Abstract:
:In the last two decades, nerve growth factor (NGF), initially described as a prototypical trophic factor in the development of sensory and sympathetic innervation, has emerged as a complex regulator of neural plasticity along the micturition pathways. This review aims to summarize the current experimental and clinical evidence for a role of NGF in urinary bladder. Experimental administration of NGF elicits the states of increased sensation, urgency, and bladder hyperreflexia, resembling pathologies associated with bladder overactivity and inflammatory pain, such as overactive bladder syndrome (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS). There is strong experimental evidence, including the effective therapeutic targeting, on the direct causal role of NGF in rodent models of bladder outlet obstruction, spinal cord injury, diabetic bladder dysfunction, and interstitial inflammation. In humans, there are attempts to employ urinary NGF levels as a diagnostic marker in various forms of OAB and IC/PBS. In near future, use of novel experimental tools, such as urothelium-specific NGF transgenic mice or more specific low-molecular weight NGF receptor modulators, may provide better understanding of several unresolved issues in NGF-related bladder dysfunction. Moreover, successful experimental therapeutic approaches, such as NGF sequestering proteins or modified NGF antibodies, await the translation to the clinical treatment of bladder disorders.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Ochodnický P,Cruz CD,Yoshimura N,Michel MCdoi
10.1002/nau.21022subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1227-41issue
7eissn
0733-2467issn
1520-6777journal_volume
30pub_type
杂志文章,评审abstract:AIMS:External sphincterotomy (ES) is a therapeutic option for male spinal cord injury patients with detrusor sphincter dyssynergia. However, some patients need to change their voiding management after ES. One of the potential causes of failure is reportedly detrusor dysfunction, but long-term urodynamic follow-up data ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23702
更新日期:2018-11-01 00:00:00
abstract::Better understanding of the underlying working mechanism of the neural control of the lower urinary tract will facilitate the treatment of dysfunction with a neurogenic cause. We developed a computer model to study the effect of a neural control system on lower urinary tract behavior. To model the mechanical propertie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1998)17:3<175::aid-nau3>3.
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Stakeholders from around the world came together to address the unmet needs of underactive bladder (UAB) at the 3rd International Congress for Underactive Bladder. METHODS:The main recommendation from the regulatory working group is a need for a meeting of UAB stakeholders and regulatory agencies i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23738
更新日期:2018-11-01 00:00:00
abstract:AIMS:The aim of this study was to assess medium-term outcomes of the single anterior vaginal wall incision technique with concomitant mid-urethral sling (MUS) procedure. METHODS:Patients suffering from stress urinary incontinence and who desired surgical correction for their incontinence were divided into two groups a...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22847
更新日期:2016-11-01 00:00:00
abstract:AIMS:Nociceptive behavior and its relationship with bladder dysfunction were investigated in two cystitis models, which were induced by intraperitoneal (i.p.) injection of cyclophosphamide (CYP) or intravesical instillation of acetone, using freely moving, non-catheterized conscious rats. METHODS:Female Sprague-Dawley...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20777
更新日期:2010-03-01 00:00:00
abstract:AIMS:The use of electrotherapeutics to improve filling and emptying dysfunction of the adult bladder has been well established, however the practice in children is less well known. The purpose of this review is to summarize the rationale behind the use of electro neuromodulation in children, examine the reported effica...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.10171
更新日期:2004-01-01 00:00:00
abstract::Diabetes mellitus (DM) has reached epidemic proportions world wide. Many chronic complications of DM, including neuropathy, retinopathy and nephropathy, have been well studied and although urologic complications have been recognized since 1935, little is known about DM as a pathophysiological risk factor for developme...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20533
更新日期:2008-01-01 00:00:00
abstract::Following use of botulinum toxin in the 1980s for the treatment of detrusor sphincter dyssynergia in patients with spinal cord injury (SCI), the potential therapeutic value of this neurotoxin in urology has been the subject of much interest. The DIGNITY (Double-blind InvestiGation of purified Neurotoxin complex In neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22630
更新日期:2014-07-01 00:00:00
abstract:AIMS:This study was designed to assess lower urinary tract symptoms (LUTS) following robotic-assisted laparoscopic prostatectomy. METHODS:In a single surgeon series, 938 patients underwent robotic prostatectomy and completed International Prostate Symptom Score surveys at baseline and 6-month follow-up. Patients preop...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23118
更新日期:2017-06-01 00:00:00
abstract:AIMS:To evaluate the efficacy, safety, and tolerability of repetitive Transcranial Magnetic Stimulation (rTMS) associated with standard drug therapies for neuropathic pain that does not respond to pharmacological treatment alone in patients with Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC). Secondary goals were...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23718
更新日期:2018-11-01 00:00:00
abstract:AIMS:Measurements such as the minimal levator hiatus dimension, levator plate angle, iliococcygeal angle, and anorectal angle have been used for assessing the impact of levator damage on static and dynamic imaging features. The primary aim of this study was to investigate the association between levator ani muscle defi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22509
更新日期:2015-01-01 00:00:00
abstract:AIMS:To investigate the role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro. MATERIALS AND METHODS:Longitudinal strips of trigonal muscle were isolated, and the mucosa and serosa removed. Tissues were precontracted with KCl, and beta-adrenoceptor agonists (isoprenalin...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10130
更新日期:2003-01-01 00:00:00
abstract:AIMS:We performed receiver operating characteristic (ROC) analysis to determine the ability of sphincter electromyography (EMG) to distinguish multiple system atrophy (MSA) from other parkinsonisms. The following was determined: (1) the appropriate motor unit potential (MUP) parameter among duration, phase, and amplitu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22208
更新日期:2012-09-01 00:00:00
abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract:AIMS:To estimate the prevalence and severity of bed-wetting in 1-18-year-old Chinese children. MATERIALS AND METHODS:A cross-sectional study of bed-wetting was performed by using 13,515 self-administered questionnaires distributed to the parents of 1-18-year-old Chinese children in Henan province. The prevalence of be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20373
更新日期:2007-01-01 00:00:00
abstract::Nocturia, awaking from sleep to void, has a negative impact on health and well-being. Nocturia affects men and women and is more prevalent among the elderly. More than two nocturnal voids is considered to be a clinically meaningful threshold associated with significant negative outcomes for health and well-being, and ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22595
更新日期:2014-04-01 00:00:00
abstract:AIMS:Long-term indwelling catheterisation may affect health related quality of life, but clinical assessment and monitoring of people with indwelling catheters is poorly recorded because there are no validated measures to capture these criteria. In this paper, we describe the development of the ICIQ-Long Term Catheter ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22729
更新日期:2016-03-01 00:00:00
abstract:AIMS:To determine the prevalence of urinary incontinence (UI) and associated factors in the institutionalized elderly. METHODS:A cross-sectional study is presented herein, conducted between October and December 2013, in 10 nursing homes in the city of Natal (Northeast Brazil). Individuals over the age of 60, who resid...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22675
更新日期:2016-01-01 00:00:00
abstract:AIM:The aim of the study was to assess correlations between body parameters and bladder capacity in healthy schoolboys and schoolgirls. On the basis of those anthropometric data functional bladder capacity (FBC) in children was estimated. MATERIALS AND METHODS:The questionnaires were sent to 1,055 parents of children ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20123
更新日期:2006-01-01 00:00:00
abstract::The evaluation of the incontinent patient relies on accurate assessment of urinary symptoms. Although the 7 day urinary diary is a reproducible method of data collection, the optimal means of implementing this diary is unknown. The urinary diary is usually employed after the initial clinical pathophysiologic evaluatio...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:2<143::AID-NAU3>3.
更新日期:1996-01-01 00:00:00
abstract:AIMS:To describe a pelvic floor muscle training (PFMT) isolated and associated with game therapy (PFMT + GT) for women facing mixed urinary incontinence (MUI) during climacteric period. METHODS:To standardize a randomized controlled clinical trial intervention, a protocol was created, in an attempt to decrease women's...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24350
更新日期:2020-06-01 00:00:00
abstract:AIMS:Overactive bladder (OAB), characterized by urinary urgency, with or without incontinence, and urinary frequency and nocturia, has a significant impact on patients' lives. Given the social context inherent in OAB, the purpose of this study was to identify issues faced by OAB family members. METHODS:Incontinent OAB...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20705
更新日期:2009-01-01 00:00:00
abstract:AIMS:Open surgery is the most commonly used methodological approach for generating a partial bladder outlet obstruction (pBOO) animal model. Surgical suturing closing a part of the urethral meatus induces comparable pathophysiological changes in bladder and renal functions, but the optimum degree of obstruction that cl...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23427
更新日期:2018-09-01 00:00:00
abstract:AIMS:The aims of this study were to investigate whether endogenous steroid hormones are (1) related to pathogenesis of stress urinary incontinence after menopause, (2) are related to severity of stress urinary incontinence, and (3) are related to prognostic parameters of stress urinary incontinence. METHODS:Twenty pos...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10063
更新日期:2003-01-01 00:00:00
abstract:AIMS:The aim of this study was to resolve the paradox as to whether magnetic stimulation of sacral nerve roots results in contraction or suppression of the bladder, in both normal individuals and patients with spinal cord injury (SCI). MATERIALS AND METHODS:Seven males with complete SCI and neurogenic detrusor overact...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.20009
更新日期:2004-01-01 00:00:00
abstract:AIMS:A non-invasive ultrasound method of estimating bladder weight (UEBW) has been proposed as diagnostic for outflow tract obstruction and detrusor overactivity in men and women. There are no data on asymptomatic men and women. This study aimed to examine the relationship between UEBW, age, height, body mass index (BM...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20757
更新日期:2009-01-01 00:00:00
abstract:AIMS:Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The purpose of this report is to summarize the ICI-RS meeting in Bristol in 20...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21097
更新日期:2011-06-01 00:00:00
abstract::Patients with symptoms of overactive bladder syndrome or non-obstructive urinary retention, refractory to conservative therapy, can nowadays be treated minimally invasively with sacral nerve stimulation (SNS). The use of electric currents to treat urological pathology has a long history but SNS therapy only received F...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20459
更新日期:2008-01-01 00:00:00
abstract:AIMS:Voiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction. M...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23263
更新日期:2017-11-01 00:00:00
abstract::The potential of the alpha 1 and alpha 2 antagonists to modify prostate compliance, and micturition characteristics of rats with hormonally enlarged prostates was studied. Prostate growth was induced in Sprague-Dawley rats using dihydrotestosterone (DHT) and estradiol (E) by daily subcutaneous injections of DHT 1.25 m...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:1<85::AID-NAU9>3.0
更新日期:1996-01-01 00:00:00