Abstract:
AIMS:Succinate and its receptor, GPR91, have been implicated in different aspects of metabolic syndrome. As GPR91 is expressed in the urinary bladder, the aim of this study is to show the effect of chronically increased succinate levels on bladder function. MATERIALS AND METHODS:Healthy Sprague-Dawley (SD) rats and hypertensive Dahl rats received an intraperitoneal injection of either saline or succinate (50 mg/kg) daily for a period of 4 weeks. Conscious cystometry was performed at the end of this period. Bladders were collected and used for contractility studies and morphological assessment. Two-way ANOVA was performed to compare between the two strains and student t-tests to compare treatment groups within each strain. RESULTS:Compared to SD rats, Dahl rats showed signs of bladder dysfunction. Succinate treatment led to higher urinary succinate levels and lower bladder capacities compared to saline-treated animals. In SD rats, this was associated with higher collagen content, lower GPR91 expression and an altered bladder nerve profile in the bladder. In succinate-treated Dahl rats, detrusor contractility was reduced and associated with decreased cholinergic innervation and increased collagen content. CONCLUSIONS:It is suggested that succinate negatively affects bladder function via effects through its receptor, GPR91, and that its effects are enhanced in the presence of metabolic disturbance. These findings contribute to our understanding of the pathophysiology of bladder dysfunction, specifically in a metabolic syndrome setting.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Velasquez Flores M,Mossa AH,Cammisotto P,Campeau Ldoi
10.1002/nau.23488subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1549-1558issue
5eissn
0733-2467issn
1520-6777journal_volume
37pub_type
杂志文章abstract:AIMS:In a previous study we observed impaired smooth muscle in the uterosacral ligament (USL) of patients with pelvic organ prolapse. The aims of the study were to describe the method of the novel microperfusion system and to determine normal function and pharmacology of smooth muscle in the USL. METHODS:Samples from ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22245
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:HTLV-I associated tropical spastic paraparesis (TSP) and HTLV-I associated myelopathy (HAM) is an endemic disease in Caribbean Island. Bladder-sphincter dysfunctions are almost present. The objectives of the study are to describe clinic and urodynamic characteristics of voiding disorders in Martiniquan pop...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22952
更新日期:2017-02-01 00:00:00
abstract:AIMS:To Compare the angular parameters of the pelvis of continents and incontinent women and to correlate them with the electrical activity and the function of the pelvic floor muscles. METHODS:Cross-sectional study. Incontinent and continent women, aged between 18 and 59 years. The anatomical points were marked follo...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23772
更新日期:2018-11-01 00:00:00
abstract:AIMS:Few studies have documented the effectiveness of continence promotion programs targeting older incontinent women. We sought to evaluate the impact of an interactive continence workshop on changing participants' attitudes, knowledge and skills in relation to self-managing or seeking care for incontinence. METHODS:...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20800
更新日期:2010-04-01 00:00:00
abstract:AIMS:To evaluate the reproducibility of cystometry and pressure flow studies in women. We wanted to explore any clinically relevant effect of repeated, same-session cystometry. METHODS:Thirty healthy women with a mean age of 52 years were investigated with repeat medium-fill water cystometry and pressure-flow micturit...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.10019
更新日期:2002-01-01 00:00:00
abstract:AIMS:To develop and validate a urinary diary, using the psychometric validation protocol applied to all International Consultation on Incontinence Questionnaire (ICIQ) modules. METHODS:Patient and clinician opinion was sought on diary content, format, and duration using interviews and questionnaires. Content deemed es...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.21254
更新日期:2012-06-01 00:00:00
abstract:AIM:Interstitial cystitis/painful bladder syndrome/(IC/PBS) results in recurring pain in the bladder and surrounding pelvic region caused by abnormal excitability of micturition reflexes. Spinal cord stimulation (SCS) is currently clinically used for the attenuation of neuropathic and visceral pain. The present study e...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23827
更新日期:2019-01-01 00:00:00
abstract:AIMS:Voiding dysfunction due to dysfunctional voiding (DV) and poor relaxation of the external sphincter (PRES) are commonly found among adult women with lower urinary tract symptoms (LUTS) during videourodynamic study (VUDS). This study analyzed the VUDS characteristics of DV and PRES in female voiding dysfunction. M...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23263
更新日期:2017-11-01 00:00:00
abstract::The International Continence Society Benign Prostatic Hyperplasia Study (ICS-BPH) was devised in response to the perceived underutilization of urodynamics in the diagnosis of benign prostatic obstruction (BPO), together with the apparent reliance on symptoms alone when selecting patients for invasive therapies, despit...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:AIMS:To evaluate the effect of ASP2205, a selective serotonin 5-HT2c receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. METHODS:Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The interve...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24045
更新日期:2019-08-01 00:00:00
abstract:AIMS:The aim of our study was to analyze whether uroflowmetry parameters are helpful in diagnosing overactive bladder (OAB). The working hypothesis was that the flow curves of patients with OAB symptoms would appear as a sharp peak flow rate with a short duration and high amplitude, lasting only for a short period duri...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22898
更新日期:2017-01-01 00:00:00
abstract:AIMS:Many patients take alternative medications for their lower urinary tract symptoms (LUTS) either in addition or as a substitute for traditional therapies, despite a lack of clinical data. Grapes products are hypothesized to improve bladder function due to their antioxidant and membrane-protective actions. There is ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.22289
更新日期:2013-03-01 00:00:00
abstract:AIMS:To evaluate long-term anatomical and functional outcomes of the transobturator-infracoccygeal hammock repair for complex genital prolapse with a porcine collagen-coated polypropylene mesh. METHODS:A prospective observational study comparing pre- and postoperative outcomes, using pelvic organ prolapse quantificati...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20956
更新日期:2011-03-01 00:00:00
abstract:AIM:Treatments targeting vanilloid receptor TRPV1 are effective in some bladder disorders. Our aim was to determine the expression profiles of TRPV1 in regions of human bladder and test the hypothesis that there would be an upregulation of TRPV1 in mucosa of patients with bladder hypersensitivity but not idiopathic det...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20326
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Overactive bladder syndrome (OAB) including urgency and urgency urinary incontinence (UUI) occurs frequently after stress urinary incontinence (SUI) surgery. It is important to identify the risk factors for the occurrence of OAB symptoms in order to adequately inform the patient before surgery. Furthermore...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.23328
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to use a systematic schedule, including urodynamics, to describe the rate of coexisting overactive bladder (OB) in patients with bladder outlet obstruction (BOO) caused by benign prostatic hyperplasia (BPH). We also identified differences between the patients with pure BOO compared with those...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1001
更新日期:2001-01-01 00:00:00
abstract:AIMS:This study aimed to evaluate whether the pressure readings obtained from air-filled catheters (AFCs) are the same as the readings from simultaneously inserted water-filled catheters (WFCs). It also aimed to make any possible recommendations for the use of AFCs to conform to International Continence Society (ICS) G...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22827
更新日期:2016-11-01 00:00:00
abstract:AIMS:To review the known determinants of healthcare-seeking behavior for LUTS and address unmet needs and future research priorities. METHODS:The PubMed literature was searched for currently known factors affecting treatment seeking for LUTS, OAB, and incontinence in men and women. RESULTS:Further to the great variat...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22212
更新日期:2012-03-01 00:00:00
abstract::The rhabdosphincter at the mid urethra is critical for maintaining urinary continence. In a setting of stress urinary incontinence stem cells transplanted into the site of the rhabdosphincter may augment sphincter regeneration and also release trophic factors promoting muscle and nerve integration of this muscle. We h...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.20833
更新日期:2010-01-01 00:00:00
abstract:AIMS:Nervous system involvement occurs in about half of patients with systemic lupus erythematosis (SLE). Seizures and psychiatric disorders are the most common manifestations; spinal cord lesions are uncommon. We had eight such patients who presented with urinary dysfunction. METHODS:The patients consisted of two men...
journal_title:Neurourology and urodynamics
pub_type: 临床试验,杂志文章
doi:10.1002/nau.10126
更新日期:2003-01-01 00:00:00
abstract:AIMS:Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower-extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome. METHODS:All patients who underwent fetal MMC repair at o...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23174
更新日期:2017-08-01 00:00:00
abstract:AIMS:Individuals with spinal cord injury or neurological disorders may develop bladder contractions at low volumes (neurogenic detrusor overactivity), which can lead to significant health problems. Present devices can inhibit unwanted contractions through continuous electrical stimulation of sensory nerves, but do not ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20204
更新日期:2006-01-01 00:00:00
abstract::Investigations of micromotion characteristics of bladder wall strips and pressure wave phenomena in total bladders in vitro and in vivo indicate that micromotion phenomena occur in the bladder wall. Local contractions can occur without an increase in tension or pressure, because other parts are in antiphase. Local con...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120504
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To describe and compare differences in perception of independence, urinary continence, and quality of life in an adult spina bifida (SB) population. METHODS:We collected data on adult neurogenic bladder patients which included demographics, relevant procedures, and quality of life (QoL) questionnaires. QoL a...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23511
更新日期:2018-06-01 00:00:00
abstract:AIM:To determine the psychometric properties of the total Vaizey score and its individual items. METHODS:The study was conducted as part of a prospective cohort study assessing the outcome of pelvic floor rehabilitation in patients with fecal incontinence. RESULTS:One hundred ninety-four patients were analyzed, 53 of...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20758
更新日期:2010-03-01 00:00:00
abstract::It is well known that urethane is a suitable anesthetic for acute studies and has been extensively recommended for investigations related to micturition physiology. This is mainly because of the capability of urethane anesthesia to spare reflex micturition as well as its easily established long-lasting and stable anes...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(2000)19:1<87::aid-nau9>3.0
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Stress urinary incontinence (SUI) is common in women and can significantly impact quality of life. METHODS:This is a review of the 6th International Consultation on Incontinence (ICI) chapter analyzing level of evidence on surgical treatment of SUI as well as the consensus algorithm that resulted from the...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.23879
更新日期:2019-08-01 00:00:00
abstract:AIMS:Phelan-McDermid syndrome (PMD) is a congenital syndrome caused by a deletion on chromosome 22q13.3. About 600 cases have been identified worldwide. PMD is characterized by neonatal hypotonia, moderate/severe intellectual impairment, impaired expressive language, and typical dysmorphic features. Psychological sympt...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24197
更新日期:2020-01-01 00:00:00
abstract:AIMS:Urinary incontinence is prevalent among patients with Parkinson's disease (PD). In the present study, we investigated urethral functions in a rat model of PD induced by 6-hydroxydopamine injection at their substantia nigra pars compacta as well as the roles of selective agonists/antagonist of dopamine D1- and D2-l...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23989
更新日期:2019-06-01 00:00:00
abstract:AIM:The International Continence Society (ICS) has standardized quality control and interpretation of uroflowmetry and urodynamics. We evaluated traces from two large studies of male lower urinary tract symptoms (UPSTREAM and UNBLOCS) against ICS standards of urodynamic equipment and practice. METHODS:Ten percent of u...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24337
更新日期:2020-04-01 00:00:00