Abstract:
BACKGROUND:Pacemakers in upper urinary tract (UUT) are still under study. AIM:We reviewed the role of some cells that seem to be involved in the propulsion of urinary bolus from UUT to the bladder. MATERIALS & METHODS:We focuses on evaluating studies on the mechanisms by which the UUT propels urine to the bladder via pacemaker cells. RESULTS:Electric active pacemaker cells generate pyeloureteric autorhythmicity driving adjacent smooth muscle cells (SMCs); it emphasizes the role of the interstitial cells of Cajal-like cells (ICC-LCs) localized in the UUT. Interstitial cells of Cajal (ICCs) are now thought to cooperate in conducting and amplifying pacemaker activity in the UUT. These cells produce electrical slow-wave potentials and determine the propagation of peristaltic activity. Identification of ICC-LCs is facilitated by use of c-kit antibodies. Contraction waves arising from the UUT and the propagation of these waves may require the direct involvement of ICC-LCs, as c-kit immunoreactivity appears developmentally at the same time as coordinated unidirectional peristaltic contraction. ICC-LCs observed in the UUT have morphological features similar to those of c-kitpositive ICCs in the gastrointestinal tract. In addition to gastrointestinal motility, ICCs may also play a significant role in the propagation, coordination, and modulation of ureteropelvic peristalsis. DISCUSSION:Alterations in ICC-LCs are closely associated with a variety of motility disorders and many congenital urological diseases of the UUT such as primary obstructive megaureter, congenital ureteropelvic junction obstruction, and vesicoureteral reflux. CONCLUSION:These observations open the way for further investigations of this cell type.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Di Benedetto A,Arena S,Nicotina PA,Mucciardi G,Galì A,Magno Cdoi
10.1002/nau.22310subject
Has Abstractpub_date
2013-04-01 00:00:00pages
349-53issue
4eissn
0733-2467issn
1520-6777journal_volume
32pub_type
杂志文章,评审abstract:AIMS:The aim of our study was to analyze whether uroflowmetry parameters are helpful in diagnosing overactive bladder (OAB). The working hypothesis was that the flow curves of patients with OAB symptoms would appear as a sharp peak flow rate with a short duration and high amplitude, lasting only for a short period duri...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22898
更新日期:2017-01-01 00:00:00
abstract::This is the first report of the International Continence Society (ICS) on the development of comprehensive guidelines for Good Urodynamic Practice for the measurement, quality control, and documentation of urodynamic investigations in both clinical and research environments. This report focuses on the most common urod...
journal_title:Neurourology and urodynamics
pub_type: 指南,杂志文章,实务指引
doi:10.1002/nau.10066
更新日期:2002-01-01 00:00:00
abstract:AIMS:The Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) assess symptom distress and the impact on daily life of urinary incontinence. The UDI-6 has not been validated before in males. Our aim was to validate the UDI-6 and IIQ-7 in Dutch men and women. METHODS:The translation to Dut...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22496
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Stakeholders from around the world came together to address the unmet needs of underactive bladder (UAB) at the 3rd International Congress for Underactive Bladder. METHODS:The main recommendation from the regulatory working group is a need for a meeting of UAB stakeholders and regulatory agencies i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23738
更新日期:2018-11-01 00:00:00
abstract:AIMS:To investigate the different muscle activation patterns around the abdomino-pelvic cavity in continent women and their effect on pressure generation during a correct pelvic floor muscle (PFM) contraction and a Valsalva maneuver. METHODS:Thirteen continent women were assessed. Abdominal, chest wall, and PFM activi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20203
更新日期:2006-01-01 00:00:00
abstract:AIMS:To investigate the role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro. MATERIALS AND METHODS:Longitudinal strips of trigonal muscle were isolated, and the mucosa and serosa removed. Tissues were precontracted with KCl, and beta-adrenoceptor agonists (isoprenalin...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10130
更新日期:2003-01-01 00:00:00
abstract::Published data on the safety and efficacy of finasteride in the treatment of benign prostatic hyperplasia are studied and compared with published conclusions. The need for publishing correlation studies of both the benefits and side-effects, to allow for informed physician and patient decisions, is detailed. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140603
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:We evaluated the association between lower urinary tract symptoms (LUTS) and the expression of connexin (Cx) and transient receptor potential (TRP) channel on urothelial cells non-invasively collected from voided urine in humans. METHODS:A total of 55 patients (36 males and 19 females, median age: 71 years ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23436
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To determine the relationship among flow index (FI), uroflowmetry curve shape, and electromyography (EMG) lag time in children. MATERIALS AND METHODS:A total of 294 children with lower urinary tract symptoms were included. The overall relationship between lag time and FI was investigated with curve estimation ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24349
更新日期:2020-06-01 00:00:00
abstract:AIMS:We aimed to compare the efficacy and safety of mirabegron, a β3-adrenoceptor agonist, and imidafenacin, an anticholinergic agent, in overactive bladder patients. METHODS:We conducted a multicenter, prospective randomized cross-over study at 5 hospitals in Japan from December 2012 to June 2015. We enrolled female ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.23050
更新日期:2017-04-01 00:00:00
abstract:AIMS:P(2)X(3) (ATP-gated receptors) in nociceptive neurons of dorsal root ganglion (DRG) participate in transmission of pain signals from the periphery to the spinal cord. However, the role of P(2)X(3) receptors in chronic prostate pain and continued intractable pain remains unclear. MATERIALS AND METHODS:We examined ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21060
更新日期:2011-04-01 00:00:00
abstract:AIMS:Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with subjective sense of improvement. The aim of this study was to estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ) and Overactive Bladder Question...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.21028
更新日期:2011-09-01 00:00:00
abstract:AIMS:Bladder wall stretch increases tissue tension and releases adenosine 5'-triphosphate (ATP) as part of a transduction process to sense bladder filling. Aging is associated with bladder fibrosis to produce a stiffer bladder wall: this may augment ATP release and contribute to age-dependent urgency. Muscarinic agonis...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24426
更新日期:2020-08-01 00:00:00
abstract:AIM:To elucidate the precise cellular and molecular mechanisms that underlie urethral fibrogenesis. METHODS:Endoluminal electrocautery injury (using Karl Storz 10 Fr. Pediatric urethroscope) was employed in male rabbits (n = 6) to create mucosal injury. Retrograde urethrogram (RUG) and endoluminal ultrasound technique...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24281
更新日期:2020-02-01 00:00:00
abstract:AIMS:Our objective was to determine what women find acceptable regarding treatment and outcomes for treatment of stress urinary incontinence (SUI), and correlate this to age, distress and quality of life (QOL). MATERIALS AND METHODS:This prospective cross-sectional IRB-approved study evaluated women with primary SUI. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20570
更新日期:2008-01-01 00:00:00
abstract:AIMS:Nervous system involvement occurs in about half of patients with systemic lupus erythematosis (SLE). Seizures and psychiatric disorders are the most common manifestations; spinal cord lesions are uncommon. We had eight such patients who presented with urinary dysfunction. METHODS:The patients consisted of two men...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10126
更新日期:2003-01-01 00:00:00
abstract:AIM:To characterize purinergic signaling in overactive bladder (OAB). METHODS:Mucosal biopsies were taken by flexible cystoscopy from patients with storage symptoms referred to Urology Departments of collaborating hospitals. Immunohistochemistry (n = 12) and Western blot analysis (n = 28) were used to establish the qu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24322
更新日期:2020-03-01 00:00:00
abstract:AIM:Bladder dysfunction affects up to 90% of the multiple sclerosis (MS) population. Interventions such as Pelvic Floor Training and Advice (PFTA), Electromyography (EMG) Biofeedback, and Neuromuscular Electrical Stimulation (NMES) have received limited research attention within this population. This study aimed to det...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20209
更新日期:2006-01-01 00:00:00
abstract:AIMS:Prompted by patients' changing perceptions of transvaginal mesh, this study examines how mesh has been reported in the news following the 2011 US Food and Drug Administration (FDA) updated notification about the use of mesh in the treatment of pelvic organ prolapse. METHODS:Two national newspaper databases were q...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22923
更新日期:2017-02-01 00:00:00
abstract:AIMS:The objective of the study was to compare sacral nerve stimulation (SNS) to pudendal nerve stimulation (PNS) for voiding dysfunction. METHODS:Thirty subjects with voiding dysfunction had a tined lead placed at S3 and a second electrode implanted at the pudendal nerve via a posterior approach. In a blinded, random...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20174
更新日期:2005-01-01 00:00:00
abstract:AIMS:The primary aim of this prospective study was to examine the correlations between "The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF)" score and urodynamic findings in patients with urge incontinence. In addition, we aimed to observe the alterations of these parameters with antimusca...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20389
更新日期:2007-01-01 00:00:00
abstract::The vaginal vestibule has not been the subject of a dedicated journal article. Recent terminology has suggested its division into anterior and posterior components. The case for this division has not yet been assessed. Both components extend laterally from the hymen to the junction with the labia minora. The posterior...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23064
更新日期:2017-04-01 00:00:00
abstract:AIM:To characterise the developmental changes to the normal bladder by examining the in vitro contractile properties of the fetal sheep detrusor smooth muscle bladder at different gestational ages. METHODS:Three groups of normally developing fetal sheep bladders were investigated: (1) 65-70 days gestation (2nd trimest...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20124
更新日期:2005-01-01 00:00:00
abstract:AIMS:Although several stimulation techniques are available to elicit sacral reflexes, no comparative data on their utility has been published. The aim of the present study was to determine the most sensitive stimulation technique used for neurophysiologic recording of the penilo-cavernosus reflex. METHODS:Neurophysiol...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20474
更新日期:2008-01-01 00:00:00
abstract:AIMS:To evaluate long-term anatomical and functional outcomes of the transobturator-infracoccygeal hammock repair for complex genital prolapse with a porcine collagen-coated polypropylene mesh. METHODS:A prospective observational study comparing pre- and postoperative outcomes, using pelvic organ prolapse quantificati...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20956
更新日期:2011-03-01 00:00:00
abstract:AIMS:Sacral nerve stimulation (SNS) is FDA approved as second-line therapy for both urinary and bowel control. However, there is limited evidence regarding long term safety. We determined adverse events associated with SNS among Medicare beneficiaries. METHODS:We used the 5% national random sample of Medicare claims f...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22618
更新日期:2015-09-01 00:00:00
abstract::Methods for quantification of bladder outlet obstruction (BOO) are still controversial. Parameters such as detrusor opening pressure (p(det.open)), maximum detrusor pressure (p(det.max)), minimum voiding pressure (p(det.min.void)), and detrusor pressure at maximum flow rate (P(det.Qmax)) separate obstructed from nonob...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10018
更新日期:2002-01-01 00:00:00
abstract:AIM:Interstitial cystitis/painful bladder syndrome/(IC/PBS) results in recurring pain in the bladder and surrounding pelvic region caused by abnormal excitability of micturition reflexes. Spinal cord stimulation (SCS) is currently clinically used for the attenuation of neuropathic and visceral pain. The present study e...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23827
更新日期:2019-01-01 00:00:00
abstract:AIM:To determine the importance and contribution of compliance in a pelvic muscle exercise program as a factor in reducing the severity of urinary stress incontinence amongst Chinese women. METHODS:Two hundred fourteen women presenting with urinary stress incontinence who agreed to undertake a program of pelvic muscle...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10110
更新日期:2003-01-01 00:00:00
abstract:AIM:To determine the optimal degree of pubovaginal slings (PVS) tension, measured by lax sling dimensions to minimize the risk of urinary retention. METHODS:This prospective study analyzed female patients undergoing PVS for stress urinary incontinence (SUI) by two surgeons over 24 months from January 2016. Intra-opera...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24000
更新日期:2019-06-01 00:00:00