Acrylamide exposure induces a delayed unscheduled DNA synthesis in germ cells of male mice that is correlated with the temporal pattern of adduct formation in testis DNA.

abstract：:Vanillin (VA) modulates the genotoxicity of chemical and physical agents in a complex manner. Previous studies indicate that VA inhibits the mutagenicity but increases the mitotic homologous recombination caused by at least some genotoxic agents. In the present study, we have evaluated the effects of VA on the repair ...

journal_title：Environmental and molecular mutagenesis

authors： Furlanetto MP,Sinigaglia M,Amaral VS,Dihl RR,de Andrade HH

更新日期：2007-01-01 00:00:00

abstract：:Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily occurred at 180 ppm Cr(VI) and appeared to originate from the gingiva...

journal_title：Environmental and molecular mutagenesis

authors： Thompson CM,Young RR,Suh M,Dinesdurage HR,Elbekai RH,Harris MA,Rohr AC,Proctor DM

更新日期：2015-08-01 00:00:00

abstract：:BDF1 mice were exposed in inhalation chambers to benzene (900 ppm, 300 ppm) and/or toluene (500 ppm, 250 ppm) 6 hr per day, 5 days per week, for up to 8 weeks. Benzene alone induced a slight anemia after 4 and 8 weeks and a reduction of BFU-E and CFU-E numbers in the marrow. The coexposure to toluene reduced the degre...

journal_title：Environmental and molecular mutagenesis

authors： Plappert U,Barthel E,Seidel HJ

更新日期：1994-01-01 00:00:00

abstract：:Third instar larvae of Drosophila melanogaster transdihybrid for mwh and flr were exposed to varying concentrations of cisplatin by feeding on dry media wetted with aqueous solutions of the test compound. Larval feeding continued until pupation, and surviving transdihybrid adults were collected seven days following co...

journal_title：Environmental and molecular mutagenesis

authors： Katz AJ

更新日期：1987-01-01 00:00:00

abstract：:Animal studies have linked perinatal bisphenol A (BPA) exposure to altered DNA methylation, but little attention is given to analyzing multiple physiologically relevant doses. Utilizing the viable yellow agouti (A(vy)) mouse, we examine the effects of developmental exposure through maternal diet to 50 ng BPA/kg (n = 1...

journal_title：Environmental and molecular mutagenesis

authors： Anderson OS,Nahar MS,Faulk C,Jones TR,Liao C,Kannan K,Weinhouse C,Rozek LS,Dolinoy DC

更新日期：2012-06-01 00:00:00

abstract：:It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T-cell leukemia virus type I, hepatitis B virus, and high-risk human papilloma virus, respe...

journal_title：Environmental and molecular mutagenesis

authors： Gatza ML,Chandhasin C,Ducu RI,Marriott SJ

更新日期：2005-03-01 00:00:00

abstract：:Amsacrine (4'-(9-acridinylamino)methanesulphon-m-anisidide) is an antileukemic drug which inhibits topoisomerase II (topo II) enzymes. We studied effects of two concentrations of amsacrine on the GM10115A cell line. This is a Chinese hamster line containing a single human chromosome 4, which can be readily visualised ...

journal_title：Environmental and molecular mutagenesis

authors： Ferguson LR,Whiteside G,Holdaway KM,Baguley BC

更新日期：1996-01-01 00:00:00

abstract：:Nitrous acid (NA) is often presumed to cause base substitutions in organisms with double-stranded DNA as a direct consequence of oxidative deamination of adenine and of cytosine residues. Here we summarize evidence indicating that other mechanisms are involved in the case of NA-induced G/C-->A/T transition mutations. ...

journal_title：Environmental and molecular mutagenesis

authors： Hartman Z,Henrikson EN,Hartman PE,Cebula TA

更新日期：1994-01-01 00:00:00

abstract：:Classification of micronuclei induced by lomefloxacin, a difluorinated quinolone bactericidal agent, in mouse bone marrow was performed by fluorescence in situ hybridization using DNA probes for the centromere repeated minor satellite DNA and the telomeric hexamer repeat (5'-TTAGGG-3'). Colchicine and mitomycin C were...

journal_title：Environmental and molecular mutagenesis

authors： Attia SM

更新日期：2009-06-01 00:00:00

abstract：:Radiation and many chemicals have been found to induce homologous genetic recombination. Experimental systems that allow the detection and characterization of recombinagens exist in organisms as diverse as bacteria, fungi, plants, insects, and mammals. Recombination plays an important role in many biological processes...

journal_title：Environmental and molecular mutagenesis

authors： Hoffmann GR

更新日期：1994-01-01 00:00:00

abstract：:Mitochondrial dysfunction is a global term used in the context of "unhealthy" mitochondria. In practical terms, mitochondria are extremely complex and highly adaptive in structure, chemical and enzymatic composition, subcellular distribution and functional interaction with other components of cells. Consequently, alte...

journal_title：Environmental and molecular mutagenesis

authors： Roede JR,Jones DP

更新日期：2010-06-01 00:00:00

abstract：:2,6-Dicyano-4-nitroaniline and 2-cyano-4-nitroaniline (CNNA; 2-amino-5-nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction products of many commercial azo dyes, including Disperse Blue 165, Dispers...

journal_title：Environmental and molecular mutagenesis

authors： Josephy PD,Dhanoa J,Elzawy G,Heney K,Petrie L,Senis C

更新日期：2018-03-01 00:00:00

abstract：:During the development of cancer a series of specific genetic alterations have to occur in a stepwise fashion to transform a normal somatic cell into a malignant tumor cell. These genetic changes can be roughly divided in two groups: mutations in proto-oncogenes that result in a constantly activated gene product and m...

journal_title：Environmental and molecular mutagenesis

authors： Vrieling H,Wijnhoven S,van Sloun P,Kool H,Giphart-Gassler M,van Zeeland A

更新日期：1999-01-01 00:00:00

abstract：:DNA mutations play a crucial role in the origins of cancer, and the clonal expansion of mutant cells is one of the fundamental steps in multistage carcinogenesis. In this study, we correlated tumor incidence in B6C3F1 mice during the period after exposure to N-ethyl-N-nitrosourea (ENU) with the persistence of ENU-indu...

journal_title：Environmental and molecular mutagenesis

authors： Nakayama T,Sawai T,Masuda I,Kaneko S,Yamauchi K,Blyth BJ,Shimada Y,Tachibana A,Kakinuma S

更新日期：2017-10-01 00:00:00

abstract：:A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinom...

journal_title：Environmental and molecular mutagenesis

authors： Koujitani T,Ton TV,Lahousse SA,Hong HH,Wakamatsu N,Sills RC

更新日期：2008-12-01 00:00:00

abstract：:The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and the etiology of immunological diseases. In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3'-untranslated region (3'-U...

journal_title：Environmental and molecular mutagenesis

authors： Knox B,Wang Y,Rogers LJ,Xuan J,Yu D,Guan H,Chen J,Shi T,Ning B,Kadlubar SA

更新日期：2018-03-01 00:00:00

abstract：:Prostate cancer (PC) is commonly diagnosed cancer in men but only a few risk factors, such as family history, ethnicity, and age have been established. Chromosomal instability is another possible risk factor but this has not been adequately explained previously. In this study, we tested the hypotheses that peripheral ...

journal_title：Environmental and molecular mutagenesis

authors： Dhillon VS,Yeoh E,Salisbury C,Butters J,Di Matteo A,Olver I,Fenech M

更新日期：2018-12-01 00:00:00

abstract：:A recent study conducted by our group showed that the NAT2 fast acetylator genotype is associated with an increasing risk for the development of colorectal cancer (CRC), especially for females. We therefore examined whether a higher risk of CRC in females with the NAT2 fast acetylator genotype was associated with the ...

journal_title：Environmental and molecular mutagenesis

authors： Huang CC,Chien WP,Wong RH,Cheng YW,Chen MC,Lee H

更新日期：2009-03-01 00:00:00

abstract：:Our understanding of the mutation process and how it impacts target populations has deepened steadily during the hundred years since 1919. Recent advances in engineering genetically determined social traits points towards the logical culmination of this knowledge. ...

journal_title：Environmental and molecular mutagenesis

authors： Drake JW

更新日期：1994-01-01 00:00:00

abstract：:The hydroxyl radical scavengers thiourea, ethanol, and dimethyl sulfoxide significantly reduced the killing of Escherichia coli elicited by low concentrations of H2O2 (resulting in mode 1 killing) when treatments with the oxidant and the scavengers were performed in a complete growth medium (K medium) but not in M9 sa...

journal_title：Environmental and molecular mutagenesis

authors： Brandi G,Salvaggio L,Cattabeni F,Cantoni O

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Recently, high concentrations of arsenic have been documented in ground waters of Southern Assam, India. Indiscriminate smokeless tobacco consumption is a common practice in this region. Correlation between nutritional status and arsenic and smokeless tobacco-induced health effects has not been taken up in h...

journal_title：Environmental and molecular mutagenesis

authors： Das S,Langthasa P,Barhoi D,Upadhaya P,Giri S

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to investigate genotoxic effects of lamivudine (an analogue of cytidine) using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. The cells were treated with 75, 100, 125, and 150 microg/ml concentrations of lamiv...

journal_title：Environmental and molecular mutagenesis

authors： Bayram S,Topaktaş M

更新日期：2008-05-01 00:00:00

abstract：:The mutational spectrum for 28 X-ray induced mutations and 2 spontaneous mutations, previously determined by genetic and cytogenetic methods, consisted of 20 multilocus deficiencies (19 induced and 1 spontaneous) and 10 intragenic mutations (9 induced and 1 spontaneous). One of the X-ray induced intragenic mutations w...

journal_title：Environmental and molecular mutagenesis

authors： Mahmoud J,Fossett NG,Arbour-Reily P,McDaniel M,Tucker A,Chang SH,Lee WR

更新日期：1991-01-01 00:00:00

abstract：:Based on the assumption that compounds having similar toxic modes of action induce specific gene expression changes, the toxicity of unknown compounds can be predicted after comparison of their molecular fingerprints with those obtained with compounds of known toxicity. These predictive models will therefore rely on t...

journal_title：Environmental and molecular mutagenesis

authors： Thybaud V,Le Fevre AC,Boitier E

更新日期：2007-06-01 00:00:00

abstract：:Black cohosh extract (BCE) is a popular botanical dietary supplement marketed to relieve symptoms of various gynecological ailments. Studies conducted by the National Toxicology Program (NTP) showed that BCE induces micronucleated erythrocytes in female rats and mice. Subsequently, the NTP showed that a variety of BCE...

journal_title：Environmental and molecular mutagenesis

authors： Bernacki DT,Bryce SM,Bemis JC,Dertinger SD,Witt KL,Smith-Roe SL

更新日期：2019-12-01 00:00:00

abstract：:Contamination of ground water by industrial waste poses potential health hazards for man and his environment. The improper disposal of toxic wastes could allow genotoxic chemicals to percolate into ground waters, and these contaminated ground waters may produce toxicity, including mutation and eventually cancer, in ex...

journal_title：Environmental and molecular mutagenesis

authors： Chandra S,Chauhan LK,Murthy RC,Gupta SK

更新日期：2006-06-01 00:00:00

abstract：:A wild-type strain of herpes simplex virus type 1 (HSV-1:KOS) encoding a functional thymidine kinase (tk+) and a tk- mutant strain (HSV-1:PTK3B) were used to study the role of the viral tk in the repair of UV-irradiated HSV-1 in human cells. UV survival of HSV-1:PTK3B was substantially reduced compared with that of HS...

journal_title：Environmental and molecular mutagenesis

authors： Intine RV,Rainbow AJ

更新日期：1990-01-01 00:00:00

abstract：:A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental un...

journal_title：Environmental and molecular mutagenesis

authors： Lovell DP,Yoshimura I,Hothorn LA,Margolin BH,Soper K

更新日期：2000-01-01 00:00:00

abstract：:Increased telomerase expression has been implicated in the pathogenesis of lung cancer and, since the primary cause of lung cancer is smoking, an association between telomerase reactivation and tobacco smoke has been proposed. In this work an investigation has been performed to assess the relationship between tobacco ...

journal_title：Environmental and molecular mutagenesis

authors： Marcon F,Siniscalchi E,Andreoli C,Allione A,Fiorito G,Medda E,Guarrera S,Matullo G,Crebelli R

更新日期：2017-10-01 00:00:00

abstract：:The types of chromosomal aberrations during the aging of Crepis capillaris (Hawksbeard; fam. Asteraceae) seeds were investigated. Seeds were stored at 22 degrees C for 2, 4, 6, and 8 years. Chromosomal aberrations were analyzed in metaphase chromosomes at the first and second mitotic cycles. A colchicine block was use...

journal_title：Environmental and molecular mutagenesis

authors： Dimitrov BD

更新日期：1994-01-01 00:00:00