Abstract:
:The aim of the present study was to determine to what extent adult rats can produce new contracting bladder muscle and to see if such newly formed bladder tissue possesses characteristic mechanical properties or whether the ability to recover mechanically is so pronounced that the prehistory of the bladder is unimportant. Subtotal cystectomy was performed in adult female rats, leading to a pronounced decrease in total bladder weight. At 10 weeks, bladder weight had normalized. The histological appearance of such bladders was similar to that of the controls. Active and passive length-tension relations for the detrusor muscle were determined in controls and up to 10 weeks after surgery. Immediately after surgery active and passive forces showed a leftward shift and maximum active force decreased markedly. With time the length-tension curves shifted back to normal, but a decreased active force still remained at 10 weeks. Detrusor actin concentration and detrusor myosin/actin ratio were unaffected by the subtotal cystectomy. Intermediate filament protein/actin ratio showed a significant but transitory increase. We conclude that there is a remarkable recovery of detrusor muscle function after subtotal cystectomy, leading to a normalization of optimum length for active force and a net synthesis of contractile and cytoskeletal proteins. The ability to produce active force does, however, not fully recover.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Frederiksen H,Sjuve R,Arner A,Uvelius Bdoi
10.1002/nau.1020subject
Has Abstractpub_date
2001-01-01 00:00:00pages
685-97issue
6eissn
0733-2467issn
1520-6777pii
10.1002/nau.1020journal_volume
20pub_type
杂志文章abstract:AIMS:Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower-extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome. METHODS:All patients who underwent fetal MMC repair at o...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23174
更新日期:2017-08-01 00:00:00
abstract:AIMS:To test the different formulae to calculate the bladder volume using ultrasound; the accuracy of patients hearing/feeling "bubbles" at the end of urodynamics testing as a measure of being empty; and how good we are at estimating PVR using X-ray at the end of video urodynamics testing. METHODS:This was a prospecti...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23963
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Pacemakers in upper urinary tract (UUT) are still under study. AIM:We reviewed the role of some cells that seem to be involved in the propulsion of urinary bolus from UUT to the bladder. MATERIALS & METHODS:We focuses on evaluating studies on the mechanisms by which the UUT propels urine to the bladder via...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22310
更新日期:2013-04-01 00:00:00
abstract:AIMS:Resiniferatoxin (RTX), a vanilloid compound and agonist of the transient receptor potential channel 1 (TRPV1), is known for its beneficial effects on neurogenic detrusor overactivity. The mainstream rationale for its use is the desensitization of TRPV1 on sensory bladder afferents. However, recent findings showed ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20313
更新日期:2007-01-01 00:00:00
abstract:AIMS:Our main aim was to compare the prostatic selectivity of silodosin with that of other alpha(1)-adrenoceptor (AR) antagonists. METHODS:We examined uroselectivities in two sets of experiments namely, in vitro and in vivo functional studies using male dogs. In the in vitro study, after evaluating the inhibitory effe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20312
更新日期:2006-01-01 00:00:00
abstract:AIMS:This study investigated the expressions of PGP9.5, P2 X 3 , muscarinic receptor (M3) and beta-3 adrenoreceptor (AR) in idiopathic detrusor overactivity (IDO) patients refractory to antimuscarinic treatment, and analyzed the correlation between protein expressions and clinical symptoms of IDO bladders with differe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23138
更新日期:2017-06-01 00:00:00
abstract:AIMS:Previous studies have shown that the activin-binding protein follistatin reduces inflammation in several mouse models of colitis. To determine whether follistatin also has a beneficial effect following bladder inflammation, we induced cystitis in mice using cyclophosphamide (CYP) and examined the relationship betw...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22941
更新日期:2017-02-01 00:00:00
abstract::Forty-six patients were evaluated for complaints of urinary incontinence or voiding disorders. Diagnostic testing included a detailed history, physical examination, urine analysis, and urodynamic studies consisting of a conventional urodynamic test (S.I.) including provocative manoeuvres and extramural ambulatory urod...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(1994)13:3<237::aid-nau1930130305
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). OBJECTIVES:The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urothelium in the pathophysiology of nocturia; (b) to determine whether noc...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24274
更新日期:2020-07-01 00:00:00
abstract:AIMS:Pelvic organ prolapse involves physical changes to the genitals, potentially distressing to women. We hypothesized poorer genital body image in prolapsed women versus controls and that genital body image would correlate with sexual health. METHODS:Seventy-four sexually active women, 13 with prolapse, 24 with surg...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22205
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:We evaluated the association between lower urinary tract symptoms (LUTS) and the expression of connexin (Cx) and transient receptor potential (TRP) channel on urothelial cells non-invasively collected from voided urine in humans. METHODS:A total of 55 patients (36 males and 19 females, median age: 71 years ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23436
更新日期:2018-03-01 00:00:00
abstract:AIMS:Lower urinary tract dysfunction affects up to 75% of the multiple sclerosis population. Results from our recent Pilot Study (McClurg et al., 2006) indicated that a combined programme of pelvic floor muscle training, electromyography biofeedback and neuromuscular electrical stimulation modalities may alleviate some...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20486
更新日期:2008-01-01 00:00:00
abstract:AIMS:The ultrasound assessment of bladder wall thickness (BWT) and intravesical prostatic protrusion (IPP) have emerged as a non-invasive, inexpensive, time-saving alternatives to pressure-flow studies to assess benign prostatic obstruction (BPO). Aim of our study was to evaluate the effect on detrusor mass of dutaster...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23247
更新日期:2017-11-01 00:00:00
abstract:AIMS:This study aimed to evaluate whether the pressure readings obtained from air-filled catheters (AFCs) are the same as the readings from simultaneously inserted water-filled catheters (WFCs). It also aimed to make any possible recommendations for the use of AFCs to conform to International Continence Society (ICS) G...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22827
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Turkish Continence Society aimed to analyze how overactive bladder (OAB) is being managed in routine practice by the urologists in Turkey. MATERIAL AND METHODS:Fourteen urology departments were randomly selected to represent the whole population in this multicenter study. An online data entry and storage ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究
doi:10.1002/nau.24079
更新日期:2019-11-01 00:00:00
abstract::Detrusor hyperreflexia (DH) is frequently found in patients with benign prostatic hypertrophy (BPH) and persists in 30-50% of patients after successful removal of bladder neck obstruction by transurethral prostatectomy (TUR-P) or surgical enucleation of the prostate. It would be beneficial for surgeons to be able to i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(2000)19:3<233::aid-nau4>3.
更新日期:2000-01-01 00:00:00
abstract:AIMS:To estimate the prevalence and severity of bed-wetting in 1-18-year-old Chinese children. MATERIALS AND METHODS:A cross-sectional study of bed-wetting was performed by using 13,515 self-administered questionnaires distributed to the parents of 1-18-year-old Chinese children in Henan province. The prevalence of be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20373
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To compare intermittent catheterization, sling mobilization, and sling transection for treatment of urinary retention after mid-urethral sling surgery. METHODS:Data registered in the Norwegian Female Incontinence Registry from 1998 to 2013 were analyzed in this cohort study to compare subjective and objectiv...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23046
更新日期:2017-04-01 00:00:00
abstract:AIMS:To evaluate the effect of ASP2205, a selective serotonin 5-HT2c receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. METHODS:Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The interve...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24045
更新日期:2019-08-01 00:00:00
abstract:AIMS:The purpose of this study was to describe the distal pathway of the dorsal nerve of the clitoris (DNC) from gross anatomical and histological studies of cadaver specimens. METHODS:We performed dissections on 14 intact adult cadaver vulva specimens using 2× loupe magnification and microscopy. The DNC was identifie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20996
更新日期:2011-03-01 00:00:00
abstract:AIMS:We sought to compare in-office physical exam findings via standing cough test (SCT) versus 24-hour pad weights among men seeking treatment for postprostatectomy stress urinary incontinence (SUI). METHODS:A retrospective review of a single surgeon database of incontinence procedures was performed. Documentation of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24200
更新日期:2020-01-01 00:00:00
abstract::Invasive pressure flow analysis is the gold standard for discriminating between hypocontractile bladder muscle function and infravesical obstruction in male patients with lower urinary tract symptoms. Here a non-invasive method to determine the isovolumetric bladder pressure to judge contractility is presented. This i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:5<477::aid-nau10>3
更新日期:1999-01-01 00:00:00
abstract:AIMS:To report the state of the science on primary prevention of urinary incontinence (UI) in adults from the 6th International Consultation on Incontinence with an update through January 2019. METHODS:Online databases PubMed, CINAHL, PsycInfo, and Medline were searched in March 2016 and February 2019 with a focus on ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24222
更新日期:2020-01-01 00:00:00
abstract:AIMS:Prostate cancer is the most frequently diagnosed male cancer and urinary incontinence represents a major consequence following surgery. Penile compression clamps (PCCs) which externally occlude the urethra may be used to manage the incontinence. Despite potential complication of PCCs, such as deformation-inflicted...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23172
更新日期:2017-08-01 00:00:00
abstract:AIMS:The primary aim of this prospective study was to examine the correlations between "The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF)" score and urodynamic findings in patients with urge incontinence. In addition, we aimed to observe the alterations of these parameters with antimusca...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20389
更新日期:2007-01-01 00:00:00
abstract::The objective of this study was to compare urethral resistance as determined in pressure-flow studies before and after Burch retropubic urethropexy. Urethral resistance was retrospectively determined from pressure-flow studies in 178 patients before and 1 year after Burch retropubic urethropexy. Results of cotton swab...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:6<623::aid-nau12>3
更新日期:1999-01-01 00:00:00
abstract:AIMS:To determine the antiseptic efficacy on bacterial colony counts of a 5- vs 10-minute surgical site scrub in urologic surgery. METHODS:A prospective cohort study was conducted in 101 patients presenting for elective urological procedures. Patients were randomized to a 5- or 10-minute groin scrub with Betadine (pov...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23945
更新日期:2019-03-01 00:00:00
abstract:AIMS:To investigate the test-retest reliability of Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire in a sample of stroke patients. METHODS:A prospective study design was used in which the stroke patients were invited to complete a postal self-administrated DAN-PSS-1 questionnaire twice. The questionnaire cons...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20223
更新日期:2006-01-01 00:00:00
abstract:AIM:To explore the effects of experimental subarachnoid hemorrhage (SAH) on rabbit urinary bladder and to assess the potential protective effects of hyperbaric oxygen therapy (HBOT). METHODS:A total of 15 male New Zealand white rabbits were divided randomly to one of three groups: group I was spared as the control gro...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24418
更新日期:2020-06-01 00:00:00
abstract::The present study prospectively surveyed the prevalence of anal incontinence among 283 consecutive female patients attending a urogynecologic outpatient clinic in a maternity hospital. Data concerning bowel habits, laxative use, previous anorectal surgery, and the presence, severity, and frequency of anal incontinence...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:3<199::aid-nau6>3.
更新日期:1999-01-01 00:00:00