Behavioral response and transmitter release during atonia elicited by medial medullary stimulation.

Abstract:

:Activation of the medial medulla is responsible for rapid eye movement (REM) sleep atonia and cataplexy. Dysfunction can cause REM sleep behavior disorder and other motor pathologies. Here we report the behavioral effects of stimulation of the nucleus gigantocellularis (NGC) and nucleus magnocellularis (NMC) in unrestrained cats. In waking, 62% of the medial medullary stimulation sites suppressed muscle tone. In contrast, stimulation at all sites, including sites where stimulation produced no change or increased muscle tone in waking, produced decreased muscle tone during slow-wave sleep. In the decerebrate cat electrical stimulation of the NGC increased glycine and decreased norepinephrine (NE) release in the lumbar ventral horn, with no change in γ-aminobutyric acid (GABA) or serotonin (5-HT) release. Stimulation of the NMC increased both glycine and GABA release and also decreased both NE and 5-HT release in the ventral horn. Glutamate levels in the ventral horn were not changed by either NGC or NMC stimulation. We conclude that NGC and NMC play neurochemically distinct but synergistic roles in the modulation of motor activity across the sleep-wake cycle via a combination of increased release of glycine and GABA and decreased release of 5-HT and NE. Stimulation of the medial medulla that elicited muscle tone suppression also triggered rapid eye movements, but never produced the phasic twitches that characterize REM sleep, indicating that the twitching and rapid eye movement generators of REM sleep have separate brain stem substrates.

journal_name

J Neurophysiol

authors

Lai YY,Kodama T,Schenkel E,Siegel JM

doi

10.1152/jn.00528.2010

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

2024-33

issue

4

eissn

0022-3077

issn

1522-1598

pii

jn.00528.2010

journal_volume

104

pub_type

杂志文章
  • Investigation of the juxtamembrane region of neuronal-Synaptobrevin in synaptic transmission at the Drosophila neuromuscular junction.

    abstract::In this study, the juxtamembrane region of the Drosophila SNARE protein neuronal-Synaptobrevin (n-Syb) was tested for its role in synaptic transmission. A transgenic approach was used to express n-Syb mutant genes. The transgenes carried engineered point mutations that alter the amino acid sequence of the conserved tr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00474.2013

    authors: DeMill CM,Qiu X,Kisiel M,Bolotta A,Stewart BA

    更新日期:2014-09-15 00:00:00

  • Spatiotemporal distribution of intracellular calcium transients during epileptiform activity in guinea pig hippocampal slices.

    abstract::Calcium ions are known to play an important role in epileptogenesis. Although there is clear evidence for increased neuronal calcium influx during epileptiform potentials, direct measurements of the corresponding intracellular calcium transients are rare and the origin of calcium influx is not known. Therefore the spa...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.1.491

    authors: Albowitz B,König P,Kuhnt U

    更新日期:1997-01-01 00:00:00

  • Signal transmission in the catfish retina. IV. Transmission to ganglion cells.

    abstract::1. To characterize the temporal dynamic responses of ganglion cells and to define the possible inputs giving rise to their responses in catfish retina, we recorded the ganglion cell responses evoked by 1) a step of light presented in the dark, 2) an incremental and decremental step from a background illumination, and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.58.6.1307

    authors: Sakai HM,Naka K

    更新日期:1987-12-01 00:00:00

  • Testing the classification of static gamma axons using different patterns of random stimulation.

    abstract::The possibility of using randomly generated stimulus intervals (with a Poisson distribution) to identify the type(s) of intrafusal fiber activated by the stimulation of single static gamma axons was tested in Peroneus tertius muscle spindles of anesthetized cats. Three patterns of random stimulation with different val...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.6.2823

    authors: Petit J,Banks RW,Laporte Y

    更新日期:1999-06-01 00:00:00

  • Interaction of opioids and membrane potential to modulate Ca2+ channels in rat dorsal root ganglion neurons.

    abstract::1. Using patch-clamp methods, we show that brief prepulses to very positive voltages increase (facilitate) the amplitude of current through Ca2+ channels during a subsequent test pulse in some, but not all, dorsal root ganglion (DRG) sensory neurons. The amplitude of this facilitated current generally increases when t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.5.1793

    authors: Womack MD,McCleskey EW

    更新日期:1995-05-01 00:00:00

  • Cat's medullary reticulospinal and subnucleus reticularis dorsalis noxious neurons form a coupled neural circuit through collaterals of descending axons.

    abstract::Animals and human beings sense and react to real/potential dangerous stimuli. However, the supraspinal mechanisms relating noxious sensing and nocifensive behavior are mostly unknown. The collateralization and spatial organization of interrelated neurons are important determinants of coordinated network function. Here...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00603.2015

    authors: Leiras R,Martín-Cora F,Velo P,Liste T,Canedo A

    更新日期:2016-01-01 00:00:00

  • Role of proprioceptive signals from an insect femur-tibia joint in patterning motoneuronal activity of an adjacent leg joint.

    abstract::Interjoint reflex function of the insect leg contributes to postural control at rest or to movement control during locomotor movements. In the stick insect (Carausius morosus), we investigated the role that sensory signals from the femoral chordotonal organ (fCO), the transducer of the femur-tibia (FT) joint, play in ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.4.1856

    authors: Hess D,Büschges A

    更新日期:1999-04-01 00:00:00

  • A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates.

    abstract::A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00625.2011

    authors: Feingold J,Desrochers TM,Fujii N,Harlan R,Tierney PL,Shimazu H,Amemori K,Graybiel AM

    更新日期:2012-04-01 00:00:00

  • Interaction between finger opposition movements and aftereffects of 1Hz-rTMS on ipsilateral motor cortex.

    abstract::One-hertz repetitive transcranial magnetic stimulation (1Hz-rTMS) over ipsilateral motor cortex is able to modify up to 30 min the motor performance of repetitive finger opposition movements paced with a metronome at 2 Hz. We investigated whether the long-lasting rTMS effect on motor behavior can be modulated by subse...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90428.2008

    authors: Avanzino L,Bove M,Tacchino A,Trompetto C,Ogliastro C,Abbruzzese G

    更新日期:2009-03-01 00:00:00

  • Activity patterns of the B31/B32 pattern initiators innervating the I2 muscle of the buccal mass during normal feeding movements in Aplysia californica.

    abstract::1. B31 and B32 are pattern-initiator neurons in the buccal ganglia of Aplysia. Along with the B61/B62 neurons, B31/B32 are also motor neurons that innervate the 12 buccal muscle via the I2 nerve. This research was aimed at determining the physiological functions of the B31/B32 and B61/B62 neurons, and of the I2 muscle...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.4.1309

    authors: Hurwitz I,Neustadter D,Morton DW,Chiel HJ,Susswein AJ

    更新日期:1996-04-01 00:00:00

  • Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores.

    abstract::Long-term depression (LTD) of synaptic transmission can be induced by several mechanisms, one thought to involve Ca2+-dependent activation of postsynaptic nitric oxide (NO) synthase and subsequent diffusion of NO to the presynaptic terminal. We used the stable NO donor S-nitroso-N-acetylpenicillamine (SNAP) to study t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.3.1569

    authors: Reyes-Harde M,Potter BV,Galione A,Stanton PK

    更新日期:1999-09-01 00:00:00

  • Oculomotor task switching: alternating from a nonstandard to a standard response yields the unidirectional prosaccade switch-cost.

    abstract::The completion of an antisaccade (i.e., a nonstandard task) lengthens the reaction time (RT) of a subsequent prosaccade: a behavioral phenomenon termed the unidirectional prosaccade switch-cost. One explanation for the unidirectional prosaccade switch-cost is suppressing a stimulus-driven prosaccade during the precedi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00352.2014

    authors: Weiler J,Heath M

    更新日期:2014-11-01 00:00:00

  • Functional unity of the ponto-cerebellum: evidence that intrapontine communication is mediated by a reciprocal loop with the cerebellar nuclei.

    abstract::The majority of cerebral signals destined for the cerebellum are handed over by the pontine nuclei (PN), which thoroughly reorganize the neocortical topography. The PN maps neocortical signals of wide-spread origins into adjacent compartments delineated by spatially precise distribution of cortical terminals and posts...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01060.2005

    authors: Möck M,Butovas S,Schwarz C

    更新日期:2006-06-01 00:00:00

  • Object-level visual information gets through the bottleneck of crowding.

    abstract::Natural visual scenes are cluttered. In such scenes, many objects in the periphery can be crowded, blocked from identification, simply because of the dense array of clutter. Outside of the fovea, crowding constitutes the fundamental limitation on object recognition and is thought to arise from the limited resolution o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.00904.2010

    authors: Fischer J,Whitney D

    更新日期:2011-09-01 00:00:00

  • Local interneurons and projection neurons in the antennal lobe from a spiking point of view.

    abstract::Local computation in microcircuits is an essential feature of distributed information processing in vertebrate and invertebrate brains. The insect antennal lobe represents a spatially confined local network that processes high-dimensional and redundant peripheral input to compute an efficient odor code. Social insects...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00260.2013

    authors: Meyer A,Galizia CG,Nawrot MP

    更新日期:2013-11-01 00:00:00

  • Electrophysiology of dentate gyrus granule cells.

    abstract::The orthodromic synaptic responses, membrane properties, and responses of dentate gyrus granule cells (DGCs) to several convulsant agents were studied in the in vitro hippocampal slice preparation. Orthodromic stimulation via the perforant pathway (PP) evoked excitatory-inhibitory postsynaptic potentials (EPSP-IPSP) s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.51.2.195

    authors: Fricke RA,Prince DA

    更新日期:1984-02-01 00:00:00

  • Preserved high-centrality hubs but efficient network reorganization during eyes-open state compared with eyes-closed resting state: an MEG study.

    abstract::A question to be addressed in the present study is how different the eyes-closed (EC) and eyes-open (EO) resting states are across frequency bands in terms of efficiency and centrality of the brain functional network. We investigated both the global and nodal efficiency and betweenness centrality in the EC and EO rest...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00585.2013

    authors: Jin SH,Jeong W,Lee DS,Jeon BS,Chung CK

    更新日期:2014-04-01 00:00:00

  • Corticotrophin-releasing factor augments the I(H) in rat hypothalamic paraventricular nucleus parvocellular neurons in vitro.

    abstract::The goal of this study was to characterize the effects of corticotrophin-releasing factor (CRF) on rat paraventricular nucleus (PVN) putative parvocellular neurons using whole cell patch-clamp recordings and single-cell reverse transcription-multiplex polymerase chain reaction (single-cell RT-mPCR) techniques. Under c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01325.2004

    authors: Qiu DL,Chu CP,Shirasaka T,Tsukino H,Nakao H,Kato K,Kunitake T,Katoh T,Kannan H

    更新日期:2005-07-01 00:00:00

  • Identified serotonergic neurons in the Tritonia swim CPG activate both ionotropic and metabotropic receptors.

    abstract::Although G-protein-coupled (metabotropic) receptors are known to modulate the production of motor patterns, evidence from the escape swim central pattern generator (CPG) of the nudibranch mollusk, Tritonia diomedea, suggests that they might also participate in the generation of the motor pattern itself. The dorsal swi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.1.476

    authors: Clemens S,Katz PS

    更新日期:2001-01-01 00:00:00

  • Subliminal gamma flicker draws attention even in the absence of transition-flash cues.

    abstract::We recently reported evidence indicating that selective attention is deployed to a target location in a multi-object display, when the target event (a change of one of the objects) is preceded by subliminal flicker in the gamma range. However, concerns have been raised regarding the stimuli used in this study and the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00357.2010

    authors: Cheadle SW,Parton A,Müller HJ,Usher M

    更新日期:2011-02-01 00:00:00

  • From following edges to pursuing objects.

    abstract::Primates can generate accurate, smooth eye-movement responses to moving target objects of arbitrary shape and size, even in the presence of complex backgrounds and/or the extraneous motion of non-target objects. Most previous studies of pursuit have simply used a spot moving over a featureless background as the target...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00987.2001

    authors: Masson GS,Stone LS

    更新日期:2002-11-01 00:00:00

  • Properties of the GABAA receptor of rat posterior pituitary nerve terminals.

    abstract::1. We investigated gamma-aminobutyric acid (GABA) receptors using thin slice patch-clamp techniques in the swellings along axons of posterior pituitary nerve terminals. 2. Activation of the nerve terminal GABAA receptor induced a mean conductance change of 1.5 nS. Normalizing to area gave a mean conductance density of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.3.1135

    authors: Zhang SJ,Jackson MB

    更新日期:1995-03-01 00:00:00

  • Overlap of saccadic and pursuit eye movement systems in the brain stem reticular formation.

    abstract::Recent physiological studies have suggested that there are several sites of interaction between the neural pathways that control saccadic eye movements and those that control visual pursuit movements. To address the question of saccade/pursuit interaction from a neuroanatomical point of view, we have studied the conne...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.6.3056

    authors: Yan YJ,Cui DM,Lynch JC

    更新日期:2001-12-01 00:00:00

  • Kainate receptor-mediated synaptic currents in mudpuppy inner retinal neurons reduced by D-O-phosphoserine.

    abstract::1. The effects of D-O-phosphoserine (DOS) were examined on proximal neurons in the superfused mudpuppy retinal-eyecup preparation by measuring their synaptically evoked whole-cell currents with the use of patch-clamp electrodes. 2. DOS reduced the light-evoked excitatory postsynaptic potentials (EPSPs) of amacrine and...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.62.2.495

    authors: Coleman PA,Miller RF

    更新日期:1989-08-01 00:00:00

  • Superior colliculus signals decisions rather than confidence: analysis of single neurons.

    abstract::Recent findings indicate that monkeys can report their confidence in perceptual decisions and that this information is encoded in neurons involved in making decisions, including the lateral intraparietal area (LIP) and the supplementary eye field (SEF). A key issue to consider when studying confidence is that decision...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00152.2018

    authors: Grimaldi P,Cho SH,Lau H,Basso MA

    更新日期:2018-11-01 00:00:00

  • Ocular responses to brief motion of textured backgrounds during smooth pursuit in humans.

    abstract::We studied the effects of horizontal smooth pursuit on the ocular responses to brief vertical perturbations of textured backgrounds in humans. When the subject was fixating on a stationary target, a brief vertical perturbation of the background elicited a small tracking response. When the subject was pursuing a target...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00430.2009

    authors: Miura K,Kobayashi Y,Kawano K

    更新日期:2009-09-01 00:00:00

  • A novel optic flow pattern speeds split-belt locomotor adaptation.

    abstract::Visual input provides vital information for helping us modify our walking pattern. For example, artificial optic flow can drive changes in step length during locomotion and may also be useful for augmenting locomotor training for individuals with gait asymmetries. Here we asked whether optic flow could modify the acqu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00513.2013

    authors: Finley JM,Statton MA,Bastian AJ

    更新日期:2014-03-01 00:00:00

  • Encoding of binocular disparity by simple cells in the cat's visual cortex.

    abstract::1. Spatiotemporal receptive fields (RFs) for left and right eyes were studied for simple cells in the cat's striate cortex to examine the idea that stereoscopic depth information is encoded via structural differences of RFs between the two eyes. Traditional models are based on neurons that possess matched RF profiles ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.5.1779

    authors: Ohzawa I,DeAngelis GC,Freeman RD

    更新日期:1996-05-01 00:00:00

  • Sound-level-dependent representation of frequency modulations in human auditory cortex: a low-noise fMRI study.

    abstract::Recognition of sound patterns must be largely independent of level and of masking or jamming background sounds. Auditory patterns of relevance in numerous environmental sounds, species-specific vocalizations and speech are frequency modulations (FM). Level-dependent activation of the human auditory cortex (AC) in resp...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00187.2001

    authors: Brechmann A,Baumgart F,Scheich H

    更新日期:2002-01-01 00:00:00

  • Receptive field of the retinal bipolar cell: a pharmacological study in the tiger salamander.

    abstract::1. It is widely believed that signals contributing to the receptive field surrounds of retinal bipolar cells pass from horizontal cells to bipolar cells via GABAergic synapses. To test this notion, we applied gamma-aminobutyric acid (GABA) agonists and antagonists to isolated, perfused retinas of the salamander Ambyst...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.3.2005

    authors: Hare WA,Owen WG

    更新日期:1996-09-01 00:00:00