NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.

abstract：:Maintenance of the mitochondrial genome is essential for proper cellular function. For this purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed, translated, and repaired in the face of constant onslaught from endogenous and environmental agents. Although only 13 polypeptides are encoded w...

journal_title：Environmental and molecular mutagenesis

authors： Sharma N,Pasala MS,Prakash A

更新日期：2019-10-01 00:00:00

abstract：:DNA damage and its subsequent repair occur heterogeneously throughout the genome, which reflects the nature of the damaging agents, gross chromosomal structure, the specific nucleotide sequence, and transcriptional status. We selected to investigate the repair of DNA damage in an artificial, transgenic situation. Here...

journal_title：Environmental and molecular mutagenesis

authors： Yang H,Kotturi GP,de Boer JG,Glickman BW

更新日期：1999-01-01 00:00:00

abstract：:Chromosome aberrations can occur by secondary mechanism(s) associated with cytotoxicity, induced by chemicals that do not attack DNA. Aberrations are formed from DNA double-strand breaks, and DSBs are known to be induced by nonmutagenic (Ames test negative) noncarcinogens at toxic levels [Storer et al. (1996): Mutat R...

journal_title：Environmental and molecular mutagenesis

authors： Hilliard CA,Armstrong MJ,Bradt CI,Hill RB,Greenwood SK,Galloway SM

更新日期：1998-01-01 00:00:00

abstract：:Vanillin (VA) modulates the genotoxicity of chemical and physical agents in a complex manner. Previous studies indicate that VA inhibits the mutagenicity but increases the mitotic homologous recombination caused by at least some genotoxic agents. In the present study, we have evaluated the effects of VA on the repair ...

journal_title：Environmental and molecular mutagenesis

authors： Furlanetto MP,Sinigaglia M,Amaral VS,Dihl RR,de Andrade HH

更新日期：2007-01-01 00:00:00

abstract：:Early results from two transgenic mouse mutation assays, Big Blue [Kohler SW et al. (1991): Proc Natl Acad Sci USA 88:7958-7962] and Muta Mouse [Myhr BC (1991): Environ Mol Mutagen 18:308-315], raised questions about appropriate study design and methods for statistical analysis. First, there were a number of potential...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Thompson ED

更新日期：1994-01-01 00:00:00

abstract：:DNA mutations play a crucial role in the origins of cancer, and the clonal expansion of mutant cells is one of the fundamental steps in multistage carcinogenesis. In this study, we correlated tumor incidence in B6C3F1 mice during the period after exposure to N-ethyl-N-nitrosourea (ENU) with the persistence of ENU-indu...

journal_title：Environmental and molecular mutagenesis

authors： Nakayama T,Sawai T,Masuda I,Kaneko S,Yamauchi K,Blyth BJ,Shimada Y,Tachibana A,Kakinuma S

更新日期：2017-10-01 00:00:00

abstract：:In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not express cytochrome P450...

journal_title：Environmental and molecular mutagenesis

authors： Yauk CL,Buick JK,Williams A,Swartz CD,Recio L,Li HH,Fornace AJ Jr,Thomson EM,Aubrecht J

更新日期：2016-05-01 00:00:00

abstract：:In this study, the genotoxic effects of a widely used herbicide, trifluralin, and its commercial formulation, Treflan, were evaluated using the micronucleus test in a commercially important fish species, Oreochromis niloticus (Nile Tilapia). Fish were exposed to 1, 5, and 10 microg/L doses of trifluralin and Treflan f...

journal_title：Environmental and molecular mutagenesis

authors： Könen S,Cavaş T

更新日期：2008-07-01 00:00:00

abstract：:Arsenic is an environmental pollutant capable of causing oxidative stress, disturbance of metabolism, and cancer development. The present study was undertaken to investigate the effects of exposure to sodium arsenite on the glutathione pool, lipid peroxidation, protein carbonyl levels, global DNA methylation, and acti...

journal_title：Environmental and molecular mutagenesis

authors： Bagnyukova TV,Luzhna LI,Pogribny IP,Lushchak VI

更新日期：2007-10-01 00:00:00

abstract：:The mechanism of toxicity of the leukemogen benzene is not entirely known. This pilot study used RNA-sequencing (RNA-seq) technology to examine the effect of benzene exposure on gene expression in peripheral blood mononuclear cells obtained from 10 workers occupationally exposed to high levels of benzene (≥5 ppm) in a...

journal_title：Environmental and molecular mutagenesis

authors： Thomas R,McHale CM,Lan Q,Hubbard AE,Zhang L,Vermeulen R,Li G,Rappaport SM,Yin S,Rothman N,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinom...

journal_title：Environmental and molecular mutagenesis

authors： Koujitani T,Ton TV,Lahousse SA,Hong HH,Wakamatsu N,Sills RC

更新日期：2008-12-01 00:00:00

abstract：:It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T-cell leukemia virus type I, hepatitis B virus, and high-risk human papilloma virus, respe...

journal_title：Environmental and molecular mutagenesis

authors： Gatza ML,Chandhasin C,Ducu RI,Marriott SJ

更新日期：2005-03-01 00:00:00

abstract：:Understanding chemically induced changes in mutational spectra can aid in deciphering mechanisms of mutagenesis. In this paper, we propose the use of statistical methods that are based upon the mutation frequency, rather than simple mutant counts which have no relationship to the mutation frequency. These methods have...

journal_title：Environmental and molecular mutagenesis

authors： Carr GJ,Gorelick NJ

更新日期：1996-01-01 00:00:00

abstract：:Heritable mutations may result in a wide variety of detrimental outcomes, from embryonic lethality to genetic disease in the offspring. Despite this, today's commonly used test batteries do not include assays for germ cell mutation. Current challenges include a lack of practical assays and concrete evidence for human ...

journal_title：Environmental and molecular mutagenesis

authors： Singer TM,Yauk CL

更新日期：2010-10-01 00:00:00

abstract：:DNA damage induced by physical activity and/or exercise has been reported under different conditions but not for individuals maintaining physical fitness by regular strenuous exercise. Therefore, we compared levels of DNA damage in blood leukocytes of 40 healthy individuals (35 males, 5 females) who regularly exercise...

journal_title：Environmental and molecular mutagenesis

authors： Gandhi G,Chopra G

更新日期：2009-05-01 00:00:00

abstract：:To protect human and ecosystem health, it is necessary to develop sensitive assays and to identify responsive cells and species (and their life stages). In this study, the relative genotoxicity of two inorganic arsenicals: trivalent sodium arsenite (As(3+)) and pentavalent sodium arsenate (As(5+)), was evaluated in tw...

journal_title：Environmental and molecular mutagenesis

authors： Raisuddin S,Jha AN

更新日期：2004-01-01 00:00:00

abstract：:Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily occurred at 180 ppm Cr(VI) and appeared to originate from the gingiva...

journal_title：Environmental and molecular mutagenesis

authors： Thompson CM,Young RR,Suh M,Dinesdurage HR,Elbekai RH,Harris MA,Rohr AC,Proctor DM

更新日期：2015-08-01 00:00:00

abstract：:Human exposure to airborne particulate matter (PM) is associated with adverse cardiopulmonary health effects, including lung cancer. Ambient PM represents a heterogeneous mixture of chemical classes including transition metals, polycyclic aromatic hydrocarbons (PAHs) and their derivatives such as nitro-PAHs, many of w...

journal_title：Environmental and molecular mutagenesis

authors： Jarvis IWH,Enlo-Scott Z,Nagy E,Mudway IS,Tetley TD,Arlt VM,Phillips DH

更新日期：2018-05-01 00:00:00

abstract：:Experiments are described which elucidate some of the technical problems associated with the direct sequencing of polymerase chain reaction (PCR) amplified DNA. Sequencing primer purity, labeling methodology, and template preparation were explored. Conditions are presented for the routine sequencing of single- and dou...

journal_title：Environmental and molecular mutagenesis

authors： Zimmerman LJ,Fuscoe JC

更新日期：1991-01-01 00:00:00

abstract：:Gravid Swiss Webster dams were injected via tail vein with a single (1.1, 2.2, or 3.3 mmol/kg) dose of ethyl carbamate (urethane) on days 13-17 of pregnancy. Relative sister chromatid exchange (SCE) responses in maternal bone marrow vs. individual fetal liver cells were assessed. In addition, in order to evaluate the ...

journal_title：Environmental and molecular mutagenesis

authors： Neeper-Bradley TL,Conner MK

更新日期：1989-01-01 00:00:00

abstract：:Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP), which is a chronic inflammatory and fibrotic lung disease. Recently, chronic inflammation has been accepted as a crucial factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and form...

journal_title：Environmental and molecular mutagenesis

authors： Ulker OC,Ustundag A,Duydu Y,Yucesoy B,Karakaya A

更新日期：2008-04-01 00:00:00

abstract：:Chlorinated drinking water contains several chlorohydroxyfuranone (CHF) by-products whose contribution to cancer risk is not presently known. 3,4-Dichloro-5-hydroxy-2(5H)-furanone (MCA), 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF), and 3- chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) were studied for th...

journal_title：Environmental and molecular mutagenesis

authors： Mäki-Paakkanen J,Laaksonen M,Munter T,Kronberg L,Komulainen H

更新日期：2001-01-01 00:00:00

abstract：:Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and ...

journal_title：Environmental and molecular mutagenesis

authors： Chulasiri M,Bunyapraphatsara N,Moongkarndi P

更新日期：1992-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs), which are widely used as flame retardants, are considered persistent organic pollutants. To date, the available toxicological data on PBDEs are limited and were primarily obtained by studying technical blends. The present study was undertaken to investigate the genotoxicity of t...

journal_title：Environmental and molecular mutagenesis

authors： Evandri MG,Mastrangelo S,Costa LG,Bolle P

更新日期：2003-01-01 00:00:00

abstract：:The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and the etiology of immunological diseases. In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3'-untranslated region (3'-U...

journal_title：Environmental and molecular mutagenesis

authors： Knox B,Wang Y,Rogers LJ,Xuan J,Yu D,Guan H,Chen J,Shi T,Ning B,Kadlubar SA

更新日期：2018-03-01 00:00:00

abstract：:In this study we compared the ability of extractable organic material from particulate and semivolatile fractions of gasoline emission to induce mutations in bacteria and form adducts with calf thymus (CT) DNA with corresponding data obtained from diesel exhaust. Exhaust particles from gasoline-powered passenger cars ...

journal_title：Environmental and molecular mutagenesis

authors： Pohjola SK,Lappi M,Honkanen M,Savela K

更新日期：2003-01-01 00:00:00

abstract：:The L5178Y mouse lymphoma cell mutagenesis assay is used to detect the mutagenic activity of chemicals in a mammalian cell system. To evaluate this assay we compared the results of assays performed independently on 63 chemicals by laboratories at SRI International and Litton Bionetics, Inc. The two laboratories used s...

journal_title：Environmental and molecular mutagenesis

authors： Caspary WJ,Daston DS,Myhr BC,Mitchell AD,Rudd CJ,Lee PS

更新日期：1988-01-01 00:00:00

abstract：:The widespread application of carbon nanotubes (CNT) on industrial, biomedical, and consumer products can represent an emerging respiratory occupational hazard. Particularly, their similarity with the fiber-like shape of asbestos have raised a strong concern about their carcinogenic potential. Several in vitro and in ...

journal_title：Environmental and molecular mutagenesis

authors： Ventura C,Sousa-Uva A,Lavinha J,Silva MJ

更新日期：2018-05-01 00:00:00

abstract：:The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity Test Procedures held a second harmonization meeting just prior to the U.S. Environmental Mutagen Society Meeting in New Orleans, LA, in April 2000. The discussion focused on several important aspects of the MLA, including: 1) cytoto...

journal_title：Environmental and molecular mutagenesis

authors： Moore MM,Honma M,Clements J,Harrington-Brock K,Awogi T,Bolcsfoldi G,Cifone M,Collard D,Fellows M,Flanders K,Gollapudi B,Jenkinson P,Kirby P,Kirchner S,Kraycer J,McEnaney S,Muster W,Myhr B,O'Donovan M,Oliver J,Ould

更新日期：2002-01-01 00:00:00

abstract：:Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with re...

journal_title：Environmental and molecular mutagenesis

authors： Graupner A,Eide DM,Brede DA,Ellender M,Lindbo Hansen E,Oughton DH,Bouffler SD,Brunborg G,Olsen AK

更新日期：2017-10-01 00:00:00