Abstract:
:Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 recording sites provided high-density recording of unit and field activity with minimal tissue displacement or damage. The on-chip active circuit eliminated movement and other artifacts and greatly reduced the weight of the headgear. The precise geometry of the recording tips allowed for the estimation of the spatial location of the recorded neurons and for high-resolution estimation of extracellular current source density. Action potentials could be simultaneously recorded from the soma and dendrites of the same neurons. Silicon technology is a promising approach for high-density, high-resolution sampling of neuronal activity in both basic research and prosthetic devices.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Csicsvari J,Henze DA,Jamieson B,Harris KD,Sirota A,Barthó P,Wise KD,Buzsáki Gdoi
10.1152/jn.00116.2003subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1314-23issue
2eissn
0022-3077issn
1522-1598pii
90/2/1314journal_volume
90pub_type
杂志文章abstract::1. The modulation of reflex responses in up to 10 simultaneously recorded hindlimb muscles was studied in unrestrained cats walking on a treadmill. Single electrical shocks of various strengths were applied to different skin areas of teh hindlimb at different times of the step cycle while the resulting EMG responses w...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1980.44.5.1024
更新日期:1980-11-01 00:00:00
abstract::Two monkeys were trained to point to targets and to retrieve fruit bits from a Kluver board, bottles, and tubes. Once proficient in the tasks, the macaques underwent aseptic surgical implantation of a recording chamber over the cerebellar nuclei on the side of their preferred hand. After recovery from surgery, a serie...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.2.537
更新日期:1998-02-01 00:00:00
abstract::1. The lateral geniculate nucleus is the primary thalamic relay through which retinal signals pass en route to cortex. This relay is gated and can be suppressed by activity among local inhibitory neurons that use gamma-aminobutyric acid (GABA) as a neurotransmitter. In the cat, a major source of this GABAergic inhibit...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.6.1528
更新日期:1991-06-01 00:00:00
abstract::Gain-of-function variants in voltage-gated sodium channel NaV1.7 that increase firing frequency and spontaneous firing of dorsal root ganglion (DRG) neurons have recently been identified in 5-10% of patients with idiopathic small fiber neuropathy (I-SFN). Our previous in vitro observations suggest that enhanced sodium...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00360.2019
更新日期:2020-02-01 00:00:00
abstract::Adult rats were submitted to a complete spinal cord transection at T9 level to address peripheral and spinal reflex changes in the caudal lumbar segments. Compound muscle and nerve action potentials decreased in amplitude and increased their duration between 14 and 30 days but recovered to near to normal values therea...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01177.2003
更新日期:2004-06-01 00:00:00
abstract::Certain hand-held tools alter the mapping between hand motion and motion of the tool end point that must be controlled in order to perform a task. For example, when using a pool cue, the motion of the cue tip is reversed relative to the hand. Previous studies have shown that the time required to initiate a reaching mo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00157.2012
更新日期:2012-10-01 00:00:00
abstract::1. The statistical properties of the bursting potassium channel from fused Torpedo synaptosomes were studied by using patch-clamp recording and time series analysis. 2. Voltage steps produce channel openings; the number of channels opening fluctuates from trial to trial. The maximal current observed in each trial is s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.6.2260
更新日期:1992-12-01 00:00:00
abstract::We asked whether podokinetic adaptation to walking on a circular treadmill transfers to different forms of locomotion. Subjects were blindfolded and asked to walk straight across the floor, in the forward and backward directions, following podokinetic (PK) stimulation that consisted of 30 min of forward walking-in-pla...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.4.1666
更新日期:2001-10-01 00:00:00
abstract::Effective connectivity between cortical areas decreases during slow wave sleep. This decline can be observed in the reduced interareal propagation of activity evoked either directly in cortex by transcranial magnetic stimulation (TMS) or by sensory stimulation. We present here a large-scale model of the thalamocortica...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00059.2009
更新日期:2009-10-01 00:00:00
abstract::Rats can readily be trained to jump a gap of around 16 cm in the dark and a considerably larger gap in the light for a food reward. In the light, they use vision to estimate the distance to be jumped. In the dark, they use their vibrissae at the farthest distances. Bilateral whisker shaving or barrel field lesions red...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.4.1781
更新日期:2000-10-01 00:00:00
abstract::Studies on the expression and cellular function of sigma receptors in autonomic neurons were conducted in neonatal rat intracardiac and superior cervical (SCG) ganglia. Individual neurons from SCG and intracardiac ganglia were shown to express transcripts encoding the sigma-1 receptor using single-cell RT-PCR techniqu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.87.6.2867
更新日期:2002-06-01 00:00:00
abstract::Falls during walking are a major cause of poststroke injury, and walking faster may decrease the ability to recover following a gait perturbation. We compared gait stability between high-functioning poststroke individuals and controls and evaluated the effect of gait speed on gait stability. Ten stroke subjects and te...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00552.2012
更新日期:2013-01-01 00:00:00
abstract::In the region of the ventral respiratory group in brain stem slices from neonatal rats, intracellular pH (pHi) and membrane currents (I(m)) or potentials were measured in neurons dialyzed with the pH-sensitive dye 2',7'-bis-carboxyethyl-5(6)-carboxyfluorescein. Currents and increases in membrane conductance (g(m)) dur...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.4.1844
更新日期:1997-04-01 00:00:00
abstract::1. The behavior of the combined eye-head gaze saccade mechanism was investigated in the rhesus monkey under both normal circumstances and in the presence of perturbations delivered to the head by a torque motor. Animals were trained to follow a target light that stepped at regular intervals through an angle of 68 degr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.64.6.1873
更新日期:1990-12-01 00:00:00
abstract::Spinothalamic (ST) neurons in the C8-T5 segments of the spinal cord were examined for responses to electrical stimulation of the left thoracic vagus nerve (LTV). Seventy-one ST neurons were studied in 39 anesthetized monkeys (Macaca fascicularis). Each neuron could be excited by manipulation of its somatic field and b...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.4.926
更新日期:1983-10-01 00:00:00
abstract::When they are 1-2 mo old, domesticated Mongolian gerbils begin having initially mild seizures which become more severe with age. To evaluate the development of this increasing seizure severity, we obtained field potential responses of the dentate gyrus to paired-pulse stimulation of the perforant path during seizures....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.88.2.783
更新日期:2002-08-01 00:00:00
abstract::In this study, the juxtamembrane region of the Drosophila SNARE protein neuronal-Synaptobrevin (n-Syb) was tested for its role in synaptic transmission. A transgenic approach was used to express n-Syb mutant genes. The transgenes carried engineered point mutations that alter the amino acid sequence of the conserved tr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00474.2013
更新日期:2014-09-15 00:00:00
abstract::This study of chronic incomplete spinal cord injury (SCI) subjects investigated patterns of central motor drive (i.e., central activation) of the plantar flexors using interpolated twitches, and modulation of soleus H-reflexes during lengthening, isometric, and shortening muscle actions. In a recent study of the knee ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01074.2014
更新日期:2015-07-01 00:00:00
abstract::The activity of malic dehydrogenase, pyruvic kinase, and phosphorylase b was measured in the geniohyoid muscle of the cat after injection of 10 10 mM colchicine into the hypoglossal nerve. Experiments performed 1-60 days after the injection showed that the activity of the three enzymes gradually decreased (day 4-5), r...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.6.1236
更新日期:1976-11-01 00:00:00
abstract::Previous studies have demonstrated that locally administered cannabinoids attenuate allodynia and hyperalgesia through activation of peripheral cannabinoid receptors (CB(1) and CB(2)). However, it is currently unknown if cannabinoids alter the response properties of nociceptors. In the present study, correlative behav...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90809.2008
更新日期:2008-11-01 00:00:00
abstract::Activation of the medial medulla is responsible for rapid eye movement (REM) sleep atonia and cataplexy. Dysfunction can cause REM sleep behavior disorder and other motor pathologies. Here we report the behavioral effects of stimulation of the nucleus gigantocellularis (NGC) and nucleus magnocellularis (NMC) in unrest...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00528.2010
更新日期:2010-10-01 00:00:00
abstract::Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a numb...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01066.2011
更新日期:2012-03-01 00:00:00
abstract::The contributions of the hyperpolarization-activated current, I(h), to generation of rhythmic activities are well described for various central neurons, particularly in thalamocortical circuits. In the present study, we investigated effects of a general anesthetic, propofol, on native I(h) in neurons of thalamus and c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00389.2005
更新日期:2005-12-01 00:00:00
abstract::Cutaneous reflexes evoked in the muscles of the arms with electrical stimulation of nerves of the foot ("interlimb reflexes") are observed during walking. These reflexes have been suggested to coordinate the actions of the legs and arms when walking is disturbed. Recently, we showed that cutaneous reflexes evoked in t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00746.2006
更新日期:2006-12-01 00:00:00
abstract::Somatic sensory neurons of the dorsal root ganglia are necessary for a large part of our mechanosensory experience. However, we only have a good knowledge of the molecules required for mechanotransduction in simple invertebrates such as the nematode Caenorhabiditis elegans. In C. elegans, a number of so-called mec gen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00860.2007
更新日期:2007-12-01 00:00:00
abstract::1. The alignment of the pupillary axes and of the visual axes has been measured in 23 normally reared cats ranging in age from 14 days to adulthood. 2. In agreement with a previous report, we find that pupillary divergence, as measured from photographs, tends to decrease during the first 2 mo of life. 3. The angle bet...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1978.41.4.848
更新日期:1978-07-01 00:00:00
abstract::Manipulations of vagal activity are used to treat medical pathologies, but the underlying CNS changes caused by these treatments are not well understood. Furthermore, heart and lung transplant as well as treatments for many gastrointestinal disorders result in section of the vagus nerve (vagotomy). Following unilatera...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00168.2009
更新日期:2009-11-01 00:00:00
abstract::We investigated adaptation to simple force field scaling to determine whether the same strategy is used as during adaptation to more complex changes in the mechanical environment. Subjects initially trained in a force field, consisting of a rightward lateral force with a parabolic spatial profile (PF). The field stren...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00269.2007
更新日期:2007-11-01 00:00:00
abstract::This research was guided by the working hypothesis that the aging auditory system progressively loses its ability to process rapid acoustic transients efficiently, and in elderly listeners, this results in difficulties in speech perception. Neural correlates of age-related deficits in temporal processing were investig...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.88.2.565
更新日期:2002-08-01 00:00:00
abstract::The deep dorsal horn represents a major site for the integration of spinal sensory information. The bulbospinal monoamine transmitters, released from serotonergic, noradrenergic, and dopaminergic systems, exert modulatory control over spinal sensory systems as does acetylcholine, an intrinsic spinal cord biogenic amin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.5.2183
更新日期:2001-11-01 00:00:00