Abstract:
AIMS:To evaluate the impacts of hydrogen sulfide (H2 S) donor, sodium hydrogen sulfide (NaHS), and phosphodiesterase type-5 inhibitor (PDE5i), tadalafil per se and their combination treatment on partial bladder outlet obstruction (PBOO)-induced erectile dysfunction (ED). METHODS:Sprague-Dawley rats were equally divided into five groups: (a) sham-operated control; (b) PBOO; (c) PBOO-treated with NaHS (5.6 mg/kg/day, ip); (d) PBOO-treated with tadalafil (2 mg/kg/day, oral); and (e) PBOO-treated with combination of NaHS and tadalafil. The obstruction was created by urethral ligation for 6 weeks. In vivo erectile responses, in vitro relaxant and contractile responses in penile tissue as well as protein expression of nitric oxide synthases (NOS), H2 S synthesis enzymes, oxidative stress, hypoxia, fibrosis markers, and the smooth muscle/collagen ratio and apoptosis were analyzed. RESULTS:Combined treatment entirely returned increased bladder mass, reduced erectile responses, relaxation responses to acetylcholine, and electrical field stimulation in obstructed rats, while partial amelioration was observed after mono-treatment. Decreased neuronal NOS and 3-mercaptopiruvate transferase enzyme expressions in penile tissue from obstructed rats were also entirely restored by the combined treatment. Mono-treatment partially improved increased hypoxia, oxidative stress, fibrosis markers, decreased smooth muscle mass, and H2 S levels, while combined therapy completely recovered. CONCLUSIONS:The combination therapy with H2 S donor and PDE5i had positive effects on erectile responses through the improvement of ischemia-induced morphological and functional penile alterations in obstruction. H2 S and NO may likely play a synergistic role in the regulation of erectile function and have constructive effects on clinical outcomes in male patients with ED and benign prostatic hyperplasia/lower urinary tract symptoms.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Yilmaz-Oral D,Kaya-Sezginer E,Oztekin CV,Bayatli N,Lokman U,Gur Sdoi
10.1002/nau.24333subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1087-1097issue
4eissn
0733-2467issn
1520-6777journal_volume
39pub_type
杂志文章abstract:AIM:Urinary incontinence is one of the most common, disruptive and often disabling conditions affecting frail older people living in community. The aims of present study were to describe the prevalence of bladder catheter in a population of older women living in community and to examine the relationship between urinary...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20059
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journal_title:Neurourology and urodynamics
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.23439
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22215
更新日期:2012-03-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20843
更新日期:2010-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23187
更新日期:2017-09-01 00:00:00
abstract:AIMS:The aim of this study was to evaluate the effect of automatic event driven electrical stimulation on the dorsal penile/clitoral nerve for management of neurogenic detrusor overactivity in patients suffering from Multiple Sclerosis. METHODS:A total of 10 patients participated in the study. Detrusor pressure was re...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23827
更新日期:2019-01-01 00:00:00
abstract::Polypropylene (PP) mesh has been used as a primary or adjuvant material for vaginal reconstruction for both stress urinary incontinence (SUI) and pelvic organ prolapse (POP) for decades. Whether polypropylene is the optimal material for such indications has been called into question by clinicians, regulatory agencies ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.24312
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22827
更新日期:2016-11-01 00:00:00
abstract:AIMS:The use of electrotherapeutics to improve filling and emptying dysfunction of the adult bladder has been well established, however the practice in children is less well known. The purpose of this review is to summarize the rationale behind the use of electro neuromodulation in children, examine the reported effica...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.21251
更新日期:2012-06-01 00:00:00
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journal_title:Neurourology and urodynamics
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doi:10.1002/nau.24324
更新日期:2020-03-01 00:00:00
abstract:AIMS:SYNERGY II was a 12-month phase III trial in patients with overactive bladder (OAB) symptoms that investigated the safety and efficacy of the combination of mirabegron and solifenacin in comparison with each monotherapy. This analysis evaluated the trial findings using four age subgroups (<65, ≥65, <75, and ≥75 ye...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.23919
更新日期:2019-02-01 00:00:00
abstract::Estrogens are known to have a major role in the function of the lower urinary tract although the role of exogenous estrogen replacement therapy in the management of women with lower urinary tract dysfunction remains controversial. Whilst for many years systemic and vaginal estrogen therapy was felt to be beneficial in...
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pub_type: 杂志文章,评审
doi:10.1002/nau.22464
更新日期:2014-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23055
更新日期:2017-01-01 00:00:00
abstract::The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the variable of interest or a time-dependent accumulation of factors that ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.23035
更新日期:2017-04-01 00:00:00
abstract:AIMS:The primary aim of this prospective study was to examine the correlations between "The International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF)" score and urodynamic findings in patients with urge incontinence. In addition, we aimed to observe the alterations of these parameters with antimusca...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20389
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abstract:AIMS:Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation and lower urinary tract symptoms. This study aims to elucidate the association bet...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20938
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
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journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20988
更新日期:2011-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20490
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Turkish Continence Society aimed to analyze how overactive bladder (OAB) is being managed in routine practice by the urologists in Turkey. MATERIAL AND METHODS:Fourteen urology departments were randomly selected to represent the whole population in this multicenter study. An online data entry and storage ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,多中心研究
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更新日期:2019-11-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23138
更新日期:2017-06-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.20353
更新日期:2007-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20326
更新日期:2007-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24168
更新日期:2020-01-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22205
更新日期:2012-09-01 00:00:00
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journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23153
更新日期:2017-08-01 00:00:00