threshold, but in the range ...

journal_title：Environmental and molecular mutagenesis

authors： Udroiu I,Marinaccio J,Bedini A,Giliberti C,Palomba R,Sgura A

更新日期：2018-01-01 00:00:00

abstract：:In industrialized countries, heart disease rates are higher among women after menopause. Recent studies indicate that consumption of phytoestorogens, e.g., isoflavones such as genistein (GE), may have potential cardiovascular health benefits; however, no studies have evaluated the effect of these agents on toxicant-in...

journal_title：Environmental and molecular mutagenesis

authors： Manjanatha MG,Shelton SD,Rhodes BS,Bishop ME,Lyn-Cook LE,Aidoo A

更新日期：2005-01-01 00:00:00

abstract：:DNA damage and its subsequent repair occur heterogeneously throughout the genome, which reflects the nature of the damaging agents, gross chromosomal structure, the specific nucleotide sequence, and transcriptional status. We selected to investigate the repair of DNA damage in an artificial, transgenic situation. Here...

journal_title：Environmental and molecular mutagenesis

authors： Yang H,Kotturi GP,de Boer JG,Glickman BW

更新日期：1999-01-01 00:00:00

abstract：:The phenoxyherbicide and peroxisome proliferator 2-methyl-4-chlorophenoxyacetic acid (MCPA) was tested for its ability to induce sister-chromatid exchanges (SCE) in chick embryos. Erbitox E30 (a commercial formulation containing 28% MCPA sodium potassium salt as active ingredient) was injected into the air chamber in ...

journal_title：Environmental and molecular mutagenesis

authors： Arias E

更新日期：1992-01-01 00:00:00

abstract：:Genetic polymorphisms have been reported in several cytochrome P450 (CYP) genes, including CYP1B1 which metabolically activates procarcinogens present in tobacco to carcinogenic intermediates. This study used a case-control approach in North Indian population to determine associations between genetic variants in CYP1B...

journal_title：Environmental and molecular mutagenesis

authors： Katiyar T,Maurya SS,Hasan F,Singh AP,Khan AJ,Hadi R,Singh S,Bhatt MLB,Parmar D

更新日期：2017-07-01 00:00:00

abstract：:Mitochondrial dysfunction is a global term used in the context of "unhealthy" mitochondria. In practical terms, mitochondria are extremely complex and highly adaptive in structure, chemical and enzymatic composition, subcellular distribution and functional interaction with other components of cells. Consequently, alte...

journal_title：Environmental and molecular mutagenesis

authors： Roede JR,Jones DP

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Recently, high concentrations of arsenic have been documented in ground waters of Southern Assam, India. Indiscriminate smokeless tobacco consumption is a common practice in this region. Correlation between nutritional status and arsenic and smokeless tobacco-induced health effects has not been taken up in h...

journal_title：Environmental and molecular mutagenesis

authors： Das S,Langthasa P,Barhoi D,Upadhaya P,Giri S

更新日期：2018-06-01 00:00:00

abstract：:Malignant gliomas are heterogeneous populations of dynamically interacting cells. Genomic and transcriptional changes define this cellular hierarchy and allow certain tumor cells to co-opt metabolic machinery and adopt gene expression profiles that promote cellular reprogramming. Resultant expansion of privileged subp...

journal_title：Environmental and molecular mutagenesis

authors： Baulch JE,Geidzinski E,Tran KK,Yu L,Zhou YH,Limoli CL

更新日期：2016-06-01 00:00:00

abstract：:The accessibility of reactive metabolites to test cells is critical for a genotoxic response. However, sulfo-conjugates formed outside may not readily enter cells, and some metabolites formed by cytochromes P450 (CYPs) may not endure transport. This topic was addressed in the present study, using V79 cells engineered ...

journal_title：Environmental and molecular mutagenesis

authors： Zhu N,Hu K,Li Z,Chen Y,Liu Y

更新日期：2020-02-01 00:00:00

abstract：:The modulating effects of tannic acid (TA) on somatic mutation and mitotic recombination induced by methylmethanesulfonate (MMS), nitrogen mustard (HN2), and mitomycin C (MMC) were evaluated in the standard (ST) cross of the wing spot test in Drosophila melanogaster using co- and posttreatment protocols. It was shown ...

journal_title：Environmental and molecular mutagenesis

authors： Lehmann M,Graf U,Reguly ML,Rodrigues De Andrade HH

更新日期：2000-01-01 00:00:00

abstract：:Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and ...

journal_title：Environmental and molecular mutagenesis

authors： Chulasiri M,Bunyapraphatsara N,Moongkarndi P

更新日期：1992-01-01 00:00:00

abstract：:Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents are well established in clinical use, and numerous repair proteins have been imp...

journal_title：Environmental and molecular mutagenesis

authors： Hlavin EM,Smeaton MB,Miller PS

更新日期：2010-07-01 00:00:00

abstract：:The potential of 1,3-dichloropropene (1,3-DCP) to induce dominant lethal mutations in the germ cells of male CD rats following inhalation exposure was investigated. Groups of 11-week-old males (30 animals/group) were exposed to 1,3-DCP vapors by inhalation at targeted concentrations of 0 (negative control), 10, 60, an...

journal_title：Environmental and molecular mutagenesis

authors： Gollapudi BB,Cieszlak FS,Day SJ,Carney EW

更新日期：1998-01-01 00:00:00

abstract：:The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in s...

journal_title：Environmental and molecular mutagenesis

authors： Szyf M,McGowan P,Meaney MJ

更新日期：2008-01-01 00:00:00

abstract：:Sodium/copper chlorophyllin (CHL) is a water-soluble derivative of chlorophyll that exhibits antimutagenic activity in several short-term genotoxicity assays and inhibits carcinogen-DNA binding in vivo. The effect of CHL pretreatment on the excretion of mutagens in the urine and feces of male Sprague-Dawley rats has b...

journal_title：Environmental and molecular mutagenesis

authors： Dashwood R,Liew C

更新日期：1992-01-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by-products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA-mediated inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This mo...

journal_title：Environmental and molecular mutagenesis

authors： Dad A,Jeong CH,Pals JA,Wagner ED,Plewa MJ

更新日期：2013-10-01 00:00:00

abstract：:We evaluated the effects of urban air pollutants on human nasal mucosa over an 8-month period on 102 subjects living in Florence, Tuscany, Italy. A group of subjects living in a city with a lower level of pollution (Sassari, Sardinia, Italy) was also analyzed. Nasal mucosa cells were harvested by brushing, a noninvasi...

journal_title：Environmental and molecular mutagenesis

authors： Pacini S,Giovannelli L,Gulisano M,Peruzzi B,Polli G,Boddi V,Ruggiero M,Bozzo C,Stomeo F,Fenu G,Pezzatini S,Pitozzi V,Dolara P

更新日期：2003-01-01 00:00:00

abstract：:The DNA repair proteins XPD and XRCC1 are involved in the nucleotide and base excision repair of DNA lesions induced by many tobacco and environmental carcinogens. Common variant alleles at the XPD (312Asn, 751Gln) and XRCC1 (399Gln) loci have been identified and associated with increased risk for lung cancer. We ther...

journal_title：Environmental and molecular mutagenesis

authors： Hou SM,Ryk C,Kannio A,Angelini S,Fält S,Nyberg F,Husgafvel-Pursiainen K

更新日期：2003-01-01 00:00:00