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Methyldibromoglutaronitrile (Euxyl K 400): an important "new" allergen in cosmetics.

Abstract：

:Euxyl K 400 is a preservative system for cosmetics and toiletries that contains phenoxyethanol and methyldibromoglutaronitrile in a 4:1 ratio. In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4 years and is currently 2% to 4% in patients suspected of having contact dermatitis. The allergenic ingredient is nearly always methyldibromoglutaronitrile. Causative products include both stay-on and rinse-off cosmetics and moistened toilet tissue. Because the causative products usually give false-negative reactions, the allergen, methyldibromoglutaronitrile, should be tested in all patients suspected of having cosmetic dermatitis and in those with perianal dermatitis. We suggest a test concentration of 0.3% to 0.5% in petrolatum.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

De Groot AC,van Ginkel CJ,Weijland JW

doi

10.1016/s0190-9622(96)90730-6

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

743-7

issue

5 Pt 1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(96)90730-6

journal_volume

35

pub_type

杂志文章,评审

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