Abstract:
AIMS:The ultrasound assessment of bladder wall thickness (BWT) and intravesical prostatic protrusion (IPP) have emerged as a non-invasive, inexpensive, time-saving alternatives to pressure-flow studies to assess benign prostatic obstruction (BPO). Aim of our study was to evaluate the effect on detrusor mass of dutasteride add-on therapy in men with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS:A consecutive series of BPE patients with a prostate volume (PV) ≥30 mL and an international prostate symptoms score (IPSS) ≥8 not satisfied with Tamsulosin monotherapy were enrolled. Free maximum flow (Qmax), PV, BWT, and IPP were recorded at baseline and at 24 weeks follow-up. RESULTS:Overall, 27 men were enrolled. Dutasteride significantly improved LUTS (-46.7%; P = 0.001) and Qmax (+18.7%; P = 0.001) and reduced PV (-13%; P = 0.002), BWT (-40.3%; P = 0.001), and IPP (-14.9%; P = 0.015). At baseline, based on BWT ≥5 mm and an IPP >10 mm, 13/27 (48%) and 15/27 (55%) patients were defined at risk for BPO, respectively; while after 24 weeks of treatment they were 3/27 (11.1%) and 11/27 (40%), respectively. CONCLUSIONS:Dutasteride add-on therapy significantly reduced IPP and detrusor mass and was effective in improving LUTS in patients with BPE not satisfied with αBs monotherapy. The possible role of BWT and IPP as proxies of medical treatment outcomes should be confirmed by further studies.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
De Nunzio C,Brassetti A,Proietti F,Gacci M,Serni S,Esperto F,Tubaro Adoi
10.1002/nau.23247subject
Has Abstractpub_date
2017-11-01 00:00:00pages
2096-2100issue
8eissn
0733-2467issn
1520-6777journal_volume
36pub_type
杂志文章abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:To create an animal model for neurogenic underactive bladder disease (UAB) and identify markers to describe secondary myogenic changes in the bladder wall. MATERIALS AND METHODS:Male rats underwent either bilateral pelvic nerve injury or sham surgery. Four weeks after surgery functional evaluation was perfo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23517
更新日期:2018-06-01 00:00:00
abstract:AIMS:To determine the role of opioid receptors in the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs, and explore the possible mechanism of SNM. METHODS:Both implant-driven stimulators of the S3 spinal nerve were implanted in seven pigs. Naloxone and tramadol were administered. Multiple cys...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23187
更新日期:2017-09-01 00:00:00
abstract:AIMS:To obtain improved assessment of bladder sensitivity during cystometry by using a 10 cm visual analogue scale (VAS), and comparing it with the standard method according to the International Continence Society (ICS). METHODS:Twenty-five patients with presumed normal bladder functioning underwent filling cystometri...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.20301
更新日期:2007-01-01 00:00:00
abstract:AIMS:To examine whether isolated bladder outlet obstruction in the absence of associated lower urinary tract abnormality results in hydronephrosis. Isolated obstruction causes a brief rise in bladder pressure that might not trigger hydronephrosis. METHODS:Data included adult men who underwent urodynamics for refractor...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24495
更新日期:2020-11-01 00:00:00
abstract:AIMS:The use of electrotherapeutics to improve filling and emptying dysfunction of the adult bladder has been well established, however the practice in children is less well known. The purpose of this review is to summarize the rationale behind the use of electro neuromodulation in children, examine the reported effica...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.10171
更新日期:2004-01-01 00:00:00
abstract:AIM:To characterise the developmental changes to the normal bladder by examining the in vitro contractile properties of the fetal sheep detrusor smooth muscle bladder at different gestational ages. METHODS:Three groups of normally developing fetal sheep bladders were investigated: (1) 65-70 days gestation (2nd trimest...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20124
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Overactive bladder syndrome (OAB) including urgency and urgency urinary incontinence (UUI) occurs frequently after stress urinary incontinence (SUI) surgery. It is important to identify the risk factors for the occurrence of OAB symptoms in order to adequately inform the patient before surgery. Furthermore...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.23328
更新日期:2018-01-01 00:00:00
abstract::The vaginal vestibule has not been the subject of a dedicated journal article. Recent terminology has suggested its division into anterior and posterior components. The case for this division has not yet been assessed. Both components extend laterally from the hymen to the junction with the labia minora. The posterior...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23064
更新日期:2017-04-01 00:00:00
abstract:AIMS:We evaluated the long-term results with a left antegrade continence enema (LACE) approach: "Macedo-Malone (MM) procedure" to define parameters such as clinical durability of the technique and patients' compliance with the method. METHODS:We reviewed the medical records of all patients that underwent the MM proced...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22880
更新日期:2017-01-01 00:00:00
abstract:AIM:To investigate if injection of cells in the urethral sphincter complex causes unspecific bulking effects. METHODS:Human mesenchymal stromal cells were isolated, expanded, and characterized. For transurethral injection, cells were labeled with the fluorescent dye PKH26 and in magnetic resonance imaging associated e...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23182
更新日期:2017-09-01 00:00:00
abstract:AIMS:Although overactive bladder (OAB) impacts patient health-related quality of life, the impact of OAB on family members is not known. Presently, no validated instruments exist to assess family impact, thus we examined the psychometric properties of a new instrument, the overactive bladder family impact measure (OAB-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20715
更新日期:2010-03-01 00:00:00
abstract:AIMS:To examine alterations in expression of angiotensin II type 1 receptors (AT1R) which induce organ tissue remodeling, angiotensin II type 2 receptors (AT2R) which protect against it, and related molecules in the bladder of matured rats with bladder dysfunction. METHODS:Female SD rats of three different ages were u...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22849
更新日期:2016-11-01 00:00:00
abstract:AIM:To develop and pilot test an interactive mobile telehealth program (mHealth) for behavioral treatment of women veterans with urinary incontinence (UI). METHODS:We developed an evidence-based 8-week behavioral mHealth program, MyHealtheBladder, with input from women veterans, behavioral medicine and health educatio...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24226
更新日期:2020-01-01 00:00:00
abstract:AIMS:To review the known determinants of healthcare-seeking behavior for LUTS and address unmet needs and future research priorities. METHODS:The PubMed literature was searched for currently known factors affecting treatment seeking for LUTS, OAB, and incontinence in men and women. RESULTS:Further to the great variat...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22212
更新日期:2012-03-01 00:00:00
abstract:AIMS:The Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) assess symptom distress and the impact on daily life of urinary incontinence. The UDI-6 has not been validated before in males. Our aim was to validate the UDI-6 and IIQ-7 in Dutch men and women. METHODS:The translation to Dut...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22496
更新日期:2015-01-01 00:00:00
abstract:AIMS:External sphincterotomy (ES) is a therapeutic option for male spinal cord injury patients with detrusor sphincter dyssynergia. However, some patients need to change their voiding management after ES. One of the potential causes of failure is reportedly detrusor dysfunction, but long-term urodynamic follow-up data ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23702
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Treatment patterns and costs were characterized among patients with overactive bladder (OAB) receiving later-line target therapies (combination mirabegron/antimuscarinic, sacral nerve stimulation [SNS], percutaneous tibial nerve stimulation [PTNS], or onabotulinumtoxinA). METHODS:In a retrospective cohort...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24474
更新日期:2020-11-01 00:00:00
abstract:AIM:To compare the urethral sphincter morphology and levator hiatal dimensions between white and black premenopausal nulliparous asymptomatic women using 3D/4D translabial ultrasonography. METHODS:Nulliparous black and white women were recruited in a tertiary gynecological center. All women were completely asymptomati...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21181
更新日期:2012-04-01 00:00:00
abstract:AIMS:To determine the optimal stochastic whole body vibration (SR-WBV) load modality regarding pelvic floor muscle (PFM) activity in order to complete the SR-WBV training methodology for future PFM training with SR-WBV. METHODS:The continuous and the intermittent SR-WBV modalities were tested by means of electromyogra...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21251
更新日期:2012-06-01 00:00:00
abstract:AIMS:We aimed to compare the efficacy and safety of mirabegron, a β3-adrenoceptor agonist, and imidafenacin, an anticholinergic agent, in overactive bladder patients. METHODS:We conducted a multicenter, prospective randomized cross-over study at 5 hospitals in Japan from December 2012 to June 2015. We enrolled female ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.23050
更新日期:2017-04-01 00:00:00
abstract:AIMS:To evaluate cognitive processing in elderly women with urge incontinence as compared to continent cohorts by measuring performance on neuropsychological tests of working memory, attention and inhibition. To measure speed of information processing, intensity of bladder filling sensation, and urine volume at a first...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22357
更新日期:2013-06-01 00:00:00
abstract:AIMS:To investigate whether vaginal estrogen cream combined with tolterodine is more effective than tolterodine alone in the treatment of postmenopausal women with overactive bladder (OAB). MATERIALS AND METHODS:This is an unblinded study without placebo. A preliminary study consisted of tolterodine 2 mg twice per day...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20583
更新日期:2009-01-01 00:00:00
abstract:AIM:Urinary incontinence is one of the most common, disruptive and often disabling conditions affecting frail older people living in community. The aims of present study were to describe the prevalence of bladder catheter in a population of older women living in community and to examine the relationship between urinary...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20059
更新日期:2004-01-01 00:00:00
abstract::The present study prospectively surveyed the prevalence of anal incontinence among 283 consecutive female patients attending a urogynecologic outpatient clinic in a maternity hospital. Data concerning bowel habits, laxative use, previous anorectal surgery, and the presence, severity, and frequency of anal incontinence...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:3<199::aid-nau6>3.
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:The relationship between exposure to abuse and interstitial cystitis/bladder pain syndrome (IC/BPS) is well-documented. However, studies have yet to examine posttraumatic stress disorder (PTSD), which develops following exposure to trauma and worsens health outcomes in chronic pain. We aimed to assess the preva...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23861
更新日期:2019-01-01 00:00:00
abstract:AIM:To evaluate the benefits of a newly established checklist form of behavioral therapy for overactive bladder (OAB). METHODS:Of a total of 180 patients suffering eight or more micturitions, two or more nocturia, seven or more urgency, or four more urinary urgency incontinence (UUI) episodes per day according to a 3-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23974
更新日期:2019-04-01 00:00:00
abstract:AIM:Treatments targeting vanilloid receptor TRPV1 are effective in some bladder disorders. Our aim was to determine the expression profiles of TRPV1 in regions of human bladder and test the hypothesis that there would be an upregulation of TRPV1 in mucosa of patients with bladder hypersensitivity but not idiopathic det...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20326
更新日期:2007-01-01 00:00:00
abstract:AIMS:The purpose of this study was to describe the distal pathway of the dorsal nerve of the clitoris (DNC) from gross anatomical and histological studies of cadaver specimens. METHODS:We performed dissections on 14 intact adult cadaver vulva specimens using 2× loupe magnification and microscopy. The DNC was identifie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20996
更新日期:2011-03-01 00:00:00
abstract:AIMS:We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex. METHODS:We examined (1) urinary 5-hydroxyindole acetic acid (5-HIAA) after intraperitoneal administration of saline, para-chlorophenylalanine (PCPA; a serotonin synt...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23028
更新日期:2017-03-01 00:00:00