Abstract:
AIMS:Overactive bladder (OAB) affects over 17% of the population and significantly effect the health-related quality of life. The treatments for OAB include first line (lifestyle modification, pelvic floor muscle training), second line (anticholinergic or beta-3 agonist medications), and third line therapies (intradetrusor botulinum toxin injection, sacral neurostimulation [SNM], or percutaneous tibial nerve stimulation [PTNS]). For those with urinary incontinence secondary to OAB, complete continence is the goal of therapy, though cure rates are only 5% to 40%. The use of combination therapies can be employed in refractory OAB, however, the efficacy of pooled modalities is relatively unknown. Our objective was to determine the volume of data supporting combination therapy in treating OAB. METHODS:We systematically reviewed PubMed, EMBASE, the Cochrane Library, and Google Scholar for articles published before October 2018. Each was independently reviewed by two reviewers and examined in detail if they met inclusion criteria. RESULTS:A total of 32 studies met inclusion criteria and were reviewed. Most large prospective studies evaluated combinations of medications with behavioral therapy or medications together. Combination therapy studies of third-line treatments were rare and centered on medication with PTNS. No studies examined intradetrusor botulinum toxin injections in combination with another therapy and only one retrospective study briefly examined SNM therapy in combination with medication. CONCLUSION:Combination therapy, with certain first, second, and third-line OAB therapies, appears to be efficacious. There is a further need for carefully designed combination therapy studies, particularly those including third line modalities.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Kasman A,Stave C,Elliott CSdoi
10.1002/nau.24158subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2083-2092issue
8eissn
0733-2467issn
1520-6777journal_volume
38pub_type
杂志文章abstract:AIMS:The aim of this study is to report the functional results, patient satisfaction, and morbidity of the Transobturator tape procedure (TOT) in the treatment of stress incontinence (SUI). METHODS:One hundred and thirty patients were prospectively evaluated with history, physical examination, quality of life question...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.20353
更新日期:2007-01-01 00:00:00
abstract:AIMS:To investigate patient characteristics associated with overactive bladder (OAB) symptom improvement after 1 year of monthly percutaneous tibial nerve stimulation (PTNS) therapy. METHODS:This was a retrospective chart review of women who underwent PTNS for refractory OAB symptoms between January 2011 and December ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24038
更新日期:2019-08-01 00:00:00
abstract:AIMS:The biomechanical properties of length adaptation and adjustable preload have been previously identified in detrusor smooth muscle in animal models. This in vitro study aims to show that human detrusor smooth muscle exhibits length adaptation and adjustable preload tension which could play an important role in bot...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22820
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:In clinical practice and in research patient-centred outcomes are often utilised to help improve communication between patients and clinicians and to help manage expectations from treatment. However, many of these goals are generic and do not adequately capture the details of day to day life that bother pa...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/nau.23094
更新日期:2017-04-01 00:00:00
abstract:AIMS:Urodynamic studies (UDS) are complex, invasive and may be emotionally and physically distressing. Inadequate information may heighten distress. Prior to UDS, our patients receive written and verbal information, yet concerns remains that some women may not be adequately informed. This study examined how informed wo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21014
更新日期:2011-04-01 00:00:00
abstract:AIMS:To evaluate the impacts of hydrogen sulfide (H2 S) donor, sodium hydrogen sulfide (NaHS), and phosphodiesterase type-5 inhibitor (PDE5i), tadalafil per se and their combination treatment on partial bladder outlet obstruction (PBOO)-induced erectile dysfunction (ED). METHODS:Sprague-Dawley rats were equally divide...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24333
更新日期:2020-04-01 00:00:00
abstract:AIM:Even though many agents have been implicated as modulators of ureteral contractile activity, the exact mechanisms that control human ureteral smooth muscle contractility have yet to be clearly defined. Recently, Rho-kinase has been reported to be involved in the contractile mechanism of smooth muscles in various or...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20096
更新日期:2005-01-01 00:00:00
abstract:AIM:To validate the functionality of an implantable pudendal nerve stimulator under development for Food and Drug Administration approval to restore bladder function after spinal cord injury. METHODS:In nine cats under anesthesia, two tripolar cuff electrodes were implanted bilaterally on the pudendal nerves and one b...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23994
更新日期:2019-06-01 00:00:00
abstract::We evaluated compliance in the developing bladder using a newly developed animal model of posterior urethral valves: partial infravesical obstruction in the fetal rabbit bladder. Partial bladder outlet obstruction was created in fetal rabbits at day 23 of a 31 to 32-day gestation period. An in vitro whole bladder prep...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(1997)16:3<179::aid-nau7>3.
更新日期:1997-01-01 00:00:00
abstract:AIMS:Bladder wall stretch increases tissue tension and releases adenosine 5'-triphosphate (ATP) as part of a transduction process to sense bladder filling. Aging is associated with bladder fibrosis to produce a stiffer bladder wall: this may augment ATP release and contribute to age-dependent urgency. Muscarinic agonis...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24426
更新日期:2020-08-01 00:00:00
abstract:AIMS:To discuss the role of physiotherapy in the management of women who have suffered an obstetric fistula, referring to research findings when appropriate and available, and the experiences of clinical specialists in the field. METHODS:The experiences of physiotherapists who have worked in countries where obstetric ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23851
更新日期:2019-01-01 00:00:00
abstract::The response of the abdominal muscles to voluntary contraction of the pelvic floor (PF) muscles was investigated in women with no history of symptoms of stress urinary incontinence to determine whether there is co-activation of the muscles surrounding the abdominal cavity during exercises for the PF muscles. Electromy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(2001)20:1<31::aid-nau5>3.0.co;2-
更新日期:2001-01-01 00:00:00
abstract:AIMS:Urgency is a key symptom in the diagnosis of overactive bladder (OAB), yet its definition and measurement are subject to continuing debate whether urinary urgency is a pathologic sensation or an intensification of normal desire to pass urine. The objective of this research was to explore the concept of urgency amo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21242
更新日期:2012-04-01 00:00:00
abstract::Experiments to investigate restoration of lower urinary tract control by electrical stimulation of the sacral nerve roots are mostly performed on dogs, yet little morphometric data (such as canine root and fiber diameter distributions) are available. The aim of this study was to acquire morphometric data of the intrad...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(SICI)1520-6777(1996)15:3<235::AID-NAU8>3.
更新日期:1996-01-01 00:00:00
abstract:AIMS:Pelvic organ prolapse occurs in 50% of parous women. Laparoscopic sacrocolpopexy (LSCP) is a common surgical procedure for restoring pelvic anatomy and function. The aim of this study is to evaluate surgical anatomy and anatomical modifications induced by standardized LSCP. METHODS:Ten fresh female cadavers under...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22806
更新日期:2016-09-01 00:00:00
abstract:AIM:To examine the temporal effects of diabetes on the bladder and the external urethral sphincter (EUS) activity in rats. METHODS:Female Sprague-Dawley rats (n = 24) were divided into two groups: streptozotocin-induced diabetic rats and age-matched controls. Cystometrograms (CMGs) were taken under urethane anesthesia...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20543
更新日期:2008-01-01 00:00:00
abstract:AIMS:Our objective was to determine what women find acceptable regarding treatment and outcomes for treatment of stress urinary incontinence (SUI), and correlate this to age, distress and quality of life (QOL). MATERIALS AND METHODS:This prospective cross-sectional IRB-approved study evaluated women with primary SUI. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20570
更新日期:2008-01-01 00:00:00
abstract:AIMS:Measurements such as the minimal levator hiatus dimension, levator plate angle, iliococcygeal angle, and anorectal angle have been used for assessing the impact of levator damage on static and dynamic imaging features. The primary aim of this study was to investigate the association between levator ani muscle defi...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22509
更新日期:2015-01-01 00:00:00
abstract:AIMS:Lower urinary tract dysfunction affects up to 75% of the multiple sclerosis population. Results from our recent Pilot Study (McClurg et al., 2006) indicated that a combined programme of pelvic floor muscle training, electromyography biofeedback and neuromuscular electrical stimulation modalities may alleviate some...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20486
更新日期:2008-01-01 00:00:00
abstract::It is possible that the controversy involving prostheses implanted into women with pelvic floor problems might result in the majority of, or even all such products being restricted, banned or withdrawn in certain jurisdictions. A clear distinction between "tapes" for urinary incontinence and "mesh" for prolapse has be...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23741
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The brain's role in continence is critical but poorly understood. Although regions activated during bladder stimulation have been identified, little is known about the interaction between regions. In this secondary analysis we evaluate resting state and effective connectivity in older women treated for urgen...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23766
更新日期:2018-11-01 00:00:00
abstract:AIMS:The experiences and information needs of clinicians who use pelvic floor muscle training to manage urinary incontinence were explored. METHODS:Qualitative methods were used to conduct thematic analysis of data collected from clinician focus groups and interviews. Participants were registered physiotherapists and ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23716
更新日期:2018-11-01 00:00:00
abstract::Isolated cold stress tests were used to evaluate the thermoregulatory capacity in the feet of 19 patients with interstitial cystitis (IC) and of 11 healthy volunteer control subjects. Mean pedal skin temperature fell more rapidly in the IC group as compared with controls; significant differences were found at 10-min (...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120207
更新日期:1993-01-01 00:00:00
abstract:AIM:To evaluate the benefits of a newly established checklist form of behavioral therapy for overactive bladder (OAB). METHODS:Of a total of 180 patients suffering eight or more micturitions, two or more nocturia, seven or more urgency, or four more urinary urgency incontinence (UUI) episodes per day according to a 3-...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23974
更新日期:2019-04-01 00:00:00
abstract:AIMS:A new multidisciplinary clinic specializing in female pelvic medicine and reconstructive surgery (FPMRS) opened at our institution. We sought to assess patient preference in naming this new center, and how readability and word choice informs these preferences. METHODS:We prospectively surveyed patient preference ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24168
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:We evaluated the association between lower urinary tract symptoms (LUTS) and the expression of connexin (Cx) and transient receptor potential (TRP) channel on urothelial cells non-invasively collected from voided urine in humans. METHODS:A total of 55 patients (36 males and 19 females, median age: 71 years ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23436
更新日期:2018-03-01 00:00:00
abstract:AIMS:We sought to determine whether somatic lumbar nerve transfer to the pelvic nerve's anterior vesical branch after sacral decentralization for detrusor muscle reinnervation also leads to aberrant innervation of the bladder outlet. METHODS:Twenty-six female mongrel hound dogs underwent transection of sacral dorsal a...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24217
更新日期:2020-01-01 00:00:00
abstract:AIMS:The objective of the study was to compare sacral nerve stimulation (SNS) to pudendal nerve stimulation (PNS) for voiding dysfunction. METHODS:Thirty subjects with voiding dysfunction had a tined lead placed at S3 and a second electrode implanted at the pudendal nerve via a posterior approach. In a blinded, random...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.20174
更新日期:2005-01-01 00:00:00
abstract:AIMS:To evaluate the prevalence and associated risk factors for urinary incontinence, as well as its association with multimorbidity among Brazilian women aged 50 or over. METHODS:This was a secondary analysis of a cross-sectional population-based study including 622 women 50 years or older, conducted in the city of C...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22679
更新日期:2016-01-01 00:00:00
abstract:AIMS:The use of electrotherapeutics to improve filling and emptying dysfunction of the adult bladder has been well established, however the practice in children is less well known. The purpose of this review is to summarize the rationale behind the use of electro neuromodulation in children, examine the reported effica...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.10171
更新日期:2004-01-01 00:00:00