当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis.

The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis.

Abstract：

OBJECTIVE:The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV). STUDY DESIGN:Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 2 2% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1-way global F test and McNemar's test. RESULTS:All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons). CONCLUSION:Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Nyirjesy P,McIntosh MJ,Gattermeir DJ,Schumacher RJ,Steinmetz JI,Joffrion JL

doi

10.1016/j.ajog.2005.11.006

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

1277-82

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(05)02451-8

journal_volume

194

pub_type

杂志文章

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