Lagged cells in alert monkey lateral geniculate nucleus.


:Five lagged cells were recognized by extracellular recording in the lateral geniculate nucleus of an awake, behaving macaque monkey. Previous reports of lagged cells were all in the anesthetized cat. Both parvocellular and magnocellular lagged cells were observed. Response timing was distributed continuously across the population, and both sustained and transient responses were seen in the magnocellular subpopulation. Cortex thus receives signals with a wide range of timing, which can mediate direction selectivity across multiple dimensions.


Vis Neurosci


Visual neuroscience


Saul AB




Has Abstract


2008-09-01 00:00:00














  • Effect of early monocular enucleation upon ocular dominance columns and cytochrome oxidase activity in monkey and human visual cortex.

    abstract::We examined cytochrome oxidase (CO) activity in striate cortex of four macaque monkeys after monocular enucleation at ages 1, 1, 5, and 12 weeks. These animal experiments were performed to guide our interpretation of CO patterns in occipital lobe specimens obtained from two children who died several years after monocu...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Horton JC,Hocking DR

    更新日期:1998-03-01 00:00:00

  • Radial motion bias in macaque frontal eye field.

    abstract::The visual responsiveness and spatial tuning of frontal eye field (FEF) neurons were determined using a delayed memory saccade task. Neurons with visual responses were then tested for direction selectivity using moving random dot patterns centered in the visual receptive field. The preferred axis of motion showed a si...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Xiao Q,Barborica A,Ferrera VP

    更新日期:2006-01-01 00:00:00

  • Translational read-through as an alternative approach for ocular gene therapy of retinal dystrophies caused by in-frame nonsense mutations.

    abstract::The eye has become an excellent target for gene therapy, and gene augmentation therapy of inherited retinal disorders has made major progress in recent years. Nevertheless, a recent study indicated that gene augmentation intervention might not stop the progression of retinal degeneration in patients. In addition, for ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审


    authors: Nagel-Wolfrum K,Möller F,Penner I,Wolfrum U

    更新日期:2014-09-01 00:00:00

  • Vision in mice with neuronal redundancy due to inhibition of developmental cell death.

    abstract::Transgenic mice overexpressing bcl-2, due to inhibition of naturally occurring cell death, have much larger brains and optic nerves as compared to wild-type mice. Since developmental cell death is believed to exert a crucial role in establishing the mature neural circuitry and function, we asked the question of whethe...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Porciatti V,Pizzorusso T,Maffei L

    更新日期:1999-07-01 00:00:00

  • Spatio-temporal characterization of retinal opsin gene expression during thyroid hormone-induced and natural development of rainbow trout.

    abstract::The abundance and spatial distribution of retinal cone photoreceptors change during thyroid hormone (TH)-induced and natural development of rainbow trout (Oncorhynchus mykiss). These changes are thought to allow the fish to adapt to different photic environments throughout its life history. To date, the ontogeny of ra...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Veldhoen K,Allison WT,Veldhoen N,Anholt BR,Helbing CC,Hawryshyn CW

    更新日期:2006-03-01 00:00:00

  • Peripheral shift reduces visual sensitivity in cat geniculate neurones.

    abstract::The sudden displacement of the retinal image during a saccade raises the visual threshold of human observers to foveal stimuli. The fall in visual sensitivity observed during this phenomenon, known as saccadic suppression, seems to occur very early in the visual processing chain. The lateral geniculate nucleus (LGN) i...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Derrington AM,Felisberti F

    更新日期:1998-09-01 00:00:00

  • Long-range interactions modulate the contrast gain in the lateral geniculate nucleus of cats.

    abstract::In previous work, we have shown that sudden image displacements well outside the classical receptive field modulate the visual sensitivity of LGN relay cells. Here we report the effect of image displacements on the response versus contrast function. The stimuli consisted of a central spot of optimal size and polarity ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Felisberti F,Derrington AM

    更新日期:1999-09-01 00:00:00

  • The effects of saccadic eye movements on the activity of geniculate relay neurons in the monkey.

    abstract::Saccadic suppression is the reduced visibility that occurs during saccadic eye movements. Recent psychophysical studies have suggested that this is due to a reduction in responsiveness of magnocellular (M), but not parvocellular (P), cells of the lateral geniculate nucleus. To address this and other phenomena of respo...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Ramcharan EJ,Gnadt JW,Sherman SM

    更新日期:2001-03-01 00:00:00

  • Is the input to a GABAergic synapse the sole asymmetry in turtle's retinal directional selectivity?

    abstract::We examined the effects of picrotoxin and pentylenetetrazol (PTZ) on the responses to motions of ON-OFF directionally selective (DS) ganglion cells of the turtle's retina. These drugs are antagonists of the inhibitory neurotransmitter GABA. For continuous motions, picrotoxin markedly reduced the overall directionality...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Smith RD,Grzywacz NM,Borg-Graham LJ

    更新日期:1996-05-01 00:00:00

  • The retinal targets of centrifugal neurons and the retinal neurons projecting to the accessory optic system.

    abstract::In birds, neurons of the isthmo-optic nucleus (ION), as well as "ectopic" neurons, send axons to the retina, where they synapse on cells in the inner nuclear layer (INL). Previous work has shown that centrifugal axons can be divided into two anatomically distinct types depending on their model of termination: either "...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Nickla DL,Gottlieb MD,Marin G,Rojas X,Britto LR,Wallman J

    更新日期:1994-03-01 00:00:00

  • Whole-cell recording of light-evoked photoreceptor responses in a slice preparation of the cuttlefish retina.

    abstract::A new tissue slice preparation of the cuttlefish eye is described that permits patch-clamp recordings to be acquired from intact photoreceptors during stimulation of the retina with controlled light flashes. Whole-cell recordings using this preparation, from the retinas of very young Sepia officinalis demonstrated tha...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Chrachri A,Nelson L,Williamson R

    更新日期:2005-05-01 00:00:00

  • Changing distribution of GABA-like immunoreactivity in pigeon visual areas during the early posthatching period and effects of retinal removal on tectal GABAergic systems.

    abstract::The distribution of GABA-like immunoreactivity in the pigeon visual system was studied during the first 9 days after hatching using a mouse monoclonal antibody, mAb 3A12, to glutaraldehyde linked GABA (Matute & Streit, 1986). GABA-like immunoreactivity was seen in cell bodies as well as in neuropil at the level of bot...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Bagnoli P,Fontanesi G,Streit P,Domenici L,Alesci R

    更新日期:1989-12-01 00:00:00

  • Visual tracking of moving targets by freely flying honeybees.

    abstract::The ability of freely-flying honeybees to track moving targets was examined by training them to collect a reward on a target, and then videotaping their approach to the target while it was in motion. Training experiments were carried out with several groups of bees, using various colors for the target and the backgrou...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Zhang SW,Wang XA,Liu ZL,Srinivasan MV

    更新日期:1990-04-01 00:00:00

  • Light-dependent delay in the falling phase of the retinal rod photoresponse.

    abstract::Using suction electrodes, photocurrent responses to 100-ms saturating flashes were recorded from isolated retinal rods of the larval-stage tiger salamander (Ambystoma tigrinum). The delay period (Tc) that preceded recovery of the dark current by a criterion amount (3 pA) was analyzed in relation to the flash intensity...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Pepperberg DR,Cornwall MC,Kahlert M,Hofmann KP,Jin J,Jones GJ,Ripps H

    更新日期:1992-01-01 00:00:00

  • Visual cortex damage-induced growth of retinal axons into the lateral posterior nucleus of the cat.

    abstract::Ablation of visual cortical areas 17 and 18 in neonatal and young adult cats induces novel retinal projections to terminate bilaterally in the lateral posterior nucleus (LP) at a position ventromedial from the medial interlaminar nucleus. Comparison with the visual-field maps of LP indicate that the terminations are f...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Payne BR,Foley HA,Lomber SG

    更新日期:1993-07-01 00:00:00

  • Beta-ionone activates and bleaches visual pigment in salamander photoreceptors.

    abstract::Vision begins with photoisomerization of 11-cis retinal to the all-trans conformation within the chromophore-binding pocket of opsin, leading to activation of a biochemical cascade. Release of all-trans retinal from the binding pocket curtails but does not fully quench the ability of opsin to activate transducin. All-...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Isayama T,McCabe England SL,Crouch RK,Zimmerman AL,Makino CL

    更新日期:2009-05-01 00:00:00

  • Toward a unified model of vertebrate rod phototransduction.

    abstract::Recently, we introduced a phototransduction model that was able to account for the reproducibility of vertebrate rod single-photon responses (SPRs) (Hamer et al., 2003). The model was able to reproduce SPR statistics by means of stochastic activation and inactivation of rhodopsin (R*), transducin (G alpha ), and phosp...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Hamer RD,Nicholas SC,Tranchina D,Lamb TD,Jarvinen JL

    更新日期:2005-07-01 00:00:00

  • Visual responsiveness and direction selectivity of cells in area 18 during local reversible inactivation of area 17 in cats.

    abstract::We have investigated the effects of inactivation of localized sites in area 17 on the visual responses of cells in visuotopically corresponding regions of area 18. Experiments were performed on adult normal cats. The striate cortex was inactivated by the injection of nanoliters of lidocaine hydrochloride or of gamma-a...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Casanova C,Michaud Y,Morin C,McKinley PA,Molotchnikoff S

    更新日期:1992-12-01 00:00:00

  • The interstitial nucleus of the superior fasciculus, posterior bundle (INSFp) in the guinea pig: another nucleus of the accessory optic system processing the vertical retinal slip signal.

    abstract::As in rabbit, gerbil, and rat, the guinea pig interstitial nucleus of the superior fasciculus, posterior bundle (INSFp) is a sparse assemblage of neurons scattered among the fibers forming the fasciculus bearing this name. Most of the INSFp neurons are small and are ovoid in shape. Interspersed among these, are a few ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Benassi C,Biral GP,Lui F,Porro CA,Corazza R

    更新日期:1989-01-01 00:00:00

  • A phenomenological model of visually evoked spike trains in cat geniculate nonlagged X-cells.

    abstract::The visual information that first-order cortical cells receive is contained in the visually evoked spike trains of geniculate relay cells. To address functional issues such as the ON/OFF structure of visual cortical receptive fields with modelling studies, a geniculate cell model is needed where the spatial and tempor...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Gazères N,Borg-Graham LJ,Frégnac Y

    更新日期:1998-11-01 00:00:00

  • Central origin of the efferent neurons projecting to the eyes of Limulus polyphemus.

    abstract::Circadian rhythms affect the anatomy, physiology, and biochemistry of the visual cells in the eyes of the horseshoe crab (Limulus polyphemus). These rhythms are mediated by the activity of efferent neurons that project from the central nervous system to all of the eyes. In this study, the optic nerves of Limulus were ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Calman BG,Battelle BA

    更新日期:1991-05-01 00:00:00

  • Spatial geometry of the dopamine innervation in the avascular area of the human fovea.

    abstract::The dopamine (DA) innervation, labeled by tyrosine hydroxylase immunohistochemistry in a wholemounted human retina, is described in the avascular area of the fovea. Eleven DA neurons give rise to this innervation, among which five are interplexiform cells, so that the DA innervation consists of two plexuses: one is in...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Savy C,Simon A,Nguyen-Legros J

    更新日期:1991-11-01 00:00:00

  • Synaptic inputs to retrogradely labeled ganglion cells in the retina of the cane toad, Bufo marinus.

    abstract::The entire population of ganglion cells in the retina of the toad Bufo marinus was labeled by retrograde transport of a lysine-fixable biotinylated dextran amine of 3000 molecular weight. Synaptic connections between bipolar, amacrine, and ganglion cells in the inner plexiform layer were quantitatively analyzed, with ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Zhu BS,Gibbins IL

    更新日期:1997-11-01 00:00:00

  • Receptor targets of amacrine cells.

    abstract::Amacrine cells are a morphologically and functionally diverse group of inhibitory interneurons. Morphologically, they have been divided into approximately 30 types. Although this diversity is probably important to the fine structure and function of the retinal circuit, the amacrine cells have been more generally divid...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审


    authors: Zhang C,McCall MA

    更新日期:2012-01-01 00:00:00

  • Visual latency and brightness: an interpretation based on the responses of rods and ganglion cells in the frog retina.

    abstract::Rod and cone photoresponses in a variety of species have been accurately described with linear multistage filter models. In this study, the response latency and initial coding of intensity at two higher levels of visual processing are related to such photoreceptor responses. One level is the retinal output (spiking di...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Donner K

    更新日期:1989-07-01 00:00:00

  • Development of multibank rod retinae in deep-sea fishes.

    abstract::We studied the development of multibank rod retinae by monitoring the size-related addition of new layers of rod inner and outer segments in four species of deep-sea fishes and found two different growth paradigms. In the mesopelagic Chauliodus sloani, new banks of rod inner and outer segments are added as long as the...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Fröhlich E,Wagner HJ

    更新日期:1998-05-01 00:00:00

  • The role of spontaneous retinal activity before eye opening in the maturation of form and function in the retinogeniculate pathway of the ferret.

    abstract::During early mammalian development, inputs from the two retinas intermix within the lateral geniculate nucleus (LGN), then segregate during the first postnatal week into layers that receive input from a single retina. Functionally, the LGN also changes markedly during the first postnatal month; early geniculate respon...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Cook PM,Prusky G,Ramoa AS

    更新日期:1999-05-01 00:00:00

  • Visual experience promotes the isotropic representation of orientation preference.

    abstract::Within the visual cortex of several mammalian species, more circuitry is devoted to the representation of vertical and horizontal orientations than oblique orientations. The sensitivity of this representation of orientation preference to visual experience during cortical maturation and the overabundance of cardinal co...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Coppola DM,White LE

    更新日期:2004-01-01 00:00:00

  • Reaction time measures of adaptation to chromatic contrast.

    abstract::Simple reaction times (RTs) were measured to brief temporally blurred (total onset 570 ms) Gaussian isoluminant chromatic patches (s.d. 0.5 degrees) whose chromaticities lay along the cardinal chromatic axes (0 degrees, 90 degrees, 180 degrees, and 270 degrees in MBDKL color space). Bipolar adapting stimuli were emplo...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Parry NR,Murray IJ,McKeefry DJ

    更新日期:2008-05-01 00:00:00

  • Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys.

    abstract::Four experiments were performed to assess the effects of ON channel blockade with the glutamate analog 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. In Experiment 1, we demonstrate that stimuli brighter than background (incremental stimuli) appear less bright following ON channel ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章


    authors: Dolan RP,Schiller PH

    更新日期:1994-01-01 00:00:00