Abstract:
AIMS:Progressive weakness in pelvic floor tissues is extremely common and leads to the distressing problems of stress urinary incontinence (SUI) and pelvic organ prolapse (POP). There has been extensive work on a vast array of materials spanning synthetics, autografts, allografts, and xenografts. Uniaxial testing of materials has been used to predict their success and rates of erosion. We aimed to compare the uniaxial properties of prostheses to native paravaginal tissue and correlate these to their success and erosion rates. METHODS:We performed a systematic review of the literature to identify the biomechanical properties of paravaginal tissue and of prostheses used in the treatment of SUI and POP. We examined to what extent these findings correlated to their reported success and erosion rates. RESULTS:Biomechanical properties have been determined for prostheses used in the treatment of POP and SUI both pre- and post-implantation in animal models. Implantation generally led to a decrease in ultimate tensile strength and Young's modulus. We were unable to find any simple correlation between the uniaxial mechanical properties of materials and their success or erosion rates. CONCLUSIONS:Mechanical properties of prostheses, as measured by uniaxial testing, only appears to form part of the picture. We suggest implant integration and host responses to materials, as well as the biomechanical properties of the materials need to be considered to design materials to achieve lasting clinical benefit.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Mangera A,Bullock AJ,Chapple CR,Macneil Sdoi
10.1002/nau.21156subject
Has Abstractpub_date
2012-01-01 00:00:00pages
13-21issue
1eissn
0733-2467issn
1520-6777journal_volume
31pub_type
杂志文章,评审abstract:AIMS:To estimate the prevalence and severity of bed-wetting in 1-18-year-old Chinese children. MATERIALS AND METHODS:A cross-sectional study of bed-wetting was performed by using 13,515 self-administered questionnaires distributed to the parents of 1-18-year-old Chinese children in Henan province. The prevalence of be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20373
更新日期:2007-01-01 00:00:00
abstract:AIMS:The purpose of this study was to describe the distal pathway of the dorsal nerve of the clitoris (DNC) from gross anatomical and histological studies of cadaver specimens. METHODS:We performed dissections on 14 intact adult cadaver vulva specimens using 2× loupe magnification and microscopy. The DNC was identifie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20996
更新日期:2011-03-01 00:00:00
abstract:AIMS:To investigate the role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro. MATERIALS AND METHODS:Longitudinal strips of trigonal muscle were isolated, and the mucosa and serosa removed. Tissues were precontracted with KCl, and beta-adrenoceptor agonists (isoprenalin...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10130
更新日期:2003-01-01 00:00:00
abstract:AIMS:Reflex bladder activation and inhibition by electrical stimulation of pudendal nerve (PN) afferents is a promising approach to restore control of bladder function in persons with lower urinary tract dysfunction caused by disease or injury. The objective of this work was to determine whether bladder activation evok...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22822
更新日期:2016-11-01 00:00:00
abstract:AIMS:To test the validity of three patient global ratings, satisfaction, perception of improvement, and estimated percent improvement, for measuring outcomes of behavioral treatment for urinary incontinence. METHODS:This report is a secondary analysis of data from three randomized controlled trials testing behavioral ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,meta分析
doi:10.1002/nau.20243
更新日期:2006-01-01 00:00:00
abstract:AIM:To explore the relationship between urinary incontinence and genital sensory functioning in females with sexual dysfunction disorders. METHODS:A retrospective consecutive chart review was conducted for all women who were referred to our tertiary female urology clinic with a primary complaint of sexual dysfunction ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20988
更新日期:2011-09-01 00:00:00
abstract:AIMS:Rodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24415
更新日期:2020-08-01 00:00:00
abstract:AIMS:This study was designed to assess lower urinary tract symptoms (LUTS) following robotic-assisted laparoscopic prostatectomy. METHODS:In a single surgeon series, 938 patients underwent robotic prostatectomy and completed International Prostate Symptom Score surveys at baseline and 6-month follow-up. Patients preop...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23118
更新日期:2017-06-01 00:00:00
abstract:AIMS:Many patients take alternative medications for their lower urinary tract symptoms (LUTS) either in addition or as a substitute for traditional therapies, despite a lack of clinical data. Grapes products are hypothesized to improve bladder function due to their antioxidant and membrane-protective actions. There is ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.22289
更新日期:2013-03-01 00:00:00
abstract::Better understanding of the underlying working mechanism of the neural control of the lower urinary tract will facilitate the treatment of dysfunction with a neurogenic cause. We developed a computer model to study the effect of a neural control system on lower urinary tract behavior. To model the mechanical propertie...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1998)17:3<175::aid-nau3>3.
更新日期:1998-01-01 00:00:00
abstract:AIM:To linguistically validate the translation of the Lower Urinary Tract Symptoms (LUTS) Tool from English to 10 European languages and assess whether the translations adequately reflected the concepts in the original version and if urological terms and the individual items were readily understood. METHODS:Residents ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22265
更新日期:2013-01-01 00:00:00
abstract:AIMS:To evaluate if pelvic floor innervation differed in patients with rectocele compared to control subjects and to assess if nerve fiber density of the rectovaginal wall correlated to the clinical presentation of rectocele. METHODS:Biopsies from 24 female patients with posterior vaginal wall prolapse stage II (ICS-c...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20249
更新日期:2006-01-01 00:00:00
abstract:AIM:Treatments targeting vanilloid receptor TRPV1 are effective in some bladder disorders. Our aim was to determine the expression profiles of TRPV1 in regions of human bladder and test the hypothesis that there would be an upregulation of TRPV1 in mucosa of patients with bladder hypersensitivity but not idiopathic det...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20326
更新日期:2007-01-01 00:00:00
abstract:AIM:To determine the psychometric properties of the total Vaizey score and its individual items. METHODS:The study was conducted as part of a prospective cohort study assessing the outcome of pelvic floor rehabilitation in patients with fecal incontinence. RESULTS:One hundred ninety-four patients were analyzed, 53 of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20758
更新日期:2010-03-01 00:00:00
abstract:AIM:Even though many agents have been implicated as modulators of ureteral contractile activity, the exact mechanisms that control human ureteral smooth muscle contractility have yet to be clearly defined. Recently, Rho-kinase has been reported to be involved in the contractile mechanism of smooth muscles in various or...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20096
更新日期:2005-01-01 00:00:00
abstract:AIMS:Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation and lower urinary tract symptoms. This study aims to elucidate the association bet...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20938
更新日期:2011-03-01 00:00:00
abstract:AIMS:The aim of this study was to resolve the paradox as to whether magnetic stimulation of sacral nerve roots results in contraction or suppression of the bladder, in both normal individuals and patients with spinal cord injury (SCI). MATERIALS AND METHODS:Seven males with complete SCI and neurogenic detrusor overact...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.20009
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to investigate the prevalence and risk of developing stress urinary incontinence (SUI) in each type of high-intensity sport, and the associated impact on quality of life in sportswomen. METHODS:This cross-sectional study was conducted between March and November 2016. The study ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23538
更新日期:2018-08-01 00:00:00
abstract:AIMS:To evaluate whether the treatment based on urodynamics (UDS) leads to better treatment response compared to where the treatment is based on symptoms alone. STUDY DESIGN, MATERIALS AND METHODS:All patients referred with lower urinary tract symptoms (LUTS) were offered the opportunity to participate in this patient...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/nau.20810
更新日期:2010-04-01 00:00:00
abstract:AIMS:To report for the first time bladder rupture during filling cystometry many years after bladder augmentation. METHODS:A 17-year-old girl with T10 meningomyelocele had received an ileocystoplasty, continent catheterizable stoma, and bladder neck sling for neurogenic bladder dysfunction and intractable incontinence...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20394
更新日期:2007-01-01 00:00:00
abstract:AIM:Interstitial cystitis/painful bladder syndrome/(IC/PBS) results in recurring pain in the bladder and surrounding pelvic region caused by abnormal excitability of micturition reflexes. Spinal cord stimulation (SCS) is currently clinically used for the attenuation of neuropathic and visceral pain. The present study e...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23827
更新日期:2019-01-01 00:00:00
abstract::The present study prospectively surveyed the prevalence of anal incontinence among 283 consecutive female patients attending a urogynecologic outpatient clinic in a maternity hospital. Data concerning bowel habits, laxative use, previous anorectal surgery, and the presence, severity, and frequency of anal incontinence...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:3<199::aid-nau6>3.
更新日期:1999-01-01 00:00:00
abstract:AIMS:Lower urinary tract symptoms (LUTS) are common in the aging population. LUTS cause profoundly negative impacts on their quality of life. Pathophysiology of LUTS is multifactorial, and recently, bladder ischemia and metabolic syndrome have been suggested as etiological factors. To evaluate chronic hyperlipidemia on...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20843
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Stakeholders from around the world came together to address the unmet needs of underactive bladder (UAB) at the 3rd International Congress for Underactive Bladder. METHODS:The main recommendation from the regulatory working group is a need for a meeting of UAB stakeholders and regulatory agencies i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23738
更新日期:2018-11-01 00:00:00
abstract:AIMS:This article reviews current knowledge of the underpinning mechanisms of how the bladder senses fullness locally and also revisits clinical measurements of lower urinary tract sensation. The former represents cellular sensing during bladder filling whereas the latter describes the sensations leading to conscious p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24273
更新日期:2020-07-01 00:00:00
abstract:AIMS:Bladder wall stretch increases tissue tension and releases adenosine 5'-triphosphate (ATP) as part of a transduction process to sense bladder filling. Aging is associated with bladder fibrosis to produce a stiffer bladder wall: this may augment ATP release and contribute to age-dependent urgency. Muscarinic agonis...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24426
更新日期:2020-08-01 00:00:00
abstract::Abnormalities of micturition occur in many different diseases, have a variety of causes and take several forms. This review will focus exclusively on those abnormalities in which antidiuretic therapy may be of benefit. These conditions are primarily characterized by an increase in the total amount of urine produced (p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20437
更新日期:2007-01-01 00:00:00
abstract:AIMS:This article aims to identify quality control (QC) best practice, to review published QC audits in order to identify how closely good practice is followed, and to carry out a market survey of the software features that support QC offered by urodynamics machines available in the UK. METHODS AND RESULTS:All UK dist...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21133
更新日期:2011-11-01 00:00:00
abstract:AIM:The aim of the study was to assess correlations between body parameters and bladder capacity in healthy schoolboys and schoolgirls. On the basis of those anthropometric data functional bladder capacity (FBC) in children was estimated. MATERIALS AND METHODS:The questionnaires were sent to 1,055 parents of children ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20123
更新日期:2006-01-01 00:00:00
abstract:AIMS:To determine the role of opioid receptors in the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs, and explore the possible mechanism of SNM. METHODS:Both implant-driven stimulators of the S3 spinal nerve were implanted in seven pigs. Naloxone and tramadol were administered. Multiple cys...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23187
更新日期:2017-09-01 00:00:00