Abstract:
:Gene expression profiles may offer more or additional information than classic morphologic- and histologic-based tumor classification systems. Because the number of tissue samples examined is usually much smaller than the number of genes examined, efficient data reduction and analysis methods are critical. In this report, we propose a principal component and discriminant analysis method of tumor classification using gene expression profile data. Expression of 2000 genes in 40 tumor and 22 normal colon tissue samples is used to examine the feasibility of gene expression-based tumor classification systems. Using this method, the percentage of correctly classified normal and tumor tissue was 87.0%. The combined approach using principal components and discriminant analysis provided superior sensitivity and specificity compared to an approach using simple differences in the expression levels of individual genes.
journal_name
Biotechniquesjournal_title
BioTechniquesauthors
Xiong M,Jin L,Li W,Boerwinkle Edoi
10.2144/00296bc02subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1264-8, 1270issue
6eissn
0736-6205issn
1940-9818journal_volume
29pub_type
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