Abstract:
:The treatment of overactive bladder (OAB) has evolved over the past 20 years to include a number of behavioral, pharmacological, and minimally invasive treatments. After behavioral therapy, pharmacological therapy with antimuscarinics remains the mainstay of treatment. Despite this, a large number of patients will "fail" or be unsatisfied with drugs therapy. It would be extremely helpful to patients and clinicians to be able to predict who those patients are. However, there are a number of barriers. First and foremost are defining "success" and "failure" and this can vary dramatically from one patient to another. Endpoints other than the traditional variables used in clinical trials may be more effective in evaluating treatments and helping to predict outcomes. Along similar lines, there are various definitions for OAB that is "refractory" to conventional treatments and this term needs clarification. In many cases, response to therapy may be affected by factors such as comorbidities, metabolism of drugs, concurrent therapies, etc. These factors are sometimes obvious and sometimes not, and for a variety of reasons it can be quite difficult to predict or determine their effect on outcome. Finally, many patients with OAB include have mixed (stress and urgency) symptoms. It is important to sort out the OAB component of mixed symptoms and mixed urinary incontinence (MUI) when determining effects of therapy.
journal_name
Neurourol Urodynjournal_title
Neurourology and urodynamicsauthors
Nitti VW,Kopp Z,Lin AT,Moore KH,Oefelein M,Mills IWdoi
10.1002/nau.20910subject
Has Abstractpub_date
2010-04-01 00:00:00pages
652-7issue
4eissn
0733-2467issn
1520-6777journal_volume
29pub_type
杂志文章,评审abstract:AIMS:To present a narrated video designed to demonstrate the steps involved in the procedure of videourodynamics. METHODS:The technique shown and described in this teaching video is that performed in the urogynaecology Department at King's College Hospital, London. The equipment utilizes fluid filled lines and externa...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23437
更新日期:2018-03-01 00:00:00
abstract::A model of the mechanics of smooth muscle reservoirs was derived from the stress-strain relation in smooth muscle strips. The model was applied to the intestinal bladder reservoir but may also be applied to natural reservoirs such as the bladder. The relation between reservoir volume and pressure was calculated at dif...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120108
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Pacemakers in upper urinary tract (UUT) are still under study. AIM:We reviewed the role of some cells that seem to be involved in the propulsion of urinary bolus from UUT to the bladder. MATERIALS & METHODS:We focuses on evaluating studies on the mechanisms by which the UUT propels urine to the bladder via...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.22310
更新日期:2013-04-01 00:00:00
abstract::In epidemiological surveys of female urinary incontinence, it is not feasible to demonstrate urine loss objectively. The aim of this study was to develop a valid epidemiological instrument (a severity index) for assessing the severity of incontinence. The severity index is based on information about frequency (four le...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/(sici)1520-6777(2000)19:2<137::aid-nau4>3.
更新日期:2000-01-01 00:00:00
abstract:AIMS:Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation and lower urinary tract symptoms. This study aims to elucidate the association bet...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20938
更新日期:2011-03-01 00:00:00
abstract:AIMS:Prolapse surgery has been shown to positively alter body image and decrease pelvic floor symptoms, hereby possibly improving sexual function. However, the surgical trauma itself may adversely affect sexual function, by damaging vaginal innervation and vascularization. The aim of this study is to evaluate the effec...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22491
更新日期:2014-11-01 00:00:00
abstract:AIM:To describe how the use of new and established animal models and methods can generate vital and far reaching experimental data in the study of mechanism underlying neurogenic bladder overactivity. METHODS:Bladder and colonic irradiated mice and those with upper and lower motor neuron lesions were used to study neu...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.21120
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:The terminology for anorectal dysfunction in women has long been in need of a specific clinically-based Consensus Report. METHODS:This Report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23055
更新日期:2017-01-01 00:00:00
abstract:AIMS:Long-term indwelling catheterisation may affect health related quality of life, but clinical assessment and monitoring of people with indwelling catheters is poorly recorded because there are no validated measures to capture these criteria. In this paper, we describe the development of the ICIQ-Long Term Catheter ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22729
更新日期:2016-03-01 00:00:00
abstract:AIMS:To evaluate the functional and molecular alterations of contractile and relaxant machinery in the bladder and urethra that lead to the underactive bladder (UAB) in old female mice. METHODS:Female young (3-months) and old (18-months) C57BL/6 mice were used. Urodynamic was assessed in awake and anaesthetized mice. ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23990
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The brain's role in continence is critical but poorly understood. Although regions activated during bladder stimulation have been identified, little is known about the interaction between regions. In this secondary analysis we evaluate resting state and effective connectivity in older women treated for urgen...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.23766
更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to use a systematic schedule, including urodynamics, to describe the rate of coexisting overactive bladder (OB) in patients with bladder outlet obstruction (BOO) caused by benign prostatic hyperplasia (BPH). We also identified differences between the patients with pure BOO compared with those...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1001
更新日期:2001-01-01 00:00:00
abstract:AIMS:To examine whether isolated bladder outlet obstruction in the absence of associated lower urinary tract abnormality results in hydronephrosis. Isolated obstruction causes a brief rise in bladder pressure that might not trigger hydronephrosis. METHODS:Data included adult men who underwent urodynamics for refractor...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24495
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:Patients with lower urinary tract symptoms often report urgency and incontinence episodes which are triggered by environmental scenarios, for example, "latch-key incontinence." To better understand the extent of this phenomenon, and how best to reduce its impact, we tested ways to recreate these situationa...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24524
更新日期:2020-11-01 00:00:00
abstract:AIMS:Rodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24415
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:We aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations. METHODS:A secondary analysis of women with urge incontinence or urge predominant MUI enrolled in the Urinary Incontinence Treatment Network BE-DRI rand...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20922
更新日期:2011-01-01 00:00:00
abstract::A newly revised operation for controlling spasticity in cerebral palsy patients, selective dorsal rhizotomy (SDR), has the potential to affect bladder function. The goal of this multidisciplinary study is to investigate the potential change in bladder function by characterizing and comparing pre- and post-operative sy...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930140110
更新日期:1995-01-01 00:00:00
abstract:AIMS:To evaluate whether bladder outlet obstruction index (BOOI), a mathematical index of outlet resistance, in association with maximal flow rate (Qmax) obtained during multichannel urodynamics (UDS) or detrusor pressure at maximal flow rate (PdetQmax) could help the identification of obstruction in women. METHODS:Fr...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20375
更新日期:2007-01-01 00:00:00
abstract:AIMS:The aim of this paper is to stablish de position of the Ibero-American Society of Neurourology and Urogynecology (SINUG) in relation to the use of suburethral meshes for the surgical treatment of female stress incontinence. METHODS:Tension-free mid-urethral slings (MUS) have become the most popular procedure for ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,实务指引
doi:10.1002/nau.24178
更新日期:2020-01-01 00:00:00
abstract:AIMS:To characterize urodynamic findings in patients referred with transverse myelitis (TM) and lower urinary tract symptoms (LUTS), as well as to identify any characteristics predictive of urodynamics findings. METHODS:This is a retrospective review of an IRB-approved neurogenic bladder database of patients followed ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22930
更新日期:2017-02-01 00:00:00
abstract:AIMS:To evaluate the effect of ASP2205, a selective serotonin 5-HT2c receptor agonist, and Duloxetine on the urethral pressure in healthy female subjects. METHODS:Healthy females aged 18 to 55 years were recruited for this phase 1, single site, placebo-controlled, randomized, four-period, cross-over study. The interve...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,随机对照试验
doi:10.1002/nau.24045
更新日期:2019-08-01 00:00:00
abstract::Forty-six patients were evaluated for complaints of urinary incontinence or voiding disorders. Diagnostic testing included a detailed history, physical examination, urine analysis, and urodynamic studies consisting of a conventional urodynamic test (S.I.) including provocative manoeuvres and extramural ambulatory urod...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/1520-6777(1994)13:3<237::aid-nau1930130305
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Overactive bladder syndrome (OAB) including urgency and urgency urinary incontinence (UUI) occurs frequently after stress urinary incontinence (SUI) surgery. It is important to identify the risk factors for the occurrence of OAB symptoms in order to adequately inform the patient before surgery. Furthermore...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章,评审
doi:10.1002/nau.23328
更新日期:2018-01-01 00:00:00
abstract:AIM:To characterise the developmental changes to the normal bladder by examining the in vitro contractile properties of the fetal sheep detrusor smooth muscle bladder at different gestational ages. METHODS:Three groups of normally developing fetal sheep bladders were investigated: (1) 65-70 days gestation (2nd trimest...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.20124
更新日期:2005-01-01 00:00:00
abstract:AIM OF THE STUDY:To estimate the prevalence and 5-year incidence of lower urinary tract symptoms (LUTS) after the first delivery and to evaluate the impact of pregnancy per se and delivery per se on long-lasting symptoms. MATERIALS AND METHODS:A longitudinal cohort study of 305 primiparae questioned a few days, 3 mont...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.2198
更新日期:2002-01-01 00:00:00
abstract:AIM:Characterize clinical factors related to nocturia and sleep disruption in Parkinson disease (PD) using polysomnography (PSG). METHODS:Sixty-three PD patients were recruited regardless of sleep or voiding complaints from a university-based movement disorders clinic for a 48 hr inpatient PSG protocol. Nocturia frequ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22365
更新日期:2013-11-01 00:00:00
abstract:AIMS:The biomechanical properties of length adaptation and adjustable preload have been previously identified in detrusor smooth muscle in animal models. This in vitro study aims to show that human detrusor smooth muscle exhibits length adaptation and adjustable preload tension which could play an important role in bot...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22820
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To determine the relationship among flow index (FI), uroflowmetry curve shape, and electromyography (EMG) lag time in children. MATERIALS AND METHODS:A total of 294 children with lower urinary tract symptoms were included. The overall relationship between lag time and FI was investigated with curve estimation ...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.24349
更新日期:2020-06-01 00:00:00
abstract:AIMS:To evaluate the feasibility and reliability of current perception threshold (CPT) measurement for sensory assessment of distinct locations in the male lower urinary tract (LUT). METHODS:Twelve male subjects (>18 years) without LUT symptoms or medical comorbidities were eligible. CPTs were determined twice (interv...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.22956
更新日期:2017-02-01 00:00:00
abstract::Isolated cold stress tests were used to evaluate the thermoregulatory capacity in the feet of 19 patients with interstitial cystitis (IC) and of 11 healthy volunteer control subjects. Mean pedal skin temperature fell more rapidly in the IC group as compared with controls; significant differences were found at 10-min (...
journal_title:Neurourology and urodynamics
pub_type: 杂志文章
doi:10.1002/nau.1930120207
更新日期:1993-01-01 00:00:00