Abstract:
AIMS:To examine alterations in expression of angiotensin II type 1 receptors (AT1R) which induce organ tissue remodeling, angiotensin II type 2 receptors (AT2R) which protect against it, and related molecules in the bladder of matured rats with bladder dysfunction. METHODS:Female SD rats of three different ages were used: 8 weeks old (8W; n = 5), 9 months old (9M; n = 5), and 15 months old (15M; n = 5). After cystometry, the expression levels of AT1R, connexin43 (Cx43), MAP kinase (MAPK), collagen1, AT2R, PPAR-γ, adiponectin (Adipo), and adiponectin receptor (Adipo-R) were investigated in the bladder. RESULTS:Pressure threshold, post-void residual volume and the number of non-voiding contractions were significantly increased in 15M versus 8W rats (P < 0.01). Maximum voiding pressure was significantly decreased in 15M versus 8W rats (P < 0.05). There was no significant difference in CMG parameters between 8W and 9M rats. In the bladder, the mRNA expression of AT1R, Cx43, MAPK, collagen 1, AT2R, PPAR-γ, Adipo, and Adipo-R were significantly higher in 15M than in 8W rats. The relative expression ratio of AT1R protein against AT2R protein in the mucosa and detrusor was significantly increased in 15M versus 8W rats. CONCLUSIONS:These results indicate that matured rats exhibit not only bladder overactivity but also impaired voiding, which are associated with upregulation of AT1R. The upregulation of AT2R also may play a significant role in the suppressing of AT1R induced remodelling. However, because AT1R upregulation is more dominant than AT2R increases, AT2R activation may not be sufficient to suppress AT1R stimulation in matured rats. Neurourol. Urodynam. 35:908-913, 2016. © 2015 Wiley Periodicals, Inc.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Mori K,Noguchi M,Tobu S,Sato F,Mimata H,Tyagi P,Chancellor MB,Yoshimura Ndoi
10.1002/nau.22849subject
Has Abstractpub_date
2016-11-01 00:00:00pages
908-913issue
8eissn
0733-2467issn
1520-6777journal_volume
35pub_type
杂志文章abstract:AIMS:Lower urinary tract symptoms (LUTS) are common in the aging population. LUTS cause profoundly negative impacts on their quality of life. Pathophysiology of LUTS is multifactorial, and recently, bladder ischemia and metabolic syndrome have been suggested as etiological factors. To evaluate chronic hyperlipidemia on...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20843
更新日期:2010-09-01 00:00:00
abstract::This review will highlight appropriate animal models for the study of a number of disorders involving changes to lower urinary tract function. A major hurdle to the development of animal models for human lower urinary tract disorders is that the clinical pathophysiology of the latter mostly remain idiopathic. Acute in...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20903
更新日期:2010-04-01 00:00:00
abstract:AIMS:Progressive weakness in pelvic floor tissues is extremely common and leads to the distressing problems of stress urinary incontinence (SUI) and pelvic organ prolapse (POP). There has been extensive work on a vast array of materials spanning synthetics, autografts, allografts, and xenografts. Uniaxial testing of ma...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21156
更新日期:2012-01-01 00:00:00
abstract::In our hospital, we have followed a group of patients with familial amyloidotic polyneuropathy (FAP), type I. This disease is characterized by a progressive sensitive-motor and autonomic polyneuropathy. The amyloid fibrils of FAP I contain a mutant transthyretin (TTR) molecule. More than 90% of TTR production occurs i...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/(sici)1520-6777(1997)16:1<55::aid-nau7>3.0
更新日期:1997-01-01 00:00:00
abstract:AIM:To describe how the use of new and established animal models and methods can generate vital and far reaching experimental data in the study of mechanism underlying neurogenic bladder overactivity. METHODS:Bladder and colonic irradiated mice and those with upper and lower motor neuron lesions were used to study neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21120
更新日期:2011-06-01 00:00:00
abstract:AIMS:To report for the first time bladder rupture during filling cystometry many years after bladder augmentation. METHODS:A 17-year-old girl with T10 meningomyelocele had received an ileocystoplasty, continent catheterizable stoma, and bladder neck sling for neurogenic bladder dysfunction and intractable incontinence...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20394
更新日期:2007-01-01 00:00:00
abstract:AIMS:Since the publication of the 2006 International Children's Continence Society (ICCS) guidelines on terminologies for lower urinary tract dysfunction in children, little is known of their impact. In this study, we aim to quantify the adherence to the guidelines in the published literature, and to examine whether Me...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22341
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abstract:AIMS:Previous studies have shown that the activin-binding protein follistatin reduces inflammation in several mouse models of colitis. To determine whether follistatin also has a beneficial effect following bladder inflammation, we induced cystitis in mice using cyclophosphamide (CYP) and examined the relationship betw...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22941
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2017-04-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
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abstract:AIMS:Minimum important difference (MID) estimates the minimum degree of change in an instrument's score that correlates with subjective sense of improvement. The aim of this study was to estimate the MID for the Urogenital Distress Inventory (UDI), Incontinence Impact Questionnaire (IIQ) and Overactive Bladder Question...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:AIMS:To estimate the frequency of double incontinence, and to identify associated risk factors during pregnancy and postpartum in previously continent nulliparous women. METHODS:A cohort study in healthy, nulliparous, continent pregnant women, attending the public healthcare system of Catalonia (Spain) was designed. T...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22249
更新日期:2012-11-01 00:00:00
abstract::The modern era of patient-centered, multidisciplinary professional practice comes with the expectation of effective interaction between specialties dealing with closely related clinical areas. Interaction between adult and pediatric urology is generally limited in terms of training, conferences, and joint diagnostic/t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22215
更新日期:2012-03-01 00:00:00
abstract:AIMS:To evaluate the reproducibility of cystometry and pressure flow studies in women. We wanted to explore any clinically relevant effect of repeated, same-session cystometry. METHODS:Thirty healthy women with a mean age of 52 years were investigated with repeat medium-fill water cystometry and pressure-flow micturit...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10019
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Women with urodynamic stress incontinence (USI) have lower opening and closing detrusor pressures than women without USI. This study was undertaken to determine whether a change occurs in opening and closing detrusor pressures after colposuspension, whether cure is associated with change, and whether age infl...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10165
更新日期:2004-01-01 00:00:00
abstract::The aim of the study was to determine the contribution of intra-abdominal pressure transmission to urinary continence in the female. Five patients with genuine stress incontinence (GSI) were studied. Pressure transmission was measured in equivalent positions inside and outside the urethra and bladder during the Intrav...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140406
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). OBJECTIVES:The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urothelium in the pathophysiology of nocturia; (b) to determine whether noc...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
abstract:AIMS:The aim was to assess complications of urinary incontinence (UI) for women who had a hospital contact within 30 days and to evaluate the conventional method of classifying complications vs grading complications into the Clavien-Dindo classification (CDC) system. METHODS:A historical cohort study based on a nation...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24244
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abstract:AIMS:The purpose of this scoping review was to examine research activity comparing suprapubic catheterization to any other method of chronic bladder emptying such as intermittent and indwelling catheterization in adults in relation to complications, patient satisfaction, and health-related quality of life (QoL). METHO...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22356
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abstract::Experiments to investigate restoration of lower urinary tract control by electrical stimulation of the sacral nerve roots are mostly performed on dogs, yet little morphometric data (such as canine root and fiber diameter distributions) are available. The aim of this study was to acquire morphometric data of the intrad...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:3<235::AID-NAU8>3.
更新日期:1996-01-01 00:00:00
abstract:AIMS:Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower-extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome. METHODS:All patients who underwent fetal MMC repair at o...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23174
更新日期:2017-08-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20705
更新日期:2009-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23562
更新日期:2018-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,meta分析
doi:10.1002/nau.20243
更新日期:2006-01-01 00:00:00
abstract:AIMS:Parkinson's disease (PD) affects the nigrostriatal projections leading to micturition disturbance in most cases. Overactive bladder (OAB) symptoms such as urinary urgency or urgent urinary incontinence are common amongst PD patients. Several urodynamic studies have revealed that detrusor overactivity causes OAB sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20682
更新日期:2009-01-01 00:00:00
abstract:AIMS:To examine early trends in the use of overactive bladder (OAB) agents across Canada, with a focus on initial uptake and reimbursement of two newer agents: fesoterodine, an anticholinergic, and mirabegron, a therapeutically novel beta-3 agonist. METHODS:We conducted a population-based cross-sectional study of outp...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23469
更新日期:2018-06-01 00:00:00
abstract::This study investigated the effects of outlet obstruction on blood flow and high energy phosphates content in the rabbit urinary bladder. Mild bladder outlet obstruction was induced by placing a silicon ring (diameter 7 mm) around the bladder neck of each male New Zealand White rabbit (n = 7). Before and immediately a...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140309
更新日期:1995-01-01 00:00:00
abstract:AIMS:Firm bladder neck support during cough, suggested to be needed for effective abdominal pressure transmission to the urethra, might depend on activity of the levator ani muscle and elasticity of endopelvic fascia. METHODS:The study group of 32 patients with stress urinary incontinence and hypermobile bladder neck,...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10116
更新日期:2003-01-01 00:00:00
abstract:AIMS:Estrogen is essential for physiological maintenance of the female urogenital tract. It is believed that alterations in female sex hormones play a major role in the etiology and response to urinary tract dysfunctions. In animal studies, ovariectomy (Ovx) results in smooth muscle (SM) weakness and atrophy whereas es...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20258
更新日期:2006-01-01 00:00:00
abstract:AIMS:The aim of the study was to compare the effect of hypopressive exercises including pelvic floor muscle contraction, pelvic floor muscle training (PFMT) alone and control on pelvic floor muscle function in women with pelvic organ prolapse (POP). METHODS:Fifty-eight women with a mean age of 55.4 (± 9.8) years old w...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21149
更新日期:2012-01-01 00:00:00