SPR imaging-based salivary diagnostics system for the detection of small molecule analytes.

Abstract:

:Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic device for the rapid detection of the antiepileptic drug (AED) phenytoin in saliva. The multicomponent system includes a hand-portable surface plasmon resonance (SPR) imaging instrument and a disposable microfluidic assay card.

journal_name

Ann N Y Acad Sci

authors

Fu E,Chinowsky T,Nelson K,Johnston K,Edwards T,Helton K,Grow M,Miller JW,Yager P

doi

10.1196/annals.1384.026

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

335-44

eissn

0077-8923

issn

1749-6632

pii

1098/1/335

journal_volume

1098

pub_type

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