Myasthenia gravis in individuals over 40.

Abstract:

:Myasthenia gravis (MG) in individuals over 40 years of age comprises three groups: early-onset MG with prolonged disease duration, late-onset MG with thymoma, and late-onset of nonthymomatous MG. The clinical features do not differ between the three groups, except that early-onset patients with prolonged disease duration usually have a less severe disease. More than 60% of our MG patients are now more than 50 years of age, often with disease onset after age 40. Although 2 out of the 3 patients in Erb's original description had onset of myasthenic symptoms after age 40, this was apparently infrequent in 1879, when the disease was first identified. Onset of MG after age 40 is now common. For example, in our material, 88/184 (47.8%) had onset of MG after age 40. Eighteen (20.5%) had a thymoma. The female:male ratio in the early-onset group was 2.4:1, whereas it was 1:1.1 among those with onset after age 40. There was no human leukocyte antigen association for MG with thymoma. Antibodies to the acetylcholine receptor were detected in 88% of sera from nonthymomatous MG and in 100% of those with late-onset MG with thymoma. Antibodies to titin were found in sera from 85.7% of MG patients with thymoma (all age groups) and in 58% of nonthymomatous MG with late onset and acetylcholine receptor antibodies. Late-onset, nonthymomatous MG comprises two subgroups, one corresponding to delayed early onset and one immunologically similar to that seen in patients with MG and thymoma.

journal_name

Ann N Y Acad Sci

authors

Aarli JA,Romi F,Skeie GO,Gilhus NE

doi

10.1196/annals.1254.055

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

424-31

eissn

0077-8923

issn

1749-6632

journal_volume

998

pub_type

杂志文章
  • Social stratification, health, and violence in the very young.

    abstract::Inequalities in human social groups contribute in important ways to the initiation and perpetuation of violence. Because both social inequalities and interpersonal aggression emerge in early life, it is important to study their developmental origins in the collective and individual behavior of young children. As young...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1330.003

    authors: Boyce WT

    更新日期:2004-12-01 00:00:00

  • Implicit and explicit emotional memory for melodies in Alzheimer's disease and depression.

    abstract::The present study investigates the impact of emotional deficits on implicit and explicit memory for musical stimuli in patients with Alzheimer's disease and elderly depressed patients. Results showed that unlike Alzheimer's patients, depressed patients were unable to develop a positive affective bias of judgment for p...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1284.047

    authors: Quoniam N,Ergis AM,Fossati P,Peretz I,Samson S,Sarazin M,Allilaire JF

    更新日期:2003-11-01 00:00:00

  • The neuropeptide alpha-MSH in HIV infection and other disorders in humans.

    abstract::We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09622.x

    authors: Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

    更新日期:1998-05-01 00:00:00

  • Fermented wheat germ extract (avemar) inhibits adjuvant arthritis.

    abstract::Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethaso...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1423.037

    authors: Telekes A,Resetar A,Balint G,Blazso G,Falkay G,Lapis K,Raso E,Szende B,Ehrenfeld M,Shoenfeld Y,Hidvegi M

    更新日期:2007-09-01 00:00:00

  • Long-term antibody production is sustained by antibody-secreting cells in the bone marrow following acute viral infection.

    abstract::Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb52958.x

    authors: Slifka MK,Ahmed R

    更新日期:1996-10-25 00:00:00

  • Modeling thiamine fortification: a case study from Kuria atoll, Republic of Kiribati.

    abstract::In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14561

    authors: Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

    更新日期:2021-01-12 00:00:00

  • Nutrition meets the microbiome: micronutrients and the microbiota.

    abstract::There is increasing evidence that food is an important factor that influences and shapes the composition and configuration of the gut microbiota. Most studies have focused on macronutrients (fat, carbohydrate, protein) in particular and their effects on the gut microbiota. Although the microbiota can synthesize differ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13145

    authors: Biesalski HK

    更新日期:2016-05-01 00:00:00

  • Effects of age and caloric restriction on brain neuronal cell death/survival.

    abstract::Aging may pose a challenge to the central nervous system, increasing its susceptibility to apoptotic events. Recent findings indicate that caloric restriction (CR) may have a profound effect on brain function and vulnerability to injury and diseases, by enhancing neuroprotection, stimulating the production of new neur...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1297.018

    authors: Hiona A,Leeuwenburgh C

    更新日期:2004-06-01 00:00:00

  • Is steady-state capitalism viable? A review of the issues and an answer in the affirmative.

    abstract::Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological ec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.05966.x

    authors: Lawn P

    更新日期:2011-02-01 00:00:00

  • Arousal regulation, emotional flexibility, medial amygdala function, and the impact of early experience: comments on the paper of Lewis et al.

    abstract::The balance between optimal levels of emotional arousal and cognitive performance reflects the integration of several dopaminergically and adrenergically regulated neural systems. The amygdalar system is a key region for gating stimulation to cortical regions and the medial amygdala appears to play an especially key r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 评论,杂志文章,评审

    doi:10.1196/annals.1376.018

    authors: Mayes LC

    更新日期:2006-12-01 00:00:00

  • Selected methods of investigation for blood-contact surfaces.

    abstract::It is imperative that operating personnel and regulatory agencies have secure, advance, and accurate knowledge of the true surface properties of materials to be contacted with flowing blood. The actual devices must be characterized in their sterile, immediate pre-exposure states. Although very sensitive electronic ins...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1987.tb33031.x

    authors: Baier RE

    更新日期:1987-01-01 00:00:00

  • Induction of oocytic maturation and differentiation: mode of progesterone action.

    abstract::Full-grown amphibian oocytes, arrested in prophase I or meiosis, respond in vitro to progesterone and certain other steroids. They undergo an apparently normal sequence of nuclear maturation and cytoplasmic differentiation, which are necessary precedents for fertilization and embryogenesis. Individual oocytes or popul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1977.tb29433.x

    authors: Schuetz AW

    更新日期:1977-03-11 00:00:00

  • Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western societies mainly accounts for clinical dementia. A high proportion of women are affected by this disease, especially at a very advanced age, which might to a large extent be associated with the fact that women live l...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1386.008

    authors: Candore G,Balistreri CR,Grimaldi MP,Vasto S,Listì F,Chiappelli M,Licastro F,Lio D,Caruso C

    更新日期:2006-11-01 00:00:00

  • Effect of indoor lighting on normal skin.

    abstract::A small but measurable component of some indoor lighting is ultraviolet radiation (UVR); whether it is sufficient to modify the indoor worker's risk for chronic skin changes is not directly answerable with available technology. A first approach to this question involves a) estimating a range of annual background solar...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb11819.x

    authors: Cole C,Forbes PD,Davies RE,Urbach F

    更新日期:1985-01-01 00:00:00

  • Cryptic eco-evolutionary dynamics.

    abstract::Natural systems harbor complex interactions that are fundamental parts of ecology and evolution. These interactions challenge our inclinations and training to seek the simplest explanations of patterns in nature. Not least is the likelihood that some complex processes might be missed when their patterns look similar t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12974

    authors: Kinnison MT,Hairston NG Jr,Hendry AP

    更新日期:2015-12-01 00:00:00

  • Mediterranean spotted fever in crete, Greece: clinical and therapeutic data of 15 consecutive patients.

    abstract::The clinical, epidemiological, and therapeutic aspects of 15 patients with Mediterranean spotted fever (MSF), admitted to the Internal Medicine Department of the General Hospital of Sitia (southeastern Crete, Greece) between December 2000 and July 2003, were studied. Diagnosis was made on the basis of clinical signs a...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1374.049

    authors: Germanakis A,Psaroulaki A,Gikas A,Tselentis Y

    更新日期:2006-10-01 00:00:00

  • TNF alpha is an effective therapeutic target for rheumatoid arthritis.

    abstract::Rheumatoid arthritis is the most common of a number of diseases in which inflammation and tissue destruction is driven by an autoimmune process. Current therapy is inadequate, and this has prompted major research efforts, both in academia and industry, to understand more about the pathogenesis, and hence provide the r...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1995.tb26675.x

    authors: Feldmann M,Brennan FM,Elliott MJ,Williams RO,Maini RN

    更新日期:1995-09-07 00:00:00

  • A polymorphic form of steroidogenic factor 1 associated with ACTH receptor deficiency in mouse adrenal cell mutants.

    abstract::We have described a family of adrenocortical tumor cell mutants (including clones OS3, Y6, and 10r9) that are resistant to ACTH because they fail to express the gene encoding the ACTH receptor (MC2R). The MC2R deficiency results from a mutation that impairs the activity of the nuclear receptor steroidogenic factor 1 (...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb03174.x

    authors: Schimmer BP,Cordova M,Tsao J,Frigeri C

    更新日期:2003-06-01 00:00:00

  • Effect of ethanol on lipid-mediated transfection of primary cortical neurons.

    abstract::Successful introduction of nucleic acids into mammalian neurons has revolutionized the analyses of gene regulation and cellular function. Various methods, including viral infection, have been developed to introduce plasmid DNA into primary neuronal cultures. However, transfection of primary cultures of neurons using t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07516.x

    authors: Anji A,Shaik KA,Kumari M

    更新日期:2003-05-01 00:00:00

  • Neuropathology of suicide. A review and an approach.

    abstract::Neuropathology is one approach to the effort to elucidate the pathophysiology of suicide. Initial neurochemical studies focusing on the roles of serotonin (5-HT) and noradrenaline (NE) abnormalities in brains of suicide victims have been somewhat inconsistent. More recently developed methodologies, including quantitat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb52361.x

    authors: Bachus SE,Hyde TM,Akil M,Weickert CS,Vawter MP,Kleinman JE

    更新日期:1997-12-29 00:00:00

  • Negative regulation of placental fibronectin expression by glucocorticoids and cyclic adenosine 3',5'-monophosphate.

    abstract::Fibronectin is a ubiquitous extracellular matrix (ECM) protein known to play a critical role in cell adhesion. In the present study we dissected the effects of glucocorticoids and cyclic adenosine 3',5'-monophosphate (cAMP) on FN expression in cultures of cytotrophoblasts isolated from human term placentas to identify...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb21741.x

    authors: Guller S,Wozniak R,Leibman MI,Lockwood CJ

    更新日期:1994-09-30 00:00:00

  • Peptides from anchovy sauce induce apoptosis in a human lymphoma cell (U937) through the increase of caspase-3 and -8 activities.

    abstract::Various biological activities of peptides have been found. In this study, the induction of apoptosis in a human lymphoma cell line (U937) by peptide fraction separated from anchovy sauce was studied using biochemical and flow cytometric methods. After U937 was treated with a hydrophobic peptide fraction of the anchovy...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1299.073

    authors: Lee YG,Kim JY,Lee KW,Kim KH,Lee HJ

    更新日期:2003-12-01 00:00:00

  • Reporter transgenic mouse models highlight the dual endocrine and neural facet of GnRH receptor function.

    abstract::In the pituitary of mammals, the GnRH receptor (GnRHR) plays crucial roles in the neuroendocrine control of reproductive function. This receptor is specifically expressed by the gonadotrope cells scattered among the five other endocrine cell types constituting the anterior pituitary; it is also expressed in other orga...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05886.x

    authors: Schang AL,Counis R,Magre S,Bleux C,Granger A,Ngô-Muller V,Chenut MC,Ishaq M,Cohen-Tannoudji J,Laverrière JN

    更新日期:2011-03-01 00:00:00

  • Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts.

    abstract::Release of the amyloid precursor protein (APP) of Alzheimer's disease from Swiss 3T3 fibroblasts was stimulated in a concentration-dependent manner by phorbol 12-myristate 13-acetate. In fibroblasts overexpressing protein kinase C alpha (PKC alpha), the EC50 for this response was 7 nM, while in control cells the EC50 ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb23040.x

    authors: Slack BE,Nitsch RM,Livneh E,Kunz GM Jr,Eldar H,Wurtman RJ

    更新日期:1993-09-24 00:00:00

  • The developing mouse dentition: a new tool for apoptosis study.

    abstract::Developing limb or differentiating neural and blood cells are traditional models used to study programmed cell death in mammals. The developing mouse dentition can also be an attractive model for studying apoptosis regulation. Apoptosis is most extant during early odontogenesis in mice. The embryonic tooth pattern is ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1299.083

    authors: Peterková R,Peterka M,Lesot H

    更新日期:2003-12-01 00:00:00

  • Effect of endothelin on sodium/hydrogen exchanger activity of human monocytes and atherosclerosis-related functions.

    abstract::The objective of this article is to investigate the influence of endothelin-1 (ET-1) on human monocyte Na(+)/H(+) exchanger (NHE) activity and on the atherosclerosis-related monocyte functions. ET-1 caused an increase in pHi and in (22)Na influx of monocytes. A reversal of ET-1 effect on pHi was observed in the presen...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1397.031

    authors: Koliakos G,Befani C,Paletas K,Kaloyianni M

    更新日期:2007-01-01 00:00:00

  • Diffusion tensor tractography of the motor white matter tracts in man: Current controversies and future directions.

    abstract::The anatomy of the brain is extremely complex, and certain, even large structures, such as the corticospinal tract (CST), remain poorly understood. Diffusion tractography provides an opportunity to explore the white matter tracts in a fundamentally new way. In the current paper, we show how this technique has already ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1340.016

    authors: Holodny AI,Watts R,Korneinko VN,Pronin IN,Zhukovskiy ME,Gor DM,Ulug A

    更新日期:2005-12-01 00:00:00

  • DNA methylation, a biomarker for colorectal cancer: implications for screening and pathological utility.

    abstract::Currently up to one-third of colorectal cancer patients present with locally advanced or metastatic disease that precludes a surgical cure. Performance limitations and low uptake of current screening tools have fueled research to develop minimally invasive approaches that can detect early-stage neoplasms. The observat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb05980.x

    authors: Jubb AM,Quirke P,Oates AJ

    更新日期:2003-03-01 00:00:00

  • Inhibition of herpesvirus DNA synthesis by 9-beta-D-arabinofuranosyladenine in cellular and cell-free systems.

    abstract::9-beta-D-Arabinofuranosyladenine 5'-triphosphate (ara-ATP) is an inhibitor both of DNA polymerase-alpha and -beta from noninfected rabbit kidney cells and of the DNA-dependent DNA polymerase induced by herpes simplex virus Type 1 (strain IES). The studies were performed with partially purified enzymes, and each of the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1977.tb21935.x

    authors: Müller WE,Zahn RK,Bittlingmaier K,Falke D

    更新日期:1977-03-04 00:00:00

  • Interactions of vitamin C with lead and mercury.

    abstract::Ascorbic acid has been found to interact with several elements in such a manner as to render them less available for animals. This property of the vitamin has a negative effect on the animals fed a copper-deficient diet, but a positive effect on those fed toxic levels of copper, selenium, vanadium, and cobalt. The eff...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1980.tb21344.x

    authors: Hill CH

    更新日期:1980-01-01 00:00:00