当前位置： SCI文献检索 > NEUROUROLOGY AND URODYNAMICS期刊下所有文献 > Minimum important difference for validated instruments in women with urge incontinence.

Minimum important difference for validated instruments in women with urge incontinence.

Abstract：

AIMS:Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with subjective sense of improvement. The aim of this study was to estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ) and Overactive Bladder Questionnaire (OAB-q) using anchor and distribution-based approaches in patients with urge-predominant incontinence and whether MID changes over time. METHODS:This was a sub-analysis of a multi-center trial of 307 women with pure urge (11) or urge-predominant (296) incontinence who completed condition-specific instruments 10 weeks and 8 months after randomization to anticholinergic medication with or without behavioral therapy. We applied anchor-based methods only when the Kendall's rank correlations between the anchors (Global Perception of Improvement (GPI), Patient Satisfaction Questionnaire (PSQ), and incontinence episodes) and the incontinence instruments (UDI, UDI irritative subscale, IIQ, and OAB-q subscales) were ≥ 0.3. We applied three distribution-based methods to all instruments: effect sizes of ± 0.2 SD (small) and ± 0.5 SD (medium), and standard error of measurement of ± 1. Analyses were performed at both time points. RESULTS:Anchor-based MIDs for the UDI ranged from -35 to -45 and -15 to -25 for the irritative subscale distribution-based methods MIDs for UDI and IIQ ranged between -10 to -25 and -19 to -49, respectively, reflective of a reduction in bother and symptom severity (SS). OAB-q subscale MIDs ranged from +5 to +12, denoting improved quality of life (HRQL) and -13 to -25, consistent with a reduction in SS. CONCLUSIONS:The MID in women with urge-predominant UI for the UDI and UDI irritative are -35 and -15. Our findings are consistent with previously reported MIDs for the OAB-q subscales. Distribution-based method MIDs are lower values than anchor-based values. The MID did not typically change over the time.

journal_name

Neurourol Urodyn

journal_title

Neurourology and urodynamics

authors

Dyer KY,Xu Y,Brubaker L,Nygaard I,Markland A,Rahn D,Chai TC,Stoddard A,Lukacz E,Urinary Incontinence Treatment Network (UITN).

doi

10.1002/nau.21028

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1319-24

issue

eissn

0733-2467

issn

1520-6777

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

在线工具

Minimum important difference for validated instruments in women with urge incontinence.