Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels.

abstract：:To program a goal-directed response in the presence of acoustic reflections, the audio-motor system should suppress the detection of time-delayed sources. We examined the effects of spatial separation and inter-stimulus delay on the ability of human listeners to localize a pair of broadband sounds in the horizontal pl...

journal_title：Journal of neurophysiology

authors： van Bentum GC,van Wanrooij MM,Van Opstal AJ

更新日期：2020-12-30 00:00:00

abstract：:1. The lateral geniculate nucleus is the primary thalamic relay through which retinal signals pass en route to cortex. This relay is gated and can be suppressed by activity among local inhibitory neurons that use gamma-aminobutyric acid (GABA) as a neurotransmitter. In the cat, a major source of this GABAergic inhibit...

journal_title：Journal of neurophysiology

authors： Uhlrich DJ,Cucchiaro JB,Humphrey AL,Sherman SM

更新日期：1991-06-01 00:00:00

abstract：:The rapid detection of sensory inputs is crucial for survival. Sensory detection explicitly requires the integration of incoming sensory information and the ability to distinguish between relevant information and ongoing neural activity. In this study, head-fixed rats were trained to detect the presence of a brief def...

journal_title：Journal of neurophysiology

authors： Ollerenshaw DR,Bari BA,Millard DC,Orr LE,Wang Q,Stanley GB

更新日期：2012-07-01 00:00:00

abstract：:Normative theories posit that value-based decision-making is context independent. However, decisions between two high-value options can be suboptimally biased by the introduction of a third low-value option. This context-dependent modulation is consistent with the divisive normalization of the value of each stimulus b...

journal_title：Journal of neurophysiology

authors： Itthipuripat S,Cha K,Rangsipat N,Serences JT

更新日期：2015-07-01 00:00:00

abstract：:Single midbrain neurons were examined for effects of ovarian hormone administration on responsiveness to an array of lordosis-controlling types of somatosensory stimuli in anesthetized, ovariectomized Syrian hamsters. Neuronal responses were recorded under four different hormonal treatment conditions: 1) estradiol ben...

journal_title：Journal of neurophysiology

authors： Rose JD,Bieber SL

更新日期：1984-05-01 00:00:00

abstract：:The dorsal nucleus of the lateral lemniscus (DNLL) receives afferent inputs from many brain stem nuclei and, in turn, is a major source of inhibitory inputs to the inferior colliculus (IC). The goal of this study was to characterize the monaural and binaural response properties of neurons in the DNLL of unanesthetized...

journal_title：Journal of neurophysiology

authors： Davis KA,Lomakin O,Pesavento MJ

更新日期：2007-09-01 00:00:00

abstract：:1. Spontaneous synaptic activity in networks formed by dissociated neurons from embryonic rat midbrain was analyzed in tight seal whole cell recordings. 2. Application of furosemide (0.5 mM) to the cell and its surrounding area increased the frequency of spontaneous synaptic currents. Incubation of the culture with fu...

journal_title：Journal of neurophysiology

authors： Jarolimek W,Brunner H,Lewen A,Misgeld U

更新日期：1996-06-01 00:00:00

abstract：:Substance P (SP) is an undecapeptide that is co-localized with conventional transmitters in the nucleus accumbens (NAc). Its neurochemical and behavioral effects resemble those of cocaine and amphetamine. How SP accomplishes these effects is not known, partly because its cellular and synaptic effects are not well char...

journal_title：Journal of neurophysiology

authors： Kombian SB,Ananthalakshmi KV,Parvathy SS,Matowe WC

更新日期：2003-02-01 00:00:00

abstract：:The aim of this study was to determine whether neuronal activity in the macaque supplementary eye field (SEF) is influenced by the rule used for saccadic target selection. Two monkeys were trained to perform a variant of the memory-guided saccade task in which any of four visible dots (rightward, upward, leftward, and...

journal_title：Journal of neurophysiology

authors： Olson CR,Gettner SN,Ventura V,Carta R,Kass RE

更新日期：2000-09-01 00:00:00

abstract：:1. A task was used by Posner (1980) to measure shifts of attention that occurred covertly, in the absence of an eye movement or other orienting response. This paradigm was used here to assess the nature of covert attentional orienting in monkeys to develop an animal model for neurophysiological studies. Shifts of atte...

journal_title：Journal of neurophysiology

authors： Bowman EM,Brown VJ,Kertzman C,Schwarz U,Robinson DL

更新日期：1993-07-01 00:00:00

abstract：:M current relaxations recorded in PC12 cells were subjected to nonstationary noise analysis (NSNA) to obtain estimates of single-channel current (i), channel number (N), and open probability (Po) for the channels responsible for M current. The analysis was constrained such that N and single-channel conductance were th...

journal_title：Journal of neurophysiology

authors： Villarroel A

更新日期：1997-04-01 00:00:00

abstract：:Multi electrode recordings of neuronal activity provide an overwhelming amount of data that is often difficult to analyze and interpret. Although various methods exist for treating multielectrode datasets quantitatively, there is a particularly prominent lack of techniques that enable a quick visual exploration of suc...

journal_title：Journal of neurophysiology

authors： Jurjut OF,Nikolić D,Pipa G,Singer W,Metzler D,Mureşan RC

更新日期：2009-12-01 00:00:00

abstract：:The activity of malic dehydrogenase, pyruvic kinase, and phosphorylase b was measured in the geniohyoid muscle of the cat after injection of 10 10 mM colchicine into the hypoglossal nerve. Experiments performed 1-60 days after the injection showed that the activity of the three enzymes gradually decreased (day 4-5), r...

journal_title：Journal of neurophysiology

authors： Inestrosa NC,Fernandez HL

更新日期：1976-11-01 00:00:00

abstract：:We constantly make eye movements to bring objects of interest onto the fovea for more detailed processing. Activity in area V4, a prestriate visual area, is enhanced at the location corresponding to the target of an eye movement. However, the precise role of activity in V4 in relation to these saccades and the modulat...

journal_title：Journal of neurophysiology

authors： Gee AL,Ipata AE,Goldberg ME

更新日期：2010-10-01 00:00:00

abstract：:We have studied how rewards modulate the occurrence of microsaccades by manipulating the size of an expected reward and the location of the cue that sets the expectations for future reward. We found an interaction between the size of the reward and the location of the cue. When monkeys fixated on a cue that signaled t...

journal_title：Journal of neurophysiology

authors： Joshua M,Tokiyama S,Lisberger SG

更新日期：2015-11-01 00:00:00

abstract：:Since sensory systems operate with a finite quantity of processing resources, an animal would benefit from prioritizing processing of sensory stimuli within a time window that is expected to provide key information. This behavioral manifestation of such prioritization is known as attention. Here, we investigate attent...

journal_title：Journal of neurophysiology

authors： Lee CCY,Clifford CWG,Arabzadeh E

更新日期：2019-03-01 00:00:00

abstract：:1. The horizontal eye movements induced by acceleration along the interaural axis were recorded from five monkeys (Macaca mulatta) by the use of the electromagnetic search-coil technique. Animals sat on a sled that was moved briefly in darkness along a linear track (bell-shaped acceleration profile: peak, 400 mm/s2; d...

journal_title：Journal of neurophysiology

authors： Schwarz U,Miles FA

更新日期：1991-09-01 00:00:00

abstract：:This study examined the effects of selective inactivation of the cerebellar nuclei in the cat on the control of multijoint trajectories and trajectory adaptation to avoid obstacles. Animals were restrained in a hammock and trained to perform a prehension task in which they reached to grasp a small cube of meat from a ...

journal_title：Journal of neurophysiology

authors： Martin JH,Cooper SE,Hacking A,Ghez C

更新日期：2000-04-01 00:00:00

abstract：:1. The statistical properties of the bursting potassium channel from fused Torpedo synaptosomes were studied by using patch-clamp recording and time series analysis. 2. Voltage steps produce channel openings; the number of channels opening fluctuates from trial to trial. The maximal current observed in each trial is s...

journal_title：Journal of neurophysiology

authors： Rahamimoff R,Edry-Schiller J,Ginsburg S

更新日期：1992-12-01 00:00:00

abstract：:C-mechanoreceptors in humans comprise a population of unmyelinated afferents exhibiting a wide range of mechanical sensitivities. C-mechanoreceptors are putatively divided into those signaling gentle touch (C-tactile afferents, CTs) and nociception (C-mechanosensitive nociceptors, CMs), giving rise to positive and neg...

journal_title：Journal of neurophysiology

authors： Watkins RH,Wessberg J,Backlund Wasling H,Dunham JP,Olausson H,Johnson RD,Ackerley R

更新日期：2017-04-01 00:00:00

abstract：:Children do not typically appear to move with the same skill and dexterity as adults, although they can still improve their motor performance in specific tasks with practice. One possible explanation is that their motor performance is limited by an inherently higher level of movement variability, but that their motor ...

journal_title：Journal of neurophysiology

authors： Takahashi CD,Nemet D,Rose-Gottron CM,Larson JK,Cooper DM,Reinkensmeyer DJ

更新日期：2003-08-01 00:00:00

abstract：:Membrane retrieval following exocytosis in synaptic terminals is fast and compensatory, however, little is known about the factors that regulate or contribute to this special form of endocytosis. We used whole-terminal capacitance measurements to examine the effect of hydrostatic pressure on compensatory endocytosis i...

journal_title：Journal of neurophysiology

authors： Heidelberger R,Zhou ZY,Matthews G

更新日期：2002-11-01 00:00:00

abstract：:Frequency facilitation is a process whereby neurosecretion increases as a function of stimulation frequency during repetitive synaptic activity. To examine the physiological basis underlying facilitation, we have estimated the frequency dependence of the synaptic parameters n (number of units capable of responding to ...

journal_title：Journal of neurophysiology

authors： Worden MK,Bykhovskaia M,Hackett JT

更新日期：1997-07-01 00:00:00

abstract：:Although metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5 are often found to have similar functions, there is considerable evidence that the two receptors also serve distinct functions in neurons. In hippocampal area CA1, mGluR5 has been most strongly implicated in long-term synaptic depression (LTD), where...

journal_title：Journal of neurophysiology

authors： Volk LJ,Daly CA,Huber KM

更新日期：2006-04-01 00:00:00

abstract：:A mathematical model is developed for simulation of action potential propagation through a single branch point of a myelinated nerve fiber with a parent branch bifurcating into two identical daughter branches. This model is based on a previously published multi-layer compartmental model for single unbranched myelinate...

journal_title：Journal of neurophysiology

authors： Zhou L,Chiu SY

更新日期：2001-01-01 00:00:00

abstract：:Responses to tones, clicks, and noise were recorded from chinchilla auditory-nerve fibers (ANFs). The responses to noise were analyzed by computing the zeroth-, first-, and second-order Wiener kernels (h0, h1, and h2). The h1s correctly predicted the frequency tuning and phases of responses to tones of ANFs with low c...

journal_title：Journal of neurophysiology

authors： Temchin AN,Recio-Spinoso A,van Dijk P,Ruggero MA

更新日期：2005-06-01 00:00:00

abstract：:A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system...

journal_title：Journal of neurophysiology

authors： Feingold J,Desrochers TM,Fujii N,Harlan R,Tierney PL,Shimazu H,Amemori K,Graybiel AM

更新日期：2012-04-01 00:00:00

abstract：:We investigated whether heptanol and other long-chain alcohols that are known to block gap junctions interfere with the generation or the propagation of spreading depression (SD). Waves of SD were triggered by micro-injection of concentrated KCl solution in stratum (s.) radiatum of CA1 of rat hippocampal tissue slices...

journal_title：Journal of neurophysiology

authors： Largo C,Tombaugh GC,Aitken PG,Herreras O,Somjen GG

更新日期：1997-01-01 00:00:00

abstract：:Synchronization between the firing times of simultaneously active motor units (MUs) is generally assumed to increase during fatiguing contractions. To date, however, estimates of MU synchronization have relied on indirect measures, derived from surface electromyographic (EMG) interference signals. This study used intr...

journal_title：Journal of neurophysiology

authors： McManus L,Hu X,Rymer WZ,Suresh NL,Lowery MM

更新日期：2016-06-01 00:00:00

abstract：:Despite its widespread use, high-resolution imaging with multiphoton microscopy to record neuronal signals in vivo is limited to the surface of brain tissue because of limited light penetration. Moreover, most imaging studies do not simultaneously record electrical neural activity, which is, however, crucial to unders...

journal_title：Journal of neurophysiology

authors： Hirai Y,Nishino E,Ohmori H

更新日期：2015-06-01 00:00:00