Abstract:
:Myelin basic protein (MBP) can be used as an antigen for inducing experimental allergic encephalomyelitis (EAE). In various studies, EAE animals have been used as an experimental model of demyelinating diseases. The aim of this study was to determine whether EAE, induced by MBP in rats, can be useful for investigation of bladder dysfunction associated with demyelinating disease. Female Lewis rats were used. In Study 1, the time course of behavioral and cystometric changes were observed consecutively after MBP sensitization. In Study 2, the correlations between behavioral, cystometric, and histologic abnormalities were studied. The degree of paralysis and histologic findings were evaluated. In Study 1, transient hind limb paralysis was observed in all rats. Cystometric findings were characterized by three different patterns: 1) detrusor areflexia (DA), 2) detrusor hyperactivity (DH), and 3) normal. Ten (77%) of the 13 rats given MBP showed bladder dysfunction, including DA (seven), DA/DH (two) and DH (one). Study 2 showed DA in 10 rats, DH in one, and normal findings in nine animals. The difference in degree of paralysis between the DA and the cystometrically normal animals was statistically significant (P<0.01). The mean value of the degree of inflammation in the spinal cord (L6-S1) in the DA group was significantly (P<0.05) higher than that in the cystometrically normal group. The degrees of paralysis and spinal inflammation were weakly correlated (R = 0.47, P = 0.05). The present rat model seems useful for studies of bladder dysfunction associated with spinal myelitis/demyelinating diseases.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Mizusawa H,Igawa Y,Nishizawa O,Ichikawa M,Ito M,Andersson KEdoi
10.1002/1520-6777(2000)19:6<689::aid-nau7>3.0.co;2subject
Has Abstractpub_date
2000-01-01 00:00:00pages
689-99issue
6eissn
0733-2467issn
1520-6777pii
10.1002/1520-6777(2000)19:6<689::AID-NAU7>3.0.CO;2journal_volume
19pub_type
杂志文章abstract:OBJECTIVE:To evaluate whether filling phase urodynamic parameters can predict the success of the artificial urinary sphincter (AUS) in treating post-prostatectomy incontinence (PPI). MATERIALS AND METHODS:We reviewed the pre-AUS urodynamics of 99 patients with PPI at two tertiary referral centers. We documented the pe...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23147
更新日期:2017-08-01 00:00:00
abstract:AIMS:The ultrasound assessment of bladder wall thickness (BWT) and intravesical prostatic protrusion (IPP) have emerged as a non-invasive, inexpensive, time-saving alternatives to pressure-flow studies to assess benign prostatic obstruction (BPO). Aim of our study was to evaluate the effect on detrusor mass of dutaster...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23247
更新日期:2017-11-01 00:00:00
abstract:AIMS:A non-invasive ultrasound method of estimating bladder weight (UEBW) has been proposed as diagnostic for outflow tract obstruction and detrusor overactivity in men and women. There are no data on asymptomatic men and women. This study aimed to examine the relationship between UEBW, age, height, body mass index (BM...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20757
更新日期:2009-01-01 00:00:00
abstract:AIMS:The primary aim of this prospective study was to examine the correlations between "The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF)" score and urodynamic findings in patients with urge incontinence. In addition, we aimed to observe the alterations of these parameters with antimusca...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20389
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Widely accepted consensus terminology and calculations of detrusor contractility in females do not exist but may be useful. We report the output of a proposal session at the International Consultation on Incontinence Research Society meeting 2019, addressing the title topic. METHODS:Three formal presentat...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24260
更新日期:2020-07-01 00:00:00
abstract:AIMS:To evaluate the feasibility and reliability of current perception threshold (CPT) measurement for sensory assessment of distinct locations in the male lower urinary tract (LUT). METHODS:Twelve male subjects (>18 years) without LUT symptoms or medical comorbidities were eligible. CPTs were determined twice (interv...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22956
更新日期:2017-02-01 00:00:00
abstract::Polypropylene (PP) mesh has been used as a primary or adjuvant material for vaginal reconstruction for both stress urinary incontinence (SUI) and pelvic organ prolapse (POP) for decades. Whether polypropylene is the optimal material for such indications has been called into question by clinicians, regulatory agencies ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24312
更新日期:2020-07-01 00:00:00
abstract:AIMS:Voiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction. M...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23263
更新日期:2017-11-01 00:00:00
abstract:AIMS:Both clinical and neurophysiologic testing of the penilo-cavernosus reflex is used in clinical practice. The aim of the present study was to determine the as yet unestablished potential contribution of sacral reflex testing to the diagnostic evaluation of patients with suspected neuropathic sacral lesions. METHOD...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20520
更新日期:2008-01-01 00:00:00
abstract::A newly revised operation for controlling spasticity in cerebral palsy patients, selective dorsal rhizotomy (SDR), has the potential to affect bladder function. The goal of this multidisciplinary study is to investigate the potential change in bladder function by characterizing and comparing pre- and post-operative sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140110
更新日期:1995-01-01 00:00:00
abstract:AIMS:To verify if hypopressive exercises (HEs) can improve pelvic organ prolapse (POP) symptoms equally or better than pelvic floor muscle training (PFMT). METHODS:Randomized controlled trial. Symptomatic women with untreated stage II POP according to the Pelvic Organ Prolapse Quantification System (POP-Q) having the ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23819
更新日期:2019-01-01 00:00:00
abstract::Diabetes mellitus (DM) has reached epidemic proportions world wide. Many chronic complications of DM, including neuropathy, retinopathy and nephropathy, have been well studied and although urologic complications have been recognized since 1935, little is known about DM as a pathophysiological risk factor for developme...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20533
更新日期:2008-01-01 00:00:00
abstract:AIMS:To determine the prevalence of urinary incontinence (UI) and associated factors in the institutionalized elderly. METHODS:A cross-sectional study is presented herein, conducted between October and December 2013, in 10 nursing homes in the city of Natal (Northeast Brazil). Individuals over the age of 60, who resid...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22675
更新日期:2016-01-01 00:00:00
abstract::The potential of the alpha 1 and alpha 2 antagonists to modify prostate compliance, and micturition characteristics of rats with hormonally enlarged prostates was studied. Prostate growth was induced in Sprague-Dawley rats using dihydrotestosterone (DHT) and estradiol (E) by daily subcutaneous injections of DHT 1.25 m...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:1<85::AID-NAU9>3.0
更新日期:1996-01-01 00:00:00
abstract:AIM:To evaluate the immediate effect on natural fill urodynamic parameters and bladder function during transcutaneous electrical nerve stimulation (TENS) in children with overactive bladder (OAB) and daytime urinary incontinence (DUI). MEETHODS:In this double-blind, placebo-controlled study, 24 children with severe OA...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23179
更新日期:2017-09-01 00:00:00
abstract:AIMS:To inform and guide patient-centred care for men with lower urinary tract symptoms (LUTS), by providing in-depth qualitative evidence regarding men's perspectives on treatment decision-making for LUTS. METHODS:An interview study of men recruited from 26 English urology departments. Purposive sampling captured sur...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24533
更新日期:2020-10-14 00:00:00
abstract:AIMS:The objective of the study was to compare sacral nerve stimulation (SNS) to pudendal nerve stimulation (PNS) for voiding dysfunction. METHODS:Thirty subjects with voiding dysfunction had a tined lead placed at S3 and a second electrode implanted at the pudendal nerve via a posterior approach. In a blinded, random...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20174
更新日期:2005-01-01 00:00:00
abstract:AIMS:Given the relative frequency of lower urinary tract dysfunction (LUTD) after major pelvic surgery, the main question for this debate is: "Should we [actively] screen for LUTD after major pelvic surgery," with the intention to treat and improve patient care. METHODS:The discussants selected relevant papers from a ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22218
更新日期:2012-03-01 00:00:00
abstract:AIMS:To estimate the prevalence and severity of bed-wetting in 1-18-year-old Chinese children. MATERIALS AND METHODS:A cross-sectional study of bed-wetting was performed by using 13,515 self-administered questionnaires distributed to the parents of 1-18-year-old Chinese children in Henan province. The prevalence of be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20373
更新日期:2007-01-01 00:00:00
abstract:AIMS:The aim of this study is to investigate whether ketamine could relieve the social stress (SS)-related bladder dysfunction in mice. MATERIALS AND METHODS:The FVB mice were randomly assigned to either undergo SS exposure for 60 minutes per day on seven consecutive days for 4 weeks (SS1) or control without SS (SS0)....
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24324
更新日期:2020-03-01 00:00:00
abstract:AIM:To validate the functionality of an implantable pudendal nerve stimulator under development for Food and Drug Administration approval to restore bladder function after spinal cord injury. METHODS:In nine cats under anesthesia, two tripolar cuff electrodes were implanted bilaterally on the pudendal nerves and one b...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23994
更新日期:2019-06-01 00:00:00
abstract:AIMS:To evaluate the prevalence and associated risk factors for urinary incontinence, as well as its association with multimorbidity among Brazilian women aged 50 or over. METHODS:This was a secondary analysis of a cross-sectional population-based study including 622 women 50 years or older, conducted in the city of C...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22679
更新日期:2016-01-01 00:00:00
abstract:AIMS:The aim of our study was to analyze whether uroflowmetry parameters are helpful in diagnosing overactive bladder (OAB). The working hypothesis was that the flow curves of patients with OAB symptoms would appear as a sharp peak flow rate with a short duration and high amplitude, lasting only for a short period duri...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22898
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to use a systematic schedule, including urodynamics, to describe the rate of coexisting overactive bladder (OB) in patients with bladder outlet obstruction (BOO) caused by benign prostatic hyperplasia (BPH). We also identified differences between the patients with pure BOO compared with those...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1001
更新日期:2001-01-01 00:00:00
abstract::Abnormalities of micturition occur in many different diseases, have a variety of causes and take several forms. This review will focus exclusively on those abnormalities in which antidiuretic therapy may be of benefit. These conditions are primarily characterized by an increase in the total amount of urine produced (p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20437
更新日期:2007-01-01 00:00:00
abstract:AIMS:Pubovisceral (PV) muscle tears are associated with pelvic floor disorders. The goal of this study was to determine whether index finger palpatory assessment of PV muscle body integrity through the lateral vaginal wall is a reliable indicator of PV muscle tear severity diagnosed by magnetic resonance imaging (MRI)....
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23967
更新日期:2019-04-01 00:00:00
abstract:AIM:To compare the urethral sphincter morphology and levator hiatal dimensions between white and black premenopausal nulliparous asymptomatic women using 3D/4D translabial ultrasonography. METHODS:Nulliparous black and white women were recruited in a tertiary gynecological center. All women were completely asymptomati...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21181
更新日期:2012-04-01 00:00:00
abstract:AIM:To characterize purinergic signaling in overactive bladder (OAB). METHODS:Mucosal biopsies were taken by flexible cystoscopy from patients with storage symptoms referred to Urology Departments of collaborating hospitals. Immunohistochemistry (n = 12) and Western blot analysis (n = 28) were used to establish the qu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24322
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:We aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations. METHODS:A secondary analysis of women with urge incontinence or urge predominant MUI enrolled in the Urinary Incontinence Treatment Network BE-DRI rand...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20922
更新日期:2011-01-01 00:00:00
abstract:AIMS:This article reviews current knowledge of the underpinning mechanisms of how the bladder senses fullness locally and also revisits clinical measurements of lower urinary tract sensation. The former represents cellular sensing during bladder filling whereas the latter describes the sensations leading to conscious p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24273
更新日期:2020-07-01 00:00:00