The effect of biological and synthetic meshes on vaginal smooth muscle cell proliferation.

Abstract:

AIMS:To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation. RESULTS:Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular collagen matrix mesh exposed cells compared to the type I polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.03 vs. 0.21 ± 0.01, P = 0.03). Under estradiol supplementation cell proliferation in the porcine mesh exposed cells remained significantly higher compared to the polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.04 vs. 0.15 ± 0.03, P < 0.01). CONCLUSION:The decreased rate of erosion found with the utilization of biological absorbable mesh in vaginal reconstructive surgery may partially be explained by the significantly increased VaSMC proliferation with porcine dermal acellular collagen mesh compared to polypropylene mesh.

journal_name

Neurourol Urodyn

authors

Gualtieri M,Zhang Y,Candiotti K,Yavagal S,Medina CA,Takacs P

doi

10.1002/nau.21064

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

435-7

issue

3

eissn

0733-2467

issn

1520-6777

journal_volume

30

pub_type

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