Abstract：
:Gramicidin-perforated patch-clamp recordings were made from slices of the suprachiasmatic nucleus (SCN) of adult rats to characterize the role of gamma-amino butyric acid (GABA) in the circadian timing system. During the day, activation of GABA(A) receptors hyperpolarized the membrane of SCN neurons. During the night, however, activation of GABA(A) receptors either hyperpolarized or depolarized the membrane. These night-restricted depolarizations in a large subset of SCN neurons were capable of triggering spikes and thus appeared to be excitatory. The GABA(A) reversal potentials of SCN neurons revealed a significant day-night difference with more depolarized GABA(A) reversal potentials during the night than during the day. The emergence of depolarizing GABA(A)-mediated responses in a subset of SCN neurons at night can be ascribed to a depolarizing shift in GABA(A) reversal potential. The GABA(A) receptor antagonist bicuculline (12.5 microM) increased the spontaneous firing rate of all SCN neurons during the day, indicating that spontaneous GABA(A)-mediated inputs inhibited the SCN neurons during this period. The effect of bicuculline (12.5 microM) on the spontaneous firing rate of SCN neurons during the night was heterogeneous due to the mixture of depolarizing and hyperpolarizing GABA(A)-mediated inputs during this period. We conclude that GABA uniformly acts as an inhibitory transmitter during the day but excites a large subset of SCN neurons at night. This day-night modulation of GABAergic neurotransmission provides the SCN with a time-dependent gating mechanism that may counteract propagation of excitatory signals throughout the biological clock at day but promotes it at night.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
De Jeu M,Pennartz Cdoi
10.1152/jn.00241.2001subject
Has Abstractpub_date
2002-02-01 00:00:00pages
834-44issue
2eissn
0022-3077issn
1522-1598journal_volume
87pub_type
杂志文章abstract：:Mesencephalic trigeminal (M-V) neurons are primary somatosensory neurons with somata located within the CNS, instead of in peripheral sensory ganglia. In amphibians, these unipolar cells are found within the optic tectum and have a single axon that runs along the mandibular branch of the trigeminal nerve. The axon has...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
abstract：:1. Whole cell patch-clamp experiments were conducted to determine whether rat aortic baroreceptor neurons contain mechano-sensitive conductances. 2. Putative aortic baroreceptor neurons in the nodose ganglia were identified by injecting DiI onto the adventitia of the aortic arch. Nodose ganglia neurons were dissociate...
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pub_type： 杂志文章
doi：10.1152/jn.1995.73.5.2094
更新日期：1995-05-01 00:00:00
abstract：:1. One hundred seventy-nine single units were studied in the superior colliculus of seven Dutch-belted rabbits following ablation of the ipsilateral visual cortex. The response characteristics of these units were compared with those of 284 single units recorded from the superior colliculus of 20 intact animals. 2. In ...
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pub_type： 杂志文章
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：10.1152/jn.00129.2016
更新日期：2016-09-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00508.2003
更新日期：2004-07-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2014-08-15 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00763.2001
更新日期：2002-04-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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更新日期：2006-06-01 00:00:00
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更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2003-06-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：1991-06-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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journal_title：Journal of neurophysiology
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更新日期：2013-11-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2004-09-01 00:00:00
