Abstract:
AIM:Treatments targeting vanilloid receptor TRPV1 are effective in some bladder disorders. Our aim was to determine the expression profiles of TRPV1 in regions of human bladder and test the hypothesis that there would be an upregulation of TRPV1 in mucosa of patients with bladder hypersensitivity but not idiopathic detrusor overactivity (IDO). MATERIALS AND METHODS:Women with sensory urgency (SU), interstitial cystitis (IC), and IDO were investigated by videourodynamics and cystoscopy. Control biopsies were used for comparison. Biopsies were dissected into mucosa and muscle, and evaluated for TRPV1 mRNA expression using quantitative competitive RT-PCR (QC-RT-PCR). RESULTS:TRPV1 mRNA from SU trigonal mucosa was significantly higher than control trigonal mucosa or SU bladder body mucosa. In contrast, in IDO patients, there was no difference between trigonal mucosa and body mucosa. In IC biopsies, RNA quality was substandard and unable to be used for analysis. The most striking finding was that TRPV1 mRNA expressed in SU trigonal mucosa was significantly inversely correlated with the bladder volume at first sensation of filling during cystometry. No such relationship was seen for IDO trigonal mucosa. No difference was seen in bladder body mucosa from any disease groups compared with age-matched control. CONCLUSIONS:The symptoms of SU were associated with the increased expression of TRPV1 mRNA in the trigonal mucosa. No upregulation or regional differences of TRPV1 mRNA were seen in IDO patients. TRPV1 may play a role in SU and premature first bladder sensation on filling.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Liu L,Mansfield KJ,Kristiana I,Vaux KJ,Millard RJ,Burcher Edoi
10.1002/nau.20326subject
Has Abstractpub_date
2007-01-01 00:00:00pages
433-8; discussion 439; discussion 451-3issue
3eissn
0733-2467issn
1520-6777journal_volume
26pub_type
杂志文章abstract::The aim of the study was to determine the contribution of intra-abdominal pressure transmission to urinary continence in the female. Five patients with genuine stress incontinence (GSI) were studied. Pressure transmission was measured in equivalent positions inside and outside the urethra and bladder during the Intrav...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140406
更新日期:1995-01-01 00:00:00
abstract:AIMS:To evaluate the prevalence and associated risk factors for urinary incontinence, as well as its association with multimorbidity among Brazilian women aged 50 or over. METHODS:This was a secondary analysis of a cross-sectional population-based study including 622 women 50 years or older, conducted in the city of C...
journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.20027
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.20988
更新日期:2011-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.10130
更新日期:2003-01-01 00:00:00
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journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930130507
更新日期:1994-01-01 00:00:00
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journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
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journal_title:Neurourology and urodynamics
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-06-01 00:00:00
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journal_title:Neurourology and urodynamics
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doi:10.1002/(sici)1520-6777(1998)17:5<473::aid-nau3>3.
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/nau.22357
更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
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更新日期:2019-08-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract:AIMS:Percutaneous tibial nerve stimulation (PTNS) is an effective neuromodulation therapy for treating overactive bladder (OAB). The therapeutic effects are achieved by repeatedly applying electrical stimulation through a percutaneous needle electrode that is used to target the tibial nerve (TN). Anatomical studies ind...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23323
更新日期:2018-02-01 00:00:00
abstract:AIMS:P(2)X(3) (ATP-gated receptors) in nociceptive neurons of dorsal root ganglion (DRG) participate in transmission of pain signals from the periphery to the spinal cord. However, the role of P(2)X(3) receptors in chronic prostate pain and continued intractable pain remains unclear. MATERIALS AND METHODS:We examined ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21060
更新日期:2011-04-01 00:00:00
abstract::The modern era of patient-centered, multidisciplinary professional practice comes with the expectation of effective interaction between specialties dealing with closely related clinical areas. Interaction between adult and pediatric urology is generally limited in terms of training, conferences, and joint diagnostic/t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22215
更新日期:2012-03-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
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更新日期:2019-06-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21254
更新日期:2012-06-01 00:00:00
abstract:AIMS:SYNERGY II was a 12-month phase III trial in patients with overactive bladder (OAB) symptoms that investigated the safety and efficacy of the combination of mirabegron and solifenacin in comparison with each monotherapy. This analysis evaluated the trial findings using four age subgroups (<65, ≥65, <75, and ≥75 ye...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23919
更新日期:2019-02-01 00:00:00
abstract:AIMS:Nociceptive behavior and its relationship with bladder dysfunction were investigated in two cystitis models, which were induced by intraperitoneal (i.p.) injection of cyclophosphamide (CYP) or intravesical instillation of acetone, using freely moving, non-catheterized conscious rats. METHODS:Female Sprague-Dawley...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20777
更新日期:2010-03-01 00:00:00