Abstract:
AIMS:To systematically assess all available evidence on efficacy and safety of vanilloids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). METHODS:This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane register, Embase, Medline, Scopus, (last search January 8, 2016). RESULTS:After screening of 7848 abstracts, 4 randomized controlled trials (RCTs) and 3 prospective cohort studies were included. Pooled data from three RCTs evaluating intravesical capsaicin showed the standardized mean difference to be -2.16 (95% confidence interval [CI] -2.87 to -1.45) in incontinence episodes per 24 h and -0.54 (95%CI -1.03 to -0.05) in voids per 24 h. There was no statistically significant effect on maximum cystometric capacity and maximum storage detrusor pressure. Overall, adverse events were reported by >50% of the patients, most commonly were pelvic pain, facial flush, worsening of incontinence, autonomic dysreflexia, urinary tract infection and haematuria. Risk of bias and confounding was relevant in both RCTs and non-RCTs. CONCLUSIONS:Preliminary data suggest that intravesical vanilloids might be effective for treating NLUTD in patients with MS. However, the safety profile seems unfavorable, the overall quality of evidence is low and no licensed substance is currently available warranting well-designed, adequately sampled and properly powered RCTs.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Phé V,Schneider MP,Peyronnet B,Abo Youssef N,Mordasini L,Chartier-Kastler E,Bachmann LM,Kessler TMdoi
10.1002/nau.23314subject
Has Abstractpub_date
2018-01-01 00:00:00pages
67-82issue
1eissn
0733-2467issn
1520-6777journal_volume
37pub_type
杂志文章,meta分析,实务指引abstract:AIMS:We evaluated the long-term results with a left antegrade continence enema (LACE) approach: "Macedo-Malone (MM) procedure" to define parameters such as clinical durability of the technique and patients' compliance with the method. METHODS:We reviewed the medical records of all patients that underwent the MM proced...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22880
更新日期:2017-01-01 00:00:00
abstract:AIMS:The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pel...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23995
更新日期:2019-06-01 00:00:00
abstract:AIM:The maximum urethral closure pressure (MUCPs) and functional urethral length (FUL) obtained with water-filled and air-charged catheters during urethral pressure profile (UPP) determination was compared in a single, blind, randomized, and prospective trial. METHODS:Thirty-three males with spinal cord injuries and n...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24071
更新日期:2019-08-01 00:00:00
abstract:AIMS:To evaluate the prevalence and associated risk factors for urinary incontinence, as well as its association with multimorbidity among Brazilian women aged 50 or over. METHODS:This was a secondary analysis of a cross-sectional population-based study including 622 women 50 years or older, conducted in the city of C...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22679
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:We evaluated the association between lower urinary tract symptoms (LUTS) and the expression of connexin (Cx) and transient receptor potential (TRP) channel on urothelial cells non-invasively collected from voided urine in humans. METHODS:A total of 55 patients (36 males and 19 females, median age: 71 years ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23436
更新日期:2018-03-01 00:00:00
abstract:AIMS:The prevalence rate of severe fecal incontinence (FI) in adults with spina bifida (SB) is high. The physiological basis of FI in SB has not been clearly established, which contributes to inadequate care. The aim was to better characterize a large cohort of adults with special consideration of anorectal physiology....
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23417
更新日期:2018-03-01 00:00:00
abstract:AIM:To explore the effects of experimental subarachnoid hemorrhage (SAH) on rabbit urinary bladder and to assess the potential protective effects of hyperbaric oxygen therapy (HBOT). METHODS:A total of 15 male New Zealand white rabbits were divided randomly to one of three groups: group I was spared as the control gro...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24418
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To compare intermittent catheterization, sling mobilization, and sling transection for treatment of urinary retention after mid-urethral sling surgery. METHODS:Data registered in the Norwegian Female Incontinence Registry from 1998 to 2013 were analyzed in this cohort study to compare subjective and objectiv...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23046
更新日期:2017-04-01 00:00:00
abstract:AIMS:To determine the role of opioid receptors in the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs, and explore the possible mechanism of SNM. METHODS:Both implant-driven stimulators of the S3 spinal nerve were implanted in seven pigs. Naloxone and tramadol were administered. Multiple cys...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23187
更新日期:2017-09-01 00:00:00
abstract:AIMS:While the effect of different types of incontinence on the quality of life (QoL) has been clearly documented, the information about the impact of incontinence severity on QoL in women is lacking. Therefore, we investigated whether increasingly severe degrees of incontinence were linearly correlated with poorer QoL...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23568
更新日期:2018-08-01 00:00:00
abstract:AIMS:To report the state of the science on primary prevention of urinary incontinence (UI) in adults from the 6th International Consultation on Incontinence with an update through January 2019. METHODS:Online databases PubMed, CINAHL, PsycInfo, and Medline were searched in March 2016 and February 2019 with a focus on ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24222
更新日期:2020-01-01 00:00:00
abstract:AIM:To evaluate the benefits of a newly established checklist form of behavioral therapy for overactive bladder (OAB). METHODS:Of a total of 180 patients suffering eight or more micturitions, two or more nocturia, seven or more urgency, or four more urinary urgency incontinence (UUI) episodes per day according to a 3-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23974
更新日期:2019-04-01 00:00:00
abstract:AIMS:To investigate the feasibility of conditional short duration electrical stimulation of the penile/clitoral nerve as treatment for detrusor hyperreflexia, the present study was initiated. METHODS:Ten patients with spinal cord injury, 4 women and 6 men, with lesions at different levels above the sacral micturition ...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10031
更新日期:2003-01-01 00:00:00
abstract:AIMS:To evaluate the effect of ASP2205, a selective serotonin 5-HT2c receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. METHODS:Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The interve...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24045
更新日期:2019-08-01 00:00:00
abstract:AIM:To evaluate the association between lower urinary tract symptoms (LUTS) and incidental falls and fear of falling. METHODS:We used data obtained from the 2011 Korean Community Health Survey (KCHS) conducted between August and October 2011 in South Korea. The survey was carried out to estimate patterns of disease pr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23345
更新日期:2018-02-01 00:00:00
abstract:AIMS:The ICI-RS Think Tank discussed the diagnostic process for patients who present with symptoms and signs of lower urinary tract (LUT) dysfunction. This manuscript reflects the Think Tank's summary and opinion. METHODS:An overview of the existing evidence and consensus regarding urodynamic testing was presented and...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22580
更新日期:2014-06-01 00:00:00
abstract:AIMS:Our objective was to determine what women find acceptable regarding treatment and outcomes for treatment of stress urinary incontinence (SUI), and correlate this to age, distress and quality of life (QOL). MATERIALS AND METHODS:This prospective cross-sectional IRB-approved study evaluated women with primary SUI. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20570
更新日期:2008-01-01 00:00:00
abstract:AIMS:Estrogen is essential for physiological maintenance of the female urogenital tract. It is believed that alterations in female sex hormones play a major role in the etiology and response to urinary tract dysfunctions. In animal studies, ovariectomy (Ovx) results in smooth muscle (SM) weakness and atrophy whereas es...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20258
更新日期:2006-01-01 00:00:00
abstract:AIMS:This study was designed to assess lower urinary tract symptoms (LUTS) following robotic-assisted laparoscopic prostatectomy. METHODS:In a single surgeon series, 938 patients underwent robotic prostatectomy and completed International Prostate Symptom Score surveys at baseline and 6-month follow-up. Patients preop...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23118
更新日期:2017-06-01 00:00:00
abstract::Hypoxia induced by partial outlet obstruction is believed to play a major role in both the hypertrophic and degenerative effects of partial outlet obstruction. Doxazosin (dox) is a clinically effective alpha-adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia (BPH). Although the maj...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10045
更新日期:2002-01-01 00:00:00
abstract:AIMS:To obtain improved assessment of bladder sensitivity during cystometry by using a 10 cm visual analogue scale (VAS), and comparing it with the standard method according to the International Continence Society (ICS). METHODS:Twenty-five patients with presumed normal bladder functioning underwent filling cystometri...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.20301
更新日期:2007-01-01 00:00:00
abstract:AIM:To determine the importance and contribution of compliance in a pelvic muscle exercise program as a factor in reducing the severity of urinary stress incontinence amongst Chinese women. METHODS:Two hundred fourteen women presenting with urinary stress incontinence who agreed to undertake a program of pelvic muscle...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10110
更新日期:2003-01-01 00:00:00
abstract:AIM OF THE STUDY:To estimate the prevalence and 5-year incidence of lower urinary tract symptoms (LUTS) after the first delivery and to evaluate the impact of pregnancy per se and delivery per se on long-lasting symptoms. MATERIALS AND METHODS:A longitudinal cohort study of 305 primiparae questioned a few days, 3 mont...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.2198
更新日期:2002-01-01 00:00:00
abstract:AIMS:Few studies have documented the effectiveness of continence promotion programs targeting older incontinent women. We sought to evaluate the impact of an interactive continence workshop on changing participants' attitudes, knowledge and skills in relation to self-managing or seeking care for incontinence. METHODS:...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20800
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Hydrodistention (HD) has been utilized as a diagnostic and therapeutic tool in patients with refractory and diverse pelvic floor symptoms, including bladder pain with or without irritative bladder symptoms such as urinary urgency and urinary frequency. We sought to determine whether we could better define ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20200
更新日期:2005-01-01 00:00:00
abstract:AIMS:This study was conducted to try to objectify assessment of pediatric uroflowmetry curves. MATERIALS AND METHODS:Nine professionals in pediatric incontinence care judged 480 pediatric uroflows. On a 1-5 scale, where 1 = anomalous and 5 = normal, uroflows were assessed on four items: staccato, interrupted, flow tim...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21152
更新日期:2011-11-01 00:00:00
abstract:AIM:NK-1 receptors in sensory nerves, the spinal cord and bladder smooth muscle participate in complex sensory mechanisms that regulate bladder activity. This study was designed to assess the efficacy and safety of a new NK-1 receptor antagonist, netupitant, in patients with OAB. METHODS:This was a phase II, multicent...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.22406
更新日期:2014-03-01 00:00:00
abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract:AIMS:Sacral nerve stimulation (SNS) is FDA approved as second-line therapy for both urinary and bowel control. However, there is limited evidence regarding long term safety. We determined adverse events associated with SNS among Medicare beneficiaries. METHODS:We used the 5% national random sample of Medicare claims f...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22618
更新日期:2015-09-01 00:00:00
abstract::In the last two decades, nerve growth factor (NGF), initially described as a prototypical trophic factor in the development of sensory and sympathetic innervation, has emerged as a complex regulator of neural plasticity along the micturition pathways. This review aims to summarize the current experimental and clinical...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21022
更新日期:2011-09-01 00:00:00