Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage.

abstract：:Nitrous acid (NA) is often presumed to cause base substitutions in organisms with double-stranded DNA as a direct consequence of oxidative deamination of adenine and of cytosine residues. Here we summarize evidence indicating that other mechanisms are involved in the case of NA-induced G/C-->A/T transition mutations. ...

journal_title：Environmental and molecular mutagenesis

authors： Hartman Z,Henrikson EN,Hartman PE,Cebula TA

更新日期：1994-01-01 00:00:00

abstract：:Occupational exposure to wood dust is associated with the occurrence of nasal cancer. In this study, we investigated micronuclei and nuclear changes (NCs: binucleates, karyorrhexis, karyolysis, and the "broken egg" effect) in exfoliated buccal cells of 20 workers exposed to wood dust and 20 age- and sex-matched contro...

journal_title：Environmental and molecular mutagenesis

authors： Celik A,Kanik A

更新日期：2006-12-01 00:00:00

abstract：:This study presents the first application of an in vivo alkaline comet assay using haemocytes of Drosophila melanogaster larvae. These cells, which play a role similar to that of mammalian blood, can be easily obtained and represent an overall exposure of the treated larvae. To validate the assay, we evaluated the res...

journal_title：Environmental and molecular mutagenesis

authors： Carmona ER,Guecheva TN,Creus A,Marcos R

更新日期：2011-03-01 00:00:00

abstract：:We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation detects large chromosomal events, including mitotic recombination, chr...

journal_title：Environmental and molecular mutagenesis

authors： Stambrook PJ,Shao C,Stockelman M,Boivin G,Engle SJ,Tischfield JA

更新日期：1996-01-01 00:00:00

abstract：:The modulating effects of tannic acid (TA) on somatic mutation and mitotic recombination induced by methylmethanesulfonate (MMS), nitrogen mustard (HN2), and mitomycin C (MMC) were evaluated in the standard (ST) cross of the wing spot test in Drosophila melanogaster using co- and posttreatment protocols. It was shown ...

journal_title：Environmental and molecular mutagenesis

authors： Lehmann M,Graf U,Reguly ML,Rodrigues De Andrade HH

更新日期：2000-01-01 00:00:00

abstract：:Molybdenum is an essential element in plants and animals as a cofactor for enzymes. Molybdenum trioxide is used in metallurgical processes, in cosmetics as a pigment, and in contact lens solution, yet limited information is available on molybdenum genotoxicity. In the present study the micronucleus (MN) assay in human...

journal_title：Environmental and molecular mutagenesis

authors： Titenko-Holland N,Shao J,Zhang L,Xi L,Ngo H,Shang N,Smith MT

更新日期：1998-01-01 00:00:00

abstract：:Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppress...

journal_title：Environmental and molecular mutagenesis

authors： Yu LB,Tu YT,Huang JW,Zhang YN,Zheng GQ,Xu XW,Wang JW,Xiao JQ,Christiani DC,Xia ZL

更新日期：2018-07-01 00:00:00

abstract：:The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow D...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Andrews JL,deBoer JG,Young R,Gibson DP,Walker VE

更新日期：1999-01-01 00:00:00

abstract：:The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a cr...

journal_title：Environmental and molecular mutagenesis

authors： do Nascimento NC,Fragoso V,Moura DJ,e Silva AC,Fett-Neto AG,Saffi J

更新日期：2007-12-01 00:00:00

abstract：:This collection of articles was inspired by the long-standing relationship between the Environmental Mutagen Society and Latin American scientists, and by the program for the 39th Environmental Mutagen Society meeting in Puerto Rico in 2008, which included a symposium featuring "South of the border" scientists. This c...

journal_title：Environmental and molecular mutagenesis

authors： Olivero OA,Larramendy M,Soloneski S,Menck CF,Matta J,Folle GA,Zamorano-Ponce E,Spivak G

更新日期：2010-10-01 00:00:00

abstract：:Animal studies have linked perinatal bisphenol A (BPA) exposure to altered DNA methylation, but little attention is given to analyzing multiple physiologically relevant doses. Utilizing the viable yellow agouti (A(vy)) mouse, we examine the effects of developmental exposure through maternal diet to 50 ng BPA/kg (n = 1...

journal_title：Environmental and molecular mutagenesis

authors： Anderson OS,Nahar MS,Faulk C,Jones TR,Liao C,Kannan K,Weinhouse C,Rozek LS,Dolinoy DC

更新日期：2012-06-01 00:00:00

abstract：:The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

journal_title：Environmental and molecular mutagenesis

authors： Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

更新日期：1997-01-01 00:00:00

abstract：:The DNA repair proteins XPD and XRCC1 are involved in the nucleotide and base excision repair of DNA lesions induced by many tobacco and environmental carcinogens. Common variant alleles at the XPD (312Asn, 751Gln) and XRCC1 (399Gln) loci have been identified and associated with increased risk for lung cancer. We ther...

journal_title：Environmental and molecular mutagenesis

authors： Hou SM,Ryk C,Kannio A,Angelini S,Fält S,Nyberg F,Husgafvel-Pursiainen K

更新日期：2003-01-01 00:00:00

abstract：:Two freshwater species of planarians, Girardia schubarti Marcus and G. tigrina Girard, were used for measuring chromosome aberration (CA) induction under laboratory conditions. Three genotoxicants were tested: methyl methanesulfonate (MMS), a direct-acting genotoxicant; cyclophosphamide, a metabolism-dependent genotox...

journal_title：Environmental and molecular mutagenesis

authors： Lau AH,Knakievicz T,Prá D,Erdtmann B

更新日期：2007-07-01 00:00:00

abstract：:The in vivo model Drosophila melanogaster was used here to determine the detrimental effects induced by silver nanoparticles (AgNPs) exposure. The main aim was to explore its interaction with the intestinal barrier and the genotoxic effects induced in hemocytes. The observed effects were compared with those obtained b...

journal_title：Environmental and molecular mutagenesis

authors： Alaraby M,Romero S,Hernández A,Marcos R

更新日期：2019-04-01 00:00:00

abstract：:Combinations of antiretroviral drugs that include nucleoside reverse transcriptase inhibitors (NRTIs) are superior to single-agent regimens in treating or preventing HIV infection, but the potential long-term health hazards of these treatments in humans are uncertain. In earlier studies, our group found that coexposur...

journal_title：Environmental and molecular mutagenesis

authors： Meng Q,Su T,O'Neill JP,Walker VE

更新日期：2002-01-01 00:00:00

abstract：:Phosphine is an important fumigant in the grain industry and has been reported to be genotoxic in occupationally exposed fumigators. This study reports on the effects of phosphine inhalation exposure at up to, and exceeding, occupational relevant levels in a subchronic (0.3, 1.0 and 4.5 ppm, 13 weeks) and a short term...

journal_title：Environmental and molecular mutagenesis

authors： Barbosa A,Rosinova E,Dempsey J,Bonin AM

更新日期：1994-01-01 00:00:00

abstract：:Benzene is an important industrial chemical and widespread environmental pollutant known to induce leukemia and other blood disorders. To be carcinogenic, benzene must be metabolized to produce toxic metabolites. To investigate whether single nucleotide polymorphisms (SNPs) in the metabolic enzyme genes are associated...

journal_title：Environmental and molecular mutagenesis

authors： Xing C,Chen Q,Li G,Zhang L,Zheng M,Zou Z,Hou L,Wang QF,Liu X,Guo X

更新日期：2013-07-01 00:00:00

abstract：:Identification of mutations induced by xenotoxins is a common task in the field of genetic toxicology. Mutations are often detected by clonally expanding potential mutant cells and genotyping each viable clone by Sanger sequencing. Such a "clone-by-clone" approach requires significant time and effort, and sometimes is...

journal_title：Environmental and molecular mutagenesis

authors： Revollo JR,Crabtree NM,Pearce MG,Pacheco-Martinez MM,Dobrovolsky VN

更新日期：2016-03-01 00:00:00

abstract：:Methyl 3,4-diphenyl-5-hydroxylamino-2-furoate (N-OH-MDPF) (I), methyl 3,4-diphenyl-5-acetoxyamino-2-furoate (N-OAc-MDPF) (II), methyl 3,4-diphenyl-N-hydroxy-5-acetylamino-2-furoate (N-OH-MDPAF) (III), and methyl 3,4-diphenyl-N-acetoxy-5-acetylamino-2-furoate (N-OAc-MDPAF) (IV) were synthesized and tested for mutagenic...

journal_title：Environmental and molecular mutagenesis

authors： Swaminathan S,Hatcher JF,Yamamoto K,Tanaka A,Ichikawa M,Bryan GT

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to investigate genotoxic effects of lamivudine (an analogue of cytidine) using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. The cells were treated with 75, 100, 125, and 150 microg/ml concentrations of lamiv...

journal_title：Environmental and molecular mutagenesis

authors： Bayram S,Topaktaş M

更新日期：2008-05-01 00:00:00

abstract：:The modulation of 1,3-butadiene (BD)-induced DNA adducts by occupational exposure, glutathione S-transferase (GST) genotypes, single-strand breaks, and cytogenetic end points was studied in 15 workers and 11 controls. The exposed group consisted of 8 smokers and 7 nonsmokers, whereas the control group consisted of 7 n...

journal_title：Environmental and molecular mutagenesis

authors： Zhao C,Vodicka P,Sram RJ,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:Two phenotypic classes of selectable tk-/- mutants have been isolated from the TK6 human lymphoblast cell line; one has a normal growth rate (tkn) relative to the parental cell line; the other has a slow growth rate (tks). Complete karyotypes of metaphase chromosomes were prepared and analyzed from 16 tks mutants (eig...

journal_title：Environmental and molecular mutagenesis

authors： Kodama Y,Boreiko CJ,Skopek TR,Recio L

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Recently, high concentrations of arsenic have been documented in ground waters of Southern Assam, India. Indiscriminate smokeless tobacco consumption is a common practice in this region. Correlation between nutritional status and arsenic and smokeless tobacco-induced health effects has not been taken up in h...

journal_title：Environmental and molecular mutagenesis

authors： Das S,Langthasa P,Barhoi D,Upadhaya P,Giri S

更新日期：2018-06-01 00:00:00

abstract：:Comparison of spontaneous mutation spectra derived from different transgenic constructs can provide valuable insights for interpreting the mechanisms of spontaneous mutation. In this study, spontaneous mutation frequencies and spectra of the lacI transgene are compared in the liver of C57BL/6, B6C3F1, and BC-1 mice an...

journal_title：Environmental and molecular mutagenesis

authors： Zhang S,Glickman BW,de Boer JG

更新日期：2001-01-01 00:00:00

abstract：:National and international regulatory agencies historically have used genotoxicity information as part of a weight-of-evidence approach to evaluate potential human carcinogenicity. Additionally, some agencies consider heritable mutation a regulatory endpoint. Furthermore, genotoxicity has the potential to contribute t...

journal_title：Environmental and molecular mutagenesis

authors： Cimino MC

更新日期：2006-06-01 00:00:00

abstract：:In order to characterize in vivo gene mutations that occur during fetal development, molecular analyses were undertaken of mutant 6-thioguanine resistant T-lymphocytes isolated from placental cord blood samples of 13 normal male newborns. These mutant T-cells were studied to define hypoxanthine-guanine phosphoribosylt...

journal_title：Environmental and molecular mutagenesis

authors： McGinniss MJ,Nicklas JA,Albertini RJ

更新日期：1989-01-01 00:00:00

abstract：:DNA damage induced by physical activity and/or exercise has been reported under different conditions but not for individuals maintaining physical fitness by regular strenuous exercise. Therefore, we compared levels of DNA damage in blood leukocytes of 40 healthy individuals (35 males, 5 females) who regularly exercise...

journal_title：Environmental and molecular mutagenesis

authors： Gandhi G,Chopra G

更新日期：2009-05-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality in Taiwanese women. Cigarette smoking cannot explain the high lung cancer mortality in this population because less than 10% of women in Taiwan are smokers. Therefore, environmental factors other than smoking may play an important role in lung cancer development in ...

journal_title：Environmental and molecular mutagenesis

authors： Cheng YW,Hsieh LL,Lin PP,Chen CP,Chen CY,Lin TS,Su JM,Lee H

更新日期：2001-01-01 00:00:00

abstract：:Human lymphocytes and Chinese hamster ovary (CHO) fibroblasts were analyzed for cytogenetic and cytotoxic endpoints to determine whether exposure to power frequency (60 Hz) electromagnetic fields (EMF) interferes with normal cell growth and reproduction. An exposure chamber was built to apply variable electric current...

journal_title：Environmental and molecular mutagenesis

authors： Livingston GK,Witt KL,Gandhi OP,Chatterjee I,Roti Roti JL

更新日期：1991-01-01 00:00:00