Abstract:
AIMS:Nociceptive behavior and its relationship with bladder dysfunction were investigated in two cystitis models, which were induced by intraperitoneal (i.p.) injection of cyclophosphamide (CYP) or intravesical instillation of acetone, using freely moving, non-catheterized conscious rats. METHODS:Female Sprague-Dawley rats were used. Cystitis was induced by i.p. injection of CYP (100 and 200 mg/kg) or intravesical instillation of acetone (10%, 30%, and 50%) via a polyethylene catheter temporarily inserted into the bladder through the urethra. Then the incidence of nociceptive behavior (immobility with decreased breathing rates) was scored. Voided urine was collected simultaneously and continuously to measure bladder capacity. The plasma extravasation in the bladder was quantified by an Evans blue (EB) dye leakage technique. RESULTS:CYP (100 mg/kg, i.p.) induced nociceptive behavior without affecting bladder capacity or EB concentration in the bladder. A higher dose of CYP (200 mg/kg, i.p.) decreased bladder capacity and increased EB levels as well as nociceptive behavior. In contrast, intravesical instillation of acetone (30%) decreased bladder capacity and increased EB levels, but evoked nociceptive behavior less frequently compared with CYP-treated animals. In capsaicin-pretreated rats, nociceptive behavior induced by CYP or acetone was reduced; however, the overall effects of CYP or acetone on bladder capacity and bladder EB levels were unaffected. CONCLUSIONS:These results suggest that there is a difference in the induction process of nociceptive behavior and small bladder capacity after two different types of bladder irritation, and that C-fiber sensitization is more directly involved in pain sensation than reduced bladder capacity.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Saitoh C,Yokoyama H,Chancellor MB,de Groat WC,Yoshimura Ndoi
10.1002/nau.20777subject
Has Abstractpub_date
2010-03-01 00:00:00pages
501-5issue
3eissn
0733-2467issn
1520-6777journal_volume
29pub_type
杂志文章abstract:AIMS:The biomechanical properties of length adaptation and adjustable preload have been previously identified in detrusor smooth muscle in animal models. This in vitro study aims to show that human detrusor smooth muscle exhibits length adaptation and adjustable preload tension which could play an important role in bot...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22820
更新日期:2016-09-01 00:00:00
abstract:AIMS:To discuss the role of physiotherapy in the management of women who have suffered an obstetric fistula, referring to research findings when appropriate and available, and the experiences of clinical specialists in the field. METHODS:The experiences of physiotherapists who have worked in countries where obstetric ...
journal_title:Neurourology and urodynamics
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abstract::In epidemiological surveys of female urinary incontinence, it is not feasible to demonstrate urine loss objectively. The aim of this study was to develop a valid epidemiological instrument (a severity index) for assessing the severity of incontinence. The severity index is based on information about frequency (four le...
journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.24168
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journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.20570
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abstract::The response of the abdominal muscles to voluntary contraction of the pelvic floor (PF) muscles was investigated in women with no history of symptoms of stress urinary incontinence to determine whether there is co-activation of the muscles surrounding the abdominal cavity during exercises for the PF muscles. Electromy...
journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1002/nau.20846
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doi:10.1002/nau.21000
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pub_type: 杂志文章
doi:10.1002/nau.1930140206
更新日期:1995-01-01 00:00:00
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更新日期:2020-07-01 00:00:00
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更新日期:2018-11-01 00:00:00
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abstract:AIMS:Urgency is a key symptom in the diagnosis of overactive bladder (OAB), yet its definition and measurement are subject to continuing debate whether urinary urgency is a pathologic sensation or an intensification of normal desire to pass urine. The objective of this research was to explore the concept of urgency amo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21242
更新日期:2012-04-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22998
更新日期:2017-03-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20823
更新日期:2010-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1997)16:3<179::aid-nau7>3.
更新日期:1997-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930130507
更新日期:1994-01-01 00:00:00