A long closed state of the synaptosomal bursting potassium channel confers a statistical memory.

Abstract:

:1. The statistical properties of the bursting potassium channel from fused Torpedo synaptosomes were studied by using patch-clamp recording and time series analysis. 2. Voltage steps produce channel openings; the number of channels opening fluctuates from trial to trial. The maximal current observed in each trial is strongly dependent on the previous history of the membrane patch. Trials with no activity are frequently clumped together and so are trials with intense activity. 3. Autocorrelation analysis reveals a strong interdependence of successive responses, which is voltage dependent. 4. We propose that the strong statistical interdependence of responses to successive depolarizing pulses (the statistical "memory") is a manifestation of a long lived closed state. We speculate that this statistical memory may be of significance in frequency modulation of transmitter release.

journal_name

J Neurophysiol

authors

Rahamimoff R,Edry-Schiller J,Ginsburg S

doi

10.1152/jn.1992.68.6.2260

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

2260-3

issue

6

eissn

0022-3077

issn

1522-1598

journal_volume

68

pub_type

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