Abstract:
AIMS:To investigate whether vaginal estrogen cream combined with tolterodine is more effective than tolterodine alone in the treatment of postmenopausal women with overactive bladder (OAB). MATERIALS AND METHODS:This is an unblinded study without placebo. A preliminary study consisted of tolterodine 2 mg twice per day for 3 months had been conducted for 25 postmenopausal women with OAB. Over a period of 11 months, 80 postmenopausal women with OAB underwent a prospective randomized trial. These patients were equally randomized into two groups. The interventions for the 12-week treatment period included 2 mg tolterodine twice per day for the group A and 2 mg tolterodine twice per day/vaginal conjugated equine estrogen 0.625 mg twice a week for the group B. Identical pre- and post-treatment assessments included bladder diary, Urogenital Distress Inventory-6 (UDI-6), and Incontinence Impact Questionnaire-7 (IIQ-7). RESULTS:All 80 women (65.2 years, range 58-73) completed this study. The between groups comparison showed that the group B had significant improvements in mean daytime frequency and voided volume after treatment (14.8-5.8 vs. 14.1-6.4, P = 0.001 and 115.8-141.9 vs. 108.5-134.5, P = 0.007, respectively). Additionally, a comparison of the final total scores of UDI-6 and IIQ-7 between the two groups revealed that the group B had a statistically significant improvement in quality of life than that in the group A (8.6-6.9 vs. 9.5-7.2, P < 0.001 and 9.4-6.1 vs. 10.2-6.5, P < 0.001, respectively). Changes in the other symptoms, including nocturia, urgency and urge incontinence, were not statistically significant but actually achieved improved in both groups. CONCLUSIONS:A combination of vaginal estrogen cream and tolterodine is a potential therapy for postmenopausal women with OAB.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Tseng LH,Wang AC,Chang YL,Soong YK,Lloyd LK,Ko YJdoi
10.1002/nau.20583subject
Has Abstractpub_date
2009-01-01 00:00:00pages
47-51issue
1eissn
0733-2467issn
1520-6777journal_volume
28pub_type
杂志文章,随机对照试验abstract:AIMS:To review the literature on toilet training (TT) in healthy children. METHODS:Through an extended literature search, all data on developmental signs of readiness for TT, TT methods, definitions of being toilet trained, TT problems, and predictive factors for success were reviewed. RESULTS:Specific studies on thi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20490
更新日期:2008-01-01 00:00:00
abstract::Detrusor hyperreflexia (DH) is frequently found in patients with benign prostatic hypertrophy (BPH) and persists in 30-50% of patients after successful removal of bladder neck obstruction by transurethral prostatectomy (TUR-P) or surgical enucleation of the prostate. It would be beneficial for surgeons to be able to i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(2000)19:3<233::aid-nau4>3.
更新日期:2000-01-01 00:00:00
abstract:AIMS:To investigate the use of an inflatable perile cuff to obstruct flow progressively during voiding in order to provide a noninvasive measure of bladder pressure. METHODS:In this study, we explain the observed relationship of flow rate with applied cuff pressure by analogy with a simple physical model. The model co...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10059
更新日期:2003-01-01 00:00:00
abstract:AIMS:To determine whether activity of the pelvic floor (PF) and abdominal muscles differs between continent and incontinent women in response to a postural perturbation with a moderately full or empty bladder. METHODS:Electromyographic (EMG) activity of the PF and abdominal muscles was recorded with surface electrodes...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20336
更新日期:2007-01-01 00:00:00
abstract:AIMS:Long-term indwelling catheterisation may affect health related quality of life, but clinical assessment and monitoring of people with indwelling catheters is poorly recorded because there are no validated measures to capture these criteria. In this paper, we describe the development of the ICIQ-Long Term Catheter ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22729
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Pacemakers in upper urinary tract (UUT) are still under study. AIM:We reviewed the role of some cells that seem to be involved in the propulsion of urinary bolus from UUT to the bladder. MATERIALS & METHODS:We focuses on evaluating studies on the mechanisms by which the UUT propels urine to the bladder via...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22310
更新日期:2013-04-01 00:00:00
abstract:AIMS:The biomechanical properties of length adaptation and adjustable preload have been previously identified in detrusor smooth muscle in animal models. This in vitro study aims to show that human detrusor smooth muscle exhibits length adaptation and adjustable preload tension which could play an important role in bot...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22820
更新日期:2016-09-01 00:00:00
abstract:AIMS:The aim of this study is to report the functional results, patient satisfaction, and morbidity of the Transobturator tape procedure (TOT) in the treatment of stress incontinence (SUI). METHODS:One hundred and thirty patients were prospectively evaluated with history, physical examination, quality of life question...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.20353
更新日期:2007-01-01 00:00:00
abstract:AIMS:The aim of the study was to compare the effect of hypopressive exercises including pelvic floor muscle contraction, pelvic floor muscle training (PFMT) alone and control on pelvic floor muscle function in women with pelvic organ prolapse (POP). METHODS:Fifty-eight women with a mean age of 55.4 (± 9.8) years old w...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21149
更新日期:2012-01-01 00:00:00
abstract:AIM:Here, we present the clinical presentation and surgical outcomes of women with symptomatic urethral prolapse presenting to our institution over 20 years, and seek to provide treatment recommendations for management of symptomatic urethral prolapse and caruncle. METHODS:A retrospective review of medical records fro...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23232
更新日期:2017-11-01 00:00:00
abstract:AIMS:Vaginal distention (VD) is a validated model of birth-related trauma in rats. Recently a mouse VD model was reported. Our study was originally conducted to evaluate the impact of age on VD in mice. This manuscript describes the study and reports on the lack of reproducibility of VD models in mice. METHODS:We util...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23886
更新日期:2019-02-01 00:00:00
abstract:AIMS:To compare severity and characteristics of urologic pain, other urinary symptoms, sexual pain, psychosocial health, and the distribution and intensity of non-urologic pain between men and women with and without Hunner lesions. METHODS:All cystoscopies were performed and documented by the same clinician to ensure ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23812
更新日期:2018-11-01 00:00:00
abstract:AIMS:Overactive bladder (OAB), characterized by urinary urgency, with or without incontinence, and urinary frequency and nocturia, has a significant impact on patients' lives. Given the social context inherent in OAB, the purpose of this study was to identify issues faced by OAB family members. METHODS:Incontinent OAB...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20705
更新日期:2009-01-01 00:00:00
abstract:AIMS:To characterize levator ani muscle (LAM) activity in nulligravidas using magnetomyography (MMG) and define MMG characteristics associated with LAM activity with and without accessory muscle contributions. METHODS:MMG data were collected from eight nulligravidas during rest and voluntary LAM contractions (Kegels) ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23870
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Hydrodistention (HD) has been utilized as a diagnostic and therapeutic tool in patients with refractory and diverse pelvic floor symptoms, including bladder pain with or without irritative bladder symptoms such as urinary urgency and urinary frequency. We sought to determine whether we could better define ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20200
更新日期:2005-01-01 00:00:00
abstract::Nocturia, awaking from sleep to void, has a negative impact on health and well-being. Nocturia affects men and women and is more prevalent among the elderly. More than two nocturnal voids is considered to be a clinically meaningful threshold associated with significant negative outcomes for health and well-being, and ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22595
更新日期:2014-04-01 00:00:00
abstract::Complex repetitive discharges (CRDs) are a form of abnormal needle electromyographic (EMG) activity associated with a variety of neuromuscular disorders, including chronic denervation. Urethral CRDs have also been associated with symptoms of voiding dysfunction. We reviewed the findings of 351 consecutive urethral sph...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2000)19:5<577::aid-nau4>3.0.co;2
更新日期:2000-01-01 00:00:00
abstract:AIM:The aim was to evaluate the voiding function over time after the TVT procedure for stress incontinence. MATERIALS AND METHODS:Thirty-eight women with urodynamic stress urinary incontinence were included in the study. For voiding function assessment the patients were asked if voiding had changed postoperatively, an...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20401
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To create an animal model for neurogenic underactive bladder disease (UAB) and identify markers to describe secondary myogenic changes in the bladder wall. MATERIALS AND METHODS:Male rats underwent either bilateral pelvic nerve injury or sham surgery. Four weeks after surgery functional evaluation was perfo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23517
更新日期:2018-06-01 00:00:00
abstract:AIMS:To investigate the effect of the bladder sensation grade on uroflowmetry parameters. METHODS:Fifty healthy volunteering young men were enrolled in the present study. In total, three uroflowmetry evaluations were made. Qmax , Qave , VV, and PVR urine was obtained three times in three described bladder sensation gr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22762
更新日期:2016-06-01 00:00:00
abstract:AIMS:This study was conducted to try to objectify assessment of pediatric uroflowmetry curves. MATERIALS AND METHODS:Nine professionals in pediatric incontinence care judged 480 pediatric uroflows. On a 1-5 scale, where 1 = anomalous and 5 = normal, uroflows were assessed on four items: staccato, interrupted, flow tim...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21152
更新日期:2011-11-01 00:00:00
abstract:AIMS:We sought to determine whether somatic lumbar nerve transfer to the pelvic nerve's anterior vesical branch after sacral decentralization for detrusor muscle reinnervation also leads to aberrant innervation of the bladder outlet. METHODS:Twenty-six female mongrel hound dogs underwent transection of sacral dorsal a...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24217
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:The terminology for anorectal dysfunction in women has long been in need of a specific clinically-based Consensus Report. METHODS:This Report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23055
更新日期:2017-01-01 00:00:00
abstract:AIMS:Parkinson's disease (PD) affects the nigrostriatal projections leading to micturition disturbance in most cases. Overactive bladder (OAB) symptoms such as urinary urgency or urgent urinary incontinence are common amongst PD patients. Several urodynamic studies have revealed that detrusor overactivity causes OAB sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20682
更新日期:2009-01-01 00:00:00
abstract:AIMS:Urinary tract infection (UTI) is a common complication after pelvic floor surgery. Antibiotics as prophylaxis may reduce the prevalence of UTI's by 50%, but bacterial resistance may be a large disadvantage, necessitating the search for other possible prophylactic options. Recent research found a 50% reduction in t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24391
更新日期:2020-06-01 00:00:00
abstract::The present study prospectively surveyed the prevalence of anal incontinence among 283 consecutive female patients attending a urogynecologic outpatient clinic in a maternity hospital. Data concerning bowel habits, laxative use, previous anorectal surgery, and the presence, severity, and frequency of anal incontinence...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:3<199::aid-nau6>3.
更新日期:1999-01-01 00:00:00
abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract::Myelin basic protein (MBP) can be used as an antigen for inducing experimental allergic encephalomyelitis (EAE). In various studies, EAE animals have been used as an experimental model of demyelinating diseases. The aim of this study was to determine whether EAE, induced by MBP in rats, can be useful for investigation...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2000)19:6<689::aid-nau7>3.0.co;2
更新日期:2000-01-01 00:00:00
abstract:AIMS:In the bladder, ATP is an important signaling molecule, which is released by bladder stretch and acid. We hypothesized that ATP might play a unique role in patients with OAB, characterized by low bladder volumes at first desire to void (FDV) and maximal cystometric capacity (MCC) and symptoms of frequency/urgency ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22344
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:We aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations. METHODS:A secondary analysis of women with urge incontinence or urge predominant MUI enrolled in the Urinary Incontinence Treatment Network BE-DRI rand...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20922
更新日期:2011-01-01 00:00:00