Abstract:
AIMS:Uncoordinated reflex contractions of the external urethral sphincter (EUS) are a major component of voiding dysfunction after neurologic injury. Patterned stimulation of sacral afferent pathways can reduce abnormal EUS reflexes after acute spinal cord injury (SCI); however, effectiveness following chronic SCI is unknown. METHODS:Four adult male cats were implanted with bilateral extradural sacral root electrodes to allow bladder activation and underwent subsequent spinal transection (T10-12). Nine weeks after SCI urethral and bladder pressures were recorded with and without sacral afferent stimulation. Surface electrodes were applied to sacral and lumbar dermatomes and stimulus amplitude set below the muscle fasciculation threshold. The stimulation pattern was varied by on/off times of fixed frequency at each location. RESULTS:Reflexive EUS contractions were observed in all animals after chronic SCI. Patterned sacral dermatome stimulation reduced EUS reflex rate and amplitude in two of four cats. Suppression was dependent on both the stimulus location and pattern. Sacral locations and a stimulation pattern of (0.75 sec on, 0.25 sec off, 20 Hz) were effective in both responder animals. CONCLUSIONS:Patterned sacral dermatome stimulation can reduce abnormal urethral reflexes following chronic SCI. Reflex suppression is dependent on both the stimulation location and stimulus pattern. Reduction of reflexive EUS activity after chronic SCI with this non-destructive and non-invasive approach may provide an advance for the treatment of detrusor-sphincter-dyssynergia.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
McCoin JL,Bhadra N,Gustafson KJdoi
10.1002/nau.22276subject
Has Abstractpub_date
2013-01-01 00:00:00pages
92-7issue
1eissn
0733-2467issn
1520-6777journal_volume
32pub_type
杂志文章abstract:AIMS:Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The purpose of this report is to summarize the ICI-RS meeting in Bristol in 20...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21097
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.20715
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journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20312
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abstract:AIM:To characterize purinergic signaling in overactive bladder (OAB). METHODS:Mucosal biopsies were taken by flexible cystoscopy from patients with storage symptoms referred to Urology Departments of collaborating hospitals. Immunohistochemistry (n = 12) and Western blot analysis (n = 28) were used to establish the qu...
journal_title:Neurourology and urodynamics
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pub_type: 杂志文章,随机对照试验
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abstract::The vaginal vestibule has not been the subject of a dedicated journal article. Recent terminology has suggested its division into anterior and posterior components. The case for this division has not yet been assessed. Both components extend laterally from the hymen to the junction with the labia minora. The posterior...
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doi:10.1002/nau.24418
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doi:10.1002/nau.10018
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abstract:AIM:To elucidate the precise cellular and molecular mechanisms that underlie urethral fibrogenesis. METHODS:Endoluminal electrocautery injury (using Karl Storz 10 Fr. Pediatric urethroscope) was employed in male rabbits (n = 6) to create mucosal injury. Retrograde urethrogram (RUG) and endoluminal ultrasound technique...
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pub_type: 杂志文章,随机对照试验
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.22449
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journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/nau.20110
更新日期:2005-01-01 00:00:00
abstract:AIM:The International Continence Society (ICS) has standardized quality control and interpretation of uroflowmetry and urodynamics. We evaluated traces from two large studies of male lower urinary tract symptoms (UPSTREAM and UNBLOCS) against ICS standards of urodynamic equipment and practice. METHODS:Ten percent of u...
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pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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