Abstract:
AIM:To describe how the use of new and established animal models and methods can generate vital and far reaching experimental data in the study of mechanism underlying neurogenic bladder overactivity. METHODS:Bladder and colonic irradiated mice and those with upper and lower motor neuron lesions were used to study neurogenic bladder overactivity. Methods included cystometry, tension measurements, afferent nerve recordings and optical mapping of action potentials and intracellular Ca(2+) transients. Recordings were made in a number of innovative preparations including in-line cultured cells, bladder-urethra sheets and cross-sections, spinal cord slices and the cerebral cortex. RESULTS:The animal models and methods used allow for the study of peripheral and central mechanisms of neurogenic overactivity. While colonic irradiation results in solely neurogenic dysfunction, spinal cord lesions also induce non-neural changes resulting in increased spontaneous detrusor contractions that can directly stimulate afferent nerves. Imaging of cultured bladder interstitial cells reveals spontaneous firing that could contribute to detrusor overactivity, while optical imaging of the spinal cord and brain could identify changes in central pathways that underlie lower urinary tract dysfunction. CONCLUSIONS:The animal models and methods described allow for the study of neurogenic overactivity at the peripheral, spinal and cortical levels. This may lead to greater understanding of sensory and motor mechanisms involved in incontinence, the contributions of interstitial cells and spontaneous detrusor contractions, and the involvement of the cortex.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Kanai A,Zabbarova I,Ikeda Y,Yoshimura N,Birder L,Hanna-Mitchell A,de Groat Wdoi
10.1002/nau.21120subject
Has Abstractpub_date
2011-06-01 00:00:00pages
658-67issue
5eissn
0733-2467issn
1520-6777journal_volume
30pub_type
杂志文章,评审abstract:AIMS:To identify clinical and urodynamic factors leading to spontaneous voiding in men with detrusor underactivity (DU) and suspected bladder outlet obstruction who underwent an outlet de-obstruction procedure. METHODS:We identified 614 men who underwent an outlet procedure at our institution from 2005 to 2014. Men we...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24122
更新日期:2019-11-01 00:00:00
abstract::In our hospital, we have followed a group of patients with familial amyloidotic polyneuropathy (FAP), type I. This disease is characterized by a progressive sensitive-motor and autonomic polyneuropathy. The amyloid fibrils of FAP I contain a mutant transthyretin (TTR) molecule. More than 90% of TTR production occurs i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/(sici)1520-6777(1997)16:1<55::aid-nau7>3.0
更新日期:1997-01-01 00:00:00
abstract:AIMS:The biomechanical properties of length adaptation and adjustable preload have been previously identified in detrusor smooth muscle in animal models. This in vitro study aims to show that human detrusor smooth muscle exhibits length adaptation and adjustable preload tension which could play an important role in bot...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22820
更新日期:2016-09-01 00:00:00
abstract:AIMS:Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with subjective sense of improvement. The aim of this study was to estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ) and Overactive Bladder Question...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.21028
更新日期:2011-09-01 00:00:00
abstract:AIMS:Nervous system involvement occurs in about half of patients with systemic lupus erythematosis (SLE). Seizures and psychiatric disorders are the most common manifestations; spinal cord lesions are uncommon. We had eight such patients who presented with urinary dysfunction. METHODS:The patients consisted of two men...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10126
更新日期:2003-01-01 00:00:00
abstract:AIMS:Relaxation of detrusor muscle via β-adrenoceptors may contribute to urine storage during bladder filling. Thus there is increasing interest in β-adrenoceptor agonists as a potential treatment for detrusor overactivity. The role of the urothelium in bladder responses to β-adrenoceptor agonists is not yet clear, alt...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20838
更新日期:2010-09-01 00:00:00
abstract:AIM:To evaluate the benefits of a newly established checklist form of behavioral therapy for overactive bladder (OAB). METHODS:Of a total of 180 patients suffering eight or more micturitions, two or more nocturia, seven or more urgency, or four more urinary urgency incontinence (UUI) episodes per day according to a 3-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23974
更新日期:2019-04-01 00:00:00
abstract::Methods for quantification of bladder outlet obstruction (BOO) are still controversial. Parameters such as detrusor opening pressure (p(det.open)), maximum detrusor pressure (p(det.max)), minimum voiding pressure (p(det.min.void)), and detrusor pressure at maximum flow rate (P(det.Qmax)) separate obstructed from nonob...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10018
更新日期:2002-01-01 00:00:00
abstract:AIMS:Both clinical and neurophysiologic testing of the penilo-cavernosus reflex is used in clinical practice. The aim of the present study was to determine the as yet unestablished potential contribution of sacral reflex testing to the diagnostic evaluation of patients with suspected neuropathic sacral lesions. METHOD...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20520
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:HTLV-I associated tropical spastic paraparesis (TSP) and HTLV-I associated myelopathy (HAM) is an endemic disease in Caribbean Island. Bladder-sphincter dysfunctions are almost present. The objectives of the study are to describe clinic and urodynamic characteristics of voiding disorders in Martiniquan pop...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22952
更新日期:2017-02-01 00:00:00
abstract::It is well known that urethane is a suitable anesthetic for acute studies and has been extensively recommended for investigations related to micturition physiology. This is mainly because of the capability of urethane anesthesia to spare reflex micturition as well as its easily established long-lasting and stable anes...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(2000)19:1<87::aid-nau9>3.0
更新日期:2000-01-01 00:00:00
abstract:AIMS:In the bladder, ATP is an important signaling molecule, which is released by bladder stretch and acid. We hypothesized that ATP might play a unique role in patients with OAB, characterized by low bladder volumes at first desire to void (FDV) and maximal cystometric capacity (MCC) and symptoms of frequency/urgency ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22344
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Hydrodistention (HD) has been utilized as a diagnostic and therapeutic tool in patients with refractory and diverse pelvic floor symptoms, including bladder pain with or without irritative bladder symptoms such as urinary urgency and urinary frequency. We sought to determine whether we could better define ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20200
更新日期:2005-01-01 00:00:00
abstract:AIMS:SYNERGY II was a 12-month phase III trial in patients with overactive bladder (OAB) symptoms that investigated the safety and efficacy of the combination of mirabegron and solifenacin in comparison with each monotherapy. This analysis evaluated the trial findings using four age subgroups (<65, ≥65, <75, and ≥75 ye...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23919
更新日期:2019-02-01 00:00:00
abstract:AIMS:Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disease, which is difficult to treat. Patients usually seek for new therapies and might not follow-up regularly. This study investigated long-term symptom changes in patients with IC/BPS, especially in those who were lost to follow-up. METHODS:We e...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24104
更新日期:2019-09-01 00:00:00
abstract::Experiments to investigate restoration of lower urinary tract control by electrical stimulation of the sacral nerve roots are mostly performed on dogs, yet little morphometric data (such as canine root and fiber diameter distributions) are available. The aim of this study was to acquire morphometric data of the intrad...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:3<235::AID-NAU8>3.
更新日期:1996-01-01 00:00:00
abstract::The aim of the present study was to determine to what extent adult rats can produce new contracting bladder muscle and to see if such newly formed bladder tissue possesses characteristic mechanical properties or whether the ability to recover mechanically is so pronounced that the prehistory of the bladder is unimport...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1020
更新日期:2001-01-01 00:00:00
abstract:AIMS:To discuss the role of physiotherapy in the management of women who have suffered an obstetric fistula, referring to research findings when appropriate and available, and the experiences of clinical specialists in the field. METHODS:The experiences of physiotherapists who have worked in countries where obstetric ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23851
更新日期:2019-01-01 00:00:00
abstract:AIMS:We studied preoperative and postoperative pressure transmission ratio (PTR) and urethral pressure profilometry in patients undergoing the vaginal wall patch sling technique as a first surgical approach for genuine stress incontinence (GSI) with urethral hypermobility. The specific aims were to determine the exact ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20051
更新日期:2005-01-01 00:00:00
abstract:AIMS:This article reviews current knowledge of the underpinning mechanisms of how the bladder senses fullness locally and also revisits clinical measurements of lower urinary tract sensation. The former represents cellular sensing during bladder filling whereas the latter describes the sensations leading to conscious p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24273
更新日期:2020-07-01 00:00:00
abstract:AIMS:Urodynamic studies (UDS) are complex, invasive and may be emotionally and physically distressing. Inadequate information may heighten distress. Prior to UDS, our patients receive written and verbal information, yet concerns remains that some women may not be adequately informed. This study examined how informed wo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21014
更新日期:2011-04-01 00:00:00
abstract::The modern era of patient-centered, multidisciplinary professional practice comes with the expectation of effective interaction between specialties dealing with closely related clinical areas. Interaction between adult and pediatric urology is generally limited in terms of training, conferences, and joint diagnostic/t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22215
更新日期:2012-03-01 00:00:00
abstract::Investigations of micromotion characteristics of bladder wall strips and pressure wave phenomena in total bladders in vitro and in vivo indicate that micromotion phenomena occur in the bladder wall. Local contractions can occur without an increase in tension or pressure, because other parts are in antiphase. Local con...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120504
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The brain's role in continence is critical but poorly understood. Although regions activated during bladder stimulation have been identified, little is known about the interaction between regions. In this secondary analysis we evaluate resting state and effective connectivity in older women treated for urgen...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23766
更新日期:2018-11-01 00:00:00
abstract:AIMS:Previous studies have shown that the activin-binding protein follistatin reduces inflammation in several mouse models of colitis. To determine whether follistatin also has a beneficial effect following bladder inflammation, we induced cystitis in mice using cyclophosphamide (CYP) and examined the relationship betw...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22941
更新日期:2017-02-01 00:00:00
abstract:AIMS:External sphincterotomy (ES) is a therapeutic option for male spinal cord injury patients with detrusor sphincter dyssynergia. However, some patients need to change their voiding management after ES. One of the potential causes of failure is reportedly detrusor dysfunction, but long-term urodynamic follow-up data ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23702
更新日期:2018-11-01 00:00:00
abstract:AIMS:We sought to compare in-office physical exam findings via standing cough test (SCT) versus 24-hour pad weights among men seeking treatment for postprostatectomy stress urinary incontinence (SUI). METHODS:A retrospective review of a single surgeon database of incontinence procedures was performed. Documentation of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24200
更新日期:2020-01-01 00:00:00
abstract::Following use of botulinum toxin in the 1980s for the treatment of detrusor sphincter dyssynergia in patients with spinal cord injury (SCI), the potential therapeutic value of this neurotoxin in urology has been the subject of much interest. The DIGNITY (Double-blind InvestiGation of purified Neurotoxin complex In neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22630
更新日期:2014-07-01 00:00:00
abstract:AIMS:We sought to determine whether somatic lumbar nerve transfer to the pelvic nerve's anterior vesical branch after sacral decentralization for detrusor muscle reinnervation also leads to aberrant innervation of the bladder outlet. METHODS:Twenty-six female mongrel hound dogs underwent transection of sacral dorsal a...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24217
更新日期:2020-01-01 00:00:00
abstract:AIMS:To determine cohort urethral length, identify epidemiological factors influencing the parameter and to establish the percentage of cases with clinically relevant outsized urethras. METHODS:Prospective cohort study conducted in two tertiary clinical centers between 2013 and 2017. Nine hundred and twenty seven cons...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23509
更新日期:2018-06-01 00:00:00