Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.

abstract：:Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α-modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expre...

journal_title：Journal of cellular biochemistry

authors： Liang Y,Zhang T,Shi M,Zhang S,Guo Y,Gao J,Yang X

更新日期：2019-04-01 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00

abstract：:The bone marrow stroma contains pre-adipocyte cells which are part of the hemopoietic microenvironment. Cloned stromal cell lines differ both in their ability to support myeloid and lymphoid development and in their ability to undergo adipocyte differentiation in vitro. These processes have been examined in the +/+2.4...

journal_title：Journal of cellular biochemistry

authors： Gimble JM,Youkhana K,Hua X,Bass H,Medina K,Sullivan M,Greenberger J,Wang CS

更新日期：1992-09-01 00:00:00

abstract：:Fibroblast-collagen matrix contraction has been used as a model system to study how cells organize connective tissue. Previous work showed that lysophosphatidic acid (LPA)-stimulated floating collagen matrix contraction is independent of Rho kinase while platelet-derived growth factor (PDGF)-stimulated contraction is ...

journal_title：Journal of cellular biochemistry

authors： Abe M,Sogabe Y,Syuto T,Yokoyama Y,Ishikawa O

更新日期：2007-12-01 00:00:00

abstract：:We have examined the composition and ultrastructure of the nuclear periphery during in vitro myogenesis of the rat myoblast cell line, L6E9. Immunofluorescence labelling and immunoblotting showed that lamins A/C and B were all present in undifferentiated cells, but that they increased significantly before extensive ce...

journal_title：Journal of cellular biochemistry

authors： Chaly N,Munro SB,Swallow MA

更新日期：1996-07-01 00:00:00

abstract：:Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induct...

journal_title：Journal of cellular biochemistry

authors： Al-Rasheed NM,Al-Rasheed NM,Al-Rabeeah DA,Al-Barrak HS,Al-Salman SA,Ibrahim SA,Al-Hassab SA,Al-Amin MA,Hasan IH,Al-Ajmi HN,Al-Shammari TK

更新日期：2018-05-01 00:00:00

abstract：:There were 134,000 new diagnosis and 49,000 deaths in 2016 due to colorectal cancer. Similar to most cancers, early diagnosis increases the chance of successful treatment. Detection of tumor-associated antigens or the immune response against such markers is one of the most common methods of diagnosis. In that regard, ...

journal_title：Journal of cellular biochemistry

authors： Veisi Malekshahi Z,Amani J,Negahdari B,Rajabibazl M,Ebrahimizadeh W

更新日期：2018-04-01 00:00:00

abstract：:Extracellular matrix (ECM) accumulation plays a key role in the progression of bladder outlet obstruction (BOO). Muscarinic receptors have been widely reported to serve as pivotal regulators in lung tissue remodeling. However, the influence of them on human bladder smooth muscle cells (HBSMCs) and the underlying molec...

journal_title：Journal of cellular biochemistry

authors： Chen S,Liao B,Jin X,Wei T,He Q,Lin Y,Ai J,Gong L,Li H,Wang K

更新日期：2020-11-01 00:00:00

abstract：:Rat CYP1A1 promoter-luciferase, transiently transfected wild-type and 4S PAH receptor (glycine N-methyl transferase, GNMT)-transformed Chinese hamster ovary (CHO) cells were exposed to benzo[a]pyrene and assayed for luciferase activity as an indicator of CYP1A1 promoter activity. CHO cells transformed with the rat 4S ...

journal_title：Journal of cellular biochemistry

authors： Sterling KM

更新日期：2011-08-01 00:00:00

abstract：:Melphalan (MEL) is a chemotherapeutic agent used in breast cancer therapy; however, MEL's side effects limit its clinical applications. In the last 20 years, resveratrol (RSV), a polyphenol found in grape skins, has been proposed to reduce the risk of cancer development. The aim of this study was to investigate whethe...

journal_title：Journal of cellular biochemistry

authors： Casanova F,Quarti J,da Costa DC,Ramos CA,da Silva JL,Fialho E

更新日期：2012-08-01 00:00:00

abstract：:It is well accepted, that there is communication between osteoblasts and endothelial cells. However, the influence of endothelial cells on the differentiation of bone precursors into mature osteoblasts is not yet well understood. We therefore studied the effect of human umbilical vein endothelial cells (HUVEC) on huma...

journal_title：Journal of cellular biochemistry

authors： Meury T,Verrier S,Alini M

更新日期：2006-07-01 00:00:00

abstract：:Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the c...

journal_title：Journal of cellular biochemistry

authors： Benzakour O,Kanthou C,Lupu F,Dennehy U,Goodwin C,Scully MF,Kakkar VV,Cooper DN

更新日期：1995-12-01 00:00:00

abstract：:Oncostatin M (OSM) is a member of the interleukin (IL)-6 family cytokines. We previously demonstrated that OSM induces blood-brain barrier (BBB) impairment. However, functional characterization of IL-6 family cytokines in BBB regulation and the cytokine-related intracellular signaling pathway remain unclear. In this s...

journal_title：Journal of cellular biochemistry

authors： Takata F,Dohgu S,Matsumoto J,Machida T,Sakaguchi S,Kimura I,Yamauchi A,Kataoka Y

更新日期：2018-11-01 00:00:00

abstract：:Anoikis is a form of programmed cell death induced by loss of contact from neighboring cells or from their extracellular matrix (ECM). Many tumorigenic cells are anoikis resistant, facilitating cancer progression and metastasis. Trastuzumab is a monoclonal antibody used for the treatment of breast and gastric cell can...

journal_title：Journal of cellular biochemistry

authors： Onyeisi JOS,Castanho de Almeida Pernambuco Filho P,de Araujo Lopes S,Nader HB,Lopes CC

更新日期：2019-08-01 00:00:00

abstract：:The main mechanisms of interaction between Human T-lymphotropic virus type 1 (HTLV-1) and its hosts in the manifestation of the related disease including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T-cell leukemia/lymphoma (ATLL) are yet to be determined. It is pivotal to find out the...

journal_title：Journal of cellular biochemistry

authors： Mozhgani SH,Zarei-Ghobadi M,Teymoori-Rad M,Mokhtari-Azad T,Mirzaie M,Sheikhi M,Jazayeri SM,Shahbahrami R,Ghourchian H,Jafari M,Rezaee SA,Norouzi M

更新日期：2018-05-01 00:00:00

abstract：:The 25-hydroxyvitamin D(3)-24-hydroxylase mRNA is tightly and reciprocally regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and parathyroid hormone (PTH). The upregulation of the 24-hydroxylase by 1,25(OH)(2)D(3) is well established and occurs at the transcriptional level through two vitamin D response elemen...

journal_title：Journal of cellular biochemistry

authors： Zierold C,Mings JA,DeLuca HF

更新日期：2003-02-01 00:00:00

abstract：:The early 1980s revelation of cis-acting genomic elements, known as transcriptional enhancers, is still regarded as one of the fundamental discoveries in the genomic field. However, only with the emergence of genome-wide techniques has the genuine biological scope of enhancers begun to be fully uncovered. Massive scie...

journal_title：Journal of cellular biochemistry

authors： Blum R

更新日期：2014-11-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postnatal growth plate (G...

journal_title：Journal of cellular biochemistry

authors： Wu LN,Lu M,Genge BR,Guo GY,Nie D,Wuthier RE

更新日期：2002-01-01 00:00:00

abstract：:Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel with decreased bone formation by osteoblasts. A widely accepted strategy for improving bone health is targeting osteoprogenitor cells in order to stimulate thei...

journal_title：Journal of cellular biochemistry

authors： Amantea CM,Kim WK,Meliton V,Tetradis S,Parhami F

更新日期：2008-10-01 00:00:00

abstract：:Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

journal_title：Journal of cellular biochemistry

authors： Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

更新日期：2019-02-19 00:00:00

abstract：:The conditions favoring expression of a reporter gene microinjected into a male pronucleus of naturally ovulated and fertilized rabbit eggs have been studied. Injection of the reporter gene during S phase of the cell-cycle allows the highest level of expression of the gene. Incorporation of DNA loop anchorage regions ...

journal_title：Journal of cellular biochemistry

authors： Goldman IL,Razin SV,Kadulin SG,Vassetzky YS

更新日期：2004-08-15 00:00:00

abstract：:We aimed to understand whether metformin imposes the inhibitory effect on the HBV-associated tumorigenesis by regulating the HULC and its downstream signaling pathway. Luciferase assay, RT-PCR, and Western-blot, MTT and flow cytometry analysis were performed to understand and the mechanism, by which metformin enhance ...

journal_title：Journal of cellular biochemistry

authors： Jiang Z,Liu H

更新日期：2018-06-01 00:00:00

abstract：:Glioblastoma is one of the most malignant cancers, with a distinguishing dismal prognosis: surgery followed by chemo- and radiotherapy represents the current standard of care, and chemo- and radioresistance underlie disease recurrence and short overall survival of patients suffering from this malignancy. ATM is a kina...

journal_title：Journal of cellular biochemistry

authors： Romano FJ,Guadagno E,Solari D,Borrelli G,Pignatiello S,Cappabianca P,Del Basso De Caro M

更新日期：2018-06-01 00:00:00

abstract：:The cholesterol hydroxylase/lyase (CHL) system, consisting of cytochrome P450scc, adrenodoxin (Adx) and adrenodoxin reductase (AdR), initiates mammalian steroidogenesis, converting cholesterol to pregnenolone. The foot-and-mouth disease virus 2A-based method allows to express multiple proteins from a single transcript...

journal_title：Journal of cellular biochemistry

authors： Efimova VS,Isaeva LV,Labudina AA,Tashlitsky VN,Rubtsov MA,Novikova LA

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood. METHODS:The blood lnc...

journal_title：Journal of cellular biochemistry

authors： Sheng Y,Ma J,Zhao J,Qi S,Hu R,Yang Q

更新日期：2019-06-01 00:00:00

abstract：:Lipopolysaccharide (LPS) released from gram-negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS-induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular...

journal_title：Journal of cellular biochemistry

authors： Tsai KD,Lee WX,Chen W,Chen BY,Chen KL,Hsiao TC,Wang SH,Lee YJ,Liang SY,Shieh JC,Lin TH

更新日期：2018-04-01 00:00:00

abstract：:The F1F0 ATP synthase has recently become the focus of anti-cancer research. It was once thought that ATP synthases were located strictly on the inner mitochondrial membrane; however, in 1994, it was found that some ATP synthases localized to the cell surface. The cell surface ATP synthases are involved in angiogenesi...

journal_title：Journal of cellular biochemistry

authors： Wang WJ,Shi XX,Liu YW,He YQ,Wang YZ,Yang CX,Gao F

更新日期：2013-07-01 00:00:00

abstract：:The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibro...

journal_title：Journal of cellular biochemistry

authors： Weich HA,Iberg N,Klagsbrun M,Folkman J

更新日期：1991-10-01 00:00:00

abstract：:Ubiquitin activating enzyme 2 (UBA2) is a basic component of E1-activating enzyme in the SUMOylation system. Expression and function of UBA2 in human cancers are largely unknown. In this study we investigate UBA2 expression the function in human non-small-cell lung cancer. Immunochemistry study showed that UBA2 was ov...

journal_title：Journal of cellular biochemistry

authors： Jiang B,Fan X,Zhang D,Liu H,Fan C

更新日期：2019-08-01 00:00:00

abstract：:Diclofenac is the most commonly used phenylacetic acid derivative non-steroidal anti-inflammatory drug (NSAID) that demonstrates significant analgesic, antipyretic, and anti-inflammatory effects. Several epidemiological studies have demonstrated anti-proliferative activity of NSAIDs and examined their apoptotic induct...

journal_title：Journal of cellular biochemistry

authors： Amanullah A,Upadhyay A,Chhangani D,Joshi V,Mishra R,Yamanaka K,Mishra A

更新日期：2017-05-01 00:00:00