Spinal cord stimulation ameliorates detrusor over-activity and visceromotor pain responses in rats with cystitis.

Abstract:

AIM:Interstitial cystitis/painful bladder syndrome/(IC/PBS) results in recurring pain in the bladder and surrounding pelvic region caused by abnormal excitability of micturition reflexes. Spinal cord stimulation (SCS) is currently clinically used for the attenuation of neuropathic and visceral pain. The present study examined whether SCS at upper lumbar segments modulates detrusor overactivity and visceral hyperalgesia associated with cystitis in a rat model of cyclophosphamide (CYP)-induced cystitis. METHODS:Cystitis was induced by intraperitoneal injection of CYP (200 mg/kg) in six adult female Sprague Dawley rats 48 h prior to urodynamic recordings. Another six rats served as-controls with saline injection. Cystometry and the external urethral sphincter (EUS) electromyography during bladder infusion were evaluated under urethane anesthesia. The visceromotor reflexes (VMR) obtained from the external abdominal oblique muscle were quantified during bladder infusion and isotonic bladder distension (IBD), respectively. After baseline recordings were taken, SCS was applied on the dorsal surface of L3 for 25 min. Urodynamic recordings and VMR during bladder infusion and IBD were repeated 2 h after SCS. RESULTS:CYP resulted in detrusor overactivity, stronger EUS tonic contractions, and increased VMR. SCS significantly reduced non-voiding contractions, prolonged EUS relaxation, and delayed VMR appearance during bladder infusion as well as significantly decreased VMR during IBD in cystitis rats. CONCLUSION:SCS improved bladder function and EUS relaxation during bladder infusion and significantly attenuated visceral nociceptive-related VMR during IBD in cystitis rats. SCS may have therapeutic potential for patients with hyperalgesia and IC/PBS.

journal_name

Neurourol Urodyn

authors

Chang HH,Yeh JC,Mao J,Ginsberg DA,Ghoniem G,Rodriguez LV

doi

10.1002/nau.23827

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

116-122

issue

1

eissn

0733-2467

issn

1520-6777

journal_volume

38

pub_type

杂志文章
  • The relationship among flow index, uroflowmetry curve shape, and EMG lag time in children.

    abstract:PURPOSE:To determine the relationship among flow index (FI), uroflowmetry curve shape, and electromyography (EMG) lag time in children. MATERIALS AND METHODS:A total of 294 children with lower urinary tract symptoms were included. The overall relationship between lag time and FI was investigated with curve estimation ...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.24349

    authors: Ha JS,Lee YS,Han SW,Kim SW

    更新日期:2020-06-01 00:00:00

  • Stem cell therapy for stress urinary incontinence.

    abstract::The rhabdosphincter at the mid urethra is critical for maintaining urinary continence. In a setting of stress urinary incontinence stem cells transplanted into the site of the rhabdosphincter may augment sphincter regeneration and also release trophic factors promoting muscle and nerve integration of this muscle. We h...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.20833

    authors: Nikolavsky D,Chancellor MB

    更新日期:2010-01-01 00:00:00

  • Comparative study of pressure-flow parameters.

    abstract::Methods for quantification of bladder outlet obstruction (BOO) are still controversial. Parameters such as detrusor opening pressure (p(det.open)), maximum detrusor pressure (p(det.max)), minimum voiding pressure (p(det.min.void)), and detrusor pressure at maximum flow rate (P(det.Qmax)) separate obstructed from nonob...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.10018

    authors: Eri LM,Wessel N,Tysland O,Berge V

    更新日期:2002-01-01 00:00:00

  • Clinical efficacy and safety of mirabegron and imidafenacin in women with overactive bladder: A randomized crossover study (the MICRO study).

    abstract:AIMS:We aimed to compare the efficacy and safety of mirabegron, a β3-adrenoceptor agonist, and imidafenacin, an anticholinergic agent, in overactive bladder patients. METHODS:We conducted a multicenter, prospective randomized cross-over study at 5 hospitals in Japan from December 2012 to June 2015. We enrolled female ...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/nau.23050

    authors: Torimoto K,Matsushita C,Yamada A,Goto D,Matsumoto Y,Hosokawa Y,Miyake M,Aoki K,Hirayama A,Tanaka N,Fujimoto K

    更新日期:2017-04-01 00:00:00

  • Animal models and their use in understanding lower urinary tract dysfunction.

    abstract::This review will highlight appropriate animal models for the study of a number of disorders involving changes to lower urinary tract function. A major hurdle to the development of animal models for human lower urinary tract disorders is that the clinical pathophysiology of the latter mostly remain idiopathic. Acute in...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.20903

    authors: Fry CH,Daneshgari F,Thor K,Drake M,Eccles R,Kanai AJ,Birder LA

    更新日期:2010-04-01 00:00:00

  • Trends in the use of older overactive bladder agents and uptake of fesoterodine and mirabegron in Canada.

    abstract:AIMS:To examine early trends in the use of overactive bladder (OAB) agents across Canada, with a focus on initial uptake and reimbursement of two newer agents: fesoterodine, an anticholinergic, and mirabegron, a therapeutically novel beta-3 agonist. METHODS:We conducted a population-based cross-sectional study of outp...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.23469

    authors: Minhas R,Tadrous M,Elterman D,Gomes T

    更新日期:2018-06-01 00:00:00

  • A novel, nonopiod-based treatment approach to men with urologic chronic pelvic pain syndrome using ultrasound-guided nerve hydrodissection and pelvic floor musculature trigger point injections.

    abstract:INTRODUCTION:Urological chronic pelvic pain syndrome (UCPPS) represents a group of pain symptoms relating to patients with pelvic pain for which treatment is largely unsatisfactory. The objective of this study is to analyze the effects of a novel treatment strategy in males suffering from UCPPS. METHODS:This retrospec...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.24242

    authors: Hui J,Seko K,Shrikhande G,Ahmed T,Hill C,Reutter C,Shrikhande A

    更新日期:2020-02-01 00:00:00

  • Relationship of urethral retro-resistance pressure to urodynamic measurements and incontinence severity.

    abstract:AIMS:The urethral retro-resistance pressure (URP) is a retrograde urethral pressure profile measured by a new urodynamic measurement system.1GYNECARE MoniTorr Urodynamic Measurement System (ETHICON, Inc., Somerville, NJ). URP is the pressure required to achieve and maintain an open sphincter. This clinical investigatio...

    journal_title:Neurourology and urodynamics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/nau.20010

    authors: Slack M,Culligan P,Tracey M,Hunsicker K,Patel B,Sumeray M

    更新日期:2004-01-01 00:00:00

  • Can we predict which patient will fail drug treatment for overactive bladder? A think tank discussion.

    abstract::The treatment of overactive bladder (OAB) has evolved over the past 20 years to include a number of behavioral, pharmacological, and minimally invasive treatments. After behavioral therapy, pharmacological therapy with antimuscarinics remains the mainstay of treatment. Despite this, a large number of patients will "fa...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.20910

    authors: Nitti VW,Kopp Z,Lin AT,Moore KH,Oefelein M,Mills IW

    更新日期:2010-04-01 00:00:00

  • Assessment of prostatic obstruction: A cuff may be enough.

    abstract:AIMS:To investigate the use of an inflatable perile cuff to obstruct flow progressively during voiding in order to provide a noninvasive measure of bladder pressure. METHODS:In this study, we explain the observed relationship of flow rate with applied cuff pressure by analogy with a simple physical model. The model co...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.10059

    authors: Drinnan MJ,Pickard RS,Ramsden PD,Griffiths CJ

    更新日期:2003-01-01 00:00:00

  • Estrogen-sensitive projections from the medial preoptic area to the dorsal pontine tegmentum, including Barrington's nucleus, in the rat.

    abstract:AIM:Urinary incontinence affects a significant number of post-menopausal women. There is conflicting evidence whether voiding symptoms in these women are related to hypoestrogenism or aging itself. This neuroanatomical study was designed to determine whether a specific central nervous system (CNS) pathway that projects...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20522

    authors: Rickey LM,Sarkey S,DonCarlos LL

    更新日期:2008-01-01 00:00:00

  • Quality control in urodynamics and the role of software support in the QC procedure.

    abstract:AIMS:This article aims to identify quality control (QC) best practice, to review published QC audits in order to identify how closely good practice is followed, and to carry out a market survey of the software features that support QC offered by urodynamics machines available in the UK. METHODS AND RESULTS:All UK dist...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.21133

    authors: Hogan S,Jarvis P,Gammie A,Abrams P

    更新日期:2011-11-01 00:00:00

  • Surgery for female SUI: The ICI algorithm.

    abstract:INTRODUCTION:Stress urinary incontinence (SUI) is common in women and can significantly impact quality of life. METHODS:This is a review of the 6th International Consultation on Incontinence (ICI) chapter analyzing level of evidence on surgical treatment of SUI as well as the consensus algorithm that resulted from the...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.23879

    authors: Kowalik CG,Dmochowski RR,De EJB

    更新日期:2019-08-01 00:00:00

  • Once-daily trospium chloride 60 mg extended-release provides effective, long-term relief of overactive bladder syndrome symptoms.

    abstract:AIMS:Once-daily extended-release (XR) trospium chloride has been evaluated for the treatment of overactive bladder syndrome (OAB) in two 12-week randomized, double-blind, placebo-controlled studies. This pooled analysis of the 9-month open-label extensions to these studies evaluated the long-term efficacy and tolerabil...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.21000

    authors: Zinner NR,Dmochowski RR,Staskin DR,Siami PF,Sand PK,Oefelein MG

    更新日期:2011-09-01 00:00:00

  • Exploratory factory analysis and predicted probabilities of a Chinese version of Dysfunctional Voiding Symptom Score (DVSS) questionnaire.

    abstract:AIMS:To evaluate the reliability, validity, and predicted probabilities of a Chinese version of the Dysfunctional Voiding Symptom Score (DVSS) and to explore the latent factors underlying dysfunctional voiding. MATERIALS AND METHODS:We enrolled 60 children (38 girls and 22 boys) with a diagnosis of dysfunctional voidi...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22254

    authors: Chang SJ,Chen TH,Su CC,Yang SS

    更新日期:2012-11-01 00:00:00

  • Detection of neurogenic detrusor contractions from the activity of the external anal sphincter in cat and human.

    abstract:AIMS:Individuals with spinal cord injury or neurological disorders may develop bladder contractions at low volumes (neurogenic detrusor overactivity), which can lead to significant health problems. Present devices can inhibit unwanted contractions through continuous electrical stimulation of sensory nerves, but do not ...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20204

    authors: Wenzel BJ,Boggs JW,Gustafson KJ,Creasey GH,Grill WM

    更新日期:2006-01-01 00:00:00

  • Position of the Ibero-American Society of Neurourology and Urogynecology in relation to the use of synthetic suburethral meshes for the surgical treatment of female stress incontinence.

    abstract:AIMS:The aim of this paper is to stablish de position of the Ibero-American Society of Neurourology and Urogynecology (SINUG) in relation to the use of suburethral meshes for the surgical treatment of female stress incontinence. METHODS:Tension-free mid-urethral slings (MUS) have become the most popular procedure for ...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,实务指引

    doi:10.1002/nau.24178

    authors: Müller-Arteaga C,Martín Martinez A,Padilla-Fernández B,Blasco Hernández P,Espuña Pons M,Cruz F,Errando-Smet C,Martínez-García R,Vicente Palacio E,Castro Díaz D,López-Fando L,Madurga Patuel B,Ros Cerro C,Arlandis Guzmán S

    更新日期:2020-01-01 00:00:00

  • Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).

    abstract:INTRODUCTION:HTLV-I associated tropical spastic paraparesis (TSP) and HTLV-I associated myelopathy (HAM) is an endemic disease in Caribbean Island. Bladder-sphincter dysfunctions are almost present. The objectives of the study are to describe clinic and urodynamic characteristics of voiding disorders in Martiniquan pop...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22952

    authors: Troisgros O,Barnay JL,Darbon-Naghibzadeh F,Olive P,René-Corail P

    更新日期:2017-02-01 00:00:00

  • Sling mobilization in the management of urinary retention after mid-urethral sling surgery.

    abstract:OBJECTIVE:To compare intermittent catheterization, sling mobilization, and sling transection for treatment of urinary retention after mid-urethral sling surgery. METHODS:Data registered in the Norwegian Female Incontinence Registry from 1998 to 2013 were analyzed in this cohort study to compare subjective and objectiv...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.23046

    authors: Moksnes LR,Svenningsen R,Schiøtz HA,Moe K,Staff AC,Kulseng-Hanssen S

    更新日期:2017-04-01 00:00:00

  • A new minimally invasive procedure for pudendal nerve stimulation to treat neurogenic bladder: description of the method and preliminary data.

    abstract:AIMS:Pudendal nerve stimulation has beneficial effects on numerous pelvic floor function impairments such as urinary and/or fecal incontinence, retention, and constipation. In preceding literature the implant technique required a fairly complex and invasive surgery, although recent advances with percutaneous placement ...

    journal_title:Neurourology and urodynamics

    pub_type: 临床试验,杂志文章

    doi:10.1002/nau.20118

    authors: Spinelli M,Malaguti S,Giardiello G,Lazzeri M,Tarantola J,Van Den Hombergh U

    更新日期:2005-01-01 00:00:00

  • Relationship between urinary profile of the endogenous steroids and postmenopausal women with stress urinary incontinence.

    abstract:AIMS:The aims of this study were to investigate whether endogenous steroid hormones are (1) related to pathogenesis of stress urinary incontinence after menopause, (2) are related to severity of stress urinary incontinence, and (3) are related to prognostic parameters of stress urinary incontinence. METHODS:Twenty pos...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.10063

    authors: Bai SW,Jung BH,Chung BC,Kim SU,Kim JY,Rha KH,Cho JS,Park YW,Park KH

    更新日期:2003-01-01 00:00:00

  • Should we be revisiting LUT basic science and clinical measurement of LUT sensation to improve patient care? ICI-RS 2019.

    abstract:AIMS:This article reviews current knowledge of the underpinning mechanisms of how the bladder senses fullness locally and also revisits clinical measurements of lower urinary tract sensation. The former represents cellular sensing during bladder filling whereas the latter describes the sensations leading to conscious p...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.24273

    authors: McCloskey KD,Wyndaele JJ,Speich JE,Birder L,Nelson PP

    更新日期:2020-07-01 00:00:00

  • Functional outcome of supratrigonal cystectomy and augmentation ileocystoplasty in adult patients with refractory neurogenic lower urinary tract dysfunction.

    abstract:AIMS:To investigate the functional outcome after supratrigonal cystectomy and augmentation ileocystoplasty in adult patients with refractory neurogenic lower urinary tract dysfunction (NLUTD). METHODS:Retrospective follow-up investigation in a single spinal cord injury rehabilitation center. In 29 patients, urodynamic...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22709

    authors: Krebs J,Bartel P,Pannek J

    更新日期:2016-02-01 00:00:00

  • Involvement of Rho-kinase in the contractile mechanism of human ureteral smooth muscle.

    abstract:AIM:Even though many agents have been implicated as modulators of ureteral contractile activity, the exact mechanisms that control human ureteral smooth muscle contractility have yet to be clearly defined. Recently, Rho-kinase has been reported to be involved in the contractile mechanism of smooth muscles in various or...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20096

    authors: Hong SK,Kwak C,Chang Jeong B,Kim BS,Kim HH

    更新日期:2005-01-01 00:00:00

  • Prenatal myelomeningocele repair: Do bladders better?

    abstract:AIMS:Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower-extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome. METHODS:All patients who underwent fetal MMC repair at o...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.23174

    authors: Horst M,Mazzone L,Schraner T,Bodmer C,Möhrlen U,Meuli M,Gobet R

    更新日期:2017-08-01 00:00:00

  • The Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire is reliable in stroke patients.

    abstract:AIMS:To investigate the test-retest reliability of Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire in a sample of stroke patients. METHODS:A prospective study design was used in which the stroke patients were invited to complete a postal self-administrated DAN-PSS-1 questionnaire twice. The questionnaire cons...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20223

    authors: Tibaek S,Jensen R,Klarskov P,Iversen HK,Gard G

    更新日期:2006-01-01 00:00:00

  • Association of index finger palpatory assessment of pubovisceral muscle body integrity with MRI-documented tear.

    abstract:AIMS:Pubovisceral (PV) muscle tears are associated with pelvic floor disorders. The goal of this study was to determine whether index finger palpatory assessment of PV muscle body integrity through the lateral vaginal wall is a reliable indicator of PV muscle tear severity diagnosed by magnetic resonance imaging (MRI)....

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.23967

    authors: Sheng Y,Low LK,Liu X,Ashton-Miller JA,Miller JM

    更新日期:2019-04-01 00:00:00

  • Treatment patterns and costs among patients with OAB treated with combination oral therapy, sacral nerve stimulation, percutaneous tibial nerve stimulation, or onabotulinumtoxinA in the United States.

    abstract:INTRODUCTION:Treatment patterns and costs were characterized among patients with overactive bladder (OAB) receiving later-line target therapies (combination mirabegron/antimuscarinic, sacral nerve stimulation [SNS], percutaneous tibial nerve stimulation [PTNS], or onabotulinumtoxinA). METHODS:In a retrospective cohort...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.24474

    authors: Kraus SR,Shiozawa A,Szabo SM,Qian C,Rogula B,Hairston J

    更新日期:2020-11-01 00:00:00

  • Inconclusive psychometric properties of the Vaizey score in fecally incontinent patients: a prospective cohort study.

    abstract:AIM:To determine the psychometric properties of the total Vaizey score and its individual items. METHODS:The study was conducted as part of a prospective cohort study assessing the outcome of pelvic floor rehabilitation in patients with fecal incontinence. RESULTS:One hundred ninety-four patients were analyzed, 53 of...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20758

    authors: Bols EM,Hendriks EJ,Deutekom M,Berghmans BC,Baeten CG,de Bie RA

    更新日期:2010-03-01 00:00:00

  • Effects of sacral dorsal rhizotomy on bladder function in patients with spastic cerebral palsy.

    abstract::A newly revised operation for controlling spasticity in cerebral palsy patients, selective dorsal rhizotomy (SDR), has the potential to affect bladder function. The goal of this multidisciplinary study is to investigate the potential change in bladder function by characterizing and comparing pre- and post-operative sy...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.1930140110

    authors: Sweetser PM,Badell A,Schneider S,Badlani GH

    更新日期:1995-01-01 00:00:00