Abstract:
AIMS:Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The purpose of this report is to summarize the ICI-RS meeting in Bristol in 2010 exploring current knowledge on DU and outline directions for future research. METHODS:A think tank discussion was held and the summary of discussions was presented to all ICI-RS participants. This report is based on the final discussions. RESULTS:The understanding of the pathophysiology, epidemiology, assessment, and treatment of DU remains rudimentary. DU is defined by pressure-flow analysis but no consensus exists regarding which of the available formulae should be used for quantification of detrusor work. DU is likely to be multifactorial. Aging causes a decay in detrusor activity but other concomitant causes, either myogenic or neurogenic, may aggravate the problem resulting in decrease of detrusor contractility. No effective pharmacotherapy for the condition exists. Only a few surgical therapeutic strategies have been explored, such as neuromodulation and skeletal muscle myoplasties. Consequently, the management of affected individuals remains unsatisfactory. CONCLUSIONS:Future directions recommended by the ICI-RS panel include assessment of pathogenesis by developing novel animal models in addition to new non-invasive tests allowing longitudinal trials. Furthermore, optimizing the existing evaluation algorithms to support standard testing for DU and further epidemiological studies to quantify the size of the problem are required for the development of future treatment modalities.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
van Koeveringe GA,Vahabi B,Andersson KE,Kirschner-Herrmans R,Oelke Mdoi
10.1002/nau.21097subject
Has Abstractpub_date
2011-06-01 00:00:00pages
723-8issue
5eissn
0733-2467issn
1520-6777journal_volume
30pub_type
杂志文章,评审abstract:AIMS:Urethral pressure reflectometry (UPR) is a novel reliable method for simultaneous measurement of pressure and cross-sectional area in the female urethra. The aim of this study was to report values for UPR parameters in healthy and stress urinary incontinent (SUI) women and compare UPR with urethral pressure profil...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20617
更新日期:2008-01-01 00:00:00
abstract:AIMS:To evaluate the reproducibility of bladder sensation during standardized filling cystometry in female volunteers and overactive bladder (OAB) patients, repeated with weekly interval. METHODS:We recruited 13 female nulliparous volunteers (age 21-47) and 17 female patients with OAB between (age 18-72). They partici...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21100
更新日期:2011-11-01 00:00:00
abstract:AIMS:The aim of this study is to report the functional results, patient satisfaction, and morbidity of the Transobturator tape procedure (TOT) in the treatment of stress incontinence (SUI). METHODS:One hundred and thirty patients were prospectively evaluated with history, physical examination, quality of life question...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.20353
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). OBJECTIVES:The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urothelium in the pathophysiology of nocturia; (b) to determine whether noc...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24274
更新日期:2020-07-01 00:00:00
abstract:AIMS:To characterize levator ani muscle (LAM) activity in nulligravidas using magnetomyography (MMG) and define MMG characteristics associated with LAM activity with and without accessory muscle contributions. METHODS:MMG data were collected from eight nulligravidas during rest and voluntary LAM contractions (Kegels) ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23870
更新日期:2019-01-01 00:00:00
abstract::Nocturia, awaking from sleep to void, has a negative impact on health and well-being. Nocturia affects men and women and is more prevalent among the elderly. More than two nocturnal voids is considered to be a clinically meaningful threshold associated with significant negative outcomes for health and well-being, and ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22595
更新日期:2014-04-01 00:00:00
abstract::Estrogens are known to have a major role in the function of the lower urinary tract although the role of exogenous estrogen replacement therapy in the management of women with lower urinary tract dysfunction remains controversial. Whilst for many years systemic and vaginal estrogen therapy was felt to be beneficial in...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22464
更新日期:2014-09-01 00:00:00
abstract:AIM:To elucidate the precise cellular and molecular mechanisms that underlie urethral fibrogenesis. METHODS:Endoluminal electrocautery injury (using Karl Storz 10 Fr. Pediatric urethroscope) was employed in male rabbits (n = 6) to create mucosal injury. Retrograde urethrogram (RUG) and endoluminal ultrasound technique...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24281
更新日期:2020-02-01 00:00:00
abstract:AIMS:Our purpose was to explore the involvement of cognition in voluntary and involuntary pelvic floor muscle (PFM) contraction in stress urinary incontinent women. METHODS:PFM contraction monitored by surface electromyography (EMG) was measured without a mental distraction task (DT), and with a DT called "paced audit...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.23936
更新日期:2019-03-01 00:00:00
abstract:AIMS:To evaluate the effect of ASP2205, a selective serotonin 5-HT2c receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. METHODS:Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The interve...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24045
更新日期:2019-08-01 00:00:00
abstract:AIMS:To examine alterations in expression of angiotensin II type 1 receptors (AT1R) which induce organ tissue remodeling, angiotensin II type 2 receptors (AT2R) which protect against it, and related molecules in the bladder of matured rats with bladder dysfunction. METHODS:Female SD rats of three different ages were u...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22849
更新日期:2016-11-01 00:00:00
abstract:AIMS:Long-term indwelling catheterisation may affect health related quality of life, but clinical assessment and monitoring of people with indwelling catheters is poorly recorded because there are no validated measures to capture these criteria. In this paper, we describe the development of the ICIQ-Long Term Catheter ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22729
更新日期:2016-03-01 00:00:00
abstract:AIMS:To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation. RESULTS:Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular col...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21064
更新日期:2011-03-01 00:00:00
abstract:AIMS:To determine the antiseptic efficacy on bacterial colony counts of a 5- vs 10-minute surgical site scrub in urologic surgery. METHODS:A prospective cohort study was conducted in 101 patients presenting for elective urological procedures. Patients were randomized to a 5- or 10-minute groin scrub with Betadine (pov...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23945
更新日期:2019-03-01 00:00:00
abstract:AIMS:To examine early trends in the use of overactive bladder (OAB) agents across Canada, with a focus on initial uptake and reimbursement of two newer agents: fesoterodine, an anticholinergic, and mirabegron, a therapeutically novel beta-3 agonist. METHODS:We conducted a population-based cross-sectional study of outp...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23469
更新日期:2018-06-01 00:00:00
abstract:AIMS:This study investigated the expressions of PGP9.5, P2 X 3 , muscarinic receptor (M3) and beta-3 adrenoreceptor (AR) in idiopathic detrusor overactivity (IDO) patients refractory to antimuscarinic treatment, and analyzed the correlation between protein expressions and clinical symptoms of IDO bladders with differe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23138
更新日期:2017-06-01 00:00:00
abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether filling phase urodynamic parameters can predict the success of the artificial urinary sphincter (AUS) in treating post-prostatectomy incontinence (PPI). MATERIALS AND METHODS:We reviewed the pre-AUS urodynamics of 99 patients with PPI at two tertiary referral centers. We documented the pe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23147
更新日期:2017-08-01 00:00:00
abstract:AIMS:This study examined test-retest reliability of four patient-reported outcome measures for patients with overactive bladder (OAB): Overactive Bladder Questionnaire (OAB-q), Patient Perception of Bladder Condition (PPBC), Urgency Questionnaire (UQ), and Primary OAB Symptom Questionnaire (POSQ). METHODS:Patients rec...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20110
更新日期:2005-01-01 00:00:00
abstract:AIM:Urinary incontinence affects a significant number of post-menopausal women. There is conflicting evidence whether voiding symptoms in these women are related to hypoestrogenism or aging itself. This neuroanatomical study was designed to determine whether a specific central nervous system (CNS) pathway that projects...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20522
更新日期:2008-01-01 00:00:00
abstract:AIMS:Beyond single-institution case series, limited data are available to describe risks of performing a concurrent cystectomy at the time of urinary diversion for benign end-stage lower urinary tract dysfunction. Using a population-representative sample, this study aimed to analyze factors associated with perioperativ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23135
更新日期:2017-06-01 00:00:00
abstract:AIMS:To examine whether isolated bladder outlet obstruction in the absence of associated lower urinary tract abnormality results in hydronephrosis. Isolated obstruction causes a brief rise in bladder pressure that might not trigger hydronephrosis. METHODS:Data included adult men who underwent urodynamics for refractor...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24495
更新日期:2020-11-01 00:00:00
abstract:AIM:Bladder dysfunction affects up to 90% of the multiple sclerosis (MS) population. Interventions such as Pelvic Floor Training and Advice (PFTA), Electromyography (EMG) Biofeedback, and Neuromuscular Electrical Stimulation (NMES) have received limited research attention within this population. This study aimed to det...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20209
更新日期:2006-01-01 00:00:00
abstract:AIMS:The aim of our study was to access the variability of maximum flow rate (Q(max)), average flow rate (Q(av)) and flow pattern while varying the point of impact of flow on the flowmeter. METHODS:Water was delivered through a motorised tube holder in a standardised experimental set up. Flow was directed in 4 differe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20846
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Urological chronic pelvic pain syndrome (UCPPS) represents a group of pain symptoms relating to patients with pelvic pain for which treatment is largely unsatisfactory. The objective of this study is to analyze the effects of a novel treatment strategy in males suffering from UCPPS. METHODS:This retrospec...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24242
更新日期:2020-02-01 00:00:00
abstract::We evaluated compliance in the developing bladder using a newly developed animal model of posterior urethral valves: partial infravesical obstruction in the fetal rabbit bladder. Partial bladder outlet obstruction was created in fetal rabbits at day 23 of a 31 to 32-day gestation period. An in vitro whole bladder prep...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1997)16:3<179::aid-nau7>3.
更新日期:1997-01-01 00:00:00
abstract:AIMS:To discuss the role of physiotherapy in the management of women who have suffered an obstetric fistula, referring to research findings when appropriate and available, and the experiences of clinical specialists in the field. METHODS:The experiences of physiotherapists who have worked in countries where obstetric ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23851
更新日期:2019-01-01 00:00:00
abstract:AIMS:This article reviews current knowledge of the underpinning mechanisms of how the bladder senses fullness locally and also revisits clinical measurements of lower urinary tract sensation. The former represents cellular sensing during bladder filling whereas the latter describes the sensations leading to conscious p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24273
更新日期:2020-07-01 00:00:00
abstract:AIMS:Individuals with spinal cord injury or neurological disorders may develop bladder contractions at low volumes (neurogenic detrusor overactivity), which can lead to significant health problems. Present devices can inhibit unwanted contractions through continuous electrical stimulation of sensory nerves, but do not ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20204
更新日期:2006-01-01 00:00:00
abstract:AIMS:We investigated the role of transient receptor potential ankyrin 1 (TRPA1) channel on the single unit mechanosensitive afferent activities (SAAs) primarily originating from the bladder in the rat. METHODS:Female Sprague-Dawley rats were used. Cystometry with continuous saline instillation was performed after intr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22449
更新日期:2014-06-01 00:00:00