Abstract:
AIMS:The aim of this study is to investigate whether ketamine could relieve the social stress (SS)-related bladder dysfunction in mice. MATERIALS AND METHODS:The FVB mice were randomly assigned to either undergo SS exposure for 60 minutes per day on seven consecutive days for 4 weeks (SS1) or control without SS (SS0). The SS0 were then allocated to single or no injection of ketamine (SS0K1 and SS0K0). In the group of SS1, the SS1 mice were allocated to receive single injection of saline (SS1K0), single dose (SS1K1) or five daily dose of (SS1K5) ketamine injection (25 mg/kg/day/ip) since day 22. In vivo cystometry and tissue bath wire myography were performed on day 29. Serum and urine level of brain-derived neurotrophic factor (BDNF) were measured with enzyme-linked immunosorbent assay. RESULTS:In mice without social stress exposure, ketamine administration did not significantly affect voiding frequency (P > .05). SS1 K0 , SS1 K1, and SS1 K5 had significantly lower voiding frequency than that of control (SS1 K0 ) (each n = 15, P < .05). Ketamine administration reversed the trend of decreased voiding frequency in SS1 mice. Stressed mice had significant higher serum level of BDNF that reduced by short-term ketamine. Stressed mice had detrusor overactivity and impaired detrusor contractility which were not reversed by short-term ketamine. CONCLUSIONS:Social stress leads to elevated serum BDNF, infrequent voiding, detrusor overactivity, and impaired contractility. Short-term administration of ketamine may improve SS-related infrequent voiding and elevated serum BDNF level. However, ketamine did not improve SS-related bladder dysfunction on urodynamic and myography studies.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Yang SS,Chang HH,Chang SJdoi
10.1002/nau.24324subject
Has Abstractpub_date
2020-03-01 00:00:00pages
935-944issue
3eissn
0733-2467issn
1520-6777journal_volume
39pub_type
杂志文章abstract:BACKGROUND AND AIMS:Stakeholders from around the world came together to address the unmet needs of underactive bladder (UAB) at the 3rd International Congress for Underactive Bladder. METHODS:The main recommendation from the regulatory working group is a need for a meeting of UAB stakeholders and regulatory agencies i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23738
更新日期:2018-11-01 00:00:00
abstract:AIMS:The flow of fluid along the urethra is known to facilitate detrusor contraction during micturition. This reflex, previously described in awake ewes, helps to achieve complete bladder emptying. In anesthetized cats, another urethra to bladder reflex involving urethral cold receptors has been described. The aim of t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20311
更新日期:2007-01-01 00:00:00
abstract:AIMS:This study examined test-retest reliability of four patient-reported outcome measures for patients with overactive bladder (OAB): Overactive Bladder Questionnaire (OAB-q), Patient Perception of Bladder Condition (PPBC), Urgency Questionnaire (UQ), and Primary OAB Symptom Questionnaire (POSQ). METHODS:Patients rec...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20110
更新日期:2005-01-01 00:00:00
abstract::It is well known that urethane is a suitable anesthetic for acute studies and has been extensively recommended for investigations related to micturition physiology. This is mainly because of the capability of urethane anesthesia to spare reflex micturition as well as its easily established long-lasting and stable anes...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(2000)19:1<87::aid-nau9>3.0
更新日期:2000-01-01 00:00:00
abstract:AIMS:To describe a pelvic floor muscle training (PFMT) isolated and associated with game therapy (PFMT + GT) for women facing mixed urinary incontinence (MUI) during climacteric period. METHODS:To standardize a randomized controlled clinical trial intervention, a protocol was created, in an attempt to decrease women's...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24350
更新日期:2020-06-01 00:00:00
abstract:AIM:We present the surgical management and outcomes of patients who underwent transvaginal neo-bladder vaginal fistula (NBVF) repair at our institution. METHODS:Between 2002 and 2012, eight patients underwent transvaginal NBVF repair. The surgical management entailed placing a Foley catheter into the fistula tract. A ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22687
更新日期:2016-01-01 00:00:00
abstract::Intrinsic sphincter deficiency (ISD) is frequently treated with collagen bulking at the bladder neck. The standard material used, Contigen, biodegrades over 3-19 months requiring repeated injections to maintain efficacy. The study objective was to evaluate use of autologous ear chondrocytes for treatment of ISD. Women...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1520-6777(2001)20:2<157::aid-nau18>3.0.co;
更新日期:2001-01-01 00:00:00
abstract:AIMS:No one has assessed urodynamic studies (UDS) to determine those steps that elicit the greatest anxiety, distress, and pain in children. We sought to systematically evaluate a child's UDS experience to mollify these reactions. METHODS:Prospective study involving children aged ≥5 undergoing UDS over a 6-month perio...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24339
更新日期:2020-04-01 00:00:00
abstract:AIMS:Fecal incontinence (FI) is embarrassing, resulting in poor quality of life. Rectal sensation may be more important than sphincter strength to relieve symptoms. A single-blind, randomized controlled trial among adults with FI compared the effectiveness of rectal balloon training (RBT) and pelvic floor muscle traini...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21218
更新日期:2012-01-01 00:00:00
abstract::The rhabdosphincter at the mid urethra is critical for maintaining urinary continence. In a setting of stress urinary incontinence stem cells transplanted into the site of the rhabdosphincter may augment sphincter regeneration and also release trophic factors promoting muscle and nerve integration of this muscle. We h...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20833
更新日期:2010-01-01 00:00:00
abstract:AIM:To determine the psychometric properties of the total Vaizey score and its individual items. METHODS:The study was conducted as part of a prospective cohort study assessing the outcome of pelvic floor rehabilitation in patients with fecal incontinence. RESULTS:One hundred ninety-four patients were analyzed, 53 of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20758
更新日期:2010-03-01 00:00:00
abstract::Of 120 men with benign prostatic enlargement who were evaluated urodynamically, 60 had stable bladders, with (n=30) and without (n=30) outlet obstruction (OO), whereas 60, both obstructed (n=30) and unobstructed (n=30), had detrusor instability (DI). The unstable bladders, wither in the absence or presence of OO, alwa...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1998)17:5<473::aid-nau3>3.
更新日期:1998-01-01 00:00:00
abstract:AIMS:The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pel...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23995
更新日期:2019-06-01 00:00:00
abstract::Anticholinergics are commonly used for the treatment of frequency, urgency, and urge incontinence in women. Alpha-blockers have been shown to have a modulating effect on bladder smooth muscle but are not commonly used clinically for this indication. To evaluate the clinical effectiveness of each treatment as well as t...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1520-6777(1998)17:1<31::aid-nau6>3.0
更新日期:1998-01-01 00:00:00
abstract:AIMS:To investigate the use of an inflatable perile cuff to obstruct flow progressively during voiding in order to provide a noninvasive measure of bladder pressure. METHODS:In this study, we explain the observed relationship of flow rate with applied cuff pressure by analogy with a simple physical model. The model co...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10059
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Women with urodynamic stress incontinence (USI) have lower opening and closing detrusor pressures than women without USI. This study was undertaken to determine whether a change occurs in opening and closing detrusor pressures after colposuspension, whether cure is associated with change, and whether age infl...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10165
更新日期:2004-01-01 00:00:00
abstract:AIMS:To assess the feasibility of a randomized controlled trial of a home-based integrated physical exercise and bladder-training program vs usual care in community-dwelling women with urinary incontinence (UI). METHODS:We conducted a parallel arm, nonblinded, pilot randomized controlled trial of a home-based integrat...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23999
更新日期:2019-06-01 00:00:00
abstract:AIMS:To estimate the prevalence and severity of bed-wetting in 1-18-year-old Chinese children. MATERIALS AND METHODS:A cross-sectional study of bed-wetting was performed by using 13,515 self-administered questionnaires distributed to the parents of 1-18-year-old Chinese children in Henan province. The prevalence of be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20373
更新日期:2007-01-01 00:00:00
abstract:AIM:To investigate the urethral motor function in incontinent women. MATERIALS AND METHODS:The intraurethral pressure was measured continuously in the high-pressure zone of the urethra at rest and during repeated short squeezes around the microtip transducer catheter in a group of 205 women with clinically manifest ur...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20207
更新日期:2006-01-01 00:00:00
abstract:AIMS:To identify clinical and urodynamic factors leading to spontaneous voiding in men with detrusor underactivity (DU) and suspected bladder outlet obstruction who underwent an outlet de-obstruction procedure. METHODS:We identified 614 men who underwent an outlet procedure at our institution from 2005 to 2014. Men we...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24122
更新日期:2019-11-01 00:00:00
abstract:AIMS:To evaluate the reliability, validity, and predicted probabilities of a Chinese version of the Dysfunctional Voiding Symptom Score (DVSS) and to explore the latent factors underlying dysfunctional voiding. MATERIALS AND METHODS:We enrolled 60 children (38 girls and 22 boys) with a diagnosis of dysfunctional voidi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22254
更新日期:2012-11-01 00:00:00
abstract::A model of the mechanics of smooth muscle reservoirs was derived from the stress-strain relation in smooth muscle strips. The model was applied to the intestinal bladder reservoir but may also be applied to natural reservoirs such as the bladder. The relation between reservoir volume and pressure was calculated at dif...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120108
更新日期:1993-01-01 00:00:00
abstract:AIMS:Prompted by patients' changing perceptions of transvaginal mesh, this study examines how mesh has been reported in the news following the 2011 US Food and Drug Administration (FDA) updated notification about the use of mesh in the treatment of pelvic organ prolapse. METHODS:Two national newspaper databases were q...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22923
更新日期:2017-02-01 00:00:00
abstract:AIMS:To develop and validate a urinary diary, using the psychometric validation protocol applied to all International Consultation on Incontinence Questionnaire (ICIQ) modules. METHODS:Patient and clinician opinion was sought on diary content, format, and duration using interviews and questionnaires. Content deemed es...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21254
更新日期:2012-06-01 00:00:00
abstract:AIMS:The objective of the study was to compare sacral nerve stimulation (SNS) to pudendal nerve stimulation (PNS) for voiding dysfunction. METHODS:Thirty subjects with voiding dysfunction had a tined lead placed at S3 and a second electrode implanted at the pudendal nerve via a posterior approach. In a blinded, random...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20174
更新日期:2005-01-01 00:00:00
abstract:AIMS:Reactive nitrogen and oxygen species (RNOS) likely play a role in the development of bladder dysfunction related to bladder outlet obstruction. Antioxidants protect against these free radicals. The aim of our study was to investigate the effect of bladder outlet obstruction on the endogenous antioxidant status of ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20677
更新日期:2009-01-01 00:00:00
abstract::This review will highlight appropriate animal models for the study of a number of disorders involving changes to lower urinary tract function. A major hurdle to the development of animal models for human lower urinary tract disorders is that the clinical pathophysiology of the latter mostly remain idiopathic. Acute in...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20903
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:The relationship between exposure to abuse and interstitial cystitis/bladder pain syndrome (IC/BPS) is well-documented. However, studies have yet to examine posttraumatic stress disorder (PTSD), which develops following exposure to trauma and worsens health outcomes in chronic pain. We aimed to assess the preva...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23861
更新日期:2019-01-01 00:00:00
abstract:AIMS:To determine cohort urethral length, identify epidemiological factors influencing the parameter and to establish the percentage of cases with clinically relevant outsized urethras. METHODS:Prospective cohort study conducted in two tertiary clinical centers between 2013 and 2017. Nine hundred and twenty seven cons...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23509
更新日期:2018-06-01 00:00:00
abstract::Myelin basic protein (MBP) can be used as an antigen for inducing experimental allergic encephalomyelitis (EAE). In various studies, EAE animals have been used as an experimental model of demyelinating diseases. The aim of this study was to determine whether EAE, induced by MBP in rats, can be useful for investigation...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2000)19:6<689::aid-nau7>3.0.co;2
更新日期:2000-01-01 00:00:00