Amniotic fluid tests for fetal maturity in normal and abnormal pregnancies.

Abstract:

:Amniotic fluid creatinine, percentage of lipid-positive cells, and L/S ratio were determined on 285 samples from normal pregnancies and 222 samples from abnormal pregnancy states (Rh isoimmunization, diabetes, hypertensive disorders, intrauterine growth retardation, and hydramnios). In normal pregnancy the coefficient of correlation between true gestational age and estimated period of gestation (EPG) based on the three parameters was 0.94, in Rh isoimmunization 0.77, in diabetes 0.67, and in hypertensive disorders 0.59. In intrauterine growth retardation both the L/S ratio and creatinine were depressed, the coefficient was 0.61, and the EPG was consistently less than the true gestational age. The mean L/S ratio in pre-eclampsia was slightly below the normal mean and in diabetes the mean L/S ratio was also depressed. In 150 samples taken within 48 hours of delivery L/S ratios were accurate in assessing fetal pulmonary maturity although there was a 20 per cent incidence over all of false-immature values. There were no false-mature values except in diabetes (2/9).

journal_name

Am J Obstet Gynecol

authors

Doran TA,Malone RM,Benzie RJ,Owen VJ,Thompson DW,New ML

doi

10.1016/0002-9378(76)90777-8

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

586-92

issue

5

eissn

0002-9378

issn

1097-6868

pii

0002-9378(76)90777-8

journal_volume

125

pub_type

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