Abstract:
AIMS:To investigate the functional outcome after supratrigonal cystectomy and augmentation ileocystoplasty in adult patients with refractory neurogenic lower urinary tract dysfunction (NLUTD). METHODS:Retrospective follow-up investigation in a single spinal cord injury rehabilitation center. In 29 patients, urodynamic data before and after supratrigonal cystectomy and augmentation ileocystoplasty, clinical outcome and post-operative complications were evaluated. RESULTS:The median age of the 29 patients at the time of surgery was 31 years, a median 14 years after NLUTD had occurred. At the last follow-up visit (median 2.4, range 0.4-9.0 years post-operatively), 20/29 patients (69%) were continent compared to 2/29 pre-operatively (P = 0.001). Furthermore, 16 patients required no or less detrusor relaxation therapy after augmentation ileocystoplasty. Augmentation cystoplasty resulted in a significant (P = 0.001) increase in the median bladder capacity (from 240 ml to 500 ml) and compliance (from 13 ml/cm H2 O to 50 ml/cm H2 O). The median maximum detrusor pressure had decreased significantly (P = 0.001) from 38 cm H2 O to 15 cm H2 O. Significantly (P = 0.001) fewer patients presented with a risk for renal damage (1 vs. 15 with maximum detrusor pressure >40 cm H2 O and 1 vs. 12 with detrusor compliance <20 ml/cm H2 O) at the last follow-up. The following complications were observed in 11/29 (38%) patients: paralytic and obstructive ileus, impaired bowel function, bladder stones, dehiscence, metabolic acidosis and autonomic dysreflexia. CONCLUSIONS:Protection of renal function, adequate bladder capacity and low detrusor pressure can be achieved using supratrigonal cystectomy and augmentation ileocystoplasty in patients suffering from refractory NLUTD.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Krebs J,Bartel P,Pannek Jdoi
10.1002/nau.22709subject
Has Abstractpub_date
2016-02-01 00:00:00pages
260-6issue
2eissn
0733-2467issn
1520-6777journal_volume
35pub_type
杂志文章abstract:AIMS:To determine the role of p75 neurotrophin receptor (p75NTR ) and the therapeutic effect of the selective small molecule p75NTR modulator, LM11A-31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model. METHODS:Adult female T8 -T9 transected mice were gavaged daily with LM...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23722
更新日期:2018-11-01 00:00:00
abstract:AIMS:Voiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction. M...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23263
更新日期:2017-11-01 00:00:00
abstract:AIM:To perform a systematic review summarizing the knowledge of genetic variants, gene, and protein expression changes in humans and animals associated with urgency urinary incontinence (UUI) and to provide an overview of the known molecular mechanisms related to UUI. METHODS:A systematic search was performed on March...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24512
更新日期:2020-11-01 00:00:00
abstract:AIMS:Percutaneous tibial nerve stimulation (PTNS) is an effective neuromodulation therapy for treating overactive bladder (OAB). The therapeutic effects are achieved by repeatedly applying electrical stimulation through a percutaneous needle electrode that is used to target the tibial nerve (TN). Anatomical studies ind...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23323
更新日期:2018-02-01 00:00:00
abstract:AIM:To explore the relationship between urinary incontinence and genital sensory functioning in females with sexual dysfunction disorders. METHODS:A retrospective consecutive chart review was conducted for all women who were referred to our tertiary female urology clinic with a primary complaint of sexual dysfunction ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20988
更新日期:2011-09-01 00:00:00
abstract:AIMS:To investigate the feasibility of conditional short duration electrical stimulation of the penile/clitoral nerve as treatment for detrusor hyperreflexia, the present study was initiated. METHODS:Ten patients with spinal cord injury, 4 women and 6 men, with lesions at different levels above the sacral micturition ...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10031
更新日期:2003-01-01 00:00:00
abstract:AIM:To determine the optimal degree of pubovaginal slings (PVS) tension, measured by lax sling dimensions to minimize the risk of urinary retention. METHODS:This prospective study analyzed female patients undergoing PVS for stress urinary incontinence (SUI) by two surgeons over 24 months from January 2016. Intra-opera...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24000
更新日期:2019-06-01 00:00:00
abstract:AIM:Urinary incontinence is one of the most common, disruptive and often disabling conditions affecting frail older people living in community. The aims of present study were to describe the prevalence of bladder catheter in a population of older women living in community and to examine the relationship between urinary...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20059
更新日期:2004-01-01 00:00:00
abstract::Hypoxia induced by partial outlet obstruction is believed to play a major role in both the hypertrophic and degenerative effects of partial outlet obstruction. Doxazosin (dox) is a clinically effective alpha-adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia (BPH). Although the maj...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10045
更新日期:2002-01-01 00:00:00
abstract:AIMS:Reactive nitrogen and oxygen species (RNOS) likely play a role in the development of bladder dysfunction related to bladder outlet obstruction. Antioxidants protect against these free radicals. The aim of our study was to investigate the effect of bladder outlet obstruction on the endogenous antioxidant status of ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20677
更新日期:2009-01-01 00:00:00
abstract:AIMS:Chronic pudendal nerve stimulation (CPNS) is a logical alternative particularly in those who fail sacral stimulation. We evaluated symptoms, complications, and satisfaction after CPNS. METHODS:We retrospectively reviewed patients having a tined lead placed at the pudendal nerve via the ischial-rectal approach. De...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20823
更新日期:2010-09-01 00:00:00
abstract::The aim of the present study was to determine to what extent adult rats can produce new contracting bladder muscle and to see if such newly formed bladder tissue possesses characteristic mechanical properties or whether the ability to recover mechanically is so pronounced that the prehistory of the bladder is unimport...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1020
更新日期:2001-01-01 00:00:00
abstract:AIMS:The aim was to assess complications of urinary incontinence (UI) for women who had a hospital contact within 30 days and to evaluate the conventional method of classifying complications vs grading complications into the Clavien-Dindo classification (CDC) system. METHODS:A historical cohort study based on a nation...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24244
更新日期:2020-02-01 00:00:00
abstract:AIMS:To evaluate the impacts of hydrogen sulfide (H2 S) donor, sodium hydrogen sulfide (NaHS), and phosphodiesterase type-5 inhibitor (PDE5i), tadalafil per se and their combination treatment on partial bladder outlet obstruction (PBOO)-induced erectile dysfunction (ED). METHODS:Sprague-Dawley rats were equally divide...
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23716
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:To create an animal model for neurogenic underactive bladder disease (UAB) and identify markers to describe secondary myogenic changes in the bladder wall. MATERIALS AND METHODS:Male rats underwent either bilateral pelvic nerve injury or sham surgery. Four weeks after surgery functional evaluation was perfo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23517
更新日期:2018-06-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23509
更新日期:2018-06-01 00:00:00
abstract::Nocturia, awaking from sleep to void, has a negative impact on health and well-being. Nocturia affects men and women and is more prevalent among the elderly. More than two nocturnal voids is considered to be a clinically meaningful threshold associated with significant negative outcomes for health and well-being, and ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22595
更新日期:2014-04-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20094
更新日期:2005-01-01 00:00:00
abstract:AIMS:To evaluate the prevalence and associated risk factors for urinary incontinence, as well as its association with multimorbidity among Brazilian women aged 50 or over. METHODS:This was a secondary analysis of a cross-sectional population-based study including 622 women 50 years or older, conducted in the city of C...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22679
更新日期:2016-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20800
更新日期:2010-04-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,meta分析,实务指引
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更新日期:2018-01-01 00:00:00
abstract:AIMS:Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disease, which is difficult to treat. Patients usually seek for new therapies and might not follow-up regularly. This study investigated long-term symptom changes in patients with IC/BPS, especially in those who were lost to follow-up. METHODS:We e...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24104
更新日期:2019-09-01 00:00:00
abstract:AIMS:A non-invasive ultrasound method of estimating bladder weight (UEBW) has been proposed as diagnostic for outflow tract obstruction and detrusor overactivity in men and women. There are no data on asymptomatic men and women. This study aimed to examine the relationship between UEBW, age, height, body mass index (BM...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20757
更新日期:2009-01-01 00:00:00
abstract::Investigations of micromotion characteristics of bladder wall strips and pressure wave phenomena in total bladders in vitro and in vivo indicate that micromotion phenomena occur in the bladder wall. Local contractions can occur without an increase in tension or pressure, because other parts are in antiphase. Local con...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120504
更新日期:1993-01-01 00:00:00
abstract::Invasive pressure flow analysis is the gold standard for discriminating between hypocontractile bladder muscle function and infravesical obstruction in male patients with lower urinary tract symptoms. Here a non-invasive method to determine the isovolumetric bladder pressure to judge contractility is presented. This i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:5<477::aid-nau10>3
更新日期:1999-01-01 00:00:00
abstract:AIMS:No one has assessed urodynamic studies (UDS) to determine those steps that elicit the greatest anxiety, distress, and pain in children. We sought to systematically evaluate a child's UDS experience to mollify these reactions. METHODS:Prospective study involving children aged ≥5 undergoing UDS over a 6-month perio...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24339
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to investigate the prevalence and risk of developing stress urinary incontinence (SUI) in each type of high-intensity sport, and the associated impact on quality of life in sportswomen. METHODS:This cross-sectional study was conducted between March and November 2016. The study ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23538
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:HTLV-I associated tropical spastic paraparesis (TSP) and HTLV-I associated myelopathy (HAM) is an endemic disease in Caribbean Island. Bladder-sphincter dysfunctions are almost present. The objectives of the study are to describe clinic and urodynamic characteristics of voiding disorders in Martiniquan pop...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22952
更新日期:2017-02-01 00:00:00
abstract:AIMS:We investigated the role of transient receptor potential ankyrin 1 (TRPA1) channel on the single unit mechanosensitive afferent activities (SAAs) primarily originating from the bladder in the rat. METHODS:Female Sprague-Dawley rats were used. Cystometry with continuous saline instillation was performed after intr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22449
更新日期:2014-06-01 00:00:00