Abstract:
AIMS:To provide a clinical view and interpretation on the methods for analysis of incontinence in patients with overactive bladder. METHODS:Results are analyzed using the total number of incontinence episodes in a 3-day diary period, using fixed and random effect Poisson regression models to calculate ratio of event rates and 95% confidence interval (CI) together with P-values and are compared with the analysis of the mean number of incontinence episodes/24 hr using analysis of covariance models to calculate P-values and 95% CI for the difference between treatments. RESULTS:Using random effects Poisson regression models demonstrated that the number of incontinence episodes was reduced by 26% more with mirabegron 50 mg than with placebo. For solifenacin 5 and 10 mg, treatment resulted in a 43% (41%) greater decrease in the number of incontinence episodes compared with placebo. CONCLUSION:Instead of providing a fixed number of incontinence episodes/24 hr that reflects the mean effect, the estimate using Poisson methodology provides an efficacy estimate that can be interpreted in the context of, and relative to, the patient's baseline (severity). Using the total number of incontinence episodes in the diary period, and expressing this as percent decrease in the number of episodes, may be easier to interpret; for example, because this results in a relative measure of effect that provides an alternative understanding of a patient's improvement at end of treatment compared with the comparator arm. Also, it is based on statistical methods that are more suitable for the analysis of count data. Neurourol. Urodynam. 35:728-732, 2016. © 2015 Wiley Periodicals, Inc.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Martina R,Kay R,Abrams P,van Maanen R,Ridder Adoi
10.1002/nau.22787subject
Has Abstractpub_date
2016-08-01 00:00:00pages
728-32issue
6eissn
0733-2467issn
1520-6777journal_volume
35pub_type
杂志文章,随机对照试验abstract:AIMS:Many patients take alternative medications for their lower urinary tract symptoms (LUTS) either in addition or as a substitute for traditional therapies, despite a lack of clinical data. Grapes products are hypothesized to improve bladder function due to their antioxidant and membrane-protective actions. There is ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.22289
更新日期:2013-03-01 00:00:00
abstract:AIMS:Urodynamic studies (UDS) are complex, invasive and may be emotionally and physically distressing. Inadequate information may heighten distress. Prior to UDS, our patients receive written and verbal information, yet concerns remains that some women may not be adequately informed. This study examined how informed wo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21014
更新日期:2011-04-01 00:00:00
abstract:AIMS:To determine the prevalence of urinary incontinence (UI) and associated factors in the institutionalized elderly. METHODS:A cross-sectional study is presented herein, conducted between October and December 2013, in 10 nursing homes in the city of Natal (Northeast Brazil). Individuals over the age of 60, who resid...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22675
更新日期:2016-01-01 00:00:00
abstract:AIMS:To review the literature on toilet training (TT) in healthy children. METHODS:Through an extended literature search, all data on developmental signs of readiness for TT, TT methods, definitions of being toilet trained, TT problems, and predictive factors for success were reviewed. RESULTS:Specific studies on thi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20490
更新日期:2008-01-01 00:00:00
abstract:AIMS:Reactive nitrogen and oxygen species (RNOS) likely play a role in the development of bladder dysfunction related to bladder outlet obstruction. Antioxidants protect against these free radicals. The aim of our study was to investigate the effect of bladder outlet obstruction on the endogenous antioxidant status of ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20677
更新日期:2009-01-01 00:00:00
abstract:AIMS:We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex. METHODS:We examined (1) urinary 5-hydroxyindole acetic acid (5-HIAA) after intraperitoneal administration of saline, para-chlorophenylalanine (PCPA; a serotonin synt...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23028
更新日期:2017-03-01 00:00:00
abstract:AIMS:To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation. RESULTS:Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular col...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21064
更新日期:2011-03-01 00:00:00
abstract:AIMS:To report the state of the science on primary prevention of urinary incontinence (UI) in adults from the 6th International Consultation on Incontinence with an update through January 2019. METHODS:Online databases PubMed, CINAHL, PsycInfo, and Medline were searched in March 2016 and February 2019 with a focus on ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24222
更新日期:2020-01-01 00:00:00
abstract:AIMS:The aim of our study was to analyze whether uroflowmetry parameters are helpful in diagnosing overactive bladder (OAB). The working hypothesis was that the flow curves of patients with OAB symptoms would appear as a sharp peak flow rate with a short duration and high amplitude, lasting only for a short period duri...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22898
更新日期:2017-01-01 00:00:00
abstract:AIMS:Parkinson's disease (PD) affects the nigrostriatal projections leading to micturition disturbance in most cases. Overactive bladder (OAB) symptoms such as urinary urgency or urgent urinary incontinence are common amongst PD patients. Several urodynamic studies have revealed that detrusor overactivity causes OAB sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20682
更新日期:2009-01-01 00:00:00
abstract:AIMS:Uncoordinated reflex contractions of the external urethral sphincter (EUS) are a major component of voiding dysfunction after neurologic injury. Patterned stimulation of sacral afferent pathways can reduce abnormal EUS reflexes after acute spinal cord injury (SCI); however, effectiveness following chronic SCI is u...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22276
更新日期:2013-01-01 00:00:00
abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract::The aim of the study was to determine the contribution of intra-abdominal pressure transmission to urinary continence in the female. Five patients with genuine stress incontinence (GSI) were studied. Pressure transmission was measured in equivalent positions inside and outside the urethra and bladder during the Intrav...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140406
更新日期:1995-01-01 00:00:00
abstract:AIMS:Striated muscles of continence appear to exhibit marked fatigue during voluntary efforts. This is counterintuitive considering the high proportion of slow twitch muscle fibers. One explanation is that fatigue is due to central, rather than peripheral mechanisms. Here we examined the contribution of reduced volunta...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21162
更新日期:2011-11-01 00:00:00
abstract:AIM:The aim was to evaluate the voiding function over time after the TVT procedure for stress incontinence. MATERIALS AND METHODS:Thirty-eight women with urodynamic stress urinary incontinence were included in the study. For voiding function assessment the patients were asked if voiding had changed postoperatively, an...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20401
更新日期:2007-01-01 00:00:00
abstract::Following use of botulinum toxin in the 1980s for the treatment of detrusor sphincter dyssynergia in patients with spinal cord injury (SCI), the potential therapeutic value of this neurotoxin in urology has been the subject of much interest. The DIGNITY (Double-blind InvestiGation of purified Neurotoxin complex In neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22630
更新日期:2014-07-01 00:00:00
abstract:AIMS:Lower urinary tract dysfunctions (LUTD) are very common in Multiple Sclerosis (MS), have a significant social impact, while the organic impact is discussed. We studied urinary complications and their risk factors in our cohort of MS patients, in order to improve the management of LUTD in MS. METHODS:Between 2004 ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22495
更新日期:2015-01-01 00:00:00
abstract:AIMS:To investigate patient characteristics associated with overactive bladder (OAB) symptom improvement after 1 year of monthly percutaneous tibial nerve stimulation (PTNS) therapy. METHODS:This was a retrospective chart review of women who underwent PTNS for refractory OAB symptoms between January 2011 and December ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24038
更新日期:2019-08-01 00:00:00
abstract:AIMS:To compare severity and characteristics of urologic pain, other urinary symptoms, sexual pain, psychosocial health, and the distribution and intensity of non-urologic pain between men and women with and without Hunner lesions. METHODS:All cystoscopies were performed and documented by the same clinician to ensure ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23812
更新日期:2018-11-01 00:00:00
abstract:AIMS:The purpose of this scoping review was to examine research activity comparing suprapubic catheterization to any other method of chronic bladder emptying such as intermittent and indwelling catheterization in adults in relation to complications, patient satisfaction, and health-related quality of life (QoL). METHO...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22356
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:The relationship between exposure to abuse and interstitial cystitis/bladder pain syndrome (IC/BPS) is well-documented. However, studies have yet to examine posttraumatic stress disorder (PTSD), which develops following exposure to trauma and worsens health outcomes in chronic pain. We aimed to assess the preva...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23861
更新日期:2019-01-01 00:00:00
abstract:AIMS:This study was conducted to try to objectify assessment of pediatric uroflowmetry curves. MATERIALS AND METHODS:Nine professionals in pediatric incontinence care judged 480 pediatric uroflows. On a 1-5 scale, where 1 = anomalous and 5 = normal, uroflows were assessed on four items: staccato, interrupted, flow tim...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21152
更新日期:2011-11-01 00:00:00
abstract:AIMS:To investigate the functional outcome after supratrigonal cystectomy and augmentation ileocystoplasty in adult patients with refractory neurogenic lower urinary tract dysfunction (NLUTD). METHODS:Retrospective follow-up investigation in a single spinal cord injury rehabilitation center. In 29 patients, urodynamic...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22709
更新日期:2016-02-01 00:00:00
abstract:AIMS:Once-daily extended-release (XR) trospium chloride has been evaluated for the treatment of overactive bladder syndrome (OAB) in two 12-week randomized, double-blind, placebo-controlled studies. This pooled analysis of the 9-month open-label extensions to these studies evaluated the long-term efficacy and tolerabil...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21000
更新日期:2011-09-01 00:00:00
abstract::Patients with symptoms of overactive bladder syndrome or non-obstructive urinary retention, refractory to conservative therapy, can nowadays be treated minimally invasively with sacral nerve stimulation (SNS). The use of electric currents to treat urological pathology has a long history but SNS therapy only received F...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20459
更新日期:2008-01-01 00:00:00
abstract:AIMS:Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The purpose of this report is to summarize the ICI-RS meeting in Bristol in 20...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21097
更新日期:2011-06-01 00:00:00
abstract:AIMS:Pelvic organ prolapse occurs in 50% of parous women. Laparoscopic sacrocolpopexy (LSCP) is a common surgical procedure for restoring pelvic anatomy and function. The aim of this study is to evaluate surgical anatomy and anatomical modifications induced by standardized LSCP. METHODS:Ten fresh female cadavers under...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22806
更新日期:2016-09-01 00:00:00
abstract:AIM:To determine the psychometric properties of the total Vaizey score and its individual items. METHODS:The study was conducted as part of a prospective cohort study assessing the outcome of pelvic floor rehabilitation in patients with fecal incontinence. RESULTS:One hundred ninety-four patients were analyzed, 53 of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20758
更新日期:2010-03-01 00:00:00
abstract:AIMS:We sought to compare in-office physical exam findings via standing cough test (SCT) versus 24-hour pad weights among men seeking treatment for postprostatectomy stress urinary incontinence (SUI). METHODS:A retrospective review of a single surgeon database of incontinence procedures was performed. Documentation of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24200
更新日期:2020-01-01 00:00:00
abstract:AIMS:Although overactive bladder (OAB) impacts patient health-related quality of life, the impact of OAB on family members is not known. Presently, no validated instruments exist to assess family impact, thus we examined the psychometric properties of a new instrument, the overactive bladder family impact measure (OAB-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20715
更新日期:2010-03-01 00:00:00