Abstract:
:The dopamine (DA) innervation, labeled by tyrosine hydroxylase immunohistochemistry in a wholemounted human retina, is described in the avascular area of the fovea. Eleven DA neurons give rise to this innervation, among which five are interplexiform cells, so that the DA innervation consists of two plexuses: one is internal and is formed by the dendrites of all of the DA cells, and the other is external and is formed by the scleral processes of the interplexiform cells. Five concentric zones are delineated according to the focal plane in which the internal DA plexus is observed. The central zone 1 contains DA processes crossing in all directions. Zones 2 and 3 do not contain any cell bodies. In zone 3 the internal plexus begins to undergo a concentric arrangement, which is clearly observed in zones 4 and 5. The external DA innervation displays a different appearance in zones 1, 2, and 3, in which it consists of vertically oriented thin processes and terminals penetrating the outer nuclear layer, vs. zones 4 and 5 in which it consists of both the same type and horizontal processes lying in the outer plexiform layer. On the basis of DA-innervation appearance and distribution of labeled and unlabeled cell somata, it was concluded that zones 1, 2, and 3 contained the DA innervation of the foveola. DA processes filtering between photoreceptor cells are particularly well-observed in this region. This anatomical study of the DA innervation in the human fovea leads to a better understanding of the important role of DA in primate central vision and can be used as a reference for an approach of macular pathology.
journal_name
Vis Neuroscijournal_title
Visual neuroscienceauthors
Savy C,Simon A,Nguyen-Legros Jdoi
10.1017/s0952523800009779subject
Has Abstractpub_date
1991-11-01 00:00:00pages
487-98issue
5eissn
0952-5238issn
1469-8714pii
S0952523800009779journal_volume
7pub_type
杂志文章abstract::The hypothesis that dichromatic behavior on a clinical anomaloscope can be explained by the complement and arrangement of the long- (L) and middle-wavelength (M) pigment genes was tested. It was predicted that dichromacy is associated with an X-chromosome pigment gene array capable of producing only a single functiona...
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journal_title:Visual neuroscience
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doi:10.1017/S0952523807070484
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800000171
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journal_title:Visual neuroscience
pub_type: 杂志文章,评审
doi:10.1017/s0952523800012098
更新日期:1997-05-01 00:00:00
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doi:10.1017/s0952523800003230
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doi:10.1017/s0952523800006398
更新日期:1992-07-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:1997-07-01 00:00:00
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doi:10.1017/s0952523801181125
更新日期:2001-01-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:2007-11-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:1992-03-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800007136
更新日期:1996-01-01 00:00:00
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journal_title:Visual neuroscience
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journal_title:Visual neuroscience
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journal_title:Visual neuroscience
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更新日期:2005-05-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523802196064
更新日期:2002-11-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:2000-09-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523804213360
更新日期:2004-05-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:1993-07-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800004703
更新日期:1993-05-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523807070393
更新日期:2007-03-01 00:00:00