Abstract:
AIMS:To study the influence of bladder pumping on the urinary bladder in 44 female rats. METHODS:Under halothane anesthesia, a urethral catheter was inserted into the bladder of 27 rats, and air (0.4-0.8 mL) was pumped in and out of the bladder at 0.5 cycles/second for a period of 5 minutes. Twenty-four hours after pumping, the bladder was harvested for measurement of the tissue levels of myosin, actin, and nerve growth factor, as well as for electron microscopy. In nine of the 27 rats, cystometry was performed without anesthesia before and 1, 7, 30, and 90 days after bladder pumping. The remaining 17 rats that did not undergo pumping were anesthetized and their bladders were harvested as a control. RESULTS:Bladder pumping increased the bladder capacity and decreased the maximum bladder contraction pressure, but did not increase the residual volume. Bladder pumping also increased the tissue level of nerve growth factor and decreased the levels of myosin and actin. Electron microscopy showed degeneration of bladder smooth muscle cells and nerve fibers after bladder pumping, as well as derangement and disruption of collagen fiber bundles in the bladder wall. These functional and morphological effects of pumping disappeared within 90 days. CONCLUSIONS:Bladder pumping therapy appears to have various effects on the bladder wall collagen fiber bundles, smooth muscle cells, and nerves.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Sugaya K,Nishijima S,Hatano T,Ogawa Y,Kudo T,Nishizawa Odoi
10.1002/nau.10048subject
Has Abstractpub_date
2002-01-01 00:00:00pages
511-5issue
5eissn
0733-2467issn
1520-6777journal_volume
21pub_type
杂志文章abstract:AIMS:Intrinsic sphincteric deficiency (ISD) denotes a malfunction of the distal urethral sphincter. Our objective was to produce a durable model of ISD in the rat. METHODS:Surrounding tissues lateral to the mid-urethra were cauterized to produce sphincteric injury in 24 adult female Sprague-Dawley rats. The rats were ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10173
更新日期:2004-01-01 00:00:00
abstract:AIMS:Progressive weakness in pelvic floor tissues is extremely common and leads to the distressing problems of stress urinary incontinence (SUI) and pelvic organ prolapse (POP). There has been extensive work on a vast array of materials spanning synthetics, autografts, allografts, and xenografts. Uniaxial testing of ma...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21156
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Pacemakers in upper urinary tract (UUT) are still under study. AIM:We reviewed the role of some cells that seem to be involved in the propulsion of urinary bolus from UUT to the bladder. MATERIALS & METHODS:We focuses on evaluating studies on the mechanisms by which the UUT propels urine to the bladder via...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22310
更新日期:2013-04-01 00:00:00
abstract:AIMS:Although several stimulation techniques are available to elicit sacral reflexes, no comparative data on their utility has been published. The aim of the present study was to determine the most sensitive stimulation technique used for neurophysiologic recording of the penilo-cavernosus reflex. METHODS:Neurophysiol...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20474
更新日期:2008-01-01 00:00:00
abstract:AIM:We report the rates of artificial urinary sphincter (AUS) mechanical failure in a contemporary cohort of patients stratified by component type and size to determine if the 3.5-cm cuff is at higher risk of failure. METHODS:From 2005-2016, a total of 486 male patients with stress incontinence underwent implantation ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23825
更新日期:2019-01-01 00:00:00
abstract:AIM:Urinary incontinence is one of the most common, disruptive and often disabling conditions affecting frail older people living in community. The aims of present study were to describe the prevalence of bladder catheter in a population of older women living in community and to examine the relationship between urinary...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20059
更新日期:2004-01-01 00:00:00
abstract:AIMS:Nociceptive behavior and its relationship with bladder dysfunction were investigated in two cystitis models, which were induced by intraperitoneal (i.p.) injection of cyclophosphamide (CYP) or intravesical instillation of acetone, using freely moving, non-catheterized conscious rats. METHODS:Female Sprague-Dawley...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20777
更新日期:2010-03-01 00:00:00
abstract:AIMS:Both clinical and neurophysiologic testing of the penilo-cavernosus reflex is used in clinical practice. The aim of the present study was to determine the as yet unestablished potential contribution of sacral reflex testing to the diagnostic evaluation of patients with suspected neuropathic sacral lesions. METHOD...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20520
更新日期:2008-01-01 00:00:00
abstract:AIM:To perform a systematic review summarizing the knowledge of genetic variants, gene, and protein expression changes in humans and animals associated with urgency urinary incontinence (UUI) and to provide an overview of the known molecular mechanisms related to UUI. METHODS:A systematic search was performed on March...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24512
更新日期:2020-11-01 00:00:00
abstract::It is possible that the controversy involving prostheses implanted into women with pelvic floor problems might result in the majority of, or even all such products being restricted, banned or withdrawn in certain jurisdictions. A clear distinction between "tapes" for urinary incontinence and "mesh" for prolapse has be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23741
更新日期:2018-08-01 00:00:00
abstract::Better understanding of the underlying working mechanism of the neural control of the lower urinary tract will facilitate the treatment of dysfunction with a neurogenic cause. We developed a computer model to study the effect of a neural control system on lower urinary tract behavior. To model the mechanical propertie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1998)17:3<175::aid-nau3>3.
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The brain's role in continence is critical but poorly understood. Although regions activated during bladder stimulation have been identified, little is known about the interaction between regions. In this secondary analysis we evaluate resting state and effective connectivity in older women treated for urgen...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23766
更新日期:2018-11-01 00:00:00
abstract:AIM:To compare the urethral sphincter morphology and levator hiatal dimensions between white and black premenopausal nulliparous asymptomatic women using 3D/4D translabial ultrasonography. METHODS:Nulliparous black and white women were recruited in a tertiary gynecological center. All women were completely asymptomati...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21181
更新日期:2012-04-01 00:00:00
abstract:AIMS:We analyzed the impact of radical retropubic prostatectomy (RRP) on the urethral sphincter function as assessed by urethral pressure profilometry (UPP) and its relation to post-radical prostatectomy continence status. Furthermore, we analyzed the effect of intensive pelvic floor muscle exercises (PFME) on the uret...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21243
更新日期:2012-06-01 00:00:00
abstract:AIMS:Urinary incontinence is a common symptom in many diseases as well as in general population. To measure the impact of urinary incontinence (UI) on individual's quality of life the English short form International Consultation on Incontinence questionnaire (ICIQ-UI Short Form) has been developed, which consists of t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20689
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Widely accepted consensus terminology and calculations of detrusor contractility in females do not exist but may be useful. We report the output of a proposal session at the International Consultation on Incontinence Research Society meeting 2019, addressing the title topic. METHODS:Three formal presentat...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24260
更新日期:2020-07-01 00:00:00
abstract:AIMS:Urgency is a key symptom in the diagnosis of overactive bladder (OAB), yet its definition and measurement are subject to continuing debate whether urinary urgency is a pathologic sensation or an intensification of normal desire to pass urine. The objective of this research was to explore the concept of urgency amo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21242
更新日期:2012-04-01 00:00:00
abstract:AIMS:Since the publication of the 2006 International Children's Continence Society (ICCS) guidelines on terminologies for lower urinary tract dysfunction in children, little is known of their impact. In this study, we aim to quantify the adherence to the guidelines in the published literature, and to examine whether Me...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22341
更新日期:2013-09-01 00:00:00
abstract:AIMS:The purpose of this study was to investigate efficacy, safety, and impact on quality of sleep of staggered furosemide and desmopressin in the treatment of nocturia in the elderly. METHODS:Patients aged >60 years with nocturia at least two voids per night were screened for enrollment into the study. A 3-week dose-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20986
更新日期:2011-03-01 00:00:00
abstract:AIMS:This study aimed to evaluate whether the pressure readings obtained from air-filled catheters (AFCs) are the same as the readings from simultaneously inserted water-filled catheters (WFCs). It also aimed to make any possible recommendations for the use of AFCs to conform to International Continence Society (ICS) G...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22827
更新日期:2016-11-01 00:00:00
abstract::Diabetes mellitus (DM) has reached epidemic proportions world wide. Many chronic complications of DM, including neuropathy, retinopathy and nephropathy, have been well studied and although urologic complications have been recognized since 1935, little is known about DM as a pathophysiological risk factor for developme...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20533
更新日期:2008-01-01 00:00:00
abstract:AIMS:Relaxation of detrusor muscle via β-adrenoceptors may contribute to urine storage during bladder filling. Thus there is increasing interest in β-adrenoceptor agonists as a potential treatment for detrusor overactivity. The role of the urothelium in bladder responses to β-adrenoceptor agonists is not yet clear, alt...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20838
更新日期:2010-09-01 00:00:00
abstract:AIMS:Firm bladder neck support during cough, suggested to be needed for effective abdominal pressure transmission to the urethra, might depend on activity of the levator ani muscle and elasticity of endopelvic fascia. METHODS:The study group of 32 patients with stress urinary incontinence and hypermobile bladder neck,...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10116
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:Turkish Continence Society aimed to analyze how overactive bladder (OAB) is being managed in routine practice by the urologists in Turkey. MATERIAL AND METHODS:Fourteen urology departments were randomly selected to represent the whole population in this multicenter study. An online data entry and storage ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究
doi:10.1002/nau.24079
更新日期:2019-11-01 00:00:00
abstract::In the last two decades, nerve growth factor (NGF), initially described as a prototypical trophic factor in the development of sensory and sympathetic innervation, has emerged as a complex regulator of neural plasticity along the micturition pathways. This review aims to summarize the current experimental and clinical...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21022
更新日期:2011-09-01 00:00:00
abstract:AIMS:Our objective was to determine what women find acceptable regarding treatment and outcomes for treatment of stress urinary incontinence (SUI), and correlate this to age, distress and quality of life (QOL). MATERIALS AND METHODS:This prospective cross-sectional IRB-approved study evaluated women with primary SUI. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20570
更新日期:2008-01-01 00:00:00
abstract::A newly revised operation for controlling spasticity in cerebral palsy patients, selective dorsal rhizotomy (SDR), has the potential to affect bladder function. The goal of this multidisciplinary study is to investigate the potential change in bladder function by characterizing and comparing pre- and post-operative sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140110
更新日期:1995-01-01 00:00:00
abstract:AIMS:To test the different formulae to calculate the bladder volume using ultrasound; the accuracy of patients hearing/feeling "bubbles" at the end of urodynamics testing as a measure of being empty; and how good we are at estimating PVR using X-ray at the end of video urodynamics testing. METHODS:This was a prospecti...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23963
更新日期:2019-04-01 00:00:00
abstract:AIMS:Estrogen is essential for physiological maintenance of the female urogenital tract. It is believed that alterations in female sex hormones play a major role in the etiology and response to urinary tract dysfunctions. In animal studies, ovariectomy (Ovx) results in smooth muscle (SM) weakness and atrophy whereas es...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20258
更新日期:2006-01-01 00:00:00
abstract:AIM:To describe how the use of new and established animal models and methods can generate vital and far reaching experimental data in the study of mechanism underlying neurogenic bladder overactivity. METHODS:Bladder and colonic irradiated mice and those with upper and lower motor neuron lesions were used to study neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21120
更新日期:2011-06-01 00:00:00