Abstract:
:We have studied the presence and distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR1, 2, 3, and 4) in the adult cat visual cortical areas 17, 18, 19, and the lateral suprasylvian areas (LSA). Reverse transcription-polymerase chain reaction (RT-PCR) amplification indicated that the genes encoding GluR1, 2, 3, and 4 are expressed in these areas and Western blot analysis revealed that the size of the corresponding peptides is similar to those described in the rat brain. In situ hybridization (ISH) using digoxigenin-labeled riboprobes showed that mRNAs coding for GluR1 and GluR3 were located in cells in all layers of the areas examined and also in the underlying white matter. GluR1 mRNA was relatively abundant throughout layers II-VI while GluR3 mRNA revealed a more laminated pattern of expression, preferentially labeling cells in layers II, III, V, and VI. The distribution of AMPA-selective receptor subunit peptides was studied by immunohistochemistry using subunit specific antibodies and found to be consistent with ISH results. In addition, we observed that most of the cells strongly labeled by the anti-GluR1 antibody were non-pyramidal neurons and that intense GluR2/3 immunoreactivity was seen preferentially in pyramidal neurons. Interestingly, double-labeling experiments indicated that neurons expressing gamma-aminobutyric acid (GABA) as well as the GluR1 subunit were particularly abundant in deeper layers. The GluR4 peptide was predominantly found in a relatively low number of layer III and layer V neurons with either pyramidal or non-pyramidal morphology. Finally, the distribution of neurons expressing the various receptor subunits was similar in all the visual cortical areas studied. These findings indicate a high expression of GluR1-3 subunits in the cat visual cortex and that GluR1 and GluR2/3 subunits are particularly abundant in non-pyramidal and pyramidal neurons, respectively. In addition, the results described here provide a reference for future studies dealing with the effect of visual deprivation on the expression of this receptor type.
journal_name
Vis Neuroscijournal_title
Visual neuroscienceauthors
Gutiérrez-Igarza K,Fogarty DJ,Pérez-Cerdá F,Doñate-Oliver F,Albus K,Matute Cdoi
10.1017/s0952523800007136subject
Has Abstractpub_date
1996-01-01 00:00:00pages
61-72issue
1eissn
0952-5238issn
1469-8714pii
S0952523800007136journal_volume
13pub_type
杂志文章abstract::Dark-adapted rods exert a tonic suppressive influence upon cone-mediated sensitivity to rapid flicker, a phenomenon called suppressive rod-cone interaction (SRCI). However, rod dark adaptation has negligible influence upon cone-mediated thresholds measured with more usual psychophysical procedures. The present study s...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s095252380000924x
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abstract::The dopamine (DA) innervation, labeled by tyrosine hydroxylase immunohistochemistry in a wholemounted human retina, is described in the avascular area of the fovea. Eleven DA neurons give rise to this innervation, among which five are interplexiform cells, so that the DA innervation consists of two plexuses: one is in...
journal_title:Visual neuroscience
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523804041045
更新日期:2004-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S095252381300059X
更新日期:2014-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523899161042
更新日期:1999-01-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800011792
更新日期:1997-11-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523804215073
更新日期:2004-09-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523815000310
更新日期:2016-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800007975
更新日期:1995-03-01 00:00:00
abstract::The goal of the present study was to relate the dark and light-adapted flash sensitivity of the scotopic threshold response (STR) and rod b-wave of the electroretinogram (ERG) to behaviorally measured rod increment threshold responses. Small amplitudes of the dark-adapted STR and b-wave, the latter after application o...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523801184142
更新日期:2001-07-01 00:00:00
abstract::The objective of this study was to evaluate the maturity of three inhibitory mechanisms (end-inhibition, side-inhibition, and cross-orientation inhibition) in the striate cortex of kittens at 4 weeks postnatal. To accomplish this, we made extracellular recordings from area 17 neurons while presenting visual stimuli co...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800007756
更新日期:1996-11-01 00:00:00
abstract::The size, pattern of terminal arborizations, and laminar specificity of individual retinogeniculate axons were studied in the macaque following injections of HRP into the optic tract. Axons that terminated in the magnocellular layers had significantly larger fiber diameters and wider terminal fields than those that te...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800001206
更新日期:1989-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章,评审
doi:10.1017/S0952523809090038
更新日期:2009-03-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800008464
更新日期:1995-05-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S095252380522206X
更新日期:2005-03-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s095252380118404x
更新日期:2001-07-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/S0952523809090014
更新日期:2009-01-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800012499
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更新日期:1999-07-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s095252380001107x
更新日期:1994-01-01 00:00:00
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doi:10.1017/s0952523800002832
更新日期:1992-03-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523808080784
更新日期:2008-09-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800005435
更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-05-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:1997-07-01 00:00:00