Intralitter variation in murine fetal sister chromatid exchange responses to the transplacental carcinogen ethyl carbamate.


:Gravid Swiss Webster dams were injected via tail vein with a single (1.1, 2.2, or 3.3 mmol/kg) dose of ethyl carbamate (urethane) on days 13-17 of pregnancy. Relative sister chromatid exchange (SCE) responses in maternal bone marrow vs. individual fetal liver cells were assessed. In addition, in order to evaluate the significance of intralitter variability in fetal SCE responses, SCE in combined ("pooled") fetal liver tissue preparations were measured and compared with average individual responses. In contrast to maternal responses, average fetal SCE responses to ethyl carbamate varied with gestational age. In addition, significant variation was observed among individual littermate responses at all dose levels. Nonetheless, fetal SCE responses determined from "pooled" tissue preparations provided a valid estimate of average litter responses. Regardless of the method of SCE evaluation in fetal tissue or gestational age, maternal bone marrow exhibited greater sensitivity than fetal liver to SCE induction by ethyl carbamate.


Environ Mol Mutagen


Neeper-Bradley TL,Conner MK




Has Abstract


1989-01-01 00:00:00












  • Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.

    abstract::Experiments described herein were designed to evaluate the performance characteristics of a flow cytometry-based system that scores the incidence of peripheral blood micronucleated reticulocytes (MN-RETs). These procedures represent the continued refinement of a previously reported anti-CD71-based method (Dertinger et...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Dertinger SD,Camphausen K,Macgregor JT,Bishop ME,Torous DK,Avlasevich S,Cairns S,Tometsko CR,Menard C,Muanza T,Chen Y,Miller RK,Cederbrant K,Sandelin K,Pontén I,Bolcsfoldi G

    更新日期:2004-01-01 00:00:00

  • Quinoline: unscheduled DNA synthesis and mitogenesis data from the rat liver in vivo.

    abstract::Quinoline is a specific and potent carcinogen to the rat and mouse liver. Studies are described here in which it was evaluated for its ability to initiate unscheduled DNA synthesis (UDS) in the rat liver in vivo. Although some individual animals showed indications of a marginal response the absence of clear group posi...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Ashby J,Mohammed R,Lefevre PA,Bandara L

    更新日期:1989-01-01 00:00:00

  • Comparison of mutagenicity and calf thymus DNA adducts formed by the particulate and semivolatile fractions of vehicle exhausts.

    abstract::In this study we compared the ability of extractable organic material from particulate and semivolatile fractions of gasoline emission to induce mutations in bacteria and form adducts with calf thymus (CT) DNA with corresponding data obtained from diesel exhaust. Exhaust particles from gasoline-powered passenger cars ...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Pohjola SK,Lappi M,Honkanen M,Savela K

    更新日期:2003-01-01 00:00:00

  • Evaluation of cytotoxicity and genotoxicity induced by oleic acid-coated iron oxide nanoparticles in human astrocytes.

    abstract::Iron oxide nanoparticles (ION) are gaining importance as diagnostic and therapeutic tool of central nervous system diseases. Although oleic acid-coated ION (O-ION) have been described as stable and biocompatible, their potential neurotoxicity was scarcely evaluated in human nervous cells so far. The primary aim of thi...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Fernández-Bertólez N,Costa C,Brandão F,Duarte JA,Teixeira JP,Pásaro E,Valdiglesias V,Laffon B

    更新日期:2019-12-01 00:00:00

  • Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats.

    abstract::Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily occurred at 180 ppm Cr(VI) and appeared to originate from the gingiva...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Thompson CM,Young RR,Suh M,Dinesdurage HR,Elbekai RH,Harris MA,Rohr AC,Proctor DM

    更新日期:2015-08-01 00:00:00

  • Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite.

    abstract::Arsenic is an environmental pollutant capable of causing oxidative stress, disturbance of metabolism, and cancer development. The present study was undertaken to investigate the effects of exposure to sodium arsenite on the glutathione pool, lipid peroxidation, protein carbonyl levels, global DNA methylation, and acti...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Bagnyukova TV,Luzhna LI,Pogribny IP,Lushchak VI

    更新日期:2007-10-01 00:00:00

  • Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses.

    abstract::Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

    更新日期:1993-01-01 00:00:00

  • A multi-biomarker analysis of DNA damage in automobile painters.

    abstract::The genotoxic effects associated with automobile painting were analyzed using a panel of biomarkers. Chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronuclei were evaluated in 25 car painters (12 smokers, 13 nonsmokers) working in different automobile paint-shops in Italy and in 37 control subje...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Testa A,Festa F,Ranaldi R,Giachelia M,Tirindelli D,De Marco A,Owczarek M,Guidotti M,Cozzi R

    更新日期:2005-10-01 00:00:00

  • Cytokinesis Block Micronucleus Cytome (CBMN Cyt) Assay Biomarkers and Their Association With Radiation Sensitivity Phenotype in Prostate Cancer Cases and DNA Repair Gene hOGG1 (C1245G) Polymorphism.

    abstract::Prostate cancer (PC) is commonly diagnosed cancer in men but only a few risk factors, such as family history, ethnicity, and age have been established. Chromosomal instability is another possible risk factor but this has not been adequately explained previously. In this study, we tested the hypotheses that peripheral ...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Dhillon VS,Yeoh E,Salisbury C,Butters J,Di Matteo A,Olver I,Fenech M

    更新日期:2018-12-01 00:00:00

  • Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.

    abstract::To evaluate whether blood-based genotoxicity endpoints can provide temporal and dose-response data within the low-dose carcinogenic range that could contribute to carcinogenic mode of action (MoA) assessments, we evaluated the sensitivity of flow cytometry-based micronucleus and Pig-a gene mutation assays at and below...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Dertinger SD,Phonethepswath S,Avlasevich SL,Torous DK,Mereness J,Cottom J,Bemis JC,Macgregor JT

    更新日期:2014-05-01 00:00:00

  • DNA adduct formation in primary mouse embryo cells induced by 7H-dibenzo[c,g]carbazole and its organ-specific carcinogenic derivatives.

    abstract::The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

    更新日期:1997-01-01 00:00:00

  • Roles of human sulfotransferases in genotoxicity of carcinogens using genetically engineered umu test strains.

    abstract::Human sulfotransferase (SULT) 1A1, 1A2, and 1A3 cDNA genes were subcloned separately into the pTrc99A(KM) vector. The generated plasmids were introduced into the Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1,8-DNP/pSK1002), resulting in the new strains NM7001, NM7002, and NM7003. We comp...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Oda Y,Zhang Y,Buchinger S,Reifferscheid G,Yang M

    更新日期:2012-03-01 00:00:00

  • Report and summary of the major conclusions from statistics in genotoxicity testing working group from the International Workshop on Genotoxicity Test Procedures (IWGTP), March 1999.

    abstract::A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental un...

    journal_title:Environmental and molecular mutagenesis



    authors: Lovell DP,Yoshimura I,Hothorn LA,Margolin BH,Soper K

    更新日期:2000-01-01 00:00:00

  • Early years of the Salmonella mutagen tester strains: lessons from hycanthone.

    abstract::The 1960s witnessed detailed studies on the genetic properties of a large number of histidine-requiring mutants of Salmonella typhimurium. The early 1970s saw development of selected strains, the Ames strains, for use in rapid, cheap, sensitive, and manipulable tests of chemicals and chemical mixtures for genotoxic ac...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 历史文章,杂志文章


    authors: Hartman PE

    更新日期:1989-01-01 00:00:00

  • Centromere detection in vinblastine- and radiation-induced micronuclei of cytokinesis-blocked mouse cells by using in situ hybridization with a mouse gamma (major) satellite DNA probe.

    abstract::Non-isotopic in situ hybridization using a mouse gamma (major) satellite probe DNA was applied to detect centromeres in micronuclei, which were induced in vitro in mouse liver cells by ionizing radiation and by vinblastine sulfate. In a cytokinesis-blocked micronucleus assay a dose-dependent induction of micronuclei w...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Salassidis K,Huber R,Zitzelsberger H,Bauchinger M

    更新日期:1992-01-01 00:00:00

  • Chromosomal effects of non-alkylating drug exposure in oncology personnel.

    abstract::Therapy-related leukemia has been a recognized sequela of cancer treatment for decades with "signature" abnormalities of chromosomes 5, 7, and 11 observed in treated patients. Risk to oncology personnel handling anti-cancer agents has also been documented by non-specific measures of genotoxicity in blood and urine. Us...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: McDiarmid MA,Rogers B,Oliver MS

    更新日期:2014-05-01 00:00:00

  • The social environment and the epigenome.

    abstract::The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in s...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章,评审


    authors: Szyf M,McGowan P,Meaney MJ

    更新日期:2008-01-01 00:00:00

  • APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity.

    abstract::We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation detects large chromosomal events, including mitotic recombination, chr...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Stambrook PJ,Shao C,Stockelman M,Boivin G,Engle SJ,Tischfield JA

    更新日期:1996-01-01 00:00:00

  • Mutation spectrum in Salmonella induced by environmental tobacco smoke.

    abstract::Environmental tobacco smoke (ETS) is a major source of indoor air pollution. Extractable-respirable particulate (ERP) from the ETS-contaminated indoor air (ERP-ETS) was collected from six passenger train cars and one control room. The mutagenicity of ERP-ETS was tested in the Ames/Salmonella test in the presence of ma...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Zhou R,Yu G,Zhou Y,Zeng X

    更新日期:1999-01-01 00:00:00

  • The fate is not always written in the genes: epigenomics in epidemiologic studies.

    abstract::Cost-effective, high-throughput epigenomic technologies have begun to emerge, rapidly replacing the candidate gene approach to molecular epidemiology and offering a comprehensive strategy for the study of epigenetics in human subjects. Epigenome-wide association studies (EWAS) provide new opportunities for advancing o...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章,评审


    authors: Langevin SM,Kelsey KT

    更新日期:2013-08-01 00:00:00

  • Micronucleated erythrocytes in peripheral blood from neonate rats fed by nursing mothers exposed to X-rays.

    abstract::Most women with breast cancer can become pregnant and give birth while undergoing radiation therapy and breastfeeding is generally not contraindicated. The induction of long-lived reactive species in proteins, such as casein by X-ray radiation and DNA damage to unexposed organisms, has been shown when ingesting irradi...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Solórzano-Meléndez A,Rodrigo-Alarcón R,Gómez-Meda BC,Zamora-Pérez AL,Ortiz-García RG,Bayardo-López LH,González-Virgen R,Gallegos-Arreola MP,Zúñiga-González GM

    更新日期:2021-01-26 00:00:00

  • Oral exposure to commercially available coal tar-based pavement sealcoat induces murine genetic damage and mutations.

    abstract::Coal tar (CT) is a thick black liquid produced as a by-product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of polycyclic aromatic compounds, including a wide range of polycyclic aromatic hydrocarbons (PAHs), many of which are genotoxic and carcinogenic. CT is used in so...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Long AS,Watson M,Arlt VM,White PA

    更新日期:2016-08-01 00:00:00

  • Coexposure to benzo[a]pyrene and UVA induces DNA damage: first proof of double-strand breaks in a cell-free system.

    abstract::DNA damage induced by solar ultraviolet (UV) radiation plays an important role in the induction of skin cancer. Although UVA constitutes the majority of solar UV radiation, it is less damaging to DNA than UVB. The DNA damage produced by UVA radiation, however, can be augmented in the presence of a photosensitizer. We ...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Toyooka T,Ibuki Y,Takabayashi F,Goto R

    更新日期:2006-01-01 00:00:00

  • Genotoxic effects of cisplatin in somatic tissue of Drosophila melanogaster.

    abstract::Third instar larvae of Drosophila melanogaster transdihybrid for mwh and flr were exposed to varying concentrations of cisplatin by feeding on dry media wetted with aqueous solutions of the test compound. Larval feeding continued until pupation, and surviving transdihybrid adults were collected seven days following co...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Katz AJ

    更新日期:1987-01-01 00:00:00

  • Genotoxicity testing of the herbicide trifluralin and its commercial formulation Treflan using the piscine micronucleus test.

    abstract::In this study, the genotoxic effects of a widely used herbicide, trifluralin, and its commercial formulation, Treflan, were evaluated using the micronucleus test in a commercially important fish species, Oreochromis niloticus (Nile Tilapia). Fish were exposed to 1, 5, and 10 microg/L doses of trifluralin and Treflan f...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Könen S,Cavaş T

    更新日期:2008-07-01 00:00:00

  • Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay.

    abstract::The Pig-a assay is an emerging and promising in vivo method to determine mutagenic potential of chemicals. Since its development in 2008, remarkable progress has been made in harmonizing and characterizing the test procedures, primarily using known mutagenic chemicals. The purpose of the present study was to evaluate ...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Ji Z,Settivari RS,LeBaron MJ

    更新日期:2019-01-01 00:00:00

  • The influence of DNA repair by Ogt alkyltransferase on the distribution of alkylnitrosourea-induced mutations in Escherichia coli.

    abstract::To determine the influence of DNA repair by Ogt alkyltransferase on the distribution of alkylnitrosourea-induced mutations, we have analysed in Ogt-proficient and Ogt-deficient bacterial strains the DNA sequence changes of a total of 357 independent mutations occurring within the initial part of the lacl gene of Esche...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Vidal A,Abril N,Pueyo C

    更新日期:1997-01-01 00:00:00

  • Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13.

    abstract::AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

    更新日期:2001-01-01 00:00:00

  • Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey.

    abstract::Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP), which is a chronic inflammatory and fibrotic lung disease. Recently, chronic inflammation has been accepted as a crucial factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and form...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Ulker OC,Ustundag A,Duydu Y,Yucesoy B,Karakaya A

    更新日期:2008-04-01 00:00:00

  • Evidence for an involvement of thymidine kinase in the excision repair of ultraviolet-irradiated herpes simplex virus in human cells.

    abstract::A wild-type strain of herpes simplex virus type 1 (HSV-1:KOS) encoding a functional thymidine kinase (tk+) and a tk- mutant strain (HSV-1:PTK3B) were used to study the role of the viral tk in the repair of UV-irradiated HSV-1 in human cells. UV survival of HSV-1:PTK3B was substantially reduced compared with that of HS...

    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Intine RV,Rainbow AJ

    更新日期:1990-01-01 00:00:00