The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis.

abstract：:Scaffolds porosity has an important role in in vitro and in vivo differentiation process of stem cells with given the amount of space available to the cells to proliferate and differentiate. In the present study, chitosan with three porosities including 10%, 15%, and 20% that created by gelatin were used for investiga...

journal_title：Journal of cellular biochemistry

authors： Ardeshirylajimi A,Delgoshaie M,Mirzaei S,Khojasteh A

更新日期：2018-01-01 00:00:00

abstract：:To evaluate the diagnosis and prognosis of the tumor microenvironment (immunization and stromal cells) in kidney renal clear cell carcinoma (KIRC), KIRC cases selected from The Cancer Genome Atlas database were divided into two groups according to the ESTIMATE algorithm-derived immune scores. Our data suggested that t...

journal_title：Journal of cellular biochemistry

authors： Li S,Xu W

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood. METHODS:The blood lnc...

journal_title：Journal of cellular biochemistry

authors： Sheng Y,Ma J,Zhao J,Qi S,Hu R,Yang Q

更新日期：2019-06-01 00:00:00

abstract：:The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bones, and it's crucial to understand the mechanism of tumor progression to metastasis in order to develop therapies that may reduce the morbidity and mortality of PCa patients. Although we had identified that microRNA(miR)-14...

journal_title：Journal of cellular biochemistry

authors： Guo W,Ren D,Chen X,Tu X,Huang S,Wang M,Song L,Zou X,Peng X

更新日期：2013-07-01 00:00:00

abstract：:The activated c-Ha-rasVal12 oncogene is often involved in the genesis of human malignancies. We show here that in c-Ha-rasVal12 oncogene-transformed mouse NIH 3T3 fibroblasts the copy number and expression level of the mutant ras oncogene correlates with the degree of chromatin decondensation, as assessed by micrococc...

journal_title：Journal of cellular biochemistry

authors： Laitinen J,Sistonen L,Alitalo K,Hölttä E

更新日期：1995-01-01 00:00:00

abstract：:Bruton's tyrosine kinase (Btk) plays a crucial role in the maturation and differentiation of B-lymphocytes and immunoglobulin synthesis. Recently Btk has been described to be present in significant amount in human platelets. To investigate the regulation of this kinase in the platelets we studied its subcellular redis...

journal_title：Journal of cellular biochemistry

authors： Mukhopadhyay S,Ramars AS,Dash D

更新日期：2001-01-01 00:00:00

abstract：:Muscular dystrophies are characterized by continuous cycles of degeneration and regeneration that result in extensive fibrosis and a progressive diminution of muscle mass. Cell surface heparan sulfate proteoglycans are found almost ubiquitously on the surface and in the extracellular matrix (ECM) of mammalian cells. T...

journal_title：Journal of cellular biochemistry

authors： Alvarez K,Fadic R,Brandan E

更新日期：2002-01-01 00:00:00

abstract：:Long-term treatment with heparin has been associated with an increased risk of osteoporosis. Given the importance of heparan sulfate proteoglycans for bone metabolism, it can be anticipated that heparin due to its structural similarity with heparan sulfate chains somehow interferes with the biological activities of th...

journal_title：Journal of cellular biochemistry

authors： Hausser HJ,Brenner RE

更新日期：2004-04-01 00:00:00

abstract：:Oncostatin M (OSM) is a member of the interleukin (IL)-6 family cytokines. We previously demonstrated that OSM induces blood-brain barrier (BBB) impairment. However, functional characterization of IL-6 family cytokines in BBB regulation and the cytokine-related intracellular signaling pathway remain unclear. In this s...

journal_title：Journal of cellular biochemistry

authors： Takata F,Dohgu S,Matsumoto J,Machida T,Sakaguchi S,Kimura I,Yamauchi A,Kataoka Y

更新日期：2018-11-01 00:00:00

abstract：:Embryonic data and ultrastructural analyses suggest that the primitive endothelium signals undifferentiated mesenchymal cells to migrate to the forming blood vessel and subsequently regulates mural cell growth and behavior. Upon maturation of the blood vessel, chemotactic and mitogenic signals are apparently diminishe...

journal_title：Journal of cellular biochemistry

authors： Dodge AB,Lu X,D'Amore PA

更新日期：1993-09-01 00:00:00

abstract：:It is known that the MyoD family members (MyoD, Myf5, myogenin, and MRF4) play a pivotal role in the complex mechanism of skeletal muscle cell differentiation. However, fragmentary information on transcription factor-specific regulation is available and data on their post-transcriptional and post-translational behavio...

journal_title：Journal of cellular biochemistry

authors： Ferri P,Barbieri E,Burattini S,Guescini M,D'Emilio A,Biagiotti L,Del Grande P,De Luca A,Stocchi V,Falcieri E

更新日期：2009-12-15 00:00:00

abstract：:The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances pe...

journal_title：Journal of cellular biochemistry

authors： Reddi AH

更新日期：1994-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) is the most common of the hepatitis viruses that cause chronic liver infections in humans and it is considered a major global health problem. However, the mechanisms of HBV replication are complex and not yet fully understood. In this study, the HBV DNA-transfected HepG2.2.15 cell line and its ...

journal_title：Journal of cellular biochemistry

authors： Tong SW,Yang YX,Hu HD,An X,Ye F,Ren H,Li SL,Zhang DZ

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) has a high morbidity and mortality around the world, yet the effective therapeutic option for HCC is still limited. NPAC, also known as glyoxylate reductase 1 homolog, is a new nuclear protein recently implicated in tumor biology. However, the role of NPAC in HCC remains unclear...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Sun N,Guo W,Wu X,Yang X,Jin H,Zhang Y,Wu X,Zhang F,Hu L,Hu H,Gao Y

更新日期：2018-11-26 00:00:00

abstract：:Arsenic trioxide (ATO) is a first-line anti-cancer agent for acute promyelocytic leukemia, and induces apoptosis in other solid cancer cell lines including breast cancer cells. However, as with arsenites found in drinking water and used as raw materials for wood preservatives, insecticides, and herbicides, low doses o...

journal_title：Journal of cellular biochemistry

authors： Liu Y,Hock JM,Sullivan C,Fang G,Cox AJ,Davis KT,Davis BH,Li X

更新日期：2010-12-15 00:00:00

abstract：:Breast cancer cells preferentially metastasize to bone, leading to the formation of primarily osteolytic lesions. Osteoprotegerin (OPG) plays multifactorial roles in the development of osteolytic bone metastases. An increase in the ratio of receptor activator of nuclear factor kappaB ligand (RANKL) to OPG increases os...

journal_title：Journal of cellular biochemistry

authors： Kapoor P,Suva LJ,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:The DNA tumor virus oncogenes (adenovirus E1A, simian virus 40 (SV40) large T antigen, and papillomavirus E7) have been instrumental in illuminating the molecules and mechanisms of cell cycle progression and carcinogenesis. However, since these multifunctional proteins target so many important cellular regulators, it ...

journal_title：Journal of cellular biochemistry

authors： Kalejta RF

更新日期：2004-09-01 00:00:00

abstract：:We studied how deficiency in lamins A/C and lamina-associated polypeptide 2α (Lap2α) affects DNA repair after irradiation. A-type lamins and Lap2α were not recruited to local DNA lesions and did not accumulate to γ-irradiation-induced foci (IRIF), as it is generally observed for well-known marker of DNA lesions, 53BP1...

journal_title：Journal of cellular biochemistry

authors： Bártová E,Legartová S,Krejčí J,Řezníčková P,Kovaříková AS,Suchánková J,Fedr R,Smirnov E,Hornáček M,Raška I

更新日期：2018-11-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) action is known to be initiated by its binding to multiple cell surface receptors containing serine/threonine kinase domains that act to stimulate a cascade of signaling events in a variety of cell types. We have previously shown that TGF-beta1 and BMP-2 treatment of primar...

journal_title：Journal of cellular biochemistry

authors： Nesti LJ,Caterson EJ,Li WJ,Chang R,McCann TD,Hoek JB,Tuan RS

更新日期：2007-05-15 00:00:00

abstract：:The early 1980s revelation of cis-acting genomic elements, known as transcriptional enhancers, is still regarded as one of the fundamental discoveries in the genomic field. However, only with the emergence of genome-wide techniques has the genuine biological scope of enhancers begun to be fully uncovered. Massive scie...

journal_title：Journal of cellular biochemistry

authors： Blum R

更新日期：2014-11-01 00:00:00

abstract：:Bone formation in the embryo, and during adult fracture repair and remodeling, involves the progeny of a small number of cells called mesenchymal stem cells (MSCs). These cells continuously replicate themselves, while a portion become committed to mesenchymal cell lineages such as bone, cartilage, tendon, ligament, an...

journal_title：Journal of cellular biochemistry

authors： Bruder SP,Fink DJ,Caplan AI

更新日期：1994-11-01 00:00:00

abstract：:Expression of cyclin, a non-histone nuclear protein, during recombinant interleukin 2 (rIL2)-driven cell-cycle progression of cloned T lymphocytes has been assessed. We found that expression of cyclin protein, as detected by immunofluorescence, is tightly associated with proliferation, and not merely S-phase, of L2 ce...

journal_title：Journal of cellular biochemistry

authors： Shipman PM,Sabath DE,Fischer AH,Comber PG,Sullivan K,Tan EM,Prystowsky MB

更新日期：1988-11-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a matrix protein that has been implicated in mechanisms of tumor progression. Our laboratory previously showed that the CSVTCG (cys-ser-val-thr-cys-gly) sequence of TSP-1 functioned as a tumor cell adhesion domain and CSVTCG peptides as well as an anti-peptide antibody possessed anti-metast...

journal_title：Journal of cellular biochemistry

authors： Zhou J,Rothman VL,Sargiannidou I,Dimitrov S,Qiu C,Smith E,Sheffield J,Sharma M,Tuszynski GP

更新日期：2004-05-01 00:00:00

abstract：:We characterized a human cDNA clone encoding a 36-kDa carboxyl terminal LIM domain protein with a PDZ domain at the amino terminal. This full-length cDNA clone has a predicted open reading frame (ORF) of 329 amino-acid residues. The ORF of this cDNA encodes the human homolog of rat CLP36, and the putative protein is n...

journal_title：Journal of cellular biochemistry

authors： Kotaka M,Ngai SM,Garcia-Barcelo M,Tsui SK,Fung KP,Lee CY,Waye MM

更新日期：1999-02-01 00:00:00

abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

journal_title：Journal of cellular biochemistry

authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

更新日期：1989-02-01 00:00:00

abstract：:As the aged population is soaring, prevalence of osteoporosis is increasing. However, the molecular basis underlying the regulation of bone mass is still incompletely understood. Sympathetic tone acts via beta2 adrenergic receptors in bone and regulates the mass of bone which is the target organ of parathyroid hormone...

journal_title：Journal of cellular biochemistry

authors： Moriya S,Hayata T,Notomi T,Aryal S,Nakamaoto T,Izu Y,Kawasaki M,Yamada T,Shirakawa J,Kaneko K,Ezura Y,Noda M

更新日期：2015-01-01 00:00:00

abstract：:The study aims to investigate the analgesic effects of microRNA-129-5p (miR-129-5p) on bone cancer pain (BCP) by targeting Eph receptor B1 (EphB1) through the EphB1/EphrinB2 signaling pathway. BCP mice models were established, and C3H/HeJ female mice were classified into the normal, blank, negative control (NC), miR-1...

journal_title：Journal of cellular biochemistry

authors： Yu SN,Liu GF,Li LY,Zhao GQ,Liu L,Li XF

更新日期：2019-03-01 00:00:00

abstract：:Long noncoding RNA HOXD cluster antisense RNA 1 (HOXD-AS1) has been found to play a crucial role in the tumorigenesis and progression of human cancer. However, the role of HOXD-AS1 in papillary thyroid cancer is still unknown. The purpose of this study was to investigate the clinical value and biological function of H...

journal_title：Journal of cellular biochemistry

authors： Xu K,Feng Y

更新日期：2019-04-01 00:00:00

abstract：:Regulation of mesenchymal stem cell (MSC) lineage selection is important for the generation of bone mass. Inhibition of cyclooxygenase-2 (COX2) may increase adipogenesis at the cost of decreasing osteoprogenitor output. Here we investigated the role of COX2 and its products during MSC differentiation. Indomethacin sti...

journal_title：Journal of cellular biochemistry

authors： Styner M,Sen B,Xie Z,Case N,Rubin J

更新日期：2010-11-01 00:00:00

abstract：:Receptor activator of NF-kappaB ligand (RANKL) is crucial in osteoclastogenesis but signaling events involved in osteoclast differentiation are far from complete and other signals may play a role in osteoclastogenesis. A more direct pathway for cellular crosstalk is provided by gap junction intercellular channel, whic...

journal_title：Journal of cellular biochemistry

authors： Matemba SF,Lie A,Ransjö M

更新日期：2006-10-01 00:00:00