Abstract:
AIMS:Our main aim was to compare the prostatic selectivity of silodosin with that of other alpha(1)-adrenoceptor (AR) antagonists. METHODS:We examined uroselectivities in two sets of experiments namely, in vitro and in vivo functional studies using male dogs. In the in vitro study, after evaluating the inhibitory effects of silodosin on noradrenaline (NA)-induced contractions in the isolated prostate and isolated carotid artery using the Magnus method, we calculated prostatic selectivity. In the in vivo study, we examined the effects of drugs on the hypogastric nerve stimulation (HNS)-induced increase in intraurethral pressure (IUP) and on blood pressure. The uroselectivity of silodosin was compared with those of tamsulosin and naftopidil. RESULTS:In vitro, all drugs antagonized NA-induced contraction in both prostate and carotid artery. The prostatic selectivity of silodosin (79.4) was much higher than those of tamsulosin (1.78), naftopidil (0.55), BMY 7378 (0.115), and prazosin (0.01). In vivo, intravenously (i.v.) administered silodosin dose-dependently inhibited the HNS-induced increase in IUP with much less hypotensive effect than either tamsulosin or naftopidil, the uroselectivity (ED(15)/ID(50)) of silodosin (237) being significantly higher than those of tamsulosin (1.21) and naftopidil (2.65). CONCLUSIONS:Our results clearly demonstrate that silodosin is a potent and highly selective alpha(1A)-AR antagonist. A selective alpha(1A)-AR antagonist such as silodosin may have good potential as a less-hypotensive drug for the treatment of urinary dysfunction in benign prostatic hyperplasia patients.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Tatemichi S,Tomiyama Y,Maruyama I,Kobayashi S,Kobayashi K,Maezawa A,Kobayashi M,Yamazaki Y,Shibata Ndoi
10.1002/nau.20312subject
Has Abstractpub_date
2006-01-01 00:00:00pages
792-9; discussion 800-1issue
7eissn
0733-2467issn
1520-6777journal_volume
25pub_type
杂志文章abstract:AIMS:The purpose of this study was to adapt the IIQ-7 to suit the Egyptian culture and then to assess validity and reliability of the adapted and translated IIQ-7 and UDI-6. METHODS:IIQ-7 was modified to suit Egyptian culture. Linguistic validation of the two questionnaires was done. Initial test-retest reliability an...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20609
更新日期:2009-01-01 00:00:00
abstract:AIMS:Many patients take alternative medications for their lower urinary tract symptoms (LUTS) either in addition or as a substitute for traditional therapies, despite a lack of clinical data. Grapes products are hypothesized to improve bladder function due to their antioxidant and membrane-protective actions. There is ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.22289
更新日期:2013-03-01 00:00:00
abstract:AIMS:Although overactive bladder (OAB) impacts patient health-related quality of life, the impact of OAB on family members is not known. Presently, no validated instruments exist to assess family impact, thus we examined the psychometric properties of a new instrument, the overactive bladder family impact measure (OAB-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20715
更新日期:2010-03-01 00:00:00
abstract:AIM:To report a reconstructive technique of large vesicovaginal fistula repairs, which is a rare complication of the most modern anti-incontinence procedures (tension-free tapes) using the "oldie but goodie" Lehoczky's island flap. METHODS:Women with large vesicovaginal fistulas caused by mid-urethral transobturator t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21114
更新日期:2011-11-01 00:00:00
abstract:AIMS:To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation. RESULTS:Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular col...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21064
更新日期:2011-03-01 00:00:00
abstract::Of 120 men with benign prostatic enlargement who were evaluated urodynamically, 60 had stable bladders, with (n=30) and without (n=30) outlet obstruction (OO), whereas 60, both obstructed (n=30) and unobstructed (n=30), had detrusor instability (DI). The unstable bladders, wither in the absence or presence of OO, alwa...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1998)17:5<473::aid-nau3>3.
更新日期:1998-01-01 00:00:00
abstract:AIMS:The aim of our study was to access the variability of maximum flow rate (Q(max)), average flow rate (Q(av)) and flow pattern while varying the point of impact of flow on the flowmeter. METHODS:Water was delivered through a motorised tube holder in a standardised experimental set up. Flow was directed in 4 differe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20846
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to investigate the prevalence and risk of developing stress urinary incontinence (SUI) in each type of high-intensity sport, and the associated impact on quality of life in sportswomen. METHODS:This cross-sectional study was conducted between March and November 2016. The study ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23538
更新日期:2018-08-01 00:00:00
abstract:AIMS:To evaluate whether the treatment based on urodynamics (UDS) leads to better treatment response compared to where the treatment is based on symptoms alone. STUDY DESIGN, MATERIALS AND METHODS:All patients referred with lower urinary tract symptoms (LUTS) were offered the opportunity to participate in this patient...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/nau.20810
更新日期:2010-04-01 00:00:00
abstract:AIMS:To evaluate the effect of ASP2205, a selective serotonin 5-HT2c receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. METHODS:Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The interve...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24045
更新日期:2019-08-01 00:00:00
abstract:AIMS:To present a narrated video designed to demonstrate the steps involved in the procedure of videourodynamics. METHODS:The technique shown and described in this teaching video is that performed in the urogynaecology Department at King's College Hospital, London. The equipment utilizes fluid filled lines and externa...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23437
更新日期:2018-03-01 00:00:00
abstract:AIMS:To investigate the different muscle activation patterns around the abdomino-pelvic cavity in continent women and their effect on pressure generation during a correct pelvic floor muscle (PFM) contraction and a Valsalva maneuver. METHODS:Thirteen continent women were assessed. Abdominal, chest wall, and PFM activi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20203
更新日期:2006-01-01 00:00:00
abstract::A newly revised operation for controlling spasticity in cerebral palsy patients, selective dorsal rhizotomy (SDR), has the potential to affect bladder function. The goal of this multidisciplinary study is to investigate the potential change in bladder function by characterizing and comparing pre- and post-operative sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140110
更新日期:1995-01-01 00:00:00
abstract:AIMS:Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with subjective sense of improvement. The aim of this study was to estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ) and Overactive Bladder Question...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/nau.21028
更新日期:2011-09-01 00:00:00
abstract:AIMS:To evaluate whether bladder outlet obstruction index (BOOI), a mathematical index of outlet resistance, in association with maximal flow rate (Qmax) obtained during multichannel urodynamics (UDS) or detrusor pressure at maximal flow rate (PdetQmax) could help the identification of obstruction in women. METHODS:Fr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20375
更新日期:2007-01-01 00:00:00
abstract::Hypoxia induced by partial outlet obstruction is believed to play a major role in both the hypertrophic and degenerative effects of partial outlet obstruction. Doxazosin (dox) is a clinically effective alpha-adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia (BPH). Although the maj...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10045
更新日期:2002-01-01 00:00:00
abstract:AIMS:The purpose of this study was to describe the distal pathway of the dorsal nerve of the clitoris (DNC) from gross anatomical and histological studies of cadaver specimens. METHODS:We performed dissections on 14 intact adult cadaver vulva specimens using 2× loupe magnification and microscopy. The DNC was identifie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20996
更新日期:2011-03-01 00:00:00
abstract:AIMS:To review the literature on toilet training (TT) in healthy children. METHODS:Through an extended literature search, all data on developmental signs of readiness for TT, TT methods, definitions of being toilet trained, TT problems, and predictive factors for success were reviewed. RESULTS:Specific studies on thi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20490
更新日期:2008-01-01 00:00:00
abstract:AIMS:Prostate cancer is the most frequently diagnosed male cancer and urinary incontinence represents a major consequence following surgery. Penile compression clamps (PCCs) which externally occlude the urethra may be used to manage the incontinence. Despite potential complication of PCCs, such as deformation-inflicted...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23172
更新日期:2017-08-01 00:00:00
abstract:AIMS:The aim was to assess complications of urinary incontinence (UI) for women who had a hospital contact within 30 days and to evaluate the conventional method of classifying complications vs grading complications into the Clavien-Dindo classification (CDC) system. METHODS:A historical cohort study based on a nation...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24244
更新日期:2020-02-01 00:00:00
abstract:INTRODUCTION:Urological chronic pelvic pain syndrome (UCPPS) represents a group of pain symptoms relating to patients with pelvic pain for which treatment is largely unsatisfactory. The objective of this study is to analyze the effects of a novel treatment strategy in males suffering from UCPPS. METHODS:This retrospec...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24242
更新日期:2020-02-01 00:00:00
abstract:AIMS:Pubovisceral (PV) muscle tears are associated with pelvic floor disorders. The goal of this study was to determine whether index finger palpatory assessment of PV muscle body integrity through the lateral vaginal wall is a reliable indicator of PV muscle tear severity diagnosed by magnetic resonance imaging (MRI)....
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23967
更新日期:2019-04-01 00:00:00
abstract::In our hospital, we have followed a group of patients with familial amyloidotic polyneuropathy (FAP), type I. This disease is characterized by a progressive sensitive-motor and autonomic polyneuropathy. The amyloid fibrils of FAP I contain a mutant transthyretin (TTR) molecule. More than 90% of TTR production occurs i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/(sici)1520-6777(1997)16:1<55::aid-nau7>3.0
更新日期:1997-01-01 00:00:00
abstract:AIM:To characterize purinergic signaling in overactive bladder (OAB). METHODS:Mucosal biopsies were taken by flexible cystoscopy from patients with storage symptoms referred to Urology Departments of collaborating hospitals. Immunohistochemistry (n = 12) and Western blot analysis (n = 28) were used to establish the qu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24322
更新日期:2020-03-01 00:00:00
abstract:AIMS:To evaluate the efficacy, safety, and tolerability of repetitive Transcranial Magnetic Stimulation (rTMS) associated with standard drug therapies for neuropathic pain that does not respond to pharmacological treatment alone in patients with Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC). Secondary goals were...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23718
更新日期:2018-11-01 00:00:00
abstract:AIMS:To provide a clinical view and interpretation on the methods for analysis of incontinence in patients with overactive bladder. METHODS:Results are analyzed using the total number of incontinence episodes in a 3-day diary period, using fixed and random effect Poisson regression models to calculate ratio of event r...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.22787
更新日期:2016-08-01 00:00:00
abstract::The response of the abdominal muscles to voluntary contraction of the pelvic floor (PF) muscles was investigated in women with no history of symptoms of stress urinary incontinence to determine whether there is co-activation of the muscles surrounding the abdominal cavity during exercises for the PF muscles. Electromy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2001)20:1<31::aid-nau5>3.0.co;2-
更新日期:2001-01-01 00:00:00
abstract:AIMS:Estrogen is essential for physiological maintenance of the female urogenital tract. It is believed that alterations in female sex hormones play a major role in the etiology and response to urinary tract dysfunctions. In animal studies, ovariectomy (Ovx) results in smooth muscle (SM) weakness and atrophy whereas es...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20258
更新日期:2006-01-01 00:00:00
abstract:AIM:To perform a systematic review summarizing the knowledge of genetic variants, gene, and protein expression changes in humans and animals associated with urgency urinary incontinence (UUI) and to provide an overview of the known molecular mechanisms related to UUI. METHODS:A systematic search was performed on March...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24512
更新日期:2020-11-01 00:00:00
abstract:AIM:The aim of the study was to assess correlations between body parameters and bladder capacity in healthy schoolboys and schoolgirls. On the basis of those anthropometric data functional bladder capacity (FBC) in children was estimated. MATERIALS AND METHODS:The questionnaires were sent to 1,055 parents of children ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20123
更新日期:2006-01-01 00:00:00