T- and L-type calcium channels mediate alpha(1)-adrenoceptor-evoked contraction in the guinea-pig vas deferens.

Abstract:

AIMS:The importance of the T- and L-type Ca(2+) channels on the alpha(1)-adrenoceptor-mediated contraction of guinea-pig vas deferens was investigated in relation to the SK and BK channels. METHODS:Isometric contractile response to electrical stimulation (ES) of 50 pulses at 40 Hz was recorded. ES responses were modulated via calcium and potassium channels in the presence of purinergic inhibitors. RESULTS:The alpha(1)-adrenoceptor-mediated contraction of guinea-pig vas deferens consisted of early and late alpha(1)-components. The early alpha(1)-component was insensitive to nifedipine (10 microM) but was suppressed by T-type Ca(2+) channel antagonists mibefradil and amiloride with IC50 values (microM) of 7.2 +/- 1.8 (n = 5) and 27.2 +/- 10.4 (n = 6), respectively. The late alpha(1)-component was inhibited by nifedipine, nimodipine and nicardipine with IC50 values (microM) of 0.19 +/- 0.04 (n = 5), 1.9 +/- 0.8 (n = 5), and 4.2 +/- 2.5 (n = 5), respectively. Nicardipine also inhibited the early alpha(1)-component with an IC50 value of 20.3 +/- 2.5 microM (n = 5). An SK channel antagonist apamin (1-100 nM) increased both early and late alpha(1)-components. A BK channel antagonist iberiotoxin (100 nM) increased the late alpha(1)-component without affecting the early one. CONCLUSIONS:The results may indicate that the alpha(1)-adrenoceptor-induced contraction was mediated by Ca(2+) influx through T- and L-type Ca(2+) channels for the early and late alpha(1)-components, respectively and that SK and BK channels contributed to protect the musculature of the guinea-pig vas deferens from excess tension development induced by sympathetic volley. Neurourol. Urodynam. 28:447-454, 2009. (c) 2009 Wiley-Liss, Inc.

journal_name

Neurourol Urodyn

authors

Shishido T,Sakai S,Tosaka T

doi

10.1002/nau.20654

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

447-54

issue

5

eissn

0733-2467

issn

1520-6777

journal_volume

28

pub_type

杂志文章
  • Lessons learned: impact of a continence promotion activity for older community-dwelling women.

    abstract:AIMS:Few studies have documented the effectiveness of continence promotion programs targeting older incontinent women. We sought to evaluate the impact of an interactive continence workshop on changing participants' attitudes, knowledge and skills in relation to self-managing or seeking care for incontinence. METHODS:...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20800

    authors: Tannenbaum C,Drali R,Holroyd-Leduc J,Richard L

    更新日期:2010-04-01 00:00:00

  • Terminology, epidemiology, etiology, and pathophysiology of nocturia.

    abstract::Nocturia, awaking from sleep to void, has a negative impact on health and well-being. Nocturia affects men and women and is more prevalent among the elderly. More than two nocturnal voids is considered to be a clinically meaningful threshold associated with significant negative outcomes for health and well-being, and ...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.22595

    authors: Van Kerrebroeck P,Andersson KE

    更新日期:2014-04-01 00:00:00

  • Efficacy and safety of repeated dosing of netupitant, a neurokinin-1 receptor antagonist, in treating overactive bladder.

    abstract:AIM:NK-1 receptors in sensory nerves, the spinal cord and bladder smooth muscle participate in complex sensory mechanisms that regulate bladder activity. This study was designed to assess the efficacy and safety of a new NK-1 receptor antagonist, netupitant, in patients with OAB. METHODS:This was a phase II, multicent...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/nau.22406

    authors: Haab F,Braticevici B,Krivoborodov G,Palmas M,Zufferli Russo M,Pietra C

    更新日期:2014-03-01 00:00:00

  • Long term safety of sacral nerve modulation in medicare beneficiaries.

    abstract:AIMS:Sacral nerve stimulation (SNS) is FDA approved as second-line therapy for both urinary and bowel control. However, there is limited evidence regarding long term safety. We determined adverse events associated with SNS among Medicare beneficiaries. METHODS:We used the 5% national random sample of Medicare claims f...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22618

    authors: Chughtai B,Sedrakyan A,Isaacs A,Lee R,Te A,Kaplan S

    更新日期:2015-09-01 00:00:00

  • International Children's Continence Society standardization report on urodynamic studies of the lower urinary tract in children.

    abstract:AIMS:The objective of this document created by the ICCS standardization subcommittee is to provide a uniform guideline on measurement, quality control and documentation of urodynamic studies in children. METHODS:This guideline was created using expert opinion and critical review of the published literature on urodynam...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,实务指引,评审

    doi:10.1002/nau.22783

    authors: Bauer SB,Nijman RJ,Drzewiecki BA,Sillen U,Hoebeke P,International Children's Continence Society Standardization Subcommittee.

    更新日期:2015-09-01 00:00:00

  • Correlation between cystometric volumes, ATP release, and pH in women with overactive bladder versus controls.

    abstract:AIMS:In the bladder, ATP is an important signaling molecule, which is released by bladder stretch and acid. We hypothesized that ATP might play a unique role in patients with OAB, characterized by low bladder volumes at first desire to void (FDV) and maximal cystometric capacity (MCC) and symptoms of frequency/urgency ...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22344

    authors: Cheng Y,Mansfield KJ,Allen W,Millard RJ,Burcher E,Moore KH

    更新日期:2013-09-01 00:00:00

  • Contractile properties of the developing fetal sheep bladder.

    abstract:AIM:To characterise the developmental changes to the normal bladder by examining the in vitro contractile properties of the fetal sheep detrusor smooth muscle bladder at different gestational ages. METHODS:Three groups of normally developing fetal sheep bladders were investigated: (1) 65-70 days gestation (2nd trimest...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20124

    authors: Nyirády P,Thiruchelvam N,Godley ML,David A,Cuckow PM,Fry CH

    更新日期:2005-01-01 00:00:00

  • Receiver operating characteristic analysis of sphincter electromyography for parkinsonian syndrome.

    abstract:AIMS:We performed receiver operating characteristic (ROC) analysis to determine the ability of sphincter electromyography (EMG) to distinguish multiple system atrophy (MSA) from other parkinsonisms. The following was determined: (1) the appropriate motor unit potential (MUP) parameter among duration, phase, and amplitu...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22208

    authors: Yamamoto T,Sakakibara R,Uchiyama T,Yamaguchi C,Nomura F,Ito T,Yanagisawa M,Yano M,Awa Y,Yamanishi T,Hattori T,Kuwabara S

    更新日期:2012-09-01 00:00:00

  • Transvaginal mesh in the media following the 2011 US food and drug administration public health notification update.

    abstract:AIMS:Prompted by patients' changing perceptions of transvaginal mesh, this study examines how mesh has been reported in the news following the 2011 US Food and Drug Administration (FDA) updated notification about the use of mesh in the treatment of pelvic organ prolapse. METHODS:Two national newspaper databases were q...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22923

    authors: Koo K,Gormley EA

    更新日期:2017-02-01 00:00:00

  • Characterization of voiding function and structural bladder changes in a rat model of neurogenic underactive bladder disease.

    abstract:OBJECTIVES:To create an animal model for neurogenic underactive bladder disease (UAB) and identify markers to describe secondary myogenic changes in the bladder wall. MATERIALS AND METHODS:Male rats underwent either bilateral pelvic nerve injury or sham surgery. Four weeks after surgery functional evaluation was perfo...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.23517

    authors: Weyne E,Dewulf K,Deruyer Y,Rietjens R,Everaerts W,Bivalacqua TJ,De Ridder D,Van der Aa F,Albersen M

    更新日期:2018-06-01 00:00:00

  • Use of uroflow parameters in diagnosing an overactive bladder-Back to the drawing board.

    abstract:AIMS:The aim of our study was to analyze whether uroflowmetry parameters are helpful in diagnosing overactive bladder (OAB). The working hypothesis was that the flow curves of patients with OAB symptoms would appear as a sharp peak flow rate with a short duration and high amplitude, lasting only for a short period duri...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22898

    authors: Futyma K,Nowakowski Ł,Bogusiewicz M,Ziętek A,Wieczorek AP,Rechberger T

    更新日期:2017-01-01 00:00:00

  • The adult urology perspective on management of stress urinary incontinence in pediatric urology: ICI-RS 2011.

    abstract::The modern era of patient-centered, multidisciplinary professional practice comes with the expectation of effective interaction between specialties dealing with closely related clinical areas. Interaction between adult and pediatric urology is generally limited in terms of training, conferences, and joint diagnostic/t...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.22215

    authors: Drake MJ

    更新日期:2012-03-01 00:00:00

  • A clinical perspective on the analysis and presentation of the number of incontinence episodes following treatment for OAB.

    abstract:AIMS:To provide a clinical view and interpretation on the methods for analysis of incontinence in patients with overactive bladder. METHODS:Results are analyzed using the total number of incontinence episodes in a 3-day diary period, using fixed and random effect Poisson regression models to calculate ratio of event r...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/nau.22787

    authors: Martina R,Kay R,Abrams P,van Maanen R,Ridder A

    更新日期:2016-08-01 00:00:00

  • Frequency-dependent inhibition of bladder function by saphenous nerve stimulation in anesthetized rats.

    abstract:AIMS:Percutaneous tibial nerve stimulation (PTNS) is an effective neuromodulation therapy for treating overactive bladder (OAB). The therapeutic effects are achieved by repeatedly applying electrical stimulation through a percutaneous needle electrode that is used to target the tibial nerve (TN). Anatomical studies ind...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.23323

    authors: Moazzam Z,Yoo PB

    更新日期:2018-02-01 00:00:00

  • Validity of a non-invasive determination of the isovolumetric bladder pressure during voiding in men with LUTS.

    abstract::Invasive pressure flow analysis is the gold standard for discriminating between hypocontractile bladder muscle function and infravesical obstruction in male patients with lower urinary tract symptoms. Here a non-invasive method to determine the isovolumetric bladder pressure to judge contractility is presented. This i...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-6777(1999)18:5<477::aid-nau10>3

    authors: Gommer ED,Vanspauwen TJ,Miklosi M,Wen JG,Kinder MV,Janknegt RA,van Waalwijk van Doorn ES

    更新日期:1999-01-01 00:00:00

  • Diabetes mellitus and female lower urinary tract symptoms: a review.

    abstract::Diabetes mellitus (DM) has reached epidemic proportions world wide. Many chronic complications of DM, including neuropathy, retinopathy and nephropathy, have been well studied and although urologic complications have been recognized since 1935, little is known about DM as a pathophysiological risk factor for developme...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.20533

    authors: Hill SR,Fayyad AM,Jones GR

    更新日期:2008-01-01 00:00:00

  • Reducing nocturia in the elderly: a randomized placebo-controlled trial of staggered furosemide and desmopressin.

    abstract:AIMS:The purpose of this study was to investigate efficacy, safety, and impact on quality of sleep of staggered furosemide and desmopressin in the treatment of nocturia in the elderly. METHODS:Patients aged >60 years with nocturia at least two voids per night were screened for enrollment into the study. A 3-week dose-...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/nau.20986

    authors: Fu FG,Lavery HJ,Wu DL

    更新日期:2011-03-01 00:00:00

  • Genetic variants and expression changes in urgency urinary incontinence: A systematic review.

    abstract:AIM:To perform a systematic review summarizing the knowledge of genetic variants, gene, and protein expression changes in humans and animals associated with urgency urinary incontinence (UUI) and to provide an overview of the known molecular mechanisms related to UUI. METHODS:A systematic search was performed on March...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.24512

    authors: Post WM,Ruiz-Zapata AM,Grens H,de Vries RBM,Poelmans G,Coenen MJH,Janssen DAW,Heesakkers JPFA,Oosterwijk E,Kluivers KB

    更新日期:2020-11-01 00:00:00

  • New concepts in relation to urge and detrusor activity.

    abstract::Investigations of micromotion characteristics of bladder wall strips and pressure wave phenomena in total bladders in vitro and in vivo indicate that micromotion phenomena occur in the bladder wall. Local contractions can occur without an increase in tension or pressure, because other parts are in antiphase. Local con...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.1930120504

    authors: Coolsaet BL,Van Duyl WA,Van Os-Bossagh P,De Bakker HV

    更新日期:1993-01-01 00:00:00

  • Should we be revisiting LUT basic science and clinical measurement of LUT sensation to improve patient care? ICI-RS 2019.

    abstract:AIMS:This article reviews current knowledge of the underpinning mechanisms of how the bladder senses fullness locally and also revisits clinical measurements of lower urinary tract sensation. The former represents cellular sensing during bladder filling whereas the latter describes the sensations leading to conscious p...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.24273

    authors: McCloskey KD,Wyndaele JJ,Speich JE,Birder L,Nelson PP

    更新日期:2020-07-01 00:00:00

  • What is the exact working mechanism of botulinum toxin A and sacral nerve stimulation in the treatment of overactive bladder/detrusor overactivity? ICI-RS 2017.

    abstract:AIMS:Botulinum toxin A (BTX-A) and sacral nerve stimulation (SNS) are established treatments for overactive bladder (OAB) and are standard of care in refractory cases in international guidelines. Despite long term use over decades their "exact" working mechanisms are not entirely clear. At the ICI-RS meeting in Bristol...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.23552

    authors: Malde S,Fry C,Schurch B,Marcelissen T,Averbeck M,Digesu A,Sahai A

    更新日期:2018-06-01 00:00:00

  • Surgery for female SUI: The ICI algorithm.

    abstract:INTRODUCTION:Stress urinary incontinence (SUI) is common in women and can significantly impact quality of life. METHODS:This is a review of the 6th International Consultation on Incontinence (ICI) chapter analyzing level of evidence on surgical treatment of SUI as well as the consensus algorithm that resulted from the...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,评审

    doi:10.1002/nau.23879

    authors: Kowalik CG,Dmochowski RR,De EJB

    更新日期:2019-08-01 00:00:00

  • Is voluntary pelvic floor muscles contraction important for sexual function in women with pelvic floor disorders?

    abstract:AIMS:To investigate relationships between pelvic floor muscles (PFM) and sexual function (SF) in sexually active (SA) and not-SA (NSA) women with pelvic floor disorders (PFD). METHODS:In 350 women with PFD: 173 (49.4%) SA, 177 (50.6%) NSA, Pelvic Organ Prolapse (POP)-Quantification, PFM tone, and strength were evaluat...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.24109

    authors: Grzybowska ME,Wydra DG

    更新日期:2019-09-01 00:00:00

  • Cranberries after pelvic floor surgery for urinary tract infection prophylaxis: A randomized controlled trial.

    abstract:AIMS:Urinary tract infection (UTI) is a common complication after pelvic floor surgery. Antibiotics as prophylaxis may reduce the prevalence of UTI's by 50%, but bacterial resistance may be a large disadvantage, necessitating the search for other possible prophylactic options. Recent research found a 50% reduction in t...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/nau.24391

    authors: Mooren ES,Liefers WJ,de Leeuw JW

    更新日期:2020-06-01 00:00:00

  • External validation of a model predicting de novo stress urinary incontinence after pelvic organ prolapse surgery.

    abstract:AIMS:De novo stress urinary incontinence (SUI) may develop after surgical correction of advanced pelvic organ prolapse (POP) in otherwise continent women. Prediction of which women with POP will develop SUI after the prolapse is corrected is difficult. We aimed to externally validate a previously described prediction m...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.24608

    authors: Yasa C,Gungor Ugurlucan F,Dural O,Yalcın O

    更新日期:2021-01-25 00:00:00

  • Defining urinary urgency: patient descriptions of "gotta go".

    abstract:AIMS:Urgency is a key symptom in the diagnosis of overactive bladder (OAB), yet its definition and measurement are subject to continuing debate whether urinary urgency is a pathologic sensation or an intensification of normal desire to pass urine. The objective of this research was to explore the concept of urgency amo...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.21242

    authors: Coyne KS,Harding G,Jumadilova Z,Weiss JP

    更新日期:2012-04-01 00:00:00

  • Bladder sensitivity testing using a visual analogue scale: comparative cystometric study on women.

    abstract:AIMS:To obtain improved assessment of bladder sensitivity during cystometry by using a 10 cm visual analogue scale (VAS), and comparing it with the standard method according to the International Continence Society (ICS). METHODS:Twenty-five patients with presumed normal bladder functioning underwent filling cystometri...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/nau.20301

    authors: Dompeyre P,Fritel X,Bader G,Delmas V,Fauconnier A

    更新日期:2007-01-01 00:00:00

  • A model of the mechanics of smooth muscle reservoirs applied to the intestinal bladder.

    abstract::A model of the mechanics of smooth muscle reservoirs was derived from the stress-strain relation in smooth muscle strips. The model was applied to the intestinal bladder reservoir but may also be applied to natural reservoirs such as the bladder. The relation between reservoir volume and pressure was calculated at dif...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.1930120108

    authors: Colding-Jørgensen M,Steven K

    更新日期:1993-01-01 00:00:00

  • Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder.

    abstract:AIMS:Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation and lower urinary tract symptoms. This study aims to elucidate the association bet...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.20938

    authors: Chung SD,Liu HT,Lin H,Kuo HC

    更新日期:2011-03-01 00:00:00

  • Diagnostic yield of cystoscopy in the evaluation of recurrent urinary tract infection in women.

    abstract:AIMS:Due to a paucity of evidence-based guidelines, anecdotal practice patterns often dictate clinical management of recurrent urinary tract infection (UTI) in women. Our aim was to identify pathologic findings of the urinary tract through cystoscopy and imaging in women with recurrent UTI, and to determine if specific...

    journal_title:Neurourology and urodynamics

    pub_type: 杂志文章

    doi:10.1002/nau.22998

    authors: Pagano MJ,Barbalat Y,Theofanides MC,Edokpolo L,James MB,Cooper KL

    更新日期:2017-03-01 00:00:00