Abstract:
AIMS:This study investigated the expressions of PGP9.5, P2 X 3 , muscarinic receptor (M3) and beta-3 adrenoreceptor (AR) in idiopathic detrusor overactivity (IDO) patients refractory to antimuscarinic treatment, and analyzed the correlation between protein expressions and clinical symptoms of IDO bladders with different urodynamic characteristics. METHODS:Specimens of 48 IDO and 10 control patients without lower urinary tract symptoms were included. The levels of these proteins from bladder mucosa were determined by Western blotting. RESULTS:The expression levels of β3-AR and M3 receptor were similar between IDO patients and controls. When IDO patients were divided into two subgroups, phasic DO and terminal DO, the results showed that β3-AR level in the patients with phasic DO was significantly higher than that of the controls and terminal DO (Both P < 0.05). PGP9.5 and P2 X 3 levels were also significantly increased in phasic DO subgroup than controls. P2 X 3 receptor was positively correlated with PGP9.5 and β3-AR, and negatively correlated with the first sensation of bladder filling and voided volume in phasic DO. CONCLUSIONS:Similar expression M3 receptor and increased P2 X 3 levels in phasic DO, compared with the controls, indicate that dysregulation of purinergic bladder signaling may contribute to the pathogenesis of phasic DO refractory to antimuscarinics. Elevated expression of β3-AR in phasic DO but not in terminal DO patients may explain the different urodynamic characteristics of DO between the two subgroups. Our findings suggest that β3-AR agonist or P2 X 3 antagonist might be a good treatment choice for patients with phasic DO refractory to antimuscarinic therapy.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Liu HT,Kuo HCdoi
10.1002/nau.23138subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1313-1319issue
5eissn
0733-2467issn
1520-6777journal_volume
36pub_type
杂志文章abstract:AIMS:Pelvic organ prolapse involves physical changes to the genitals, potentially distressing to women. We hypothesized poorer genital body image in prolapsed women versus controls and that genital body image would correlate with sexual health. METHODS:Seventy-four sexually active women, 13 with prolapse, 24 with surg...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22205
更新日期:2012-09-01 00:00:00
abstract:AIMS:We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex. METHODS:We examined (1) urinary 5-hydroxyindole acetic acid (5-HIAA) after intraperitoneal administration of saline, para-chlorophenylalanine (PCPA; a serotonin synt...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23028
更新日期:2017-03-01 00:00:00
abstract:AIM:To evaluate the association between lower urinary tract symptoms (LUTS) and incidental falls and fear of falling. METHODS:We used data obtained from the 2011 Korean Community Health Survey (KCHS) conducted between August and October 2011 in South Korea. The survey was carried out to estimate patterns of disease pr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23345
更新日期:2018-02-01 00:00:00
abstract::Anticholinergics are commonly used for the treatment of frequency, urgency, and urge incontinence in women. Alpha-blockers have been shown to have a modulating effect on bladder smooth muscle but are not commonly used clinically for this indication. To evaluate the clinical effectiveness of each treatment as well as t...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1520-6777(1998)17:1<31::aid-nau6>3.0
更新日期:1998-01-01 00:00:00
abstract:AIMS:Few studies have documented the effectiveness of continence promotion programs targeting older incontinent women. We sought to evaluate the impact of an interactive continence workshop on changing participants' attitudes, knowledge and skills in relation to self-managing or seeking care for incontinence. METHODS:...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20800
更新日期:2010-04-01 00:00:00
abstract::Myelin basic protein (MBP) can be used as an antigen for inducing experimental allergic encephalomyelitis (EAE). In various studies, EAE animals have been used as an experimental model of demyelinating diseases. The aim of this study was to determine whether EAE, induced by MBP in rats, can be useful for investigation...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2000)19:6<689::aid-nau7>3.0.co;2
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To compare intermittent catheterization, sling mobilization, and sling transection for treatment of urinary retention after mid-urethral sling surgery. METHODS:Data registered in the Norwegian Female Incontinence Registry from 1998 to 2013 were analyzed in this cohort study to compare subjective and objectiv...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23046
更新日期:2017-04-01 00:00:00
abstract::We report an unusual case of acute urinary retention secondary to Isaacs' syndrome due to external urethral sphincter spasm. The patient was able to resume spontaneous voiding after the treatment of the underlying disease. At 6-month follow-up, there were no voiding complaints. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1999)18:2<113::aid-nau6>3.
更新日期:1999-01-01 00:00:00
abstract:AIMS:Vaginal distention (VD) is a validated model of birth-related trauma in rats. Recently a mouse VD model was reported. Our study was originally conducted to evaluate the impact of age on VD in mice. This manuscript describes the study and reports on the lack of reproducibility of VD models in mice. METHODS:We util...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23886
更新日期:2019-02-01 00:00:00
abstract::Complex repetitive discharges (CRDs) are a form of abnormal needle electromyographic (EMG) activity associated with a variety of neuromuscular disorders, including chronic denervation. Urethral CRDs have also been associated with symptoms of voiding dysfunction. We reviewed the findings of 351 consecutive urethral sph...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2000)19:5<577::aid-nau4>3.0.co;2
更新日期:2000-01-01 00:00:00
abstract:AIM:Female urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24507
更新日期:2020-11-01 00:00:00
abstract:AIMS:Overactive bladder (OAB), characterized by urinary urgency, with or without incontinence, and urinary frequency and nocturia, has a significant impact on patients' lives. Given the social context inherent in OAB, the purpose of this study was to identify issues faced by OAB family members. METHODS:Incontinent OAB...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20705
更新日期:2009-01-01 00:00:00
abstract:AIM:Bladder outflow in women (bladder outlet obstruction [BOO]) has no well-accepted defining diagnostic criteria. Various nomograms exist based on flow rates, pressure-flow data, and fluoroscopy. We have prospectively evaluated the Solomon-Greenwell bladder outflow obstruction nomogram (SG BOO nomogram) as a measureme...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24347
更新日期:2020-06-01 00:00:00
abstract:AIMS:Overactive bladder (OAB) affects over 17% of the population and significantly effect the health-related quality of life. The treatments for OAB include first line (lifestyle modification, pelvic floor muscle training), second line (anticholinergic or beta-3 agonist medications), and third line therapies (intradetr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24158
更新日期:2019-11-01 00:00:00
abstract::Investigations of micromotion characteristics of bladder wall strips and pressure wave phenomena in total bladders in vitro and in vivo indicate that micromotion phenomena occur in the bladder wall. Local contractions can occur without an increase in tension or pressure, because other parts are in antiphase. Local con...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120504
更新日期:1993-01-01 00:00:00
abstract:AIMS:External sphincterotomy (ES) is a therapeutic option for male spinal cord injury patients with detrusor sphincter dyssynergia. However, some patients need to change their voiding management after ES. One of the potential causes of failure is reportedly detrusor dysfunction, but long-term urodynamic follow-up data ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23702
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Widely accepted consensus terminology and calculations of detrusor contractility in females do not exist but may be useful. We report the output of a proposal session at the International Consultation on Incontinence Research Society meeting 2019, addressing the title topic. METHODS:Three formal presentat...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24260
更新日期:2020-07-01 00:00:00
abstract::The evaluation of the incontinent patient relies on accurate assessment of urinary symptoms. Although the 7 day urinary diary is a reproducible method of data collection, the optimal means of implementing this diary is unknown. The urinary diary is usually employed after the initial clinical pathophysiologic evaluatio...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:2<143::AID-NAU3>3.
更新日期:1996-01-01 00:00:00
abstract:AIMS:Many patients take alternative medications for their lower urinary tract symptoms (LUTS) either in addition or as a substitute for traditional therapies, despite a lack of clinical data. Grapes products are hypothesized to improve bladder function due to their antioxidant and membrane-protective actions. There is ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.22289
更新日期:2013-03-01 00:00:00
abstract:AIMS:Lower urinary tract symptoms (LUTS) are common in the aging population. LUTS cause profoundly negative impacts on their quality of life. Pathophysiology of LUTS is multifactorial, and recently, bladder ischemia and metabolic syndrome have been suggested as etiological factors. To evaluate chronic hyperlipidemia on...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20843
更新日期:2010-09-01 00:00:00
abstract:AIMS:To determine the role of p75 neurotrophin receptor (p75NTR ) and the therapeutic effect of the selective small molecule p75NTR modulator, LM11A-31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model. METHODS:Adult female T8 -T9 transected mice were gavaged daily with LM...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23722
更新日期:2018-11-01 00:00:00
abstract:AIMS:Botulinum toxin A (BTX-A) and sacral nerve stimulation (SNS) are established treatments for overactive bladder (OAB) and are standard of care in refractory cases in international guidelines. Despite long term use over decades their "exact" working mechanisms are not entirely clear. At the ICI-RS meeting in Bristol...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.23552
更新日期:2018-06-01 00:00:00
abstract:AIMS:Urinary incontinence is a common symptom in many diseases as well as in general population. To measure the impact of urinary incontinence (UI) on individual's quality of life the English short form International Consultation on Incontinence questionnaire (ICIQ-UI Short Form) has been developed, which consists of t...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20689
更新日期:2009-01-01 00:00:00
abstract::Patients with symptoms of overactive bladder syndrome or non-obstructive urinary retention, refractory to conservative therapy, can nowadays be treated minimally invasively with sacral nerve stimulation (SNS). The use of electric currents to treat urological pathology has a long history but SNS therapy only received F...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20459
更新日期:2008-01-01 00:00:00
abstract:AIMS:We sought to compare in-office physical exam findings via standing cough test (SCT) versus 24-hour pad weights among men seeking treatment for postprostatectomy stress urinary incontinence (SUI). METHODS:A retrospective review of a single surgeon database of incontinence procedures was performed. Documentation of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24200
更新日期:2020-01-01 00:00:00
abstract:AIMS:The goal of any incontinence surgery is overall long-term patient satisfaction. The purpose of our study was to assess long-term patient satisfaction following cadaveric fascia lata pubovaginal sling surgery using the urogenital distress inventory (UDI) and the short form of the incontinence impact questionnaire (...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20318
更新日期:2007-01-01 00:00:00
abstract:AIMS:Voiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction. M...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23263
更新日期:2017-11-01 00:00:00
abstract::Following use of botulinum toxin in the 1980s for the treatment of detrusor sphincter dyssynergia in patients with spinal cord injury (SCI), the potential therapeutic value of this neurotoxin in urology has been the subject of much interest. The DIGNITY (Double-blind InvestiGation of purified Neurotoxin complex In neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22630
更新日期:2014-07-01 00:00:00
abstract:AIMS:We determined if THC-002, a galenical produced from Ba-Wei-Die-Huang-Wan, could increase skin temperature and inhibit detrusor overactivity induced by sudden whole body cooling. Further, we determined if THC-002 could decrease expression of transient receptor potential melastatin 8 (TRPM8) channels associated with...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22335
更新日期:2013-06-01 00:00:00
abstract::Abnormalities of micturition occur in many different diseases, have a variety of causes and take several forms. This review will focus exclusively on those abnormalities in which antidiuretic therapy may be of benefit. These conditions are primarily characterized by an increase in the total amount of urine produced (p...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20437
更新日期:2007-01-01 00:00:00